PE49696A1 - Compuesto carbociclico - Google Patents

Compuesto carbociclico

Info

Publication number
PE49696A1
PE49696A1 PE1995283875A PE28387595A PE49696A1 PE 49696 A1 PE49696 A1 PE 49696A1 PE 1995283875 A PE1995283875 A PE 1995283875A PE 28387595 A PE28387595 A PE 28387595A PE 49696 A1 PE49696 A1 PE 49696A1
Authority
PE
Peru
Prior art keywords
alkyl
independently
alcoxy
compound
carbon
Prior art date
Application number
PE1995283875A
Other languages
English (en)
Inventor
Calderon Jose Maria Bueno
Dorado Silvestre Garcia-Ochoa
Gabaldon Maria Teresa Fraile
Gomez Jose Ramon Ruiz
Pichel Julia Castro
Roman Jose Fiandor
Sophie Huss
Viola Domingo Gargallo
Zurita Juan Carlos Cuevas
Diaz Jose Luis Lavandera
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500173A external-priority patent/EP0712859A1/en
Priority claimed from EP94500175A external-priority patent/EP0711784A1/en
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Publication of PE49696A1 publication Critical patent/PE49696A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Abstract

SE REFIERE AL COMPUESTO ANTIFUNGICO DE FORMULA I DONDE: Z ES UN GRUPO TETRAHIDRO-PIRANO SELECCIONADO DE (a) O (b); R1 ES H, HALOGENO, OH ENTRE OTROS; R2 Y R3 INDEPENDIENTEMENTE SON H, ALQUILO DE C1-C6 o C1-C4 ALCOXI C1-C4 ALQUILO, o CONJUNTAMENTE CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS REPRESENTAN C=O, C=S o CICLOALQUILO DE C3-C8; R4 ES H o CH2R7, DONDE R7 ES H, OH, ALCOXI DE C1-C4 ENTRE OTROS; R5 Y R6 SON INDEPENDIENTEMENTE H, ALQUILO DE C1-C6 o C1-C4 ALCOXI C1-C4 ALQUILO o R5 Y R6 JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS REPRESENTAN C=O, C=S o CICLOALQUILO DE C3-C8; n ES CERO o 1; X e Y INDEPENDIENTEMENTE SON O, S o CR9R10, DONDE R9 Y R10 INDEPENDIENTEMENTE SON H, ALQUILO DE C1-C6, ALCOXI DE C1-C4 ENTRE OTROS, o JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS REPRESENTAN C=O, C=S ENTRE OTROS; R15 ES H, HALOGENO, AZIDO ENTRE OTROS; R16 ES H, o R15 Y R16 JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS REPRESENTAN C=O o C=CH2; R17 ES CH2R19, DONDE R19 ES H, OH, ALCOXI DE C1-C14 ENTRE OTROS; W ES O, S o CH2; TAMBIEN SE REFIERE AL PROCESO DE PREPARACION QUE COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA II, EN LA QUE R1, R4, X e Y YA SE DEFINIERON, EXCEPTO QUE X y/o Y NO SEA CR9R10 Y Rp ES UN GRUPO PROTECTOR DEL CARBOXILO, PARA FORMAR EL SISTEMA CICLICO DESEADO, SEGUIDO POR LA REMOCION DEL GRUPO PROTECTOR DEL CARBOXILO
PE1995283875A 1994-11-08 1995-11-06 Compuesto carbociclico PE49696A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94500173A EP0712859A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
EP94500175A EP0711784A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives

Publications (1)

Publication Number Publication Date
PE49696A1 true PE49696A1 (es) 1996-12-05

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995283875A PE49696A1 (es) 1994-11-08 1995-11-06 Compuesto carbociclico

Country Status (35)

Country Link
US (2) US5854280A (es)
EP (1) EP0753001B1 (es)
JP (1) JPH09508144A (es)
KR (1) KR100391401B1 (es)
CN (1) CN1056849C (es)
AP (1) AP614A (es)
AR (1) AR013815A1 (es)
AT (1) ATE184284T1 (es)
AU (1) AU704405B2 (es)
BG (1) BG62620B1 (es)
BR (1) BR9506473A (es)
CA (1) CA2179403A1 (es)
CO (1) CO4520226A1 (es)
CZ (1) CZ202796A3 (es)
DE (1) DE69512041T2 (es)
DK (1) DK0753001T3 (es)
EE (1) EE9600117A (es)
ES (1) ES2137549T3 (es)
FI (1) FI962773A (es)
GR (1) GR3031677T3 (es)
HK (1) HK1004222A1 (es)
HU (1) HU218611B (es)
IL (1) IL115905A0 (es)
IS (1) IS4352A (es)
MX (1) MX9602563A (es)
NO (1) NO307092B1 (es)
NZ (1) NZ296091A (es)
OA (1) OA10303A (es)
PE (1) PE49696A1 (es)
RU (1) RU2152398C1 (es)
SI (1) SI0753001T1 (es)
SK (1) SK88496A3 (es)
TW (1) TW321644B (es)
WO (1) WO1996014326A1 (es)
ZA (1) ZA959362B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042195A1 (en) * 1996-05-08 1997-11-13 Glaxo Wellcome S.A. Process for the preparation of an indacene compound
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
ATE241979T1 (de) * 1997-08-22 2003-06-15 Merck & Co Inc 4-cyano-4-deformylsordarinderivate
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) * 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
AU760975B2 (en) 1998-10-26 2003-05-22 Merck & Co., Inc. Microbial transformation product
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2003513964A (ja) 1999-11-11 2003-04-15 グラクソ、ウェルカム、ソシエダッド、アノニマ 抗真菌性ソルダリシン誘導体
AU2001289063A1 (en) * 2000-09-15 2002-03-26 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
JP2005519039A (ja) * 2001-12-14 2005-06-30 メルク　エンド　カムパニー　インコーポレーテッド 培養株の発酵産物から単離された新規ソルダリン誘導体及び抗真菌剤としての機能
EP1581182A2 (en) * 2002-12-31 2005-10-05 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
WO1998010782A1 (en) * 1996-09-12 1998-03-19 Merck & Co., Inc. Antifungal combination therapy

