PL144897B1 - Method of obtaining a solution containing lactic acid salts of piperazinylquinolono- or piperazinylazoquinolonocarboxylic compounds - Google Patents

Method of obtaining a solution containing lactic acid salts of piperazinylquinolono- or piperazinylazoquinolonocarboxylic compounds Download PDF

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Publication number
PL144897B1
PL144897B1 PL1984249591A PL24959184A PL144897B1 PL 144897 B1 PL144897 B1 PL 144897B1 PL 1984249591 A PL1984249591 A PL 1984249591A PL 24959184 A PL24959184 A PL 24959184A PL 144897 B1 PL144897 B1 PL 144897B1
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PL
Poland
Prior art keywords
acid
lactic acid
compounds
acids
group
Prior art date
Application number
PL1984249591A
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English (en)
Other versions
PL249591A1 (en
Original Assignee
Bayer Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6209428&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL144897(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PL249591A1 publication Critical patent/PL249591A1/xx
Publication of PL144897B1 publication Critical patent/PL144897B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (2)

1. Zastrzezenia patentowe 1. Sposób wytwarzania roztworów zawierajacych sole kwasu mlekowego zwiazków pipera- zynylochinolonokarboksylowych o wzorze 1 lub piperazynyloazachinolonokarboksylowych o ogól¬ nym wzorze 2, w których to wzorach X oznacza atom azotu, grupe C-H albo C-F, Z oznacza atom tlenu albo grupe CH^, FL oznacza atom wodoru, rodnik metylowy, etylowy lub/3 -hydroksyetyIo¬ wy, PU oznacza grupe cyklopropylowa lub etylowa, a R, oznacza atom wodoru, rodnik metylowy lub etylowy, ewentualnie zwykle stosowane substancje pomocnicze i dodatkowo co najmniej jeden nie prowadzacy do stracania kwas, znamienny tym, ze roztwory mleczanów kwasów o wzorze 1 lub 2 poddaje sie reakcji z nie prowadzacymi do stracania kwasami, stosujac ogrze¬ wanie.
2. Sposób wedlug zastrz. 1, znamienny tym, ze jako kwasy nie prowadza¬ ce do stracania stosuje sie kwas mlekowy, kwas metanosulfonowy, kwas propionowy, kwas bur¬ sztynowy i kwas solny. RrN N R. COOH COOH RfN N ^ . WZÓR 1 Pracownia Poligraficzna UP PRL. Naklad 100 egz VA/7rtR ? Cena 220zl VyZAJR £ PL PL PL PL PL PL
PL1984249591A 1983-09-17 1984-09-14 Method of obtaining a solution containing lactic acid salts of piperazinylquinolono- or piperazinylazoquinolonocarboxylic compounds PL144897B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833333719 DE3333719A1 (de) 1983-09-17 1983-09-17 Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren

Publications (2)

Publication Number Publication Date
PL249591A1 PL249591A1 (en) 1987-03-09
PL144897B1 true PL144897B1 (en) 1988-07-30

Family

ID=6209428

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1984249591A PL144897B1 (en) 1983-09-17 1984-09-14 Method of obtaining a solution containing lactic acid salts of piperazinylquinolono- or piperazinylazoquinolonocarboxylic compounds

Country Status (24)

Country Link
US (3) US4705789A (pl)
EP (1) EP0138018B1 (pl)
JP (1) JPS6094910A (pl)
KR (1) KR870001958B1 (pl)
AU (1) AU562507B2 (pl)
CA (1) CA1228547A (pl)
DD (1) DD227882A5 (pl)
DE (2) DE3333719A1 (pl)
DK (1) DK162811C (pl)
ES (1) ES8607021A1 (pl)
FI (1) FI83286C (pl)
GR (1) GR80364B (pl)
HK (1) HK74789A (pl)
HU (1) HU194733B (pl)
IE (1) IE57905B1 (pl)
IL (1) IL72953A (pl)
NO (1) NO171765C (pl)
NZ (1) NZ209548A (pl)
PL (1) PL144897B1 (pl)
PT (1) PT79206B (pl)
SG (1) SG21489G (pl)
SU (1) SU1384187A3 (pl)
UA (1) UA8025A1 (pl)
ZA (1) ZA847267B (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
DE3537761A1 (de) * 1985-10-24 1987-04-30 Bayer Ag Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
IL80459A (en) * 1986-10-30 1991-04-15 Abic Ltd Water-soluble adduct of norfloxacin and nicotinic acid
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
JPH01175935A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd 凍結乾燥注射剤
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
US5225413A (en) * 1988-09-16 1993-07-06 Bayer-Aktiengesellschaft pH-neutral aqueous solutions of quinolone-carboxylic acids
NZ232091A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
JP3153549B2 (ja) * 1989-12-29 2001-04-09 アボツト・ラボラトリーズ キノロンカルボン酸―金属イオン―酸錯体
KR0159540B1 (ko) * 1992-01-21 1998-12-01 김정순 퀴놀론-카복실산의 염 및 그 함유조성물
TW254855B (pl) * 1993-07-28 1995-08-21 Otsuka Pharma Co Ltd
ES2127036B1 (es) * 1994-03-21 1999-11-16 Ind Quimica Agropecuaria S A Aducto de norfloxacina soluble en agua.
KR960000223A (ko) * 1994-06-08 1996-01-25 김정순 신규한 피리돈 카르복실산 화합물을 함유한 수용액 및 이의 제조방법
ES2088742B1 (es) * 1994-06-29 1997-03-16 Salvat Lab Sa Composicion antibiotica de aplicacion otica.
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
DE19730023A1 (de) * 1997-07-11 1999-01-14 Bayer Ag Hochreine Ciprofloxacin-Infusion
IN186245B (pl) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
WO2000016774A1 (fr) * 1998-09-18 2000-03-30 Senju Pharmaceutical Co., Ltd. Procede de solubilisation de l'acide pyridonecarboxylique, solubilisant a cet effet, preparations de solutions aqueuses contenant de l'acide pyridonecarboxylique et leur procede de production
DE102004005186B3 (de) * 2004-02-02 2005-10-13 Krka Tovarna Zdravil, D.D. Verfahren zur Herstellung von gereinigtem Ciprofloxacin
DE102004054873A1 (de) 2004-11-12 2006-05-18 Bayer Healthcare Ag Behandlung von Mastitis
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
KR101217680B1 (ko) * 2004-12-09 2013-01-02 바이엘 인텔렉쳐 프로퍼티 게엠베하 산을 사용한 글루코코르티코이드 에스테르의 안정화
CN102459169B (zh) 2009-05-15 2014-12-31 莱德克斯制药有限公司 氧化还原药物衍生物
CN103479569A (zh) * 2013-01-14 2014-01-01 四川喜亚动物药业有限公司 兽用环丙沙星注射液及其制备方法
US10034690B2 (en) 2014-12-09 2018-07-31 John A. Heflin Spine alignment system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE296839C (pl) *
CH296839A (de) * 1944-03-14 1954-02-28 Knoll Ag Verfahren zur Herstellung von haltbaren, wässrigen Lösungen von Salzen von Strychninoxyd.
DE2047486A1 (de) * 1970-09-26 1972-03-30 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur Stabilisierung einer pynthioxinhaltigen, wässerigen Injektions lösung
US4022894A (en) * 1975-03-03 1977-05-10 Fainberg Samuel M Stable solution of benzthiazide (3-[benzythiol methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) suitable for parenteral administration and process of preparation
JPS6019910B2 (ja) * 1979-10-11 1985-05-18 大塚製薬株式会社 ベンゾ〔ｉｊ〕キノリジン−２−カルボン酸誘導体及びその製造法
JPS5531028A (en) * 1978-08-25 1980-03-05 Dai Ichi Seiyaku Co Ltd Injection
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
DE2918319A1 (de) * 1979-05-07 1980-11-13 Roehm Pharma Gmbh Therapeutische verabreichungsform
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS57188515A (en) * 1981-05-13 1982-11-19 Kyoto Yakuhin Kogyo Kk Stabilized aqueous dopamine preparation
ES512969A0 (es) * 1981-06-11 1983-02-16 Warner Lambert Co "un procedimiento para preparar sales de compuestos de naftiridina y quinoleina".

Also Published As

Publication number Publication date
CA1228547A (en) 1987-10-27
US4808583A (en) 1989-02-28
AU562507B2 (en) 1987-06-11
NO171765B (no) 1993-01-25
DE3333719A1 (de) 1985-04-04
DK441084A (da) 1985-03-18
DE3474915D1 (en) 1988-12-08
PL249591A1 (en) 1987-03-09
JPH0559893B2 (pl) 1993-09-01
AU3297684A (en) 1985-03-21
PT79206B (en) 1986-08-14
PT79206A (en) 1984-10-01
EP0138018A2 (de) 1985-04-24
DK441084D0 (da) 1984-09-14
FI83286B (fi) 1991-03-15
UA8025A1 (uk) 1995-12-26
US4808585A (en) 1989-02-28
ES8607021A1 (es) 1986-05-16
DK162811B (da) 1991-12-16
FI843587A0 (fi) 1984-09-13
HK74789A (en) 1989-09-22
KR870001958B1 (ko) 1987-10-23
HU194733B (en) 1988-03-28
GR80364B (en) 1985-01-14
HUT35513A (en) 1985-07-29
FI83286C (fi) 1991-06-25
NO843518L (no) 1985-03-18
KR850002096A (ko) 1985-05-06
IL72953A0 (en) 1984-12-31
DK162811C (da) 1992-05-04
ZA847267B (en) 1985-05-29
ES535832A0 (es) 1986-05-16
EP0138018B1 (de) 1988-11-02
NO171765C (no) 1993-05-05
US4705789A (en) 1987-11-10
NZ209548A (en) 1987-02-20
DD227882A5 (de) 1985-10-02
IL72953A (en) 1988-01-31
EP0138018A3 (en) 1986-10-08
FI843587L (fi) 1985-03-18
SG21489G (en) 1989-09-22
SU1384187A3 (ru) 1988-03-23
JPS6094910A (ja) 1985-05-28
IE57905B1 (en) 1993-05-05
IE842347L (en) 1985-03-17

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