DE3683541D1 - Selektionierte difluorverbindungen. - Google Patents
Selektionierte difluorverbindungen.Info
- Publication number
- DE3683541D1 DE3683541D1 DE8686304296T DE3683541T DE3683541D1 DE 3683541 D1 DE3683541 D1 DE 3683541D1 DE 8686304296 T DE8686304296 T DE 8686304296T DE 3683541 T DE3683541 T DE 3683541T DE 3683541 D1 DE3683541 D1 DE 3683541D1
- Authority
- DE
- Germany
- Prior art keywords
- difluor
- compounds
- derivatives
- difluoroketone
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858514438A GB8514438D0 (en) | 1985-06-07 | 1985-06-07 | Selected difluoro ketone dipeptide derivatives |
GB858514436A GB8514436D0 (en) | 1985-06-07 | 1985-06-07 | Selected difluoro derivatives |
GB858514440A GB8514440D0 (en) | 1985-06-07 | 1985-06-07 | Difluoro ketone tripeptide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3683541D1 true DE3683541D1 (de) | 1992-03-05 |
Family
ID=27262698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686304296T Expired - Fee Related DE3683541D1 (de) | 1985-06-07 | 1986-06-05 | Selektionierte difluorverbindungen. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4880780A (de) |
EP (1) | EP0204571B1 (de) |
JP (1) | JPH07116159B2 (de) |
AT (1) | ATE71934T1 (de) |
AU (1) | AU594683B2 (de) |
DE (1) | DE3683541D1 (de) |
DK (1) | DK267686A (de) |
ES (4) | ES8801305A1 (de) |
FI (1) | FI86859C (de) |
GR (1) | GR861488B (de) |
HU (1) | HU208438B (de) |
IE (1) | IE59146B1 (de) |
IL (1) | IL79049A0 (de) |
NO (1) | NO170585C (de) |
NZ (1) | NZ216437A (de) |
PT (1) | PT82724B (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
GB8613703D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro peptide compounds |
DE3782191T2 (de) * | 1986-06-05 | 1993-02-25 | Ici America Inc | Difluorketoverbindungen. |
GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
EP0371179A1 (de) * | 1988-10-28 | 1990-06-06 | Merrell Dow Pharmaceuticals Inc. | Analoge von Peptidase-Substraten |
EP0369391A3 (de) * | 1988-11-15 | 1991-09-25 | Boehringer Ingelheim Pharmaceuticals Inc. | N-substituierte Amide |
GB8910547D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted ketones |
US5221665A (en) * | 1989-10-27 | 1993-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | N-substituted amides |
US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
WO1992020357A1 (en) * | 1991-05-23 | 1992-11-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of cathepsin g and elastase for preventing connective tissue degradation |
US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
DE69522940T2 (de) * | 1994-06-02 | 2002-04-04 | Merrell Pharma Inc | Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren |
ATE246708T1 (de) * | 1994-06-02 | 2003-08-15 | Aventis Pharma Inc | Elatase-inhibitoren |
EP0763055B1 (de) * | 1994-06-02 | 1999-11-03 | Merrell Pharmaceuticals Inc. | Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung |
US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
US6673784B1 (en) | 1996-03-19 | 2004-01-06 | G. D. Searle & Co. | Electrophilic ketones for the treatment of herpesvirus infections |
US5739354A (en) * | 1996-03-26 | 1998-04-14 | Hoechst Marion Roussel, Inc. | Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide |
NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
CN102614490A (zh) | 2006-02-27 | 2012-08-01 | 弗特克斯药品有限公司 | 包含vx-950的共晶体和包含所述共晶体的药物组合物 |
EP2194039A1 (de) * | 2006-03-16 | 2010-06-09 | Vertex Pharmceuticals Incorporated | Verfahren zur Herstellung optisch aktiver Verbindungen |
CN101534824A (zh) * | 2006-11-17 | 2009-09-16 | 艾博特公司 | 作为化学活素受体拮抗剂的氨基吡咯烷 |
WO2008106151A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
EP2134717A2 (de) | 2007-02-27 | 2009-12-23 | Vertex Pharmceuticals Incorporated | Serinprotease-hemmer |