Also Published As

Publication number Publication date
KR100391401B1 (ko) 2003-12-31
EP0753001A1 (en) 1997-01-15
GR3031677T3 (en) 2000-02-29
SI0753001T1 (en) 1999-12-31
WO1996014326A1 (en) 1996-05-17
CO4520226A1 (es) 1997-10-15
EP0753001B1 (en) 1999-09-08
JPH09508144A (ja) 1997-08-19
FI962773A (fi) 1996-08-26
IS4352A (is) 1996-06-10
DK0753001T3 (da) 2000-05-08
BG62620B1 (en) 2000-03-31
ZA959362B (en) 1996-05-08
TW321644B (es) 1997-12-01
DE69512041T2 (de) 2000-02-03
FI962773A0 (fi) 1996-07-05
RU2152398C1 (ru) 2000-07-10
NO307092B1 (no) 2000-02-07
NO962856D0 (no) 1996-07-05
EE9600117A (et) 1997-04-15
HU218611B (hu) 2000-10-28
IL115905A0 (en) 1996-01-31
DE69512041D1 (de) 1999-10-14
NZ296091A (en) 1998-06-26
AP614A (en) 1997-09-05
BR9506473A (pt) 1997-10-07
AU704405B2 (en) 1999-04-22
AP9600824A0 (en) 1996-07-31
US5952334A (en) 1999-09-14
HU9601865D0 (en) 1996-11-28
OA10303A (en) 1997-10-07
BG100699A (bg) 1997-02-28
NO962856L (no) 1996-09-05
ES2137549T3 (es) 1999-12-16
AR013815A1 (es) 2001-01-31
ATE184284T1 (de) 1999-09-15
CN1056849C (zh) 2000-09-27
HK1004222A1 (en) 1998-11-20
HUT76292A (en) 1997-07-28
CN1143965A (zh) 1997-02-26
CA2179403A1 (en) 1996-05-17
SK88496A3 (en) 1997-04-09
CZ202796A3 (en) 1997-02-12
US5854280A (en) 1998-12-29
MX9602563A (es) 1997-05-31
AU3980995A (en) 1996-05-31

Similar Documents

Publication Publication Date Title
PE49696A1 (es) Compuesto carbociclico
PE79699A1 (es) Derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4" sustituidos
DE69100079D1 (de) Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
NO895273D0 (no) Plantebeskyttende forbindelser, deres fremstilling og anvendelse.
KR830007564A (ko) 치환된 아미노이산의 제조방법
PE51097A1 (es) Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen
ATE21699T1 (de) Verfahren zur herstellung von 2-penemverbindungen.
SE8201854L (sv) N-substituerade amino-aminosyror
ES2221440T3 (es) Derivados de acido aminofenoxiacetico como neuroprotectores.
PE46497A1 (es) ANTAGONISTAS a1-ADRENOCEPTORES, SUS EMPLEOS COMO AGENTES TERAPEUTICOS Y LOS METODOS DE SU PREPARACION
ES2127919T3 (es) 4-amino-piridinas, procedimiento para su preparacion, asi como medicamentos que contienen estos compuestos.
KR900006318A (ko) 피페리디닐 벤즈이미다졸
ATE139783T1 (de) Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung
MX165512B (es) Aditivo de carbamato para composicion lubricante
DK116480A (da) Fremgangsmaade til fremstilling af substituerede chromoner
KR920014828A (ko) 신규한 종양 성장-억제 소마토스타틴 동족체, 이 동족체를 함유하는 제약 조성물 및 그 제조방법
AR247402A1 (es) Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos
KR910009712A (ko) 세펨 화합물 및 이의 제조방법
FI850829L (fi) Foerlaekemedel foer allopurinol.
ECSP941050A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
DK0515462T3 (da) Indolderivater, fremgangsmåde til deres fremstilling samt anvendelse heraf
RO87991A (ro) Procedeu pentru prepararea unor esteri tiazolidinici substituiti ai unor acizