PT3141548T - Processos e intermediários para a produção de azaindóis - Google Patents

Processos e intermediários para a produção de azaindóis

Info

Publication number
PT3141548T
PT3141548T PT161909601T PT16190960T PT3141548T PT 3141548 T PT3141548 T PT 3141548T PT 161909601 T PT161909601 T PT 161909601T PT 16190960 T PT16190960 T PT 16190960T PT 3141548 T PT3141548 T PT 3141548T
Authority
PT
Portugal
Prior art keywords
azaindoles
intermediates
processes
producing
producing azaindoles
Prior art date
Application number
PT161909601T
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT3141548T publication Critical patent/PT3141548T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
PT161909601T 2011-07-05 2012-07-03 Processos e intermediários para a produção de azaindóis PT3141548T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161504351P 2011-07-05 2011-07-05
US201261636296P 2012-04-20 2012-04-20

Publications (1)

Publication Number Publication Date
PT3141548T true PT3141548T (pt) 2020-07-10

Family

ID=46513874

Family Applications (1)

Application Number Title Priority Date Filing Date
PT161909601T PT3141548T (pt) 2011-07-05 2012-07-03 Processos e intermediários para a produção de azaindóis

Country Status (19)

Country Link
US (5) US8513414B2 (pt)
EP (2) EP2729465A2 (pt)
JP (3) JP2014520815A (pt)
KR (1) KR20140058547A (pt)
CN (2) CN103702998A (pt)
AR (1) AR087069A1 (pt)
AU (1) AU2012279046B2 (pt)
BR (1) BR112014000115A2 (pt)
CA (1) CA2839937C (pt)
DK (1) DK3141548T3 (pt)
ES (1) ES2804528T3 (pt)
MX (1) MX2013015147A (pt)
NZ (2) NZ619699A (pt)
PL (1) PL3141548T3 (pt)
PT (1) PT3141548T (pt)
RU (1) RU2014103806A (pt)
TW (1) TW201321378A (pt)
WO (1) WO2013006634A2 (pt)
ZA (1) ZA201400049B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101216372B1 (ko) * 2004-03-30 2013-01-04 버텍스 파마슈티칼스 인코포레이티드 Ｊａｋ 및 기타 단백질 키나제의 억제제로서 유용한 아자인돌
AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
NZ619699A (en) * 2011-07-05 2016-03-31 Vertex Pharma Processes and intermediates for producing azaindoles
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2014201332A1 (en) 2013-06-14 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical combinations useful for treating rheumatoid arthritis
CA2921198A1 (en) 2013-08-22 2015-02-26 Vertex Pharmaceuticals Incorporated Isotopically enriched azaindoles
US9296727B2 (en) 2013-10-07 2016-03-29 Vertex Pharmaceuticals Incorporated Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
DK3068782T3 (en) 2013-11-13 2018-08-13 Vertex Pharma Methods for the preparation of inhibitors of influenza virus replication
EP3068776B1 (en) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2017097234A1 (en) * 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
CN105523986A (zh) * 2015-12-30 2016-04-27 江汉大学 一种外排泵抑制剂n-氢-2-芳基吲哚及其衍生物的合成方法
SI3510031T1 (sl) * 2016-09-09 2021-03-31 F. Hoffmann-La Roche Ag Postopek za pripravo 2-(6-nitropiridin-3-il)-9H-dipirido(2,3-b;3',4'-d)pirola
WO2018119039A1 (en) 2016-12-23 2018-06-28 Felicitex Therapeutics, Inc. Derivatives of quinolines as inhibitors of dyrk1a and/or dyrk1b kinases
CN113121452A (zh) * 2021-05-10 2021-07-16 甘肃堡昌化工有限公司 一种硫酸法尿嘧啶的精制工艺
CN113851244A (zh) * 2021-09-18 2021-12-28 浙江爱索拓科技有限公司 一种含放射性同位素碳-14废水的处理方法
CN113896716A (zh) * 2021-10-27 2022-01-07 浙江爱索拓科技有限公司 一种放射性同位素碳-14双标记甲磺酸伏美替尼合成方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9721437D0 (en) 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
US20020065270A1 (en) 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
CA2400447C (en) 2000-02-17 2008-04-22 Amgen Inc. Kinase inhibitors
AR031130A1 (es) * 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
AU2003237121A1 (en) 2002-04-26 2003-11-10 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
IL164209A0 (en) 2002-05-31 2005-12-18 Eisai Co Ltd Pyrazole derivatives and pharmaceutical compositions containing the same
JP2007507529A (ja) * 2003-09-30 2007-03-29 サイオス・インコーポレーテツド 複素環式アミドおよびスルホンアミド
CA2549431C (en) 2004-01-30 2010-09-14 Nagase & Co., Ltd. Optically active quaternary ammonium salt having axial asymmetry and process for producing .alpha.-amino acid and derivative thereof with the same
UA87494C2 (en) * 2004-03-30 2009-07-27 Вертекс Фармасьютикалс Инкорпорейтед Azaindoles useful as inhibitors of jak and other protein kinases
KR101216372B1 (ko) 2004-03-30 2013-01-04 버텍스 파마슈티칼스 인코포레이티드 Ｊａｋ 및 기타 단백질 키나제의 억제제로서 유용한 아자인돌
WO2006038001A1 (en) * 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors
ZA200710379B (en) 2005-05-20 2009-05-27 Vertex Pharma Pyrrolopyridines useful as inhibitors of protein kinase
CN101374839A (zh) * 2006-01-17 2009-02-25 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
CN104650077A (zh) 2006-01-17 2015-05-27 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
CN101541783B (zh) * 2006-06-30 2014-10-01 苏尼西斯制药有限公司 吡啶酮基pdk1抑制剂
MX2009001451A (es) * 2006-08-08 2009-02-18 Chugai Pharmaceutical Co Ltd Derivado de pirimidina como inhibidor de pi3k y uso del mismo.
JP5406725B2 (ja) 2006-12-14 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼ阻害剤として有用な化合物
BRPI0819223A2 (pt) * 2007-11-05 2020-08-18 Novartis Ag derivados de 4-benzilamino-1-carboxiacil-piperidina como inibidores de cetp úteis para o tratamento de doenças tais como hiperlipidemia ou arteriosclerose
MX2010008198A (es) * 2008-02-25 2010-08-23 Hoffmann La Roche Inhibidores de cinasa de pirrolopirazina.
AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
NZ619699A (en) 2011-07-05 2016-03-31 Vertex Pharma Processes and intermediates for producing azaindoles
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
AU2012336019A1 (en) 2011-11-07 2014-05-29 Vertex Pharmaceuticals Incorporated Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor
CA2921198A1 (en) 2013-08-22 2015-02-26 Vertex Pharmaceuticals Incorporated Isotopically enriched azaindoles

Also Published As

Publication number Publication date
CA2839937A1 (en) 2013-01-10
ES2804528T3 (es) 2021-02-08
CN103702998A (zh) 2014-04-02
AR087069A1 (es) 2014-02-12
JP6761448B2 (ja) 2020-09-23
US8796453B2 (en) 2014-08-05
US8946425B2 (en) 2015-02-03
US20150099884A1 (en) 2015-04-09
EP3141548B1 (en) 2020-04-08
US20130303764A1 (en) 2013-11-14
AU2012279046B2 (en) 2017-08-31
US20140309421A1 (en) 2014-10-16
WO2013006634A9 (en) 2013-03-21
NZ714502A (en) 2017-04-28
US20130102782A1 (en) 2013-04-25
BR112014000115A2 (pt) 2016-10-04
ZA201400049B (en) 2015-04-29
RU2014103806A (ru) 2015-08-10
PL3141548T3 (pl) 2020-09-07
KR20140058547A (ko) 2014-05-14
US8513414B2 (en) 2013-08-20
AU2012279046A1 (en) 2014-01-23
EP3141548B9 (en) 2020-08-12
TW201321378A (zh) 2013-06-01
WO2013006634A2 (en) 2013-01-10
EP3141548A1 (en) 2017-03-15
WO2013006634A3 (en) 2013-05-10
US20150284388A1 (en) 2015-10-08
EP2729465A2 (en) 2014-05-14
NZ619699A (en) 2016-03-31
JP2018162314A (ja) 2018-10-18
JP2014520815A (ja) 2014-08-25
US9090614B2 (en) 2015-07-28
DK3141548T3 (da) 2020-07-06
JP2017002067A (ja) 2017-01-05
MX2013015147A (es) 2014-03-27
CN106432311A (zh) 2017-02-22
CA2839937C (en) 2020-11-03

Similar Documents

Publication Publication Date Title
ZA201400049B (en) Processes and intermediates for producing azaindoles
EP2744336A4 (en) METHOD AND INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF MACROLACTAMEN
GB201121308D0 (en) Process
GB201103499D0 (en) Process
GB201107072D0 (en) Process
PL2793599T3 (pl) Sposób
ZA201305221B (en) Process
GB201218123D0 (en) Process
EP2716970A4 (en) WASTE MELTING PROCESS
SI2511868T1 (sl) Postopek za obračunavanje prostorske izrabe
GB201121557D0 (en) Process
GB201112051D0 (en) Process
GB201107073D0 (en) Process
IL229126A0 (en) process
GB201218121D0 (en) Process
GB201218124D0 (en) Process
PT2726454T (pt) Processo
GB201103092D0 (en) Process
GB201107221D0 (en) Process
IL229426A0 (en) processes and intermediates
SG11201403684YA (en) Process
GB201112370D0 (en) Process
GB2493491B (en) Process
GB201208567D0 (en) Process
GB201122406D0 (en) Process