PL163814B1 - Method of obtaining novel analogous compounds of dideoxy-didehydrocarbocyclic nucleosides - Google Patents
Method of obtaining novel analogous compounds of dideoxy-didehydrocarbocyclic nucleosidesInfo
- Publication number
- PL163814B1 PL163814B1 PL89277261A PL27726189A PL163814B1 PL 163814 B1 PL163814 B1 PL 163814B1 PL 89277261 A PL89277261 A PL 89277261A PL 27726189 A PL27726189 A PL 27726189A PL 163814 B1 PL163814 B1 PL 163814B1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- formula
- compounds
- solution
- defined above
- Prior art date
Links
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- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- GLQWRXYOTXRDNH-UHFFFAOYSA-N thiophen-2-amine Chemical compound NC1=CC=CS1 GLQWRXYOTXRDNH-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical class [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000007919 viral pathogenicity Effects 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/146,252 US4916224A (en) | 1988-01-20 | 1988-01-20 | Dideoxycarbocyclic nucleosides |
| GB888821011A GB8821011D0 (en) | 1988-09-07 | 1988-09-07 | Chemical compounds |
| US07/278,652 US4931559A (en) | 1988-01-20 | 1988-12-05 | Optically-active isomers of dideoxycarbocyclic nucleosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL277261A1 PL277261A1 (en) | 1989-09-18 |
| PL163814B1 true PL163814B1 (en) | 1994-05-31 |
Family
ID=27264063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL89277261A PL163814B1 (en) | 1988-01-20 | 1989-01-19 | Method of obtaining novel analogous compounds of dideoxy-didehydrocarbocyclic nucleosides |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JP2793825B2 (it) |
| KR (1) | KR0127137B1 (it) |
| AT (1) | AT397801B (it) |
| AU (2) | AU626278B2 (it) |
| BE (1) | BE1003815A4 (it) |
| CA (1) | CA1339896C (it) |
| CH (1) | CH679152A5 (it) |
| DE (1) | DE3901502C2 (it) |
| DK (1) | DK175131B1 (it) |
| ES (1) | ES2010091A6 (it) |
| FI (1) | FI93546C (it) |
| FR (1) | FR2626002B1 (it) |
| GB (1) | GB2217320B (it) |
| GR (1) | GR890100033A (it) |
| HU (1) | HU203755B (it) |
| IE (1) | IE62275B1 (it) |
| IL (1) | IL88999A (it) |
| IT (1) | IT1229531B (it) |
| LU (1) | LU87437A1 (it) |
| MY (1) | MY103801A (it) |
| NL (1) | NL8900122A (it) |
| NO (1) | NO169123C (it) |
| NZ (1) | NZ227663A (it) |
| OA (1) | OA09031A (it) |
| PL (1) | PL163814B1 (it) |
| PT (1) | PT89482B (it) |
| RU (1) | RU2114846C1 (it) |
| SE (1) | SE505213C2 (it) |
| YU (1) | YU47791B (it) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1215339B (it) * | 1987-01-14 | 1990-02-08 | Co Pharma Corp Srl | Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine |
| US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US4939252A (en) * | 1989-04-20 | 1990-07-03 | Hoffmann-La Roche Inc. | Novel intermediates for the preparation of Carbovir |
| ES2136061T3 (es) * | 1989-06-27 | 1999-11-16 | Wellcome Found | Nucleosidos terapeuticos. |
| GB8916479D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
| GB8916480D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
| GB8916477D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
| GB8916478D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| US5126452A (en) * | 1990-04-06 | 1992-06-30 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
| US5144034A (en) * | 1990-04-06 | 1992-09-01 | Glaxo Inc. | Process for the synthesis of cyclopentene derivatives of purines |
| US5057630A (en) * | 1990-04-06 | 1991-10-15 | Glaxo Inc. | Synthesis of cyclopentene derivatives |
| US5241069A (en) * | 1990-04-06 | 1993-08-31 | Glaxo Inc. | Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives |
| GB9108376D0 (en) * | 1991-04-19 | 1991-06-05 | Enzymatix Ltd | Cyclopentenes |
| HUT74989A (en) * | 1993-11-12 | 1997-03-28 | Merrell Pharma Inc | 6-oxo-nucleosides useful as immunosuppressants |
| GB9721780D0 (en) * | 1997-10-14 | 1997-12-10 | Glaxo Group Ltd | Process for the synthesis of chloropurine intermediates |
| DE59905679D1 (de) | 1998-10-30 | 2003-06-26 | Lonza Ag | Verfahren zur herstellung von 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]-cyclopent-2-enylmethanolen |
| DK1124805T3 (da) * | 1998-10-30 | 2003-09-15 | Lonza Ag | Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler |
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| GB9903091D0 (en) * | 1999-02-12 | 1999-03-31 | Glaxo Group Ltd | Therapeutic nucleoside compound |
| AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| EP3831388B1 (en) | 2018-07-27 | 2024-02-28 | FUJIFILM Corporation | Cyclopentenyl purine derivative or salt thereof for use in suppressing adenovirus |
| EP4125840A1 (en) | 2020-03-27 | 2023-02-08 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of synucleinopathies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268672A (en) * | 1977-02-09 | 1981-05-19 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
| US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| JPS62177234A (ja) * | 1986-01-30 | 1987-08-04 | Mitsubishi Heavy Ind Ltd | 遠心紡糸によるカ−ボン繊維の製造装置 |
| IN164556B (it) * | 1986-03-06 | 1989-04-08 | Takeda Chemical Industries Ltd | |
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
-
1989
- 1989-01-19 IT IT8947546A patent/IT1229531B/it active
- 1989-01-19 JP JP1008744A patent/JP2793825B2/ja not_active Expired - Lifetime
- 1989-01-19 AT AT0010689A patent/AT397801B/de not_active IP Right Cessation
- 1989-01-19 NO NO890253A patent/NO169123C/no not_active IP Right Cessation
- 1989-01-19 ES ES8900184A patent/ES2010091A6/es not_active Expired
- 1989-01-19 CA CA000588614A patent/CA1339896C/en not_active Expired - Lifetime
- 1989-01-19 OA OA59510A patent/OA09031A/xx unknown
- 1989-01-19 RU RU92004364A patent/RU2114846C1/ru active
- 1989-01-19 DE DE3901502A patent/DE3901502C2/de not_active Expired - Lifetime
- 1989-01-19 FR FR8900592A patent/FR2626002B1/fr not_active Expired - Lifetime
- 1989-01-19 HU HU89210A patent/HU203755B/hu unknown
- 1989-01-19 KR KR1019890000551A patent/KR0127137B1/ko not_active IP Right Cessation
- 1989-01-19 BE BE8900061A patent/BE1003815A4/fr active
- 1989-01-19 YU YU12389A patent/YU47791B/sh unknown
- 1989-01-19 CH CH172/89A patent/CH679152A5/de not_active IP Right Cessation
- 1989-01-19 SE SE8900192A patent/SE505213C2/sv not_active IP Right Cessation
- 1989-01-19 GR GR890100033A patent/GR890100033A/el not_active IP Right Cessation
- 1989-01-19 PT PT89482A patent/PT89482B/pt not_active IP Right Cessation
- 1989-01-19 PL PL89277261A patent/PL163814B1/pl unknown
- 1989-01-19 IL IL8899989A patent/IL88999A/en unknown
- 1989-01-19 IE IE15389A patent/IE62275B1/en not_active IP Right Cessation
- 1989-01-19 FI FI890286A patent/FI93546C/fi not_active IP Right Cessation
- 1989-01-19 LU LU87437A patent/LU87437A1/fr unknown
- 1989-01-19 NL NL8900122A patent/NL8900122A/nl not_active Application Discontinuation
- 1989-01-19 GB GB8901187A patent/GB2217320B/en not_active Expired - Lifetime
- 1989-01-19 MY MYPI89000064A patent/MY103801A/en unknown
- 1989-01-19 DK DK198900234A patent/DK175131B1/da not_active IP Right Cessation
- 1989-01-19 NZ NZ227663A patent/NZ227663A/xx unknown
- 1989-01-20 AU AU28671/89A patent/AU626278B2/en not_active Expired
-
1992
- 1992-01-13 AU AU10180/92A patent/AU637015B2/en not_active Expired
Also Published As
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