PT1455756E - Composição farmacêutica em nanopartículas de um antagonista do receptor da taquicinina - Google Patents

Composição farmacêutica em nanopartículas de um antagonista do receptor da taquicinina Download PDF

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Publication number
PT1455756E
PT1455756E PT02796109T PT02796109T PT1455756E PT 1455756 E PT1455756 E PT 1455756E PT 02796109 T PT02796109 T PT 02796109T PT 02796109 T PT02796109 T PT 02796109T PT 1455756 E PT1455756 E PT 1455756E
Authority
PT
Portugal
Prior art keywords
receptor antagonist
tachykinin receptor
nanoparticulate composition
pharmaceutical
pharmaceutical nanoparticulate
Prior art date
Application number
PT02796109T
Other languages
English (en)
Inventor
William H Bosch
Elaine Liversidge
Suhas D Shelukar
Karen C Thompson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23331619&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1455756(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT1455756E publication Critical patent/PT1455756E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT02796109T 2001-12-10 2002-12-09 Composição farmacêutica em nanopartículas de um antagonista do receptor da taquicinina PT1455756E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34004001P 2001-12-10 2001-12-10

Publications (1)

Publication Number Publication Date
PT1455756E true PT1455756E (pt) 2008-10-16

Family

ID=23331619

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02796109T PT1455756E (pt) 2001-12-10 2002-12-09 Composição farmacêutica em nanopartículas de um antagonista do receptor da taquicinina

Country Status (39)

Country Link
US (1) US8258132B2 (pt)
EP (1) EP1455756B2 (pt)
JP (1) JP4532114B2 (pt)
KR (1) KR20040063991A (pt)
CN (1) CN100352443C (pt)
AR (1) AR037713A1 (pt)
AT (1) ATE400254T1 (pt)
AU (1) AU2002360824B8 (pt)
BR (1) BRPI0214786B8 (pt)
CA (1) CA2469315C (pt)
CO (1) CO5590887A2 (pt)
CY (1) CY1108354T1 (pt)
DE (1) DE60227556D1 (pt)
DK (1) DK1455756T4 (pt)
DO (1) DOP2002000542A (pt)
EA (1) EA007332B1 (pt)
EC (1) ECSP045144A (pt)
ES (1) ES2307820T5 (pt)
GE (1) GEP20063875B (pt)
HK (1) HK1078017A1 (pt)
HR (1) HRP20040532B1 (pt)
HU (1) HU230736B1 (pt)
IL (3) IL162296A0 (pt)
IS (1) IS2991B (pt)
JO (1) JO3060B1 (pt)
ME (1) ME00450B (pt)
MX (1) MXPA04005563A (pt)
MY (1) MY155911A (pt)
NO (1) NO336943B1 (pt)
NZ (1) NZ534009A (pt)
PE (1) PE20030641A1 (pt)
PL (1) PL211243B6 (pt)
PT (1) PT1455756E (pt)
RS (1) RS52280B (pt)
SI (1) SI1455756T2 (pt)
TW (1) TWI249403B (pt)
UA (1) UA76810C2 (pt)
WO (1) WO2003049718A1 (pt)
ZA (1) ZA200404012B (pt)

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Also Published As

Publication number Publication date
IL201658A0 (en) 2011-08-01
EA007332B1 (ru) 2006-08-25
ECSP045144A (es) 2004-07-23
RS52280B (en) 2012-10-31
DE60227556D1 (de) 2008-08-21
IS2991B (is) 2017-12-15
RS50404A (en) 2007-04-10
JO3060B1 (ar) 2017-03-15
CO5590887A2 (es) 2005-12-30
US8258132B2 (en) 2012-09-04
HRP20040532A2 (en) 2004-10-31
PL211243B1 (pl) 2012-04-30
JP2005516003A (ja) 2005-06-02
NO20042905L (no) 2004-09-10
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JP4532114B2 (ja) 2010-08-25
DK1455756T3 (da) 2008-11-17
TWI249403B (en) 2006-02-21
UA76810C2 (uk) 2006-09-15
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AU2002360824A1 (en) 2003-06-23
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HK1078017A1 (en) 2006-03-03
CA2469315C (en) 2008-12-02
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CN1617712A (zh) 2005-05-18
PL211243B6 (pl) 2023-01-23
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ME00450B (me) 2011-10-10
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BR0214786A (pt) 2004-11-09
HRP20040532B1 (en) 2012-09-30
WO2003049718A1 (en) 2003-06-19
BRPI0214786B1 (pt) 2018-11-27
EP1455756A1 (en) 2004-09-15
IS7276A (is) 2004-05-21
SI1455756T1 (sl) 2008-12-31
US20040214746A1 (en) 2004-10-28
SI1455756T2 (sl) 2016-01-29
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ATE400254T1 (de) 2008-07-15
HUP0402596A2 (hu) 2005-03-29
GEP20063875B (en) 2006-07-10
HU230736B1 (hu) 2018-01-29
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TW200301125A (en) 2003-07-01
AU2002360824B2 (en) 2008-05-08
BRPI0214786B8 (pt) 2021-05-25
ES2307820T5 (es) 2016-01-13
CA2469315A1 (en) 2003-06-19
HUP0402596A3 (en) 2011-05-30
PE20030641A1 (es) 2003-07-23
KR20040063991A (ko) 2004-07-15
AU2002360824B8 (en) 2008-05-22
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NO336943B1 (no) 2015-11-30

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