MX360785B - Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor. - Google Patents

Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor.

Info

Publication number
MX360785B
MX360785B MX2016015761A MX2016015761A MX360785B MX 360785 B MX360785 B MX 360785B MX 2016015761 A MX2016015761 A MX 2016015761A MX 2016015761 A MX2016015761 A MX 2016015761A MX 360785 B MX360785 B MX 360785B
Authority
MX
Mexico
Prior art keywords
oxa
compounds
activity against
amide derivatives
against pain
Prior art date
Application number
MX2016015761A
Other languages
English (en)
Other versions
MX2016015761A (es
Inventor
Virgili-Bernado Marina
ALONSO-XALMA Mónica
ALEGRET-MOLINA Carlos
Almansa-Rosales Carmen
Merce-Vidal Ramón
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2016015761A publication Critical patent/MX2016015761A/es
Publication of MX360785B publication Critical patent/MX360785B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos con actividad farmacológica dual contra tanto el receptor sigma (s) como el receptor opioide µ. y más particularmente a compuestos de diazaespiroundecano que presentan esta actividad farmacológica, a procesos para preparar tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor. (ver Fórmula) en donde (ver Fórmula) Y es n es 1 o 2; q es 1, 2, 3, 4, 5 o 6; X es un enlace, -C(O)O-, -C(O)NR8-, -C(O) -, -O- o - C(R4R4')- ; R1 es C(O)R5 o S(O)2R5.
MX2016015761A 2014-06-02 2015-06-02 Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor. MX360785B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382208 2014-06-02
PCT/EP2015/001114 WO2015185208A1 (en) 2014-06-02 2015-06-02 Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain

Publications (2)

Publication Number Publication Date
MX2016015761A MX2016015761A (es) 2017-04-10
MX360785B true MX360785B (es) 2018-11-16

Family

ID=50972617

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015761A MX360785B (es) 2014-06-02 2015-06-02 Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor.

Country Status (11)

Country Link
US (1) US10065971B2 (es)
EP (1) EP3149005B1 (es)
JP (1) JP6516773B2 (es)
CN (1) CN106459083B (es)
AR (1) AR100713A1 (es)
CA (1) CA2949572A1 (es)
ES (1) ES2678770T3 (es)
MX (1) MX360785B (es)
PT (1) PT3149005T (es)
TW (1) TW201615642A (es)
WO (1) WO2015185208A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
EP3221315A1 (en) * 2014-11-21 2017-09-27 Laboratorios Del. Dr. Esteve, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
PL3365346T3 (pl) 2015-10-23 2020-06-01 Esteve Pharmaceuticals, S.A. Związki oksa-diazaspiro o działaniu przeciwbólowym
US10183918B2 (en) * 2015-10-23 2019-01-22 Laboratorios Del Dr. Esteve S.A. Oxa-azaspiro compounds having activity against pain
TWI756196B (zh) 2015-11-16 2022-03-01 西班牙商艾斯提夫製藥股份有限公司 用於治療藥物濫用和成癮之氧雜二氮雜螺環化合物
CA3076765A1 (en) 2017-10-17 2019-04-25 Esteve Pharmaceuticals, S.A. Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
JP7455133B2 (ja) * 2018-09-27 2024-03-25 シェンチェン チップスクリーン バイオサイエンシズ カンパニー、リミテッド インドールアミン－２，３－ジオキシゲナーゼ阻害活性を有するキノロン誘導体
TW202309006A (zh) * 2021-04-30 2023-03-01 西班牙商塔拉森斯調節公司 作為ｓｉｇｍａ配體的新穎吡啶磺醯胺衍生物、其製備方法及用途，以及包含該吡啶－磺醯胺衍生物的醫藥組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353900A (en) 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
EP1982714A1 (en) * 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) * 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
ES2394547T3 (es) * 2008-02-06 2013-02-01 Astrazeneca Ab Compuestos
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺
GB201107985D0 (en) * 2011-05-13 2011-06-29 Astrazeneca Ab Process
JPWO2013115294A1 (ja) * 2012-01-31 2015-05-11 東レ株式会社 ジアザスピロウレア誘導体及びその医薬用途
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物

Also Published As

Publication number Publication date
EP3149005A1 (en) 2017-04-05
MX2016015761A (es) 2017-04-10
AR100713A1 (es) 2016-10-26
CN106459083A (zh) 2017-02-22
TW201615642A (zh) 2016-05-01
JP6516773B2 (ja) 2019-05-22
ES2678770T3 (es) 2018-08-17
JP2017516817A (ja) 2017-06-22
US10065971B2 (en) 2018-09-04
WO2015185208A1 (en) 2015-12-10
CN106459083B (zh) 2019-10-01
EP3149005B1 (en) 2018-04-18
CA2949572A1 (en) 2015-12-10
PT3149005T (pt) 2018-07-24
US20170197984A1 (en) 2017-07-13

Similar Documents

Publication Publication Date Title
MX360785B (es) Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor.
PH12019500161A1 (en) Compounds and compositions as inhibitors of endosomal toll-like receptors
PH12016502307A1 (en) Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
EP4338739A3 (en) Diaryl macrocycles as modulators of protein kinases
MX2016015762A (es) Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaspiro undecano que tienen actividad multimodal contra el dolor.
MX2023000782A (es) 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia.
NZ751418A (en) Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
PH12016501570A1 (en) Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists
PH12018500904A1 (en) Peptide macrocycles against acinetobacter baumannii
MX2018000419A (es) Derivados de amida sustituida que tienen actividad multimodal contra el dolor.
PH12016502103A1 (en) Novel disubstituted 1,2, 4-triazine compound
MX2016015248A (es) Compuestos imidazo[1,2-a]pirazin-1-il-benzamida para tratar atrofia muscular espinal.
MX2017006437A (es) Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor.
MX2016006604A (es) Derivados de piperidina con actividad multimodal contra el dolor.
WO2018038988A3 (en) Imidazo[1,2-a]pyridin compounds, compositions comprising them, methods for treating diseases using them, and methods for preparing them
SG10201805267UA (en) Piperazine derivatives having multimodal activity against pain
MX2021010041A (es) Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt.
EA201890448A1 (ru) Фумагиллиновые спироциклические соединения и конденсированные бициклические соединения и способы их получения и применения
MX2017006513A (es) Compuestos de tipo 1,9-diazaespiroundecano con actividad multimodal contra el dolor.
MX2018004524A (es) Derivados de eter ciclico de pirazolo[1,5-a]pirimidin-3-carboxiami da.
PH12018502280A1 (en) Tetrahydropyran and thiopyran derivatives having multimodal activity against pain
PH12018500682A1 (en) Oxa-diazaspiro compounds having activity against pain
EA201790795A1 (ru) СОЕДИНЕНИЯ 4Н-ПИРИДО[1,2-a]ПИРИМИДИН-4-ОНА
MX2018000418A (es) Derivados de amida que tienen actividad multimodal contra el dolor.
MX2018004776A (es) Compuestos oxaazaespiricos con actividad contral el dolor.

Legal Events

Date Code Title Description
FG Grant or registration