DE60234163D1 - Zusammensetzungen zur gentherapie rheumatoider arthritis, die ein gen, das für ein anti-angiogenes protein oder teile davon kodiert, enthalten - Google Patents
Zusammensetzungen zur gentherapie rheumatoider arthritis, die ein gen, das für ein anti-angiogenes protein oder teile davon kodiert, enthaltenInfo
- Publication number
- DE60234163D1 DE60234163D1 DE60234163T DE60234163T DE60234163D1 DE 60234163 D1 DE60234163 D1 DE 60234163D1 DE 60234163 T DE60234163 T DE 60234163T DE 60234163 T DE60234163 T DE 60234163T DE 60234163 D1 DE60234163 D1 DE 60234163D1
- Authority
- DE
- Germany
- Prior art keywords
- rheumatoid arthritis
- gene therapy
- parts
- gene
- angiogenic protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 238000001415 gene therapy Methods 0.000 title abstract 5
- 230000001772 anti-angiogenic effect Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 4
- 102000012936 Angiostatins Human genes 0.000 abstract 1
- 108010079709 Angiostatins Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 210000003127 knee Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000005222 synovial tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20010000691 | 2001-01-05 | ||
PCT/KR2002/000001 WO2002053191A1 (en) | 2001-01-05 | 2002-01-03 | Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60234163D1 true DE60234163D1 (de) | 2009-12-10 |
Family
ID=36932148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60234163T Expired - Lifetime DE60234163D1 (de) | 2001-01-05 | 2002-01-03 | Zusammensetzungen zur gentherapie rheumatoider arthritis, die ein gen, das für ein anti-angiogenes protein oder teile davon kodiert, enthalten |
Country Status (8)
Country | Link |
---|---|
US (3) | US7175840B2 (de) |
EP (1) | EP1371377B1 (de) |
JP (1) | JP2004517117A (de) |
KR (1) | KR100495316B1 (de) |
CN (1) | CN1455682A (de) |
AT (1) | ATE446772T1 (de) |
DE (1) | DE60234163D1 (de) |
WO (1) | WO2002053191A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
AU2007219615B2 (en) | 2006-03-03 | 2013-11-28 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
AU2008245696B2 (en) | 2007-04-27 | 2013-11-07 | Pelican Technology Holdings, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2009038771A2 (en) * | 2007-09-19 | 2009-03-26 | Massachusetts Institute Of Technology | Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers |
JP2009091339A (ja) * | 2007-10-12 | 2009-04-30 | Seikagaku Kogyo Co Ltd | 関節リウマチの処置剤 |
EP2275437A4 (de) | 2008-03-18 | 2011-09-07 | Univ Hokkaido Nat Univ Corp | Polypeptid und das polypeptid enthaltende pharmazeutische zusammensetzung |
EP2431460B1 (de) * | 2009-05-13 | 2015-10-14 | Medipost, Co., Ltd. | Stammzellendifferenzierung assoziiertes tsp-1, tsp-2 und il-17br |
US9040298B2 (en) | 2009-05-29 | 2015-05-26 | Medipost Co., Ltd. | Method of selecting stem cells having high chondrogenic differentiation capability |
AU2014248198B2 (en) * | 2013-04-02 | 2018-11-29 | University Of Florida Research Foundation, Inc. | Compositions and methods for induction and modulation of angiogenesis and methods and assays for identifying angiogenesis modulators |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140111A (en) * | 1987-12-11 | 2000-10-31 | Whitehead Institute For Biomedical Research | Retroviral gene therapy vectors and therapeutic methods based thereon |
US6156304A (en) | 1990-12-20 | 2000-12-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Gene transfer for studying and treating a connective tissue of a mammalian host |
US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
US5792751A (en) * | 1992-04-13 | 1998-08-11 | Baylor College Of Medicine | Tranformation of cells associated with fluid spaces |
JPH064684A (ja) | 1992-06-22 | 1994-01-14 | Fujitsu Ltd | データ収集装置および方法 |
WO1994007524A1 (en) | 1992-10-02 | 1994-04-14 | California Pacific Medical Center Research Institute | Method of treatment of arthritis with platelet factor 4 |
US5885795A (en) | 1994-04-26 | 1999-03-23 | The Children's Medical Center Corporation | Methods of expressing angiostatic protein |
US5837682A (en) * | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US5861372A (en) * | 1996-02-22 | 1999-01-19 | The Children's Medical Center Corporation | Aggregate angiostatin and method of use |
CN1202932A (zh) | 1995-10-23 | 1998-12-23 | 儿童医学中心公司 | 治疗用抗血管生成的组合物和方法 |
KR100217586B1 (ko) | 1995-12-21 | 1999-09-01 | 정몽규 | 자동차의 동적 폐력 측정 장치 |
AU4401297A (en) | 1996-09-21 | 1998-04-14 | Viromedica Pacific Limited | Improved retroviral vectors for gene therapy |
WO1998051791A1 (fr) * | 1997-05-15 | 1998-11-19 | Shunichi Shiozawa | Gene responsable de l'arthrite rhumatoide, methode pour diagnostiquer l'arthrite rhumatoide et procede permettant de determiner des facteurs responsables de l'arthrite rhumatoide |
JP2002517999A (ja) | 1998-06-17 | 2002-06-25 | ベス イスラエル ディーコネス メディカル センター | 抗血管形成タンパク質およびその使用方法 |
KR20000006334A (ko) * | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
US6201104B1 (en) * | 1998-12-04 | 2001-03-13 | Entremed, Inc. | Angiogenesis—inhibiting protein binding peptides and proteins and methods of use |
KR20000046969A (ko) * | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
US20020115202A1 (en) * | 1999-08-13 | 2002-08-22 | Paul Hallenbeck | Adenoviral vectors including dna sequences encoding angiogenic inhibitors |
JP3726005B2 (ja) | 2000-03-09 | 2005-12-14 | 株式会社 日立インダストリイズ | 多段遠心圧縮機 |
JP2001256030A (ja) | 2000-03-14 | 2001-09-21 | Seiko Epson Corp | 印刷システム、印刷制御装置及びプログラム記録媒体 |
ATE328081T1 (de) | 2000-03-29 | 2006-06-15 | Beth Israel Hospital | Antiangiogene eigenschaften von vascostatin und fragmenten und varianten davon |
EP1197550A3 (de) | 2000-08-25 | 2002-11-20 | Pfizer Products Inc. | Methoden und Zusammensetzungen zur Diagnose unde Behandlung von Krankheiten an denen Angiogenese beteiligt ist |
US6803211B2 (en) | 2000-08-25 | 2004-10-12 | Pfizer Inc. | Methods and compositions for diagnosing and treating disorders involving angiogenesis |
EP1404359A2 (de) | 2000-12-07 | 2004-04-07 | Board Of Regents, The University Of Texas System | Behandlungsverfahren mit menschlichem mda-7 |
-
2002
- 2002-01-03 JP JP2002554140A patent/JP2004517117A/ja active Pending
- 2002-01-03 EP EP02727017A patent/EP1371377B1/de not_active Expired - Lifetime
- 2002-01-03 AT AT02727017T patent/ATE446772T1/de not_active IP Right Cessation
- 2002-01-03 DE DE60234163T patent/DE60234163D1/de not_active Expired - Lifetime
- 2002-01-03 US US10/220,824 patent/US7175840B2/en not_active Expired - Fee Related
- 2002-01-03 WO PCT/KR2002/000001 patent/WO2002053191A1/en active Application Filing
- 2002-01-03 CN CN02800043A patent/CN1455682A/zh active Pending
- 2002-01-04 KR KR10-2002-0000409A patent/KR100495316B1/ko not_active IP Right Cessation
-
2006
- 2006-05-11 US US11/431,663 patent/US20060198826A1/en not_active Abandoned
- 2006-05-11 US US11/431,526 patent/US20060193833A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050277603A1 (en) | 2005-12-15 |
KR100495316B1 (ko) | 2005-06-14 |
US20060198826A1 (en) | 2006-09-07 |
US7175840B2 (en) | 2007-02-13 |
KR20020057824A (ko) | 2002-07-12 |
EP1371377A1 (de) | 2003-12-17 |
ATE446772T1 (de) | 2009-11-15 |
WO2002053191A1 (en) | 2002-07-11 |
JP2004517117A (ja) | 2004-06-10 |
CN1455682A (zh) | 2003-11-12 |
US20060193833A1 (en) | 2006-08-31 |
EP1371377A4 (de) | 2006-01-18 |
EP1371377B1 (de) | 2009-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: VIROMED CO., LTD., SEOUL/SOUL, KR |
|
8364 | No opposition during term of opposition |