PT3149005T - Derivados de amida de compostos de 1-oxa-4,9-diazaespiro undecano tendo atividade multimodal contra a dor - Google Patents
Derivados de amida de compostos de 1-oxa-4,9-diazaespiro undecano tendo atividade multimodal contra a dorInfo
- Publication number
- PT3149005T PT3149005T PT157252354T PT15725235T PT3149005T PT 3149005 T PT3149005 T PT 3149005T PT 157252354 T PT157252354 T PT 157252354T PT 15725235 T PT15725235 T PT 15725235T PT 3149005 T PT3149005 T PT 3149005T
- Authority
- PT
- Portugal
- Prior art keywords
- oxa
- activity against
- amide derivatives
- against pain
- multimodal activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14382208 | 2014-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3149005T true PT3149005T (pt) | 2018-07-24 |
Family
ID=50972617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT157252354T PT3149005T (pt) | 2014-06-02 | 2015-06-02 | Derivados de amida de compostos de 1-oxa-4,9-diazaespiro undecano tendo atividade multimodal contra a dor |
Country Status (11)
Country | Link |
---|---|
US (1) | US10065971B2 (pt) |
EP (1) | EP3149005B1 (pt) |
JP (1) | JP6516773B2 (pt) |
CN (1) | CN106459083B (pt) |
AR (1) | AR100713A1 (pt) |
CA (1) | CA2949572A1 (pt) |
ES (1) | ES2678770T3 (pt) |
MX (1) | MX360785B (pt) |
PT (1) | PT3149005T (pt) |
TW (1) | TW201615642A (pt) |
WO (1) | WO2015185208A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物 |
TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物 |
EP3221315A1 (en) * | 2014-11-21 | 2017-09-27 | Laboratorios Del. Dr. Esteve, S.A. | 1,9-diazaspiro undecane compounds having multimodal activity against pain |
PL3365346T3 (pl) | 2015-10-23 | 2020-06-01 | Esteve Pharmaceuticals, S.A. | Związki oksa-diazaspiro o działaniu przeciwbólowym |
US10183918B2 (en) * | 2015-10-23 | 2019-01-22 | Laboratorios Del Dr. Esteve S.A. | Oxa-azaspiro compounds having activity against pain |
TWI756196B (zh) | 2015-11-16 | 2022-03-01 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療藥物濫用和成癮之氧雜二氮雜螺環化合物 |
CA3076765A1 (en) | 2017-10-17 | 2019-04-25 | Esteve Pharmaceuticals, S.A. | Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one |
JP7455133B2 (ja) * | 2018-09-27 | 2024-03-25 | シェンチェン チップスクリーン バイオサイエンシズ カンパニー、リミテッド | インドールアミン-2,3-ジオキシゲナーゼ阻害活性を有するキノロン誘導体 |
TW202309006A (zh) * | 2021-04-30 | 2023-03-01 | 西班牙商塔拉森斯調節公司 | 作為sigma配體的新穎吡啶磺醯胺衍生物、其製備方法及用途,以及包含該吡啶-磺醯胺衍生物的醫藥組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4353900A (en) | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones |
DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
EP1982714A1 (en) * | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-amines |
EP2020414A1 (en) * | 2007-06-20 | 2009-02-04 | Laboratorios del Dr. Esteve S.A. | spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis |
ES2394547T3 (es) * | 2008-02-06 | 2013-02-01 | Astrazeneca Ab | Compuestos |
CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
GB201107985D0 (en) * | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
JPWO2013115294A1 (ja) * | 2012-01-31 | 2015-05-11 | 東レ株式会社 | ジアザスピロウレア誘導体及びその医薬用途 |
TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物 |
-
2015
- 2015-05-29 TW TW104117388A patent/TW201615642A/zh unknown
- 2015-06-02 AR ARP150101744A patent/AR100713A1/es unknown
- 2015-06-02 MX MX2016015761A patent/MX360785B/es active IP Right Grant
- 2015-06-02 CN CN201580028856.2A patent/CN106459083B/zh not_active Expired - Fee Related
- 2015-06-02 ES ES15725235.4T patent/ES2678770T3/es active Active
- 2015-06-02 JP JP2016570784A patent/JP6516773B2/ja not_active Expired - Fee Related
- 2015-06-02 EP EP15725235.4A patent/EP3149005B1/en active Active
- 2015-06-02 PT PT157252354T patent/PT3149005T/pt unknown
- 2015-06-02 CA CA2949572A patent/CA2949572A1/en not_active Abandoned
- 2015-06-02 WO PCT/EP2015/001114 patent/WO2015185208A1/en active Application Filing
- 2015-06-02 US US15/315,095 patent/US10065971B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP3149005A1 (en) | 2017-04-05 |
MX2016015761A (es) | 2017-04-10 |
AR100713A1 (es) | 2016-10-26 |
CN106459083A (zh) | 2017-02-22 |
TW201615642A (zh) | 2016-05-01 |
JP6516773B2 (ja) | 2019-05-22 |
ES2678770T3 (es) | 2018-08-17 |
JP2017516817A (ja) | 2017-06-22 |
US10065971B2 (en) | 2018-09-04 |
WO2015185208A1 (en) | 2015-12-10 |
MX360785B (es) | 2018-11-16 |
CN106459083B (zh) | 2019-10-01 |
EP3149005B1 (en) | 2018-04-18 |
CA2949572A1 (en) | 2015-12-10 |
US20170197984A1 (en) | 2017-07-13 |
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