PE20141169A1 - Derivados de etinilo - Google Patents
Derivados de etiniloInfo
- Publication number
- PE20141169A1 PE20141169A1 PE2013002401A PE2013002401A PE20141169A1 PE 20141169 A1 PE20141169 A1 PE 20141169A1 PE 2013002401 A PE2013002401 A PE 2013002401A PE 2013002401 A PE2013002401 A PE 2013002401A PE 20141169 A1 PE20141169 A1 PE 20141169A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridin
- hydrogen
- lower alkyl
- ethinyl
- ona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P70/00—Climate change mitigation technologies in the production process for final industrial or consumer products
- Y02P70/50—Manufacturing or production processes characterised by the final manufactured product
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
- Y02T10/00—Road transport of goods or passengers
- Y02T10/60—Other road transportation technologies with climate change mitigation effect
- Y02T10/70—Energy storage systems for electromobility, e.g. batteries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Secondary Cells (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ETINILO DE LA FORMULA (I), EN LA QUE X ES N, C-R, R ES HIDROGENO, HALOGENO; G ES N, CH; R1 ES FENILO, PIRIDINILO; R2 ES H, ALQUILO INFERIOR, HIDROXI, ENTRE OTROS; R3, R3', R4, R4', R6, R6' CON INDEPENDENCIA ENTRE SI SON HIDROGENO, ALQUILO INFERIOR; R5 ES HIDROGENO, ALQUILO INFERIOR; n ES 0-2; m ES 0-1. SON COMPUESTOS PREFERIDOS (RS)-1,5,5-TRIMETIL-3-(5-(FENILETINIL)PIRIDIN-2-IL)-PIRROLIDIN-2-ONA, (RS)-1,5,5,-TRIMETIL-3-(5-(PIRIDIN-3-ILETINIL)PIRIDIN-2-IL)-PIRROLIDIN-2-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE LA ESQUIZOFRENIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11163683 | 2011-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141169A1 true PE20141169A1 (es) | 2014-09-22 |
Family
ID=46025665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002401A PE20141169A1 (es) | 2011-04-26 | 2012-04-23 | Derivados de etinilo |
Country Status (33)
Country | Link |
---|---|
US (2) | US8957213B2 (es) |
EP (1) | EP2702051B1 (es) |
JP (1) | JP5753627B2 (es) |
KR (1) | KR101554803B1 (es) |
CN (1) | CN103492373B (es) |
AR (1) | AR086036A1 (es) |
AU (1) | AU2012247653B2 (es) |
BR (1) | BR112013026116A2 (es) |
CA (1) | CA2829170C (es) |
CL (1) | CL2013003056A1 (es) |
CO (1) | CO6801734A2 (es) |
CR (1) | CR20130475A (es) |
CY (1) | CY1116391T1 (es) |
DK (1) | DK2702051T3 (es) |
EA (1) | EA022019B1 (es) |
ES (1) | ES2534090T3 (es) |
HK (1) | HK1191330A1 (es) |
HR (1) | HRP20150555T1 (es) |
HU (1) | HUE025031T2 (es) |
IL (1) | IL228835A (es) |
MA (1) | MA35133B1 (es) |
MX (1) | MX337443B (es) |
MY (1) | MY163164A (es) |
PE (1) | PE20141169A1 (es) |
PL (1) | PL2702051T3 (es) |
PT (1) | PT2702051E (es) |
RS (1) | RS53903B1 (es) |
SG (1) | SG194120A1 (es) |
SI (1) | SI2702051T1 (es) |
TW (2) | TWI436993B (es) |
UA (1) | UA110378C2 (es) |
WO (1) | WO2012146551A1 (es) |
ZA (1) | ZA201306586B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY163164A (en) * | 2011-04-26 | 2017-08-15 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
LT2875000T (lt) * | 2012-07-17 | 2016-11-10 | F.Hoffmann-La Roche Ag | Ariletinilo dariniai |
MY171517A (en) * | 2012-10-18 | 2019-10-16 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
UA116023C2 (uk) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
PL3303316T3 (pl) | 2015-06-03 | 2020-06-29 | F. Hoffmann-La Roche Ag | Pochodne etynylu |
KR20180026438A (ko) | 2015-07-15 | 2018-03-12 | 에프. 호프만-라 로슈 아게 | 대사형 글루타메이트 수용체 조절제로서의 에틴일 유도체 |
US10423423B2 (en) * | 2015-09-29 | 2019-09-24 | International Business Machines Corporation | Efficiently managing speculative finish tracking and error handling for load instructions |
LT3484889T (lt) | 2016-07-18 | 2020-11-10 | F. Hoffmann-La Roche Ag | Etinilo dariniai |
MX2020003821A (es) * | 2017-10-10 | 2023-01-12 | Biogen Inc | Proceso de elaboración de espiroderivados. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
CN101223166B (zh) * | 2004-10-07 | 2011-10-19 | 默沙东公司 | 噻唑基mglur5拮抗剂及其应用方法 |
EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
ES2328185T3 (es) | 2006-05-31 | 2009-11-10 | F. Hoffmann-La Roche Ag | Derivados de aril-4-etinil-isoxazol. |
WO2008151184A1 (en) | 2007-06-03 | 2008-12-11 | Vanderbilt University | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
US8034806B2 (en) * | 2007-11-02 | 2011-10-11 | Vanderbilt University | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same |
WO2010022125A1 (en) | 2008-08-20 | 2010-02-25 | Schering Corporation | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
US8586581B2 (en) | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
MY163164A (en) * | 2011-04-26 | 2017-08-15 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
-
2012
- 2012-04-23 MY MYPI2013003846A patent/MY163164A/en unknown
- 2012-04-23 BR BR112013026116A patent/BR112013026116A2/pt not_active IP Right Cessation
- 2012-04-23 WO PCT/EP2012/057335 patent/WO2012146551A1/en active Application Filing
- 2012-04-23 PT PT127181535T patent/PT2702051E/pt unknown
- 2012-04-23 CN CN201280019903.3A patent/CN103492373B/zh active Active
- 2012-04-23 MX MX2013011105A patent/MX337443B/es active IP Right Grant
- 2012-04-23 AU AU2012247653A patent/AU2012247653B2/en not_active Ceased
- 2012-04-23 DK DK12718153T patent/DK2702051T3/en active
- 2012-04-23 SI SI201230199T patent/SI2702051T1/sl unknown
- 2012-04-23 ES ES12718153.5T patent/ES2534090T3/es active Active
- 2012-04-23 RS RS20150192A patent/RS53903B1/en unknown
- 2012-04-23 HU HUE12718153A patent/HUE025031T2/en unknown
- 2012-04-23 PE PE2013002401A patent/PE20141169A1/es active IP Right Grant
- 2012-04-23 SG SG2013074810A patent/SG194120A1/en unknown
- 2012-04-23 CA CA2829170A patent/CA2829170C/en not_active Expired - Fee Related
- 2012-04-23 EP EP20120718153 patent/EP2702051B1/en active Active
- 2012-04-23 UA UAA201313475A patent/UA110378C2/uk unknown
- 2012-04-23 KR KR1020137031119A patent/KR101554803B1/ko active IP Right Grant
- 2012-04-23 EA EA201391537A patent/EA022019B1/ru not_active IP Right Cessation
- 2012-04-23 US US13/452,973 patent/US8957213B2/en active Active
- 2012-04-23 PL PL12718153T patent/PL2702051T3/pl unknown
- 2012-04-23 JP JP2014506826A patent/JP5753627B2/ja active Active
- 2012-04-24 AR ARP120101405 patent/AR086036A1/es unknown
- 2012-04-24 TW TW101114577A patent/TWI436993B/zh not_active IP Right Cessation
- 2012-04-24 TW TW101114538A patent/TW201306355A/zh unknown
-
2013
- 2013-08-29 CO CO13205214A patent/CO6801734A2/es active IP Right Grant
- 2013-09-02 ZA ZA2013/06586A patent/ZA201306586B/en unknown
- 2013-09-23 CR CR20130475A patent/CR20130475A/es unknown
- 2013-10-10 IL IL228835A patent/IL228835A/en active IP Right Grant
- 2013-10-22 CL CL2013003056A patent/CL2013003056A1/es unknown
- 2013-11-22 MA MA36462A patent/MA35133B1/fr unknown
-
2014
- 2014-05-09 HK HK14104405.5A patent/HK1191330A1/xx unknown
-
2015
- 2015-01-06 US US14/590,530 patent/US9212171B2/en active Active
- 2015-05-20 CY CY20151100452T patent/CY1116391T1/el unknown
- 2015-05-26 HR HRP20150555TT patent/HRP20150555T1/hr unknown
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Legal Events
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FG | Grant, registration |