PT100075A - Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo - Google Patents

Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo

Info

Publication number: PT100075A
Authority: PT; Portugal
Prior art keywords: acyl; perturbactions; hydroxidifosphonics; arilalquil; osteoarticular
Prior art date: 1991-02-01

Application number

PT100075A

Other languages

English (en)

Other versions

PT100075B (pt

Inventor

Sergio Rosini

Maurizio Mian

Original Assignee

Gentili Ist Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-01

Filing date

1992-01-30

Publication date

1993-03-31

1992-01-30 Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa

1993-03-31 Publication of PT100075A publication Critical patent/PT100075A/pt

1999-06-30 Publication of PT100075B publication Critical patent/PT100075B/pt

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 3
239000002260 anti-inflammatory agent Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Lubricants (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT100075A 1991-02-01 1992-01-30 Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo PT100075B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI910254A IT1244698B (it)	1991-02-01	1991-02-01	Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Publications (2)

Publication Number	Publication Date
PT100075A true PT100075A (pt)	1993-03-31
PT100075B PT100075B (pt)	1999-06-30

Family

ID=11358376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100075A PT100075B (pt)	1991-02-01	1992-01-30	Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo

Country Status (20)

Country	Link
US (1)	US5466682A (pt)
EP (1)	EP0569411B1 (pt)
JP (1)	JP3046624B2 (pt)
KR (1)	KR100190911B1 (pt)
AT (1)	ATE120464T1 (pt)
AU (1)	AU653780B2 (pt)
CA (1)	CA2101548C (pt)
CZ (1)	CZ288731B6 (pt)
DE (1)	DE69201863T2 (pt)
DK (1)	DK0569411T3 (pt)
ES (1)	ES2069990T3 (pt)
FI (1)	FI105403B (pt)
HK (1)	HK1006311A1 (pt)
HU (2)	HU215918B (pt)
IT (1)	IT1244698B (pt)
MX (1)	MX9200452A (pt)
PT (1)	PT100075B (pt)
RU (1)	RU2079505C1 (pt)
SK (1)	SK280053B6 (pt)
WO (1)	WO1992013864A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6452098A (en)	1997-03-07	1998-09-22	Metabasis Therapeutics, Inc.	Novel purine inhibitors of fructose-1,6-bisphosphatase
WO1998039342A1 (en)	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2530139C3 (de) *	1975-04-30	1979-06-21	Joh. A. Benckiser Gmbh, 6700 Ludwigshafen	N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung
DE2651904C2 (de) *	1976-11-13	1983-01-05	Joh. A. Benckiser Gmbh, 6700 Ludwigshafen	Verfahren zur Herstellung von N-Acyl-N-alkylaminomethandiphosphonsäuren
EP0084822B1 (de) *	1982-01-27	1986-01-08	Schering Aktiengesellschaft	Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3203308A1 (de) *	1982-01-27	1983-07-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) *	1982-07-29	1987-08-28	Sanofi Sa	Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3512536A1 (de) *	1985-04-06	1986-10-16	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ES2039237T3 (es) *	1986-04-24	1993-09-16	Fujisawa Pharmaceutical Co., Ltd.	Procedimiento para preparar nuevos compuestos de acido difosfonico.
DE3623397A1 (de) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPH0778024B2 (ja) *	1988-10-14	1995-08-23	藤沢薬品工業株式会社	医薬化合物とジホスホン酸誘導体の結合体を含有する医薬用製剤
PH26923A (en) *	1989-03-08	1992-12-03	Ciba Geigy	N-substituted amino alkanediphosphonic acids
US5159108A (en) *	1990-09-18	1992-10-27	Merck & Co., Inc.	Process for preparing an antihypercalcemic agent

1991
- 1991-02-01 IT ITMI910254A patent/IT1244698B/it active IP Right Grant
1992
- 1992-01-20 CZ CZ19931533A patent/CZ288731B6/cs not_active IP Right Cessation
- 1992-01-20 CA CA002101548A patent/CA2101548C/en not_active Expired - Fee Related
- 1992-01-20 ES ES92903398T patent/ES2069990T3/es not_active Expired - Lifetime
- 1992-01-20 KR KR1019930702242A patent/KR100190911B1/ko not_active IP Right Cessation
- 1992-01-20 US US08/094,160 patent/US5466682A/en not_active Expired - Lifetime
- 1992-01-20 EP EP92903398A patent/EP0569411B1/en not_active Expired - Lifetime
- 1992-01-20 HU HU9302188A patent/HU215918B/hu not_active IP Right Cessation
- 1992-01-20 AU AU11709/92A patent/AU653780B2/en not_active Ceased
- 1992-01-20 AT AT92903398T patent/ATE120464T1/de not_active IP Right Cessation
- 1992-01-20 DK DK92903398.3T patent/DK0569411T3/da active
- 1992-01-20 DE DE69201863T patent/DE69201863T2/de not_active Expired - Fee Related
- 1992-01-20 JP JP4503474A patent/JP3046624B2/ja not_active Expired - Fee Related
- 1992-01-20 WO PCT/EP1992/000102 patent/WO1992013864A1/en active IP Right Grant
- 1992-01-20 RU RU9293052408A patent/RU2079505C1/ru active
- 1992-01-20 SK SK799-93A patent/SK280053B6/sk unknown
- 1992-01-30 PT PT100075A patent/PT100075B/pt not_active IP Right Cessation
- 1992-01-31 MX MX9200452A patent/MX9200452A/es unknown
1993
- 1993-07-16 FI FI933231A patent/FI105403B/fi active
1995
- 1995-06-02 HU HU95P/P00154P patent/HU211203A9/hu unknown
1998
- 1998-06-16 HK HK98105383A patent/HK1006311A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU1170992A (en)	1992-09-07
ITMI910254A1 (it)	1992-08-01
SK79993A3 (en)	1993-12-08
FI933231A0 (fi)	1993-07-16
HK1006311A1 (en)	1999-02-19
JP3046624B2 (ja)	2000-05-29
CZ153393A3 (en)	1994-01-19
CA2101548C (en)	2002-08-27
ES2069990T3 (es)	1995-05-16
DK0569411T3 (da)	1995-08-28
WO1992013864A1 (en)	1992-08-20
CZ288731B6 (cs)	2001-08-15
MX9200452A (es)	1992-08-01
CA2101548A1 (en)	1992-08-02
HU9302188D0 (en)	1993-10-28
HU211203A9 (en)	1995-11-28
RU2079505C1 (ru)	1997-05-20
JPH06504783A (ja)	1994-06-02
DE69201863D1 (de)	1995-05-04
AU653780B2 (en)	1994-10-13
DE69201863T2 (de)	1995-09-07
SK280053B6 (sk)	1999-07-12
HU215918B (hu)	1999-03-29
ITMI910254A0 (it)	1991-02-01
PT100075B (pt)	1999-06-30
ATE120464T1 (de)	1995-04-15
IT1244698B (it)	1994-08-08
KR100190911B1 (ko)	1999-06-01
EP0569411B1 (en)	1995-03-29
FI105403B (fi)	2000-08-15
EP0569411A1 (en)	1993-11-18
HUT64964A (en)	1994-03-28
US5466682A (en)	1995-11-14
FI933231A (fi)	1993-07-16

Legal Events

Date

Code

Title

Description

1993-03-31

BB1A

Laying open of patent application

Effective date: 19921110

1999-06-30

FG3A

Patent granted, date of granting

Effective date: 19990317

2014-03-25

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20140317

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ATE60759T1 (de)	1991-02-15	Bisdimethoxymethyl(trimethoxybenzyl)isochinolinium salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
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FI972434A0 (fi)	1997-06-06	Lamotrigiiniä sisältävä farmaseuttinen koostumus
ZA879280B (en)	1989-08-30	Basically substituted phenylacetonitriles,their preparation and drugs containing these compounds
PT100075A (pt)	1993-03-31	Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo
SE8903529D0 (sv)	1989-10-24	Medical use
PT100216A (pt)	1993-05-31	N- 4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil carbonil -aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem
ZA90962B (en)	1991-10-30	Phenylhydrazones,the manufacture thereof and therapeutic and cosmetic compositions prepared therefrom
PT94685A (pt)	1991-03-20	Processo para a preparacao de 2-imidazolinas substituidas e de composicoes farmaceuticas que as contem
ZA903111B (en)	1991-12-24	2-hydroxy-3-phenoxypropylamino compounds and pharmaceutical compositions containing them
MX9301627A (es)	1994-07-29	Agente para utilizarse como un antiirritante y composicion que lo contiene.
NO950177D0 (no)	1995-01-17	Farmakologisk aktive erivater
ES8307778A1 (es)	1983-08-16	Procedimiento para preparar difenilbutil-1-piperazinocarboxilatos.
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