PL2280720T3 - Syntetyczne peptydoglikany wiążące kolagen, otrzymywanie oraz sposoby zastosowania - Google Patents

Syntetyczne peptydoglikany wiążące kolagen, otrzymywanie oraz sposoby zastosowania

Info

Publication number
PL2280720T3
PL2280720T3 PL09725336T PL09725336T PL2280720T3 PL 2280720 T3 PL2280720 T3 PL 2280720T3 PL 09725336 T PL09725336 T PL 09725336T PL 09725336 T PL09725336 T PL 09725336T PL 2280720 T3 PL2280720 T3 PL 2280720T3
Authority
PL
Poland
Prior art keywords
collagen
preparation
methods
binding synthetic
synthetic peptidoglycans
Prior art date
Application number
PL09725336T
Other languages
English (en)
Inventor
Alyssa Panitch
John Eric Paderi
Kinam Park
Katherine Stuart
Steve Higbee
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of PL2280720T3 publication Critical patent/PL2280720T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
PL09725336T 2008-03-27 2009-03-27 Syntetyczne peptydoglikany wiążące kolagen, otrzymywanie oraz sposoby zastosowania PL2280720T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3993308P 2008-03-27 2008-03-27
US8198408P 2008-07-18 2008-07-18
PCT/US2009/038624 WO2009120995A2 (en) 2008-03-27 2009-03-27 Collagen-binding synthetic peptidoglycans, preparation, and methods of use
EP09725336.3A EP2280720B1 (en) 2008-03-27 2009-03-27 Collagen-binding synthetic peptidoglycans, preparation, and methods of use

Publications (1)

Publication Number Publication Date
PL2280720T3 true PL2280720T3 (pl) 2019-07-31

Family

ID=41114790

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09725336T PL2280720T3 (pl) 2008-03-27 2009-03-27 Syntetyczne peptydoglikany wiążące kolagen, otrzymywanie oraz sposoby zastosowania

Country Status (15)

Country Link
US (4) US8846003B2 (pl)
EP (1) EP2280720B1 (pl)
JP (2) JP5740301B2 (pl)
AU (4) AU2009228140B2 (pl)
CA (1) CA2719254C (pl)
CY (1) CY1121954T1 (pl)
DK (1) DK2280720T3 (pl)
ES (1) ES2720368T3 (pl)
HR (1) HRP20190691T1 (pl)
HU (1) HUE044239T2 (pl)
LT (1) LT2280720T (pl)
PL (1) PL2280720T3 (pl)
PT (1) PT2280720T (pl)
SI (1) SI2280720T1 (pl)
WO (1) WO2009120995A2 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
AU2009205886B2 (en) 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
US8846003B2 (en) 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
US20120100106A1 (en) * 2009-05-04 2012-04-26 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
CN105107083B (zh) * 2010-03-19 2018-04-24 考思美德制药株式会社 含有蛋白聚糖的微针阵列
ES2742218T3 (es) * 2010-06-23 2020-02-13 Purdue Research Foundation Peptidoglicanos sintéticos que se enlazan al colágeno destinados a ser utilizados en operaciones vasculares
WO2012112767A2 (en) * 2011-02-16 2012-08-23 Purdue Research Foundation Collagen-targeted nanoparticles
ES2708076T3 (es) * 2011-05-24 2019-04-08 Symic Ip Llc Peptidoglicanos sintéticos que se unen al ácido hialurónico, preparación y métodos de uso
KR20150130419A (ko) 2013-03-15 2015-11-23 시믹 바이오메디칼, 인크. 세포외 기질 결합성 합성 펩티도글리칸
US20150044259A1 (en) * 2013-08-08 2015-02-12 Mauris N. DeSilva Scaffold for enhanced neural tissue regeneration
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
KR20170016857A (ko) 2014-05-12 2017-02-14 퍼듀 리서치 파운데이션 셀렉틴 및 icam/vcam 펩티드 리간드 접합체
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
US10865811B2 (en) 2015-02-06 2020-12-15 The University Of British Columbia Engineered tissue substitute system
ES2919964T3 (es) * 2015-08-17 2022-07-29 Univ Johns Hopkins Material compuesto que se forma in situ para la restauración de tejido
WO2017066349A1 (en) 2015-10-13 2017-04-20 Symic Ip, Llc Ve-cadherin binding bioconjugate
KR101807593B1 (ko) 2015-12-30 2017-12-11 포항공과대학교 산학협력단 흉터 최소화 상처 재생 촉진용 재조합 폴리펩타이드 및 이를 포함하는 생체 접착 소재
CN110809478A (zh) * 2017-07-07 2020-02-18 斯米克Ip有限公司 合成的生物缀合物
EP3648775A4 (en) * 2017-07-07 2021-04-21 Symic IP, LLC CHEMICALLY MODIFIED SKELETON BIOCONJUGATES
CN112384258A (zh) 2018-05-09 2021-02-19 约翰·霍普金斯大学 用于细胞和组织递送的纳米纤维-水凝胶复合物

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683298A (en) * 1985-01-10 1987-07-28 British Columbia Research Council Process for the preparation of aminated polysaccharide derivatives
US5547936A (en) 1985-06-17 1996-08-20 La Jolla Cancer Research Foundation Inhibition of cell migration with synthetic peptides
JPH04503951A (ja) 1988-12-20 1992-07-16 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 創傷治癒に活性のあるポリペプチド―ポリマー複合体
US5693625A (en) 1989-03-09 1997-12-02 Therapeutiques Substitutives Method of regenerating cells and tissues using functionalized dextrans
FR2644066B1 (fr) 1989-03-09 1994-05-13 Therapeutiques Substitutives Compositions stabilisees comprenant des fgfs, leur procede d'obtention et leurs applications therapeutiques, chirurgicales et cosmetologiques
US5342830A (en) 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
EP0567575B1 (en) 1991-01-14 1999-10-13 New York University Cytokine-induced protein, tsg-6, dna coding therefor and uses thereof
JP2901787B2 (ja) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
FR2718023B1 (fr) 1994-03-30 1996-08-14 Paris Val Marne Universite Médicament et composition pharmaceutique pour le traitement de lésions du tractus digestif.
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
DK1704878T3 (da) 1995-12-18 2013-07-01 Angiodevice Internat Gmbh Tværbundne polymerpræparater og fremgangsmåder til deres anvendelse
CA2299687C (en) 1997-08-04 2009-10-27 Bio Syntech Ltd. Temperature-controlled ph-dependant formation of ionic polysaccharide gels
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
CA2307846A1 (en) 1997-11-21 1999-06-03 Genset S.A. Chlamydia pneumoniae genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
US7691829B2 (en) 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
US20050208114A1 (en) 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
JP3103531B2 (ja) 1998-09-30 2000-10-30 延也 柳内 ヒト尿由来細胞接着糖蛋白質及びその製造方法
US6822071B1 (en) 1998-11-12 2004-11-23 The Regents Of The University Of California Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
US6703491B1 (en) 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
US20110214206A1 (en) 1999-05-06 2011-09-01 La Rosa Thomas J Nucleic acid molecules and other molecules associated with plants
FR2794976B1 (fr) 1999-06-16 2004-05-07 Solutions Compositions pharmaceutiques a action cicatrisante ou anti-complementaire comprenant un derive de dextrane
DE60043736D1 (de) 1999-09-15 2010-03-11 Euclid Systems Corp Zusammensetzung zur stabilisierung des corneagewebon kontaktlinsen
FR2799465B1 (fr) 1999-10-12 2004-02-13 Centre Nat Rech Scient Peptides ayant une activite de stimulation de la reponse immunitaire et de regeneration tissulaire
US20030158302A1 (en) 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
ATE243049T1 (de) 1999-12-09 2003-07-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
AU2001288392A1 (en) 2000-08-30 2002-03-13 University Of Delaware Delivery system for heparin-binding growth factors
WO2002018423A1 (en) 2000-08-31 2002-03-07 University Of Delaware Bioactive peptide for cell adhesion
WO2002028441A2 (en) * 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
WO2002040070A2 (en) 2000-11-15 2002-05-23 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
WO2003029401A2 (en) 2001-07-13 2003-04-10 Advanced Research And Technology Institute Peptidoglycan recognition protein encoding nucleic acids and methods of use thereof
DE60230877D1 (de) * 2001-08-15 2009-03-05 Univ Brown Res Found Behandlung von muskeldystrophien und verwandter erkrankungen
DK1448607T3 (da) 2001-11-15 2011-04-26 Piramal Healthcare Canada Ltd Sammensætning og fremgangsmåde til homogen modificering eller krydsbinding af chitosan under neutrale betingelser
US20090158452A1 (en) 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
US20050108791A1 (en) 2001-12-04 2005-05-19 Edgerton Michael D. Transgenic plants with improved phenotypes
US20090100536A1 (en) 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
WO2003075848A2 (en) * 2002-03-08 2003-09-18 Zymogenetics, Inc. Inhibitors for use in hemostasis
US7666852B2 (en) 2002-04-22 2010-02-23 Agenta Biotechnologies, Inc. Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US8673333B2 (en) 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US7862831B2 (en) 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
WO2004033631A2 (en) 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
US20050069572A1 (en) 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
FR2846659B1 (fr) 2002-10-30 2005-02-18 Centre Nat Rech Scient Fragments peptidiques du facteur harp inhibant l'angiogenese
US20040127416A1 (en) 2002-11-15 2004-07-01 Massia Stephen P. Therapeutic bioconjugates
US8404681B2 (en) 2003-03-24 2013-03-26 Luitpold Pharmaceuticals, Inc. Xanthones, thioxanthones and acridinones as DNA-PK inhibitors
WO2005019429A2 (en) 2003-08-22 2005-03-03 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
FR2861308A1 (fr) 2003-10-28 2005-04-29 Organes Tissus Regeneration Re Utilisation de polymeres biocompatibles pour la preparation d'une composition pharmaceutique, dermatologique ou cosmetique destinee a la prevention, au soulagement ou au traitement des genes, desagrements et douleurs
ES2552106T3 (es) 2003-10-28 2015-11-25 Organes Tissus Régénération Réparation Remplacement Polímeros biocompatibles para una composición médica
CA2549883A1 (en) 2003-12-15 2005-06-23 Technion Research & Development Foundation Ltd. Therapeutic drug-eluting endoluminal covering
US7842667B2 (en) 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
EP2289567A3 (en) 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
US7709439B2 (en) 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
US20060041961A1 (en) 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
WO2005116066A1 (en) 2004-05-31 2005-12-08 National University Of Singapore Peptides derived from decorin leucine rich repeats and uses thereof
US20060075522A1 (en) 2004-07-31 2006-04-06 Jaclyn Cleveland Genes and uses for plant improvement
EP1796690A4 (en) 2004-09-22 2011-08-03 Cartilix Inc KNORPELFÜLLVORRICHTUNG
JP5042025B2 (ja) 2004-09-29 2012-10-03 ナショナル ユニヴァーシティー オブ シンガポール 複合物、複合物の製造方法、およびその使用方法
US20060241022A1 (en) 2004-10-06 2006-10-26 Bowen Benjamin P Selectin targeting bioconjugates
US20080102438A1 (en) 2004-10-27 2008-05-01 Yannas Ioannis V Novel Technique to Fabricate Molded Structures Having a Patterned Porosity
WO2007044026A2 (en) * 2004-11-23 2007-04-19 The Johns Hopkins University Compositions comprising modified collagen and uses therefore
EP1853278A4 (en) 2005-02-18 2011-12-28 Cartilix Inc GLUCOSAMINMATERIALIEN
WO2006089119A2 (en) 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
WO2006096614A2 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
GB2424223C (en) 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
WO2006105161A2 (en) 2005-03-30 2006-10-05 Cartilix, Inc. Coated medical device
US8367639B2 (en) 2005-03-31 2013-02-05 University Of Delaware Hydrogels with covalent and noncovalent crosslinks
US7732427B2 (en) 2005-03-31 2010-06-08 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US7737131B2 (en) 2005-03-31 2010-06-15 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US8415325B2 (en) 2005-03-31 2013-04-09 University Of Delaware Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels
US8338390B2 (en) 2005-03-31 2012-12-25 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
EP1882392A4 (en) 2005-05-10 2009-07-01 Monsanto Technology Llc GENES AND THEIR USES FOR PLANT IMPROVEMENTS
JP5140579B2 (ja) 2005-06-08 2013-02-06 カンジェーン コーポレイション 病原菌に対する生体防御を増強するヒアルロン酸結合性ペプチド
US20080069774A1 (en) 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
WO2007103993A2 (en) 2006-03-07 2007-09-13 Axle International Bioactive scaffold for therapeutic and adhesion prevention applications
US20070212385A1 (en) 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
US20070218102A1 (en) 2006-03-15 2007-09-20 Surmodics, Inc. Biodegradable hydrophobic polysaccharide-based coatings
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
US20090162436A1 (en) 2006-06-14 2009-06-25 Carson Daniel D Compositions and methods for repair of tissues
WO2010033564A1 (en) 2008-09-17 2010-03-25 Ceres, Inc. Transgenic plants having increased biomass
PL2486938T3 (pl) 2006-09-26 2018-08-31 Infectious Disease Research Institute Kompozycja szczepionki zawierająca syntetyczny adiuwant
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US8114835B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US20100222546A1 (en) 2006-11-28 2010-09-02 David Crich Methods for the preparation of functionalized peptides, proteins and carbohydrates and their conjugates
US8188220B2 (en) 2006-12-06 2012-05-29 Sanford-Burnham Medical Research Institute Methods and compositions related to targeting wounds, regenerating tissue, and tumors
WO2008070179A2 (en) 2006-12-06 2008-06-12 Monsanto Technology, Llc Genes and uses for plant improvement
US20080293640A1 (en) 2007-01-10 2008-11-27 Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of Polypeptide inhibitors of HSP27 kinase and uses therefor
DK2497505T3 (en) 2007-04-16 2016-12-05 Regentis Biomaterials Ltd Compositions and methods of the cage-forming
KR20100005105A (ko) 2007-05-06 2010-01-13 민병현 세포외 기질 지지체를 이용한 연골질환 치료용 조성물
US20100191215A1 (en) 2007-06-12 2010-07-29 By-Pass ,Inc. Pressure pulse actuating device for delivery systems
US20090075281A1 (en) 2007-07-10 2009-03-19 Regents Of The University Of California Mtbe genes
WO2009042514A1 (en) 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
WO2009048280A2 (en) 2007-10-09 2009-04-16 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
US9029636B2 (en) 2008-02-05 2015-05-12 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
US8846003B2 (en) 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
EP2281008B1 (en) 2008-04-04 2017-01-04 University of Utah Research Foundation Alkylated and sulfated hyaluronan compounds, methods for their preparation and use thereof
US20100004196A1 (en) 2008-06-17 2010-01-07 Hopitaux Universitaires De Geneve Heparan sulfate proteoglycan composition and use thereof
WO2010011857A2 (en) 2008-07-23 2010-01-28 The Johns Hopkins University Parenteral administration of a glucosamine
US20110269208A1 (en) 2008-08-15 2011-11-03 The Trustees Of The University Of Pennsylvania Cross-linked polymer network formed by sequential cross-linking
FR2936247B1 (fr) 2008-09-24 2010-10-22 Ct Hospitalier Universitaire De Dijon Proteines recombinantes a activite hemostatique capables d'induire l'agregation plaquettaire.
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
WO2010060485A1 (de) 2008-11-28 2010-06-03 Zetascience Gmbh Bioaktives hydrogel
KR101062068B1 (ko) 2008-12-01 2011-09-02 포항공과대학교 산학협력단 유착방지용 조성물
IL195764A0 (en) 2008-12-07 2009-11-18 Technion Res & Dev Foundation Compositions and methods for drug delivery
US9012723B2 (en) 2009-01-16 2015-04-21 Monsanto Technology Llc Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits
FR2943249B1 (fr) * 2009-03-18 2011-08-12 Genethon Utilisation de la decorine pour augmenter la masse musculaire
NZ608489A (en) 2009-03-30 2014-08-29 Nestec Sa Citrullinated peptides for diagnosing and prognosing rheumatiod arthritis
US20110182862A1 (en) 2009-04-03 2011-07-28 Green Wayne A Endophytic fungus and uses therefor
JP2012523463A (ja) 2009-04-13 2012-10-04 ノースウエスタン ユニバーシティ 軟骨再生のための新規なペプチドベースの足場およびその使用方法
FI20095452A0 (fi) 2009-04-23 2009-04-23 Suomen Punainen Risti Veripalv Uudet haaraiset sokerianalyysit
US20120100106A1 (en) 2009-05-04 2012-04-26 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
GB0909671D0 (en) 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
US20130052155A1 (en) 2009-11-09 2013-02-28 Drexel University Compositions and Methods for Treating a Disorder or Defect in Soft Tissue
EA201290442A1 (ru) 2009-12-04 2012-11-30 Юклид Системз Корпорэйшн Композиция и способы профилактики и лечения макулярной дегенерации, диабетической ретинопатии и диабетического макулярного отека
CN106039401A (zh) 2009-12-16 2016-10-26 瑞吉恩提斯生物材料有限公司 由聚合物‑蛋白质结合物形成的支架，产生该支架的方法及其用途
WO2011094149A1 (en) 2010-01-26 2011-08-04 University Of Utah Research Foundation Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
EP3569241A1 (en) 2010-02-26 2019-11-20 Vascular Biosciences, Inc. Car peptide for homing, diagnosis & targeted therapy for pulmonary and fibrotic disorders
ES2742218T3 (es) * 2010-06-23 2020-02-13 Purdue Research Foundation Peptidoglicanos sintéticos que se enlazan al colágeno destinados a ser utilizados en operaciones vasculares
WO2012112767A2 (en) 2011-02-16 2012-08-23 Purdue Research Foundation Collagen-targeted nanoparticles
WO2012149515A2 (en) 2011-04-29 2012-11-01 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
ES2708076T3 (es) 2011-05-24 2019-04-08 Symic Ip Llc Peptidoglicanos sintéticos que se unen al ácido hialurónico, preparación y métodos de uso
EP2804586A4 (en) 2012-01-19 2016-03-16 Univ Johns Hopkins BIOMATERIALS COMPRISING HYALURONIC ACID-BINDING PEPTIDES AND BIFUNCTIONAL BIOPOLYMER MOLECULES FOR HYALURONIC ACID RETENTION AND TISSUE ENGINEERING APPLICATIONS
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
US9827321B2 (en) 2012-08-14 2017-11-28 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
WO2014038866A1 (ko) 2012-09-05 2014-03-13 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
DE102012108560B4 (de) 2012-09-13 2018-12-20 Leibniz-Institut Für Polymerforschung Dresden E.V. Nichtkovalente selbstorganisierende Hydrogelmatrix für biotechnologische Anwendungen
WO2014063102A1 (en) 2012-10-19 2014-04-24 Cornell University Biomimetic boundary lubricants for articular cartilage
EP2915001A4 (en) 2012-11-01 2016-05-04 Univ Johns Hopkins CONTACT LENS SURFACE MODIFICATION BY HYALURONIC ACID (HA) BINDING PEPTIDE FOR ACCUMULATION AND HA RETENTION
TW201427989A (zh) 2012-12-18 2014-07-16 Novartis Ag 長效性蛋白質之組合物及方法
KR20150130419A (ko) 2013-03-15 2015-11-23 시믹 바이오메디칼, 인크. 세포외 기질 결합성 합성 펩티도글리칸
WO2014171084A1 (ja) 2013-04-16 2014-10-23 パナソニックＩｐマネジメント株式会社 電力変換装置、電力変換方法、モータシステム、３相モータ
WO2015022326A1 (en) 2013-08-12 2015-02-19 Xiber Science Gmbh Peptides as active agents for treating primary graft dysfunction
DE102013113156A1 (de) 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
KR20170016857A (ko) 2014-05-12 2017-02-14 퍼듀 리서치 파운데이션 셀렉틴 및 icam/vcam 펩티드 리간드 접합체
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
WO2016161333A2 (en) 2015-04-01 2016-10-06 Purdue Research Foundation Compositions comprising bioconjugates
AU2016248341B2 (en) 2015-04-17 2021-08-19 Symic OA ApS Bioconjugates and uses thereof
WO2017066349A1 (en) 2015-10-13 2017-04-20 Symic Ip, Llc Ve-cadherin binding bioconjugate

Also Published As

Publication number Publication date
ES2720368T3 (es) 2019-07-19
AU2009228140B2 (en) 2015-07-02
AU2015230796A1 (en) 2015-10-15
AU2020201042A1 (en) 2020-03-05
EP2280720A2 (en) 2011-02-09
US10689425B2 (en) 2020-06-23
US20150031619A1 (en) 2015-01-29
DK2280720T3 (en) 2019-06-11
HRP20190691T1 (hr) 2019-07-12
JP2015134768A (ja) 2015-07-27
AU2017268544A1 (en) 2017-12-21
JP6049773B2 (ja) 2016-12-27
HUE044239T2 (hu) 2019-10-28
AU2009228140A1 (en) 2009-10-01
JP2011515499A (ja) 2011-05-19
CY1121954T1 (el) 2020-10-14
US9512192B2 (en) 2016-12-06
EP2280720B1 (en) 2019-01-16
US20160244495A1 (en) 2016-08-25
CA2719254C (en) 2019-04-30
US20170275345A1 (en) 2017-09-28
WO2009120995A3 (en) 2010-01-28
SI2280720T1 (sl) 2019-06-28
AU2015230796B2 (en) 2017-08-31
LT2280720T (lt) 2019-07-25
US8846003B2 (en) 2014-09-30
WO2009120995A2 (en) 2009-10-01
PT2280720T (pt) 2019-05-17
US20110020298A1 (en) 2011-01-27
CA2719254A1 (en) 2009-10-01
JP5740301B2 (ja) 2015-06-24
EP2280720A4 (en) 2013-01-09

Similar Documents

Publication Publication Date Title
HUE044239T2 (hu) Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik
ZA201107486B (en) Anti-tnf-x antibodies and their uses
EP2494062A4 (en) ANTI-GLP-1R ANTIBODIES AND THEIR USES
GB0917044D0 (en) Agents, uses and methods
GB0917054D0 (en) Agents, uses and methods
AP2011005838A0 (en) Process for the preparation of fischer-tropsch catalysts and their use.
EP2367866A4 (en) POLYESTER, MANUFACTURING METHOD THEREFOR AND USE
HK1151791A1 (en) Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
EP2579893A4 (en) MULTIVALENT GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
EP2561072A4 (en) NANOZYMES, PROCESSES FOR PRODUCING NANOZYMES, AND METHODS OF USING NANOZYMES
EP2238451A4 (en) NANOSTRUCTURES, METHODS OF PREPARATION AND USES THEREOF
HK1162538A1 (en) Novel anti-51 antibodies and uses thereof -51
ZA201106354B (en) Fischer-tropsch catalyst,preparation method and application thereof
GB0910464D0 (en) Indicator, application thereof and related products
GB0819883D0 (en) Product and uses
IL220536A0 (en) Anti - bv8 antibodies and uses thereof
EP2481722A4 (en) INTERMEDIATES OF SITAGLIPIN, PREPARATION METHODS AND USES THEREOF
EP2289104A4 (en) DIODES AND METHOD FOR FORMING DIODES
HK1161720A1 (en) Dihydroetorphines and their preparation
IL214527A0 (en) Anti-mst1r antibodies and uses thereof
EP2252306A4 (en) NEW USE OF PROBIOTICS
EP2296675A4 (en) ECHINODERM EXTRACTS, MANUFACTURING METHODS AND ITS USES
EP2350212A4 (en) POLYAMINO-ACETONITRILES, PROCESSES FOR PREPARING THEM AND USE THEREOF
EP2279221A4 (en) ORGANO-NEUTRALIZED SILICONE GEL, METHOD FOR THE PRODUCTION AND USE THEREOF
GB0900129D0 (en) Article, its manufacture and use