DE69620627T2 - Polyfluoralkyl-tryptiphan tripeptid thrombin hemmer - Google Patents

Polyfluoralkyl-tryptiphan tripeptid thrombin hemmer

Info

Publication number
DE69620627T2
DE69620627T2 DE69620627T DE69620627T DE69620627T2 DE 69620627 T2 DE69620627 T2 DE 69620627T2 DE 69620627 T DE69620627 T DE 69620627T DE 69620627 T DE69620627 T DE 69620627T DE 69620627 T2 DE69620627 T2 DE 69620627T2
Authority
DE
Germany
Prior art keywords
tryptiphane
tripeptid
polyfluoralkyl
hemmer
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620627T
Other languages
English (en)
Other versions
DE69620627D1 (en
Inventor
Joy Antony Malikayl
Joseph Paul Burkhart
Robert James Broersma
Norton Paul Peet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE69620627D1 publication Critical patent/DE69620627D1/de
Application granted granted Critical
Publication of DE69620627T2 publication Critical patent/DE69620627T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69620627T 1995-10-02 1996-09-06 Polyfluoralkyl-tryptiphan tripeptid thrombin hemmer Expired - Fee Related DE69620627T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US475595P 1995-10-02 1995-10-02
US56661595A 1995-12-04 1995-12-04
US08/698,931 US6069232A (en) 1995-10-02 1996-08-26 Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
PCT/US1996/014363 WO1997012904A1 (en) 1995-10-02 1996-09-06 Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors

Publications (2)

Publication Number Publication Date
DE69620627D1 DE69620627D1 (en) 2002-05-16
DE69620627T2 true DE69620627T2 (de) 2002-10-17

Family

ID=27357700

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620627T Expired - Fee Related DE69620627T2 (de) 1995-10-02 1996-09-06 Polyfluoralkyl-tryptiphan tripeptid thrombin hemmer

Country Status (19)

Country Link
US (1) US6069232A (de)
EP (1) EP0863916B1 (de)
KR (1) KR19990063942A (de)
CN (1) CN1137134C (de)
AR (1) AR003756A1 (de)
AT (1) ATE215963T1 (de)
AU (1) AU700312B2 (de)
CA (1) CA2233698C (de)
DE (1) DE69620627T2 (de)
DK (1) DK0863916T3 (de)
ES (1) ES2171717T3 (de)
HK (1) HK1015797A1 (de)
HU (1) HUP9901290A3 (de)
IL (1) IL123597A (de)
NO (1) NO981468D0 (de)
NZ (1) NZ318627A (de)
PT (1) PT863916E (de)
TW (1) TW339335B (de)
WO (1) WO1997012904A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289625A1 (en) 1997-05-15 1998-11-19 Charles Van Jackson Antithrombotic compound
EP1051431A1 (de) 1998-01-26 2000-11-15 Basf Aktiengesellschaft Thrombininhibitoren
YU42401A (sh) 1998-12-14 2003-12-31 Ortho-Mcneil Pharmaceuticals Inc. Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB0716992D0 (en) * 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
UA116336C2 (uk) * 2011-11-29 2018-03-12 Перосфіе Фармасьютікалз Інк. Агенти, реверсуючі дію антикоагулянтів
CN103450067B (zh) * 2012-05-29 2015-01-07 首都医科大学 乙基连接的双吲哚-3-基-乙酰氨基酸、其制备、抗血栓作用和应用
US11965041B2 (en) 2017-09-19 2024-04-23 Technische Universitaet Muenchen N-methylated cyclic peptides and their prodrugs
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs
US20200323962A1 (en) * 2017-09-19 2020-10-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipophilic peptide prodrugs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
US4247454A (en) * 1975-07-11 1981-01-27 Ab Kabi Novel chromogenic thrombin substrates
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) * 1978-12-18 1980-08-05 Abbott Laboratories Chromogenic substrates for the proteolytic enzymes
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
EP0204571B1 (de) * 1985-06-07 1992-01-22 Ici Americas Inc. Selektionierte Difluorverbindungen
JPS62126197A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規な血漿キニノゲナーゼ測定用化合物
FR2598412B1 (fr) * 1986-03-12 1988-10-21 Sanofi Sa Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
AU595309B2 (en) * 1986-05-09 1990-03-29 Dainippon Pharmaceutical Co. Ltd. Tripeptide derivatives
DE3783280T2 (de) * 1986-07-16 1993-05-06 Eniricerche Spa Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
US4929602A (en) * 1987-11-25 1990-05-29 Scripps Clinic And Research Foundation Method of inhibiting platelet dependent arterial thrombosis
CA2021660A1 (en) * 1989-07-26 1991-01-27 Philippe Bey Peptidase inhibitors
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
CA2101331A1 (en) * 1991-02-04 1992-08-05 Johannes W.F.M. Van Nispen Factor iia inhibitors
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
EP0503203A1 (de) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Neue Thrombin-Inhibitoren
JP3486412B2 (ja) * 1993-04-30 2004-01-13 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
GB2287027A (en) * 1994-03-04 1995-09-06 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
NO981468L (no) 1998-04-01
DE69620627D1 (en) 2002-05-16
IL123597A (en) 2003-01-12
US6069232A (en) 2000-05-30
IL123597A0 (en) 1998-10-30
NZ318627A (en) 1999-11-29
AU700312B2 (en) 1998-12-24
ES2171717T3 (es) 2002-09-16
CN1198748A (zh) 1998-11-11
EP0863916B1 (de) 2002-04-10
CA2233698C (en) 2002-04-09
ATE215963T1 (de) 2002-04-15
DK0863916T3 (da) 2002-07-29
HUP9901290A2 (hu) 1999-08-30
PT863916E (pt) 2002-07-31
AR003756A1 (es) 1998-09-09
NO981468D0 (no) 1998-04-01
EP0863916A1 (de) 1998-09-16
CN1137134C (zh) 2004-02-04
HK1015797A1 (en) 1999-10-22
TW339335B (en) 1998-09-01
HUP9901290A3 (en) 1999-11-29
CA2233698A1 (en) 1997-04-10
AU7015496A (en) 1997-04-28
WO1997012904A1 (en) 1997-04-10
KR19990063942A (ko) 1999-07-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee