PT2702051E - Derivados de etinilo como reguladores alostéricos positivos de rmglu5 - Google Patents

Derivados de etinilo como reguladores alostéricos positivos de rmglu5 Download PDF

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Publication number
PT2702051E
PT2702051E PT127181535T PT12718153T PT2702051E PT 2702051 E PT2702051 E PT 2702051E PT 127181535 T PT127181535 T PT 127181535T PT 12718153 T PT12718153 T PT 12718153T PT 2702051 E PT2702051 E PT 2702051E
Authority
PT
Portugal
Prior art keywords
mglur5
positive allosteric
allosteric modulators
ethynyl derivatives
ethynyl
Prior art date
Application number
PT127181535T
Other languages
English (en)
Inventor
Eric Vieira
Georg Jaeschke
Lothar Lindemann
Synese Jolidon
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT2702051E publication Critical patent/PT2702051E/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P70/00Climate change mitigation technologies in the production process for final industrial or consumer products
    • Y02P70/50Manufacturing or production processes characterised by the final manufactured product
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02TCLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
    • Y02T10/00Road transport of goods or passengers
    • Y02T10/60Other road transportation technologies with climate change mitigation effect
    • Y02T10/70Energy storage systems for electromobility, e.g. batteries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Liquid Crystal Substances (AREA)
  • Secondary Cells (AREA)
PT127181535T 2011-04-26 2012-04-23 Derivados de etinilo como reguladores alostéricos positivos de rmglu5 PT2702051E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11163683 2011-04-26

Publications (1)

Publication Number Publication Date
PT2702051E true PT2702051E (pt) 2015-05-20

Family

ID=46025665

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127181535T PT2702051E (pt) 2011-04-26 2012-04-23 Derivados de etinilo como reguladores alostéricos positivos de rmglu5

Country Status (33)

Country Link
US (2) US8957213B2 (pt)
EP (1) EP2702051B1 (pt)
JP (1) JP5753627B2 (pt)
KR (1) KR101554803B1 (pt)
CN (1) CN103492373B (pt)
AR (1) AR086036A1 (pt)
AU (1) AU2012247653B2 (pt)
BR (1) BR112013026116A2 (pt)
CA (1) CA2829170C (pt)
CL (1) CL2013003056A1 (pt)
CO (1) CO6801734A2 (pt)
CR (1) CR20130475A (pt)
CY (1) CY1116391T1 (pt)
DK (1) DK2702051T3 (pt)
EA (1) EA022019B1 (pt)
ES (1) ES2534090T3 (pt)
HK (1) HK1191330A1 (pt)
HR (1) HRP20150555T1 (pt)
HU (1) HUE025031T2 (pt)
IL (1) IL228835A (pt)
MA (1) MA35133B1 (pt)
MX (1) MX337443B (pt)
MY (1) MY163164A (pt)
PE (1) PE20141169A1 (pt)
PL (1) PL2702051T3 (pt)
PT (1) PT2702051E (pt)
RS (1) RS53903B1 (pt)
SG (1) SG194120A1 (pt)
SI (1) SI2702051T1 (pt)
TW (2) TWI436993B (pt)
UA (1) UA110378C2 (pt)
WO (1) WO2012146551A1 (pt)
ZA (1) ZA201306586B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2702051T1 (sl) * 2011-04-26 2015-06-30 F. Hoffmann-La Roche Ag Etinilni derivati kot pozitivni alosteriäśni modulatorji mglur5
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
PE20150184A1 (es) * 2012-07-17 2015-02-13 Hoffmann La Roche Derivados de ariletinilo
MX2015002823A (es) * 2012-10-18 2015-05-15 Hoffmann La Roche Derivados de etilinilo como moduladores de la actividad del receptor de glutamato metabotropico 5 (mglur5).
UA116023C2 (uk) * 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
UA120309C2 (uk) * 2015-06-03 2019-11-11 Ф. Хоффманн-Ля Рош Аг Етинільні похідні
RS58929B1 (sr) 2015-07-15 2019-08-30 Hoffmann La Roche Derivati etinila kao modulatori metabotropnih glutamatnih receptora
US10423423B2 (en) * 2015-09-29 2019-09-24 International Business Machines Corporation Efficiently managing speculative finish tracking and error handling for load instructions
RU2745068C2 (ru) 2016-07-18 2021-03-18 Ф. Хоффманн-Ля Рош Аг Производные этинила
KR20200068678A (ko) * 2017-10-10 2020-06-15 바이오젠 인크. 스피로 유도체를 제조하기 위한 공정

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
AU2005336513B2 (en) * 2004-10-07 2012-08-09 Merck Sharp & Dohme Llc Thiazolyl mGluR5 antagonists and methods for their use
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
ES2328185T3 (es) 2006-05-31 2009-11-10 F. Hoffmann-La Roche Ag Derivados de aril-4-etinil-isoxazol.
MX2009013169A (es) * 2007-06-03 2010-04-30 Univ Vanderbilt Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos.
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
TW201020245A (en) 2008-08-20 2010-06-01 Schering Corp Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8586581B2 (en) 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
SI2702051T1 (sl) * 2011-04-26 2015-06-30 F. Hoffmann-La Roche Ag Etinilni derivati kot pozitivni alosteriäśni modulatorji mglur5

Also Published As

Publication number Publication date
PL2702051T3 (pl) 2015-08-31
EP2702051A1 (en) 2014-03-05
KR20140014256A (ko) 2014-02-05
NZ614688A (en) 2015-09-25
US8957213B2 (en) 2015-02-17
JP5753627B2 (ja) 2015-07-22
CY1116391T1 (el) 2017-02-08
RS53903B1 (en) 2015-08-31
JP2014512401A (ja) 2014-05-22
CN103492373B (zh) 2015-09-16
WO2012146551A1 (en) 2012-11-01
HK1191330A1 (en) 2014-07-25
PE20141169A1 (es) 2014-09-22
EA201391537A1 (ru) 2014-04-30
AU2012247653B2 (en) 2016-05-26
UA110378C2 (en) 2015-12-25
US20120277213A1 (en) 2012-11-01
BR112013026116A2 (pt) 2016-12-27
ES2534090T3 (es) 2015-04-17
TWI436993B (zh) 2014-05-11
KR101554803B1 (ko) 2015-09-21
CO6801734A2 (es) 2013-11-29
MX2013011105A (es) 2013-10-17
AU2012247653A1 (en) 2013-09-26
CR20130475A (es) 2013-11-11
AR086036A1 (es) 2013-11-13
US9212171B2 (en) 2015-12-15
SI2702051T1 (sl) 2015-06-30
MA35133B1 (fr) 2014-05-02
CN103492373A (zh) 2014-01-01
HUE025031T2 (en) 2016-02-29
IL228835A (en) 2016-02-29
ZA201306586B (en) 2014-05-28
DK2702051T3 (en) 2015-03-16
IL228835A0 (en) 2013-12-31
EP2702051B1 (en) 2015-03-04
CA2829170C (en) 2019-02-26
TW201311657A (zh) 2013-03-16
US20150119384A1 (en) 2015-04-30
CA2829170A1 (en) 2012-11-01
HRP20150555T1 (hr) 2015-07-03
MY163164A (en) 2017-08-15
CL2013003056A1 (es) 2014-07-25
MX337443B (es) 2016-03-07
TW201306355A (zh) 2013-02-01
SG194120A1 (en) 2013-11-29
EA022019B1 (ru) 2015-10-30

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