PT2435432E - Agentes indutores de apoptose para o tratamento de cancro e doenças imunes e autoimunes - Google Patents

Agentes indutores de apoptose para o tratamento de cancro e doenças imunes e autoimunes Download PDF

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Publication number
PT2435432E
PT2435432E PT107212466T PT10721246T PT2435432E PT 2435432 E PT2435432 E PT 2435432E PT 107212466 T PT107212466 T PT 107212466T PT 10721246 T PT10721246 T PT 10721246T PT 2435432 E PT2435432 E PT 2435432E
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PT
Portugal
Prior art keywords
apoptosis
immune
cancer
treatment
autoimmune diseases
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PT107212466T
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English (en)
Inventor
Gary T Wang
Milan Bruncko
Hong Ding
Steven Elmore
Aaron R Kunzer
Lisa Hasvold
Laura Hexamer
Xiaohong Song
Andrew J Souers
Zhi-Fu Tao
Le Wang
Todd M Hansen
George Doherty
Gerard Sullivan
Xilu Wang
Michael Wendt
Robert Mantei
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Abbvie Bahamas Ltd
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Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of PT2435432E publication Critical patent/PT2435432E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
PT107212466T 2009-05-26 2010-05-26 Agentes indutores de apoptose para o tratamento de cancro e doenças imunes e autoimunes PT2435432E (pt)

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US18120309P 2009-05-26 2009-05-26

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US (1) US8580794B2 (pt)
EP (3) EP2435432B3 (pt)
JP (7) JP5747025B2 (pt)
KR (8) KR20190130676A (pt)
CN (5) CN104876927B (pt)
AR (2) AR076705A1 (pt)
AU (1) AU2010254160C1 (pt)
BR (2) BRPI1014359B1 (pt)
CA (4) CA2929347A1 (pt)
CL (1) CL2011002949A1 (pt)
CO (1) CO6480950A2 (pt)
CR (2) CR20170019A (pt)
CY (2) CY1117423T1 (pt)
DK (1) DK2435432T6 (pt)
DO (1) DOP2011000367A (pt)
EC (1) ECSP11011554A (pt)
ES (1) ES2546294T3 (pt)
FI (1) FI2435432T6 (pt)
HK (2) HK1163099A1 (pt)
HR (1) HRP20151001T4 (pt)
HU (2) HUE027698T2 (pt)
IL (5) IL299019A (pt)
LT (1) LTC2435432I2 (pt)
ME (1) ME02205B (pt)
MX (2) MX339469B (pt)
MY (1) MY155645A (pt)
NL (1) NL300873I2 (pt)
NO (1) NO2017023I1 (pt)
NZ (1) NZ595708A (pt)
PE (1) PE20120345A1 (pt)
PH (1) PH12015500297A1 (pt)
PL (1) PL2435432T6 (pt)
PT (1) PT2435432E (pt)
RS (1) RS54234B2 (pt)
RU (3) RU2535347C3 (pt)
SG (2) SG10201704742YA (pt)
SI (1) SI2435432T1 (pt)
SM (1) SMT201500225B (pt)
TW (3) TWI561523B (pt)
UA (1) UA106079C2 (pt)
UY (3) UY32668A (pt)
WO (1) WO2010138588A2 (pt)
ZA (1) ZA201108616B (pt)

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