PT2094703E - Amidas de diazabicicloalcanos selectivas de um subtipo de receptor de acetilcolina nicotínico - Google Patents

Amidas de diazabicicloalcanos selectivas de um subtipo de receptor de acetilcolina nicotínico Download PDF

Info

Publication number: PT2094703E
Authority: PT; Portugal
Prior art keywords: receptorsub; diazabicycloalkanes; nicotinic acetylcholine; type selective; amides
Prior art date: 2006-11-02

Application number

PT07863786T

Other languages

English (en)

Inventor

Lan Miao

Anatoly Mazurov

Yun-De Xiao

Original Assignee

Targacept Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-02

Filing date

2007-11-01

Publication date

2011-07-22

2007-11-01 Application filed by Targacept Inc filed Critical Targacept Inc

2011-07-22 Publication of PT2094703E publication Critical patent/PT2094703E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT07863786T 2006-11-02 2007-11-01 Amidas de diazabicicloalcanos selectivas de um subtipo de receptor de acetilcolina nicotínico PT2094703E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US85607906P	2006-11-02	2006-11-02

Publications (1)

Publication Number	Publication Date
PT2094703E true PT2094703E (pt)	2011-07-22

Family

ID=39233054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT07863786T PT2094703E (pt)	2006-11-02	2007-11-01	Amidas de diazabicicloalcanos selectivas de um subtipo de receptor de acetilcolina nicotínico

Country Status (33)

Country	Link
US (6)	US8114889B2 (pt)
EP (2)	EP2284171B1 (pt)
JP (2)	JP5539723B2 (pt)
KR (2)	KR20100124356A (pt)
CN (4)	CN102838605B (pt)
AR (2)	AR063451A1 (pt)
AT (2)	ATE545646T1 (pt)
AU (2)	AU2007317433B2 (pt)
BR (2)	BRPI0722387A2 (pt)
CA (1)	CA2663925C (pt)
CL (1)	CL2007003155A1 (pt)
CO (1)	CO6180435A2 (pt)
CY (1)	CY1112374T1 (pt)
DK (1)	DK2094703T3 (pt)
ES (2)	ES2395157T3 (pt)
HK (2)	HK1133260A1 (pt)
HR (1)	HRP20110570T1 (pt)
IL (2)	IL197618A (pt)
MX (1)	MX2009004801A (pt)
MY (2)	MY156730A (pt)
NO (1)	NO20091251L (pt)
NZ (2)	NZ575557A (pt)
PE (2)	PE20110671A1 (pt)
PL (1)	PL2094703T3 (pt)
PT (1)	PT2094703E (pt)
RS (1)	RS51834B (pt)
RU (2)	RU2448969C2 (pt)
SA (1)	SA07280584B1 (pt)
SI (1)	SI2094703T1 (pt)
TW (3)	TWI405763B (pt)
UA (2)	UA98944C2 (pt)
UY (1)	UY30686A1 (pt)
WO (1)	WO2008057938A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI405763B (zh) *	2006-11-02	2013-08-21	Targacept Inc	菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
KR20100122508A (ko) *	2008-03-05	2010-11-22	타가셉트 인코포레이티드	디아자비시클로알칸의 니코틴 아세틸콜린 수용체 서브-타입 선택성 아미드
WO2009113950A1 (en) *	2008-03-10	2009-09-17	Astrazeneca Ab	Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist
US8536169B2 (en)	2008-06-05	2013-09-17	Glaxo Group Limited	Compounds
JP5502077B2 (ja)	2008-06-05	2014-05-28	グラクソグループリミテッド	新規な化合物
JP5508400B2 (ja)	2008-06-05	2014-05-28	グラクソグループリミテッド	Ｐｉ３キナーゼの阻害剤としてのベンズピラゾール誘導体
WO2010028033A1 (en) *	2008-09-05	2010-03-11	Targacept, Inc.	Amides of diazabicyclooctanes and uses thereof
WO2010028011A1 (en) *	2008-09-05	2010-03-11	Targacept, Inc.	Amides of diazabicyclononanes and uses thereof
WO2010080757A2 (en)	2009-01-07	2010-07-15	Astrazeneca Ab	Combinations with an alpha-4beta-2 nicotinic agonist
WO2010102958A1 (en)	2009-03-09	2010-09-16	Glaxo Group Limited	4-oxadiazol-2 -yl- indazoles as inhibitors of p13 kinases
ME02900B (me)	2009-04-30	2018-04-20	Glaxo Group Ltd	Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze
RU2417082C2 (ru) *	2009-07-14	2011-04-27	Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран)	Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения
US8735423B2 (en)	2009-11-18	2014-05-27	Suven Life Sciences Limited	Bicyclic compounds as α4β2 nicotinic acetylcholine receptor ligands
EA023293B1 (ru)	2009-12-29	2016-05-31	Сувен Лайф Сайенсиз Лимитед	ЛИГАНДЫ НЕЙРОНАЛЬНОГО НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА αβ
GB201018124D0 (en)	2010-10-27	2010-12-08	Glaxo Group Ltd	Polymorphs and salts
AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
WO2015078803A1 (en)	2013-11-26	2015-06-04	F. Hoffmann-La Roche Ag	NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL
AU2015238537B2 (en)	2014-03-26	2019-08-01	F. Hoffmann-La Roche Ag	Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
US9597284B2 (en)	2014-10-20	2017-03-21	Oyster Point Pharma, Inc.	Dry eye treatments
RU2746481C1 (ru)	2015-09-04	2021-04-14	Ф. Хоффманн-Ля Рош Аг	Феноксиметильные производные
RU2018112230A (ru)	2015-09-24	2019-10-30	Ф. Хоффманн-Ля Рош Аг	Бициклические соединения в качестве ингибиторов atx
RU2725138C2 (ru)	2015-09-24	2020-06-30	Ф. Хоффманн-Ля Рош Аг	Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca)
KR20180054634A (ko) *	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
MX2018002217A (es)	2015-09-24	2018-03-23	Hoffmann La Roche	Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).
PT3439661T (pt)	2016-04-07	2021-09-30	Oyster Point Pharma Inc	Métodos de tratamento de condições oculares
WO2018167001A1 (en)	2017-03-16	2018-09-20	F. Hoffmann-La Roche Ag	Heterocyclic compounds useful as dual atx/ca inhibitors
JP7090099B2 (ja)	2017-03-16	2022-06-23	エフ．ホフマン－ラロシュアーゲー	Ａｔｘインヒビターとしての新規二環式化合物
DK3483164T3 (da)	2017-03-20	2020-03-23	Forma Therapeutics Inc	Pyrrolopyrrolsammensætninger som pyruvatkinase (pkr) aktivatorer
US20230055923A1 (en)	2018-09-19	2023-02-23	Forma Therapeutics, Inc.	Activating pyruvate kinase r
US20220031671A1 (en)	2018-09-19	2022-02-03	Forma Therapeutics, Inc.	Treating sickle cell disease with a pyruvate kinase r activating compound

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU482990A1 (ru) *	1973-09-03	1978-04-15	Предприятие П/Я Г-4059	Способ получени 1,4-диазабицикло(2,2,2)-октана
US4922901A (en)	1988-09-08	1990-05-08	R. J. Reynolds Tobacco Company	Drug delivery articles utilizing electrical energy
IL107184A (en)	1992-10-09	1997-08-14	Abbott Lab	Heterocyclic ether compounds that enhance cognitive function
US5852041A (en)	1993-04-07	1998-12-22	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en)	1993-10-25	1996-02-20	Organix, Inc.	Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5468858A (en)	1993-10-28	1995-11-21	The Board Of Regents Of Oklahoma State University Physical Sciences	N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
BR9408450A (pt) *	1993-12-29	1997-08-05	Pfizer	Antagonistas da neuroquinina diazabiciclicos
US5457121A (en)	1994-09-02	1995-10-10	Eli Lilly And Company	Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
US5604231A (en)	1995-01-06	1997-02-18	Smith; Carr J.	Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5597919A (en)	1995-01-06	1997-01-28	Dull; Gary M.	Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en)	1995-04-07	1996-12-17	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en)	1995-05-17	1996-12-10	Bencherif; Merouane	Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en)	1995-06-07	2006-10-05	Abbott Lab	Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5616716A (en)	1996-01-06	1997-04-01	Dull; Gary M.	(3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv) *	1996-02-23	1996-02-23	Astra Ab	Azabicyclic esters of carbamic acids useful in therapy
US5663356A (en)	1996-04-23	1997-09-02	Ruecroft; Graham	Method for preparation of aryl substituted alefinic secondary amino compounds
US5726189A (en)	1996-05-03	1998-03-10	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
US5952339A (en)	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
AU1996301A (en) *	1999-12-14	2001-06-25	Neurosearch A/S	Novel heteroaryl-diazabicycloalkanes
US6809105B2 (en)	2000-04-27	2004-10-26	Abbott Laboratories	Diazabicyclic central nervous system active agents
WO2002070523A1 (en)	2001-03-07	2002-09-12	Pfizer Products Inc.	Modulators of chemokine receptor activity
MXPA04000012A (es) *	2001-07-06	2004-05-21	Neurosearch As	Compuestos novedosos, su preparacion y uso.
SE0202430D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New Compounds
SE0202465D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New compounds
CN1317280C (zh) *	2003-02-27	2007-05-23	神经研究公司	新的二氮杂双环芳基衍生物
NZ540998A (en) *	2003-02-27	2008-06-30	Neurosearch As	Novel diazabicyclic aryl derivatives
US7399765B2 (en) *	2003-09-19	2008-07-15	Abbott Laboratories	Substituted diazabicycloalkane derivatives
US7365193B2 (en) *	2004-02-04	2008-04-29	Abbott Laboratories	Amino-substituted tricyclic derivatives and methods of use
MXPA06014404A (es) *	2004-06-09	2007-02-19	Hoffmann La Roche	Compuestos heterociclicos antivirales.
CN101065385A (zh)	2004-07-22	2007-10-31	坎布里制药公司	治疗微生物感染的利福霉素衍生物
RU2007146444A (ru)	2005-05-13	2009-06-20	Лексикон Фармасьютикалз, Инк. (Us)	Полициклические соединения и способы их применения
TWI405763B (zh) *	2006-11-02	2013-08-21	Targacept Inc	菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺

2007
- 2007-10-19 TW TW096139391A patent/TWI405763B/zh not_active IP Right Cessation
- 2007-10-19 TW TW101139986A patent/TWI454262B/zh not_active IP Right Cessation
- 2007-10-19 TW TW099135628A patent/TWI404532B/zh not_active IP Right Cessation
- 2007-10-30 SA SA07280584A patent/SA07280584B1/ar unknown
- 2007-10-31 PE PE2011000136A patent/PE20110671A1/es not_active Application Discontinuation
- 2007-10-31 PE PE2007001487A patent/PE20081441A1/es not_active Application Discontinuation
- 2007-10-31 CL CL200703155A patent/CL2007003155A1/es unknown
- 2007-11-01 PL PL07863786T patent/PL2094703T3/pl unknown
- 2007-11-01 AR ARP070104876A patent/AR063451A1/es not_active Application Discontinuation
- 2007-11-01 US US12/447,850 patent/US8114889B2/en not_active Expired - Fee Related
- 2007-11-01 RS RS20110339A patent/RS51834B/en unknown
- 2007-11-01 AT AT10075738T patent/ATE545646T1/de active
- 2007-11-01 MX MX2009004801A patent/MX2009004801A/es active IP Right Grant
- 2007-11-01 EP EP10075738A patent/EP2284171B1/en active Active
- 2007-11-01 WO PCT/US2007/083330 patent/WO2008057938A1/en active Application Filing
- 2007-11-01 RU RU2009120674/04A patent/RU2448969C2/ru not_active IP Right Cessation
- 2007-11-01 ES ES10075738T patent/ES2395157T3/es active Active
- 2007-11-01 UA UAA200905474A patent/UA98944C2/ru unknown
- 2007-11-01 JP JP2009535465A patent/JP5539723B2/ja active Active
- 2007-11-01 SI SI200730628T patent/SI2094703T1/sl unknown
- 2007-11-01 NZ NZ575557A patent/NZ575557A/en not_active IP Right Cessation
- 2007-11-01 CA CA2663925A patent/CA2663925C/en not_active Expired - Fee Related
- 2007-11-01 CN CN201210291637.1A patent/CN102838605B/zh not_active Expired - Fee Related
- 2007-11-01 UA UAA200912807A patent/UA106718C2/uk unknown
- 2007-11-01 RU RU2009138600/04A patent/RU2517693C2/ru not_active IP Right Cessation
- 2007-11-01 BR BRPI0722387-0A patent/BRPI0722387A2/pt not_active Application Discontinuation
- 2007-11-01 PT PT07863786T patent/PT2094703E/pt unknown
- 2007-11-01 CN CN2010105367790A patent/CN102020646B/zh not_active Expired - Fee Related
- 2007-11-01 CN CN2007800402281A patent/CN101528745B/zh not_active Expired - Fee Related
- 2007-11-01 MY MYPI2011004927A patent/MY156730A/en unknown
- 2007-11-01 AT AT07863786T patent/ATE509022T1/de active
- 2007-11-01 BR BRPI0717930-8A patent/BRPI0717930A2/pt not_active IP Right Cessation
- 2007-11-01 ES ES07863786T patent/ES2395212T3/es active Active
- 2007-11-01 AU AU2007317433A patent/AU2007317433B2/en not_active Ceased
- 2007-11-01 NZ NZ587847A patent/NZ587847A/en not_active IP Right Cessation
- 2007-11-01 EP EP07863786A patent/EP2094703B1/en active Active
- 2007-11-01 DK DK07863786.5T patent/DK2094703T3/da active
- 2007-11-01 CN CN201210401679.6A patent/CN102942569B/zh not_active Expired - Fee Related
- 2007-11-01 KR KR1020107025973A patent/KR20100124356A/ko active IP Right Grant
- 2007-11-01 KR KR1020097008122A patent/KR101415705B1/ko active IP Right Grant
- 2007-11-01 MY MYPI20091569A patent/MY145602A/en unknown
- 2007-11-01 UY UY30686A patent/UY30686A1/es not_active Application Discontinuation
2009
- 2009-03-16 IL IL197618A patent/IL197618A/en not_active IP Right Cessation
- 2009-03-26 NO NO20091251A patent/NO20091251L/no not_active Application Discontinuation
- 2009-06-01 CO CO09056352A patent/CO6180435A2/es active IP Right Grant
2010
- 2010-01-20 HK HK10100570.6A patent/HK1133260A1/xx not_active IP Right Cessation
- 2010-01-20 HK HK11103927.9A patent/HK1149751A1/xx not_active IP Right Cessation
- 2010-03-15 US US12/723,790 patent/US8268860B2/en not_active Expired - Fee Related
- 2010-09-07 AU AU2010219323A patent/AU2010219323B2/en not_active Ceased
- 2010-10-31 IL IL209026A patent/IL209026A/en not_active IP Right Cessation
2011
- 2011-01-05 AR ARP110100026A patent/AR079840A2/es not_active Application Discontinuation
- 2011-07-20 CY CY20111100706T patent/CY1112374T1/el unknown
- 2011-08-02 HR HR20110570T patent/HRP20110570T1/hr unknown
2012
- 2012-01-03 US US13/342,635 patent/US8859609B2/en active Active
- 2012-07-23 US US13/555,458 patent/US8921410B2/en active Active
- 2012-11-19 JP JP2012253103A patent/JP5739398B2/ja active Active
2014
- 2014-11-24 US US14/551,498 patent/US20150080576A1/en not_active Abandoned
2015
- 2015-10-26 US US14/922,473 patent/US9580434B2/en active Active

Also Published As

Publication number	Publication date
IL197618A (en)	2013-09-30
NZ587847A (en)	2011-09-30
AU2007317433B2 (en)	2012-05-10
TWI405763B (zh)	2013-08-21
US20120289572A1 (en)	2012-11-15
UA98944C2 (ru)	2012-07-10
EP2284171A1 (en)	2011-02-16
EP2094703B1 (en)	2011-05-11
CA2663925A1 (en)	2008-05-15
US20130005789A1 (en)	2013-01-03
WO2008057938A1 (en)	2008-05-15
US20160039833A1 (en)	2016-02-11
US9580434B2 (en)	2017-02-28
IL209026A0 (en)	2011-01-31
PL2094703T3 (pl)	2011-10-31
UA106718C2 (uk)	2014-10-10
KR20100124356A (ko)	2010-11-26
TW201305176A (zh)	2013-02-01
RU2009120674A (ru)	2010-12-10
BRPI0717930A2 (pt)	2011-05-10
CN102942569B (zh)	2015-10-28
ES2395212T3 (es)	2013-02-11
HK1133260A1 (en)	2010-03-19
UY30686A1 (es)	2009-08-03
NO20091251L (no)	2009-05-28
JP2010509230A (ja)	2010-03-25
RS51834B (en)	2012-02-29
IL197618A0 (en)	2009-12-24
DK2094703T3 (da)	2011-08-29
CY1112374T1 (el)	2015-12-09
IL209026A (en)	2014-03-31
RU2009138600A (ru)	2011-04-27
RU2448969C2 (ru)	2012-04-27
US8114889B2 (en)	2012-02-14
AU2010219323B2 (en)	2012-05-03
CN101528745A (zh)	2009-09-09
CL2007003155A1 (es)	2008-05-16
CA2663925C (en)	2015-04-21
PE20081441A1 (es)	2008-10-30
US8268860B2 (en)	2012-09-18
US8921410B2 (en)	2014-12-30
EP2284171B1 (en)	2012-02-15
US20100173932A1 (en)	2010-07-08
CN102838605A (zh)	2012-12-26
ATE509022T1 (de)	2011-05-15
AR063451A1 (es)	2009-01-28
TW200826935A (en)	2008-07-01
SA07280584B1 (ar)	2010-11-02
TWI454262B (zh)	2014-10-01
NZ575557A (en)	2011-01-28
HRP20110570T1 (hr)	2011-09-30
MY156730A (en)	2016-03-15
CN102942569A (zh)	2013-02-27
BRPI0722387A2 (pt)	2023-02-23
CN102020646A (zh)	2011-04-20
US8859609B2 (en)	2014-10-14
PE20110671A1 (es)	2011-10-20
US20150080576A1 (en)	2015-03-19
AU2007317433A1 (en)	2008-05-15
TWI404532B (zh)	2013-08-11
JP5739398B2 (ja)	2015-06-24
MY145602A (en)	2012-03-15
JP5539723B2 (ja)	2014-07-02
AU2010219323A1 (en)	2010-09-30
CN101528745B (zh)	2011-09-14
HK1149751A1 (en)	2011-10-14
KR101415705B1 (ko)	2014-07-04
ES2395157T3 (es)	2013-02-08
MX2009004801A (es)	2009-07-31
ATE545646T1 (de)	2012-03-15
US20100081683A1 (en)	2010-04-01
CN102020646B (zh)	2013-11-13
CO6180435A2 (es)	2010-07-19
RU2517693C2 (ru)	2014-05-27
AR079840A2 (es)	2012-02-22
EP2094703A1 (en)	2009-09-02
CN102838605B (zh)	2017-04-26
TW201114424A (en)	2011-05-01
KR20090074051A (ko)	2009-07-03
JP2013056919A (ja)	2013-03-28
SI2094703T1 (sl)	2011-07-29

Publication	Publication Date	Title
HK1133260A1 (en)	2010-03-19	Nicotinic acetylcholine receptorsub-type selective amides of diazabicycloalkanes
HUS000510I2 (hu)	2021-03-29	Oxatiapiprolin vagy N-oxidja vagy sója
HRP20130626T1 (en)	2013-08-31	Pyridinone compounds
IL227668A0 (en)	2013-09-30	Azadmantane derivatives and their uses as ligands for nicotinic acylcholine receptors
EP2000245A4 (en)	2009-11-04	WELDING PROCESS
DK2035004T3 (en)	2013-01-02	Phenylsubstituerede pyrazinoylguanidin-natriumkanalblokkere med beta-agonistaktivitet
HK1135090A1 (en)	2010-05-28	Pyridine carboxamides as 11-beta-hsd1 inhibitors
EP2082818A4 (en)	2014-09-10	RACK AND MANUFACTURING METHOD THEREFOR
ZA200901974B (en)	2010-06-30	Thiophene-sulfonic acid picolyl amides
EP2013903A4 (en)	2009-12-16	STRESSOR INTEGRATION AND METHOD THEREFOR
IL247957A0 (en)	2016-11-30	Anti-ephrinb2 antibodies and methods of using them
GB0705854D0 (en)	2007-05-02	Methods of construction
GB0608966D0 (en)	2006-06-14	Method and product
ZA200809112B (en)	2009-07-29	N-oxides of pyridylmethylpiperazine and -piperidine derivatives
HK1128661A1 (en)	2009-11-06	Time recorder
GB0607488D0 (en)	2006-05-24	Composition and process
GB0605004D0 (en)	2006-04-19	Composition and process
GB0610059D0 (en)	2006-06-28	Uses and methods
GB0607493D0 (en)	2006-05-24	Composition and process
TWM298391U (en)	2006-10-01	Improved structure of bar
AU2012205208B2 (en)	2014-11-06	Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes
IL194758A0 (en)	2009-08-03	N-oxides of pyridylmethylpipertazine and-piperidine derivatives
GB0622809D0 (en)	2006-12-27	Teaching aid
GB0624071D0 (en)	2007-01-10	Purification methods and materials
IL187936A0 (en)	2008-03-20	Joining device of passage block