CL2008002549A1 (es) | 2007-08-30 | 2010-09-03 | Vertex Pharma | Cocristal que comprende vx-950 y un formador de cocristal seleccionado de acido 3-metoxi-4hidroxibenzoico,acido 2,4-dihidroxibenzoico y acido 2,5-dihidroxibenzoico; metodo de preparacion; composicion farmaceutica que comprende el cocristal, util como agente antiviral en el tratamiento del hcv. |
US8623358B2 (en) | 2009-08-29 | 2014-01-07 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
EP2542582A4 (de) | 2010-03-02 | 2013-12-04 | Abbvie Inc | Therapeutische dll4-bindende proteine |
CN103298834A (zh) | 2010-08-03 | 2013-09-11 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
PE20151179A1 (es) | 2012-11-01 | 2015-09-12 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
EP3994148A1 (de) * | 2019-07-01 | 2022-05-11 | Basf Se | Peptideacetale zur stabilisierung von enzymen |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE787249A (fr) | 1971-08-05 | 1973-02-05 | Squibb & Sons Inc | Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation |
US3935280A (en) | 1975-01-10 | 1976-01-27 | Aldrich-Boranes, Inc. | Reduction of amino acids in the presence of boron trifluoride |
US4277395A (en) * | 1980-06-16 | 1981-07-07 | Richardson-Merrell Inc. | Novel enzyme inhibitors |
DE3481913D1 (de) | 1983-04-27 | 1990-05-17 | Ici America Inc | Prolin-derivate. |
US4518528A (en) * | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1986
- 1986-06-05 EP EP86304296A patent/EP0204571B1/de not_active Expired - Lifetime
- 1986-06-05 DE DE8686304296T patent/DE3683541D1/de not_active Expired - Fee Related
- 1986-06-05 AT AT86304296T patent/ATE71934T1/de not_active IP Right Cessation
- 1986-06-06 JP JP61130457A patent/JPH07116159B2/ja not_active Expired - Fee Related
- 1986-06-06 NZ NZ216437A patent/NZ216437A/xx unknown
- 1986-06-06 IL IL79049A patent/IL79049A0/xx unknown
- 1986-06-06 FI FI862434A patent/FI86859C/fi not_active IP Right Cessation
- 1986-06-06 ES ES555826A patent/ES8801305A1/es not_active Expired
- 1986-06-06 DK DK267686A patent/DK267686A/da not_active Application Discontinuation
- 1986-06-06 AU AU58454/86A patent/AU594683B2/en not_active Ceased
- 1986-06-06 HU HU862393A patent/HU208438B/hu not_active IP Right Cessation
- 1986-06-06 GR GR861488A patent/GR861488B/el unknown
- 1986-06-06 NO NO862269A patent/NO170585C/no unknown
- 1986-06-06 IE IE151386A patent/IE59146B1/en not_active IP Right Cessation
- 1986-06-06 PT PT82724A patent/PT82724B/pt not_active IP Right Cessation
-
1987
- 1987-06-04 US US07/058,079 patent/US4880780A/en not_active Expired - Lifetime
- 1987-09-16 ES ES557735A patent/ES8802321A1/es not_active Expired
- 1987-09-16 ES ES557733A patent/ES8802619A1/es not_active Expired
- 1987-09-16 ES ES557734A patent/ES8900051A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK267686D0 (da) | 1986-06-06 |
NO862269D0 (no) | 1986-06-06 |
ATE71934T1 (de) | 1992-02-15 |
NZ216437A (en) | 1990-06-26 |
FI862434A (fi) | 1986-12-08 |
ES555826A0 (es) | 1987-12-16 |
IE59146B1 (en) | 1994-01-12 |
PT82724A (en) | 1986-07-01 |
NO170585B (no) | 1992-07-27 |
IL79049A0 (en) | 1986-09-30 |
ES8801305A1 (es) | 1987-12-16 |
ES8802619A1 (es) | 1988-09-01 |
NO862269L (no) | 1986-12-08 |
AU5845486A (en) | 1986-12-18 |
FI86859C (fi) | 1992-10-26 |
ES8802321A1 (es) | 1988-05-01 |
PT82724B (pt) | 1988-12-15 |
US4880780A (en) | 1989-11-14 |
JPH07116159B2 (ja) | 1995-12-13 |
HUT40811A (en) | 1987-02-27 |
ES557734A0 (es) | 1988-11-16 |
ES8900051A1 (es) | 1988-11-16 |
GR861488B (en) | 1986-09-05 |
FI86859B (fi) | 1992-07-15 |
DK267686A (da) | 1986-12-08 |
EP0204571A3 (en) | 1988-09-21 |
AU594683B2 (en) | 1990-03-15 |
EP0204571B1 (de) | 1992-01-22 |
HU208438B (en) | 1993-10-28 |
EP0204571A2 (de) | 1986-12-10 |
FI862434A0 (fi) | 1986-06-06 |
IE861513L (en) | 1986-12-07 |
NO170585C (no) | 1992-11-04 |
ES557735A0 (es) | 1988-05-01 |
ES557733A0 (es) | 1988-09-01 |
JPS6253951A (ja) | 1987-03-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |