HRP20190691T1 - Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe - Google Patents
Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe Download PDFInfo
- Publication number
- HRP20190691T1 HRP20190691T1 HRP20190691TT HRP20190691T HRP20190691T1 HR P20190691 T1 HRP20190691 T1 HR P20190691T1 HR P20190691T T HRP20190691T T HR P20190691TT HR P20190691 T HRP20190691 T HR P20190691T HR P20190691 T1 HRP20190691 T1 HR P20190691T1
- Authority
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- Croatia
- Prior art keywords
- compound according
- glycan
- amino acid
- group
- compound
- Prior art date
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- 102000008186 Collagen Human genes 0.000 title claims 3
- 108010035532 Collagen Proteins 0.000 title claims 3
- 229920001436 collagen Polymers 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000004676 glycans Chemical class 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 229920000045 Dermatan sulfate Polymers 0.000 claims 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- DWEYIZCNGQAQTF-DKWTVANSSA-N L-cysteine-glycine Chemical compound NCC(O)=O.SC[C@H](N)C(O)=O DWEYIZCNGQAQTF-DKWTVANSSA-N 0.000 claims 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 3
- 229940051593 dermatan sulfate Drugs 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 230000010118 platelet activation Effects 0.000 claims 2
- OEANUJAFZLQYOD-CXAZCLJRSA-N (2r,3s,4r,5r,6r)-6-[(2r,3r,4r,5r,6r)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](OC)O[C@H](CO)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O1 OEANUJAFZLQYOD-CXAZCLJRSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 229920002567 Chondroitin Polymers 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 229920002971 Heparan sulfate Polymers 0.000 claims 1
- 101000777658 Homo sapiens Platelet glycoprotein 4 Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102100031574 Platelet glycoprotein 4 Human genes 0.000 claims 1
- 102000001732 Small Leucine-Rich Proteoglycans Human genes 0.000 claims 1
- 108010040068 Small Leucine-Rich Proteoglycans Proteins 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 1
- 229940099552 hyaluronan Drugs 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (19)
1. Spoj formule PnGxgdje n je 1 do 10;
x je 1 do 10
P je sintetički peptid od 5 do oko 40 amino kiselina koji obuvaća sekvencu amino kiselina izabranu iz grupe koja se sastoji od
RRANAALKAGELYKSILY i GSITTIDVPWNV; i
G je glikan;
pri čemu se sekvenca peptida može modificirati da uključi segment glicin-cistein na točki vezivanja glikana.
2. Spoj formule (PnLx)G gdje n je 1 do 5;
x je 1 do 10;
P je sintetički peptid od oko 5 do oko 40 amino kiselina koji obuhvaća sekvencu amino kiselina izabranu iz grupe koja se sastoji od
RRANAALKAGELYKSILY i GSITTIDVPWNV;
L grupa za povezivanje; i G je glikan;
pri čemu se sekvenca peptida može modificirati da uključi segment glicin-cistein na točki vezivanja glikana.
3. Spoj formule P(LGn)x pri čemu n je 1 do 5;
x je 1 do 10;
P je sintetički peptid od oko 5 do oko 40 amino kiselina koji obuhvaća sekvencu amino kiselina izabranu iz grupe koja se sastoji od
RRANAALKAGELYKSILY i GSITTIDVPWNV;
L je grupa za povezivanje; i
G je glikan;
pri čemu sekvenca peptida može biti modificirana da uključi glicin-cistein na točki vezivanja glikana.
4. Spoj prema bilo kojem od zahtjeva 1 do 3, pri čemu je glikan glikozaminoglikan ili polisaharid.
5. Spoj prema bilo kojem od zahtjeva 1 do 4, pri čemu sintetički peptid ima homologiju amino kiseline sa sekvencom amino kiselina malog proteoglikana bogatog leucinom ili sekvencom receptora za kolagen na pločicama.
6. Spoj prema bilo kojem od zahtjeva 1 do 4, pri čemu sintetički peptid ima homologiju amino kiseline sa sekvencom amino kiselina sekvence receptora za kolagen pločica.
7. Spoj prema bilo kojem od zahtjeva 1 do 6, gdje je glikan izabran iz grupe koja obuhvaća alginat, agarozu, dekstran, hondroitin, dermatan, dermatan sulfat, heparan, heparin, keratin, i hijaluronan.
8. Spoj prema bilo kojem od zahtjeva 1 do 7, gdje je glikan izabran iz grupe koja obuhvaća dermatan sulfat, dekstran, i heparin.
9. Spoj prema bilo kojem od zahtjeva 1 to 8, gdje grupa za povezivanje sadrži formulu -SCH2CH2C(O)NHN=.
10. Spoj prema zahtjevu 8, pri čemu je glikan dermatan sulfat.
11. Spoj prema zahtjevu 8, pri čemu je glikan heparin.
12. Spoj prema bilo kojem od zahtjeva 1 do 3, ili zahtjeva 10 i 11 kada zavisi od zahtjeva 1 do 3, pri čemu P obuhvaća RRANAALKAGELYKSILY.
13. Sastav koji obuhvaća spoj prema bilo kojem od zahtjeva 1 do 12 i jedan ili više farmaceuski prihvatljivih ekscipijenata, ili rastvarača, ili njihovu kombinaciju.
14. Sastav prema zahtjevu 13 u obliku koji je adaptiran za topikalnu upotrebu.
15. Sastav prema zahtjevu 14, gde je topikalni oblik izabran iz grupe koja obuhvaća prašak, gel, kremu, mast, flaster, i topikalnu tečnost.
16. Sastav prema zahtjevu 13 koja je podešena za parenteralno davanje.
17. Sastav prema zahtjevu 16, gde je parenteralno davanje intravenozno ili intraarterijsko davanje.
18. Spoj prema bilo kojem od zahtjeva 1-12 za upotrebu u in vivo postupku inhibiranja aktivacije pločica.
19. Spoj prema bilo kojim zahtjevima 1-12 za upotrebu u in vivo postupku dovođenja u kontakt i vezivanja za kolagen i inhibiranja aktivacije pločica.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3993308P | 2008-03-27 | 2008-03-27 | |
US8198408P | 2008-07-18 | 2008-07-18 | |
PCT/US2009/038624 WO2009120995A2 (en) | 2008-03-27 | 2009-03-27 | Collagen-binding synthetic peptidoglycans, preparation, and methods of use |
EP09725336.3A EP2280720B1 (en) | 2008-03-27 | 2009-03-27 | Collagen-binding synthetic peptidoglycans, preparation, and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190691T1 true HRP20190691T1 (hr) | 2019-07-12 |
Family
ID=41114790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190691TT HRP20190691T1 (hr) | 2008-03-27 | 2019-04-12 | Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe |
Country Status (15)
Country | Link |
---|---|
US (4) | US8846003B2 (hr) |
EP (1) | EP2280720B1 (hr) |
JP (2) | JP5740301B2 (hr) |
AU (4) | AU2009228140B2 (hr) |
CA (1) | CA2719254C (hr) |
CY (1) | CY1121954T1 (hr) |
DK (1) | DK2280720T3 (hr) |
ES (1) | ES2720368T3 (hr) |
HR (1) | HRP20190691T1 (hr) |
HU (1) | HUE044239T2 (hr) |
LT (1) | LT2280720T (hr) |
PL (1) | PL2280720T3 (hr) |
PT (1) | PT2280720T (hr) |
SI (1) | SI2280720T1 (hr) |
WO (1) | WO2009120995A2 (hr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
WO2009092092A1 (en) | 2008-01-18 | 2009-07-23 | Regents Of The University Of Minnesota | Stem cell aggregates and methods for making and using |
WO2009120995A2 (en) | 2008-03-27 | 2009-10-01 | Purdue Research Foundation | Collagen-binding synthetic peptidoglycans, preparation, and methods of use |
WO2010129547A1 (en) * | 2009-05-04 | 2010-11-11 | Purdue Research Foundation | Collagen-binding synthetic peptidoglycans for wound healing |
