DK0863916T3 - Polyfluoralkyl-tryptohantripeptid-thrombininhibitorer - Google Patents

Polyfluoralkyl-tryptohantripeptid-thrombininhibitorer

Info

Publication number: DK0863916T3
Authority: DK; Denmark
Prior art keywords: tryptohantripeptid; polyfluoroalkyl; thrombin
Prior art date: 1995-10-02

Application number

DK96931485T

Other languages

Danish (da)

English (en)

Inventor

Joy Antony Malikayl

Joseph Paul Burkhart

Robert James Broersma

Norton Paul Peet

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-02

Filing date

1996-09-06

Publication date

2002-07-29

1996-09-06 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-07-29 Application granted granted Critical

2002-07-29 Publication of DK0863916T3 publication Critical patent/DK0863916T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DK96931485T 1995-10-02 1996-09-06 Polyfluoralkyl-tryptohantripeptid-thrombininhibitorer DK0863916T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US475595P	1995-10-02	1995-10-02
US56661595A	1995-12-04	1995-12-04
US08/698,931 US6069232A (en)	1995-10-02	1996-08-26	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
PCT/US1996/014363 WO1997012904A1 (en)	1995-10-02	1996-09-06	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors

Publications (1)

Publication Number	Publication Date
DK0863916T3 true DK0863916T3 (da)	2002-07-29

Family

ID=27357700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96931485T DK0863916T3 (da)	1995-10-02	1996-09-06	Polyfluoralkyl-tryptohantripeptid-thrombininhibitorer

Country Status (19)

Country	Link
US (1)	US6069232A (pt)
EP (1)	EP0863916B1 (pt)
KR (1)	KR19990063942A (pt)
CN (1)	CN1137134C (pt)
AR (1)	AR003756A1 (pt)
AT (1)	ATE215963T1 (pt)
AU (1)	AU700312B2 (pt)
CA (1)	CA2233698C (pt)
DE (1)	DE69620627T2 (pt)
DK (1)	DK0863916T3 (pt)
ES (1)	ES2171717T3 (pt)
HK (1)	HK1015797A1 (pt)
HU (1)	HUP9901290A3 (pt)
IL (1)	IL123597A (pt)
NO (1)	NO981468L (pt)
NZ (1)	NZ318627A (pt)
PT (1)	PT863916E (pt)
TW (1)	TW339335B (pt)
WO (1)	WO1997012904A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6214841B1 (en)	1997-05-15	2001-04-10	Eli Lilly And Company	Antithrombotic compound
EP1051431A1 (de)	1998-01-26	2000-11-15	Basf Aktiengesellschaft	Thrombininhibitoren
YU42401A (sh) *	1998-12-14	2003-12-31	Ortho-Mcneil Pharmaceuticals Inc.	Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
GB0408164D0 (en) *	2004-04-13	2004-05-19	Immune Targeting Systems Ltd	Antigen delivery vectors and constructs
GB0716992D0 (en)	2007-08-31	2007-10-10	Immune Targeting Systems Its L	Influenza antigen delivery vectors and constructs
PE20141295A1 (es) *	2011-11-29	2014-10-01	Perosphere Inc	Agentes de reversion anticoagulante
CN103450067B (zh) *	2012-05-29	2015-01-07	首都医科大学	乙基连接的双吲哚-3-基-乙酰氨基酸、其制备、抗血栓作用和应用
EP3684417A1 (en) *	2017-09-19	2020-07-29	Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.	Lipophilic peptide prodrugs
EP3684785A1 (en)	2017-09-19	2020-07-29	Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.	N-methylated cyclic peptides and their prodrugs
US11261215B2 (en)	2017-09-19	2022-03-01	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Somatostatin prodrugs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4247454A (en) *	1975-07-11	1981-01-27	Ab Kabi	Novel chromogenic thrombin substrates
US4061625A (en) *	1975-07-11	1977-12-06	Ab Kabi	Novel chromogenic thrombin substrates
US4275153A (en) *	1978-08-03	1981-06-23	American Hospital Supply Corporation	Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) *	1978-12-18	1980-08-05	Abbott Laboratories	Chromogenic substrates for the proteolytic enzymes
US4217269A (en) *	1979-03-23	1980-08-12	Abbott Laboratories	Dipeptide chromogenic substrates
US4221706A (en) *	1979-06-14	1980-09-09	Abbott Laboratories	Chromogenic substrates
US4318904A (en) *	1980-04-25	1982-03-09	Research Corporation	Peptide affinity labels for thrombin and other trypsin-like proteases
HU184368B (en) *	1981-01-13	1984-08-28	Gyogyszerkutato Intezet	Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
JPS5856695A (ja) *	1981-09-28	1983-04-04	Nitto Boseki Co Ltd	新規なトロンビン測定用基質
FR2550447B1 (fr) *	1983-08-10	1986-01-17	Ile De France	Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
US4643991A (en) *	1984-12-18	1987-02-17	The University Of Kentucky Research Foundation	Peptide elastase inhibitors and methods
HU192646B (en) *	1984-12-21	1987-06-29	Gyogyszerkutato Intezet	Process for preparing new n-alkyl-peptide aldehydes
FR2575753B1 (fr) *	1985-01-07	1987-02-20	Adir	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1341029C (en) *	1985-02-04	2000-06-20	Michael Kolb	Peptidase inhibitors
DE3505555A1 (de) *	1985-02-18	1986-09-11	Behringwerke Ag, 3550 Marburg	Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4762821A (en) *	1985-03-22	1988-08-09	Syntex (U.S.A.) Inc.	N',N"-dialkylguanidino dipeptides
DE3683541D1 (de) *	1985-06-07	1992-03-05	Ici America Inc	Selektionierte difluorverbindungen.
JPS62126197A (ja) *	1985-11-26	1987-06-08	Nitto Boseki Co Ltd	新規な血漿キニノゲナーゼ測定用化合物
FR2598412B1 (fr) *	1986-03-12	1988-10-21	Sanofi Sa	Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
NZ220173A (en) *	1986-05-09	1990-01-29	Dainippon Pharmaceutical Co	Tripeptide derivatives as antihypertensive agents;processes for their preparation and pharmaceutical compositions thereof
EP0253190B1 (en) *	1986-07-16	1992-12-30	ENIRICERCHE S.p.A.	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
US4929602A (en) *	1987-11-25	1990-05-29	Scripps Clinic And Research Foundation	Method of inhibiting platelet dependent arterial thrombosis
ZA905737B (en) *	1989-07-26	1991-05-29	Merrell Dow Pharma	Novel peptidase inhibitors
US5053392A (en) *	1989-12-01	1991-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
EP0498508A1 (en) *	1991-02-04	1992-08-12	Akzo Nobel N.V.	Factor IIa inhibitors
EP0503203A1 (en) *	1991-03-15	1992-09-16	Merrell Dow Pharmaceuticals Inc.	Novel thrombin inhibitors
US5391705A (en) *	1991-03-15	1995-02-21	Merrell Dow Pharmaceuticals Inc.	Polyfluorinated tripeptide thrombin inhibitors
AU670381B2 (en) *	1993-04-30	1996-07-11	Merck & Co., Inc.	Thrombin inhibitors
GB2287027A (en) *	1994-03-04	1995-09-06	Lilly Co Eli	Tripeptide antithrombotic agents

1996
- 1996-08-26 US US08/698,931 patent/US6069232A/en not_active Expired - Lifetime
- 1996-09-06 DE DE69620627T patent/DE69620627T2/de not_active Expired - Fee Related
- 1996-09-06 CN CNB961973862A patent/CN1137134C/zh not_active Expired - Fee Related
- 1996-09-06 HU HU9901290A patent/HUP9901290A3/hu unknown
- 1996-09-06 AT AT96931485T patent/ATE215963T1/de not_active IP Right Cessation
- 1996-09-06 NZ NZ318627A patent/NZ318627A/xx unknown
- 1996-09-06 PT PT96931485T patent/PT863916E/pt unknown
- 1996-09-06 ES ES96931485T patent/ES2171717T3/es not_active Expired - Lifetime
- 1996-09-06 EP EP96931485A patent/EP0863916B1/en not_active Expired - Lifetime
- 1996-09-06 DK DK96931485T patent/DK0863916T3/da active
- 1996-09-06 AU AU70154/96A patent/AU700312B2/en not_active Ceased
- 1996-09-06 IL IL12359796A patent/IL123597A/xx not_active IP Right Cessation
- 1996-09-06 KR KR1019980702415A patent/KR19990063942A/ko active IP Right Grant
- 1996-09-06 CA CA002233698A patent/CA2233698C/en not_active Expired - Fee Related
- 1996-09-06 WO PCT/US1996/014363 patent/WO1997012904A1/en active IP Right Grant
- 1996-09-30 TW TW085111905A patent/TW339335B/zh active
- 1996-10-01 AR ARP960104555A patent/AR003756A1/es not_active Application Discontinuation
1998
- 1998-04-01 NO NO981468A patent/NO981468L/no not_active Application Discontinuation
1999
- 1999-03-09 HK HK99100976A patent/HK1015797A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0863916B1 (en)	2002-04-10
CA2233698C (en)	2002-04-09
IL123597A (en)	2003-01-12
CA2233698A1 (en)	1997-04-10
NZ318627A (en)	1999-11-29
ES2171717T3 (es)	2002-09-16
WO1997012904A1 (en)	1997-04-10
AU7015496A (en)	1997-04-28
ATE215963T1 (de)	2002-04-15
EP0863916A1 (en)	1998-09-16
HUP9901290A3 (en)	1999-11-29
NO981468D0 (no)	1998-04-01
AU700312B2 (en)	1998-12-24
DE69620627D1 (en)	2002-05-16
CN1137134C (zh)	2004-02-04
KR19990063942A (ko)	1999-07-26
HUP9901290A2 (hu)	1999-08-30
IL123597A0 (en)	1998-10-30
US6069232A (en)	2000-05-30
TW339335B (en)	1998-09-01
HK1015797A1 (en)	1999-10-22
PT863916E (pt)	2002-07-31
CN1198748A (zh)	1998-11-11
AR003756A1 (es)	1998-09-09
NO981468L (no)	1998-04-01
DE69620627T2 (de)	2002-10-17

Publication	Publication Date	Title
BR9609324A (pt)	1999-05-25	Macrolidas
BR9607795A (pt)	1998-07-07	Fucopeptídeos
ATA135896A (de)	2001-02-15	Skibob
DK0863916T3 (da)	2002-07-29	Polyfluoralkyl-tryptohantripeptid-thrombininhibitorer
BR9605387A (pt)	1998-07-28	1-azinil-tetrazolinonas
BR9603509A (pt)	1998-05-12	Piperidinilmetiloxazolidinonas
ATE198470T1 (de)	2001-01-15	Alkenyl-benzoylguanidine
BR9605050A (pt)	1998-06-30	Filatório
ATE240972T1 (de)	2003-06-15	Cyclopeptolide
ATA119896A (de)	2002-04-15	Scheibenmähwerk
BR9503866A (pt)	1997-10-14	Autolabor
BR9501643A (pt)	1997-09-16	Helistato
FI2028U1 (fi)	1995-07-20	Traedgaordsgunga
FI2193U1 (fi)	1995-11-21	Underlag
BR7500838U (pt)	1997-05-13	Vassourágua
BR7500437U (pt)	1997-05-13	Girolight
BR7501303U (pt)	1997-09-16	Dupla-embalagem
BR7502937U (pt)	1998-05-19	Floco-decantador multicone
BR7501299U (pt)	1997-09-16	Geladeira-prática
SE9503418D0 (sv)	1995-10-03	Distansnajen
FI955931A0 (fi)	1995-12-11	Stomme
BR7501376U (pt)	1997-09-16	Massarreal
BR7501298U (pt)	1997-09-16	Torre-audio-visual
BR7500991U (pt)	1996-06-18	Caríndio
BR9500075A (pt)	1996-12-10	Carrapetilha