PT2213730E - Adipócitos de cultura primária para terapia génica - Google Patents

Adipócitos de cultura primária para terapia génica Download PDF

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Publication number
PT2213730E
PT2213730E PT101612919T PT10161291T PT2213730E PT 2213730 E PT2213730 E PT 2213730E PT 101612919 T PT101612919 T PT 101612919T PT 10161291 T PT10161291 T PT 10161291T PT 2213730 E PT2213730 E PT 2213730E
Authority
PT
Portugal
Prior art keywords
gene therapy
primary cultured
adipocytes
cells
present
Prior art date
Application number
PT101612919T
Other languages
English (en)
Inventor
Yasushi Saito
Masashi Ito
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of PT2213730E publication Critical patent/PT2213730E/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT101612919T 2002-06-18 2003-06-18 Adipócitos de cultura primária para terapia génica PT2213730E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002177648 2002-06-18
JP2002237974 2002-08-19

Publications (1)

Publication Number Publication Date
PT2213730E true PT2213730E (pt) 2016-02-26

Family

ID=29738440

Family Applications (2)

Application Number Title Priority Date Filing Date
PT101612919T PT2213730E (pt) 2002-06-18 2003-06-18 Adipócitos de cultura primária para terapia génica
PT03736235T PT1541674E (pt) 2002-06-18 2003-06-18 Adipócitos cultivados em primário para terapia génica

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT03736235T PT1541674E (pt) 2002-06-18 2003-06-18 Adipócitos cultivados em primário para terapia génica

Country Status (20)

Country Link
US (2) US7820438B2 (pt)
EP (2) EP2213730B1 (pt)
JP (1) JPWO2003106663A1 (pt)
KR (1) KR101004086B1 (pt)
CN (1) CN1671836B (pt)
AT (1) ATE492630T1 (pt)
AU (1) AU2003242459B2 (pt)
BR (1) BRPI0312441B8 (pt)
CA (1) CA2488414C (pt)
DE (1) DE60335473D1 (pt)
DK (2) DK1541674T3 (pt)
ES (1) ES2559430T3 (pt)
HU (1) HUE025872T2 (pt)
MA (1) MA27324A1 (pt)
MX (1) MXPA04012859A (pt)
NZ (1) NZ537072A (pt)
PT (2) PT2213730E (pt)
SI (1) SI1541674T1 (pt)
WO (1) WO2003106663A1 (pt)
ZA (1) ZA200500464B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4879867B2 (ja) * 2002-06-18 2012-02-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 遺伝子治療用初代培養脂肪細胞
US8835177B2 (en) 2005-06-15 2014-09-16 Takara Bio Inc. Method for transfer of gene into fat cell or progenitor fat cell
JPWO2008108344A1 (ja) * 2007-03-02 2010-06-17 セルジェンテック株式会社 Ｌｃａｔ欠損症の遺伝子治療用細胞並びに遺伝子治療用細胞組成物
TW200927074A (en) * 2007-12-25 2009-07-01 Univ Nat Taiwan Colloidal frame used in tissue engineering
JP2009165403A (ja) * 2008-01-16 2009-07-30 Hokkaido Univ ハニカム状多孔質体を用いた脂肪細胞の長期培養方法
EP2350274B1 (en) 2008-10-21 2019-01-23 The General Hospital Corporation Cell transplantation
WO2011090091A1 (ja) * 2010-01-21 2011-07-28 セルジェンテック株式会社 遺伝子治療用脂肪細胞の調製のための外来遺伝子の導入に適した細胞集団かどうかを判定する方法
BR112013002859B1 (pt) 2010-08-06 2020-10-06 The General Hospital Corporation D/B/A Massachusetts General Hospital Método e aparelho para tratamento de células
US20140065659A1 (en) * 2011-03-16 2014-03-06 Kuraray Co., Ltd. Culture method, group of mature adipocytes, drug screening method
JP2023002772A (ja) * 2011-09-23 2023-01-10 レジニアス リミテッド 脂肪細胞および細胞分泌物を使用する治療
US20230210945A1 (en) 2020-05-29 2023-07-06 Numt Inc. Adipocytes Over-Expressing FFAR4 and Use Thereof
EP4213863A1 (en) * 2020-09-15 2023-07-26 The Brigham and Women's Hospital, Inc. In vivo adipose bioreactor and kits for the production and delivery of biologic agents
WO2023249904A1 (en) * 2022-06-20 2023-12-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating diabetes

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956455A (en) 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
IE66689B1 (en) 1985-09-12 1996-01-24 Scios Nova Inc Recombinant fibroblast growth factors
IL80944A (en) 1985-12-17 1994-10-07 Synergen Inc Boulder Colo U S A factor in the formation of blood vessels in a human placenta capable of inducing protease synthesis in the inner lining of capillary cells, DNA synthesis. And migration of materials
DK122687A (da) 1986-03-14 1987-09-15 Takeda Chemical Industries Ltd Polypeptid, dna og anvendelse deraf
JP2526965B2 (ja) 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
WO1989004832A1 (en) 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
EP0326907A1 (en) 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use
CA2015313A1 (en) 1989-04-26 1990-10-26 Masaharu Senoo Glycosylated fgf and production thereof
JP3135138B2 (ja) 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
EP1179350A3 (en) * 1993-08-12 2003-01-02 Cytotherapeutics, Inc. Encapsulated cell system for implantation into the human CNS
FR2731014B1 (fr) 1995-02-23 1997-03-28 Rhone Poulenc Rorer Sa Molecules d'adn, preparation et utilisation en therapie genique
FR2731710B1 (fr) 1995-03-14 1997-04-30 Rhone Poulenc Rorer Sa Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique
US5869037A (en) 1996-06-26 1999-02-09 Cornell Research Foundation, Inc. Adenoviral-mediated gene transfer to adipocytes
GB2327224A (en) 1997-07-09 1999-01-20 Mayo Foundation Gene transfer to adipocytes
WO1999011786A1 (fr) 1997-09-01 1999-03-11 Otsuka Pharmaceutical Co., Ltd. GENE pancpin ET COMPOSITION DE THERAPIE GENIQUE
CA2308575A1 (en) 1997-11-03 1999-05-14 Tom Tsang Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6797505B2 (en) 1998-05-27 2004-09-28 Cell Genesys, Inc. Recombinant AAV vectors for gene therapy of hemophilia A
WO2000031267A1 (en) * 1998-11-20 2000-06-02 The Autonomous University Of Barcelona Insulin production by engineered muscle cells
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
DK1226233T3 (da) 1999-08-05 2011-10-03 Abt Holding Co Multipotente voksne stamceller og fremgangsmåder til isolering heraf
US20020177551A1 (en) * 2000-05-31 2002-11-28 Terman David S. Compositions and methods for treatment of neoplastic disease
JP2004504024A (ja) * 2000-07-18 2004-02-12 ソシエテ　デ　プロデユイ　ネツスル　ソシエテ　アノニム 前脂肪細胞系
US20050008621A1 (en) * 2001-10-06 2005-01-13 James Kirkland Preadipocyte cell strains and uses therefore
EP1496978A4 (en) * 2002-04-03 2006-11-29 Artecel Sciences Inc IMPROVEMENTS IN DIFFERENTIATED ADULT DIFFERENTIATED STEM CELLS DERIVED FROM ADIPOSE TISSUE AND USES THEREOF
JPWO2008108344A1 (ja) 2007-03-02 2010-06-17 セルジェンテック株式会社 Ｌｃａｔ欠損症の遺伝子治療用細胞並びに遺伝子治療用細胞組成物

Also Published As

Publication number Publication date
KR101004086B1 (ko) 2010-12-27
US8071085B2 (en) 2011-12-06
EP1541674B9 (en) 2011-09-14
DK1541674T3 (da) 2011-03-14
CA2488414A1 (en) 2003-12-24
EP2213730B1 (en) 2015-12-02
BRPI0312441B1 (pt) 2018-03-20
SI1541674T1 (sl) 2011-04-29
CA2488414C (en) 2011-04-26
EP2213730A1 (en) 2010-08-04
AU2003242459B2 (en) 2007-05-17
EP1541674A1 (en) 2005-06-15
PT1541674E (pt) 2011-03-21
BRPI0312441B8 (pt) 2021-05-25
KR20070087062A (ko) 2007-08-27
CN1671836B (zh) 2012-02-08
JPWO2003106663A1 (ja) 2005-10-13
BR0312441A (pt) 2005-04-19
DK2213730T3 (en) 2016-01-25
US20060121008A1 (en) 2006-06-08
WO2003106663A1 (ja) 2003-12-24
HUE025872T2 (en) 2016-05-30
ES2559430T3 (es) 2016-02-12
MA27324A1 (fr) 2005-05-02
ATE492630T1 (de) 2011-01-15
MXPA04012859A (es) 2005-03-31
EP2213730A8 (en) 2010-11-10
US20090010901A1 (en) 2009-01-08
CN1671836A (zh) 2005-09-21
DE60335473D1 (de) 2011-02-03
NZ537072A (en) 2006-12-22
US7820438B2 (en) 2010-10-26
ZA200500464B (en) 2005-12-28
EP1541674B1 (en) 2010-12-22
EP1541674A4 (en) 2007-01-10
AU2003242459A1 (en) 2003-12-31

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