AU2011228020A1 (en) | 2010-03-19 | 2012-09-27 | Otsuka Pharmaceutical Co., Ltd. | Proteoglycan-containing microneedle array |
DK2585112T3 (da) * | 2010-06-23 | 2019-08-12 | Purdue Research Foundation | Kollagen-bindende syntetiske peptidoglycaner til anvendelse i vaskulær intervention |
WO2012112767A2 (en) * | 2011-02-16 | 2012-08-23 | Purdue Research Foundation | Collagen-targeted nanoparticles |
ES2708076T3 (es) * | 2011-05-24 | 2019-04-08 | Symic Ip Llc | Peptidoglicanos sintéticos que se unen al ácido hialurónico, preparación y métodos de uso |
JP6603650B2 (ja) | 2013-03-15 | 2019-11-06 | パーデュー・リサーチ・ファウンデーション | 細胞外マトリックス結合性合成ペプチドグリカン |
US20150044259A1 (en) * | 2013-08-08 | 2015-02-12 | Mauris N. DeSilva | Scaffold for enhanced neural tissue regeneration |
US10772931B2 (en) | 2014-04-25 | 2020-09-15 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
EP3142684A4 (en) | 2014-05-12 | 2018-05-23 | Purdue Research Foundation | Selectin and icam/vcam peptide ligand conjugates |
WO2016061145A1 (en) | 2014-10-13 | 2016-04-21 | Symic Biomedical, Inc. | Synthetic proteoglycans for preventing tissue adhesion |
US20170368192A1 (en) | 2014-10-13 | 2017-12-28 | Symic Ip, Llc | Luminal vessel coating for arteriovenous fistula |
WO2016065083A1 (en) | 2014-10-21 | 2016-04-28 | Symic Biomedical, Inc. | Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury |
EP3253417B1 (en) | 2015-02-06 | 2023-06-21 | The University Of British Columbia | Engineered tissue substitute system |
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2017
- 2017-11-28 AU AU2017268544A patent/AU2017268544A1/en not_active Abandoned
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2019
- 2019-04-12 HR HRP20190691TT patent/HRP20190691T1/hr unknown
- 2019-04-12 CY CY20191100411T patent/CY1121954T1/el unknown
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2020
- 2020-02-13 AU AU2020201042A patent/AU2020201042A1/en not_active Abandoned
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ES2720368T3 (es) | 2019-07-19 |
AU2015230796B2 (en) | 2017-08-31 |
CY1121954T1 (el) | 2020-10-14 |
JP6049773B2 (ja) | 2016-12-27 |
EP2280720B1 (en) | 2019-01-16 |
US9512192B2 (en) | 2016-12-06 |
US8846003B2 (en) | 2014-09-30 |
AU2009228140B2 (en) | 2015-07-02 |
US20110020298A1 (en) | 2011-01-27 |
PL2280720T3 (pl) | 2019-07-31 |
PT2280720T (pt) | 2019-05-17 |
US20170275345A1 (en) | 2017-09-28 |
DK2280720T3 (en) | 2019-06-11 |
AU2020201042A1 (en) | 2020-03-05 |
AU2009228140A1 (en) | 2009-10-01 |
US20150031619A1 (en) | 2015-01-29 |
JP2015134768A (ja) | 2015-07-27 |
JP5740301B2 (ja) | 2015-06-24 |
HUE044239T2 (hu) | 2019-10-28 |
AU2015230796A1 (en) | 2015-10-15 |
WO2009120995A3 (en) | 2010-01-28 |
SI2280720T1 (sl) | 2019-06-28 |
US10689425B2 (en) | 2020-06-23 |
US20160244495A1 (en) | 2016-08-25 |
CA2719254A1 (en) | 2009-10-01 |
LT2280720T (lt) | 2019-07-25 |
EP2280720A4 (en) | 2013-01-09 |
CA2719254C (en) | 2019-04-30 |
JP2011515499A (ja) | 2011-05-19 |
EP2280720A2 (en) | 2011-02-09 |
AU2017268544A1 (en) | 2017-12-21 |
WO2009120995A2 (en) | 2009-10-01 |
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