PT2275103E - Inibidores de mtor para o tratamento de tumores endócrinos - Google Patents
Inibidores de mtor para o tratamento de tumores endócrinos Download PDFInfo
- Publication number
- PT2275103E PT2275103E PT101751972T PT10175197T PT2275103E PT 2275103 E PT2275103 E PT 2275103E PT 101751972 T PT101751972 T PT 101751972T PT 10175197 T PT10175197 T PT 10175197T PT 2275103 E PT2275103 E PT 2275103E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- mtor inhibitors
- endocrine tumors
- endocrine
- tumors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0523658A GB0523658D0 (en) | 2005-11-21 | 2005-11-21 | Organic compounds |
GB0601082A GB0601082D0 (en) | 2006-01-19 | 2006-01-19 | Organic Compounds |
GB0602747A GB0602747D0 (en) | 2006-02-10 | 2006-02-10 | Organic compounds |
GB0607942A GB0607942D0 (en) | 2006-04-21 | 2006-04-21 | Organic compounds |
GB0609272A GB0609272D0 (en) | 2006-05-10 | 2006-05-10 | Organic compounds |
GB0609912A GB0609912D0 (en) | 2006-05-18 | 2006-05-18 | Organic compounds |
EP06120660 | 2006-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2275103E true PT2275103E (pt) | 2014-07-24 |
Family
ID=37671355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT101751972T PT2275103E (pt) | 2005-11-21 | 2006-11-20 | Inibidores de mtor para o tratamento de tumores endócrinos |
Country Status (22)
Country | Link |
---|---|
US (3) | US9006224B2 (pt) |
EP (3) | EP2275103B1 (pt) |
JP (3) | JP2009516671A (pt) |
KR (2) | KR20140012218A (pt) |
CN (1) | CN103446138A (pt) |
AU (2) | AU2006314444C1 (pt) |
BR (1) | BRPI0618808A2 (pt) |
CA (2) | CA2629245C (pt) |
CY (1) | CY1115299T1 (pt) |
DK (1) | DK2275103T3 (pt) |
ES (1) | ES2481671T3 (pt) |
HK (1) | HK1150746A1 (pt) |
HR (1) | HRP20140708T1 (pt) |
IL (3) | IL191475A (pt) |
MA (1) | MA29966B1 (pt) |
NO (4) | NO20220050A1 (pt) |
NZ (1) | NZ568182A (pt) |
PL (1) | PL2275103T3 (pt) |
PT (1) | PT2275103E (pt) |
RU (1) | RU2487711C2 (pt) |
SI (1) | SI2275103T1 (pt) |
WO (1) | WO2007057457A2 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3351246T (pt) | 2001-02-19 | 2019-06-07 | Novartis Pharma Ag | Derivado de rapamicina para o tratamento de um tumor sólido associado a angiogenese desregulada |
EP2606890A1 (en) * | 2006-04-05 | 2013-06-26 | Novartis AG | Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer |
CN101415409B (zh) | 2006-04-05 | 2012-12-05 | 诺瓦提斯公司 | 用于治疗癌症的治疗剂的组合 |
AU2013205002B2 (en) * | 2008-03-21 | 2016-09-15 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
CA2963659C (en) | 2008-09-17 | 2020-06-23 | Chiasma Inc. | Use of oral octreotride compositions |
US9057054B2 (en) | 2009-06-25 | 2015-06-16 | The Regents Of The University Of Michigan | Antigen-specific long-term memory T-cells |
SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
TWI708605B (zh) * | 2011-10-19 | 2020-11-01 | 標誌製藥公司 | 以tor激酶抑制劑治療癌症 |
WO2014134240A1 (en) * | 2013-02-28 | 2014-09-04 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
WO2014144405A1 (en) * | 2013-03-15 | 2014-09-18 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of neuroendocrine tumor development and growth |
JP6401250B2 (ja) | 2013-05-29 | 2018-10-10 | シグナル ファーマシューティカルズ,エルエルシー | 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法 |
CA3206208A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
EP3253401A4 (en) | 2015-02-03 | 2018-11-21 | Chiasma Inc. | Method of treating diseases |
US11045436B2 (en) * | 2015-06-30 | 2021-06-29 | Shanghai Jiao Tong University | Applications for sulindac in preparing anti-lung cancer products |
AU2017210227A1 (en) * | 2016-01-21 | 2018-09-06 | Amryt Endo, Inc. | Oral octreotide for the treatment of disease |
WO2018204477A1 (en) | 2017-05-02 | 2018-11-08 | Cornell University | Methods and reagents for tumor targeting with greater efficacy and less toxicity |
BR112019027402A2 (pt) | 2017-06-22 | 2020-07-07 | Celgene Corporation | tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b |
US20210024542A1 (en) * | 2018-02-09 | 2021-01-28 | Torcept Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of cancer |
AU2019262979B2 (en) | 2018-05-01 | 2023-07-06 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mTOR inhibitors |
US20220184084A1 (en) * | 2019-03-18 | 2022-06-16 | The Regents Of The University Of California | Compositions and methods for treating cushing's disease |
US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
CA3220332A1 (en) * | 2021-06-07 | 2022-12-15 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
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LU88769I2 (fr) | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
GB9013448D0 (en) * | 1990-06-15 | 1990-08-08 | Sandoz Ltd | Pharmaceutical resorption-improved somatostatin compositions,their preparation and use |
PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
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KR100716272B1 (ko) | 1998-11-20 | 2007-05-09 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
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DE60010098T2 (de) | 1999-08-24 | 2005-03-31 | Ariad Gene Therapeutics, Inc., Cambridge | 28-epirapaloge |
RU2264405C2 (ru) | 1999-12-06 | 2005-11-20 | Новартис Аг | 40-o-(2-гидрокси)этилрапамицин в кристаллической несольватированной форме, фармацевтическая композиция, содержащая такой макролид в качестве действующего вещества, и способ его получения |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
KR20080014934A (ko) | 2000-11-07 | 2008-02-14 | 노파르티스 아게 | 단백질 키나제 c 억제제로서의 인돌릴말레이미드 유도체 |
TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
PT3351246T (pt) * | 2001-02-19 | 2019-06-07 | Novartis Pharma Ag | Derivado de rapamicina para o tratamento de um tumor sólido associado a angiogenese desregulada |
SG152906A1 (en) * | 2001-04-06 | 2009-06-29 | Wyeth Corp | Antineoplastic combinations such as rapamycin together with gemcitabine or fluorouracil |
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UA78706C2 (en) | 2001-06-01 | 2007-04-25 | Wyeth Corp | Combination of rapamycin derivative and antitumor alkylating agent and method for treating soft tissue sarcoma and colonic cancer |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
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AU2003210787B2 (en) | 2002-02-01 | 2009-04-23 | Medinol Ltd. | Phosphorus-containing compounds & uses thereof |
AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
AU2003248813A1 (en) | 2002-07-05 | 2004-01-23 | Beth Israel Deaconess Medical Center | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
AU2003297740B2 (en) | 2002-12-09 | 2008-09-11 | The Board Of Regents Of The University Of Texas System | Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3) |
UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
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AU2004309499A1 (en) | 2003-12-22 | 2005-07-14 | Novartis Ag | Biomarkers for sensitivity of proliferative diseases to mTOR inhibitors |
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KR20120084333A (ko) * | 2004-02-23 | 2012-07-27 | 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | Mtor 억제제와 세포독성제의 복합 치료에 대한 바이오마커로서의 p53 야생형 |
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DK1827437T3 (da) * | 2004-12-15 | 2012-02-13 | Sigma Tau Ind Farmaceuti | Kombinationer af terapeutiske midler til cancerbehandling |
US20060160837A1 (en) | 2004-12-29 | 2006-07-20 | The Brigham And Women's Hospital, Inc. | Rapamycin compounds in the treatment of neurofibromatosis type 1 |
-
2006
- 2006-11-20 CA CA2629245A patent/CA2629245C/en active Active
- 2006-11-20 JP JP2008540626A patent/JP2009516671A/ja not_active Withdrawn
- 2006-11-20 SI SI200631791T patent/SI2275103T1/sl unknown
- 2006-11-20 US US12/094,173 patent/US9006224B2/en active Active
- 2006-11-20 EP EP10175197.2A patent/EP2275103B1/en not_active Revoked
- 2006-11-20 PT PT101751972T patent/PT2275103E/pt unknown
- 2006-11-20 WO PCT/EP2006/068656 patent/WO2007057457A2/en active Application Filing
- 2006-11-20 EP EP06819607A patent/EP1954269A2/en not_active Withdrawn
- 2006-11-20 KR KR1020147001555A patent/KR20140012218A/ko not_active Application Discontinuation
- 2006-11-20 KR KR1020087014937A patent/KR20080071600A/ko not_active Application Discontinuation
- 2006-11-20 NO NO20220050A patent/NO20220050A1/no not_active Application Discontinuation
- 2006-11-20 PL PL10175197T patent/PL2275103T3/pl unknown
- 2006-11-20 NO NO20170956A patent/NO346575B1/no unknown
- 2006-11-20 AU AU2006314444A patent/AU2006314444C1/en active Active
- 2006-11-20 EP EP08162295A patent/EP2022498A3/en not_active Withdrawn
- 2006-11-20 RU RU2008124827/15A patent/RU2487711C2/ru active
- 2006-11-20 ES ES10175197.2T patent/ES2481671T3/es active Active
- 2006-11-20 DK DK10175197.2T patent/DK2275103T3/da active
- 2006-11-20 BR BRPI0618808-7A patent/BRPI0618808A2/pt not_active Application Discontinuation
- 2006-11-20 NZ NZ568182A patent/NZ568182A/en unknown
- 2006-11-20 CA CA2933875A patent/CA2933875C/en active Active
- 2006-11-20 CN CN2013103848215A patent/CN103446138A/zh active Pending
-
2008
- 2008-05-15 IL IL191475A patent/IL191475A/en active IP Right Grant
- 2008-05-20 MA MA30950A patent/MA29966B1/fr unknown
- 2008-06-16 NO NO20082683A patent/NO344288B1/no unknown
- 2008-09-23 HK HK11104451.1A patent/HK1150746A1/xx unknown
-
2010
- 2010-07-07 AU AU2010202866A patent/AU2010202866A1/en not_active Abandoned
-
2013
- 2013-04-03 JP JP2013077748A patent/JP5833048B2/ja active Active
-
2014
- 2014-06-20 CY CY20141100454T patent/CY1115299T1/el unknown
- 2014-07-22 HR HRP20140708TT patent/HRP20140708T1/hr unknown
- 2014-12-03 JP JP2014245402A patent/JP5963836B2/ja active Active
-
2015
- 2015-01-29 US US14/608,644 patent/US20150148294A1/en not_active Abandoned
-
2016
- 2016-06-22 NO NO20161045A patent/NO341023B1/no unknown
-
2017
- 2017-01-13 US US15/405,501 patent/US20170128425A1/en not_active Abandoned
- 2017-02-21 IL IL250697A patent/IL250697A0/en unknown
- 2017-07-27 IL IL253698A patent/IL253698A0/en unknown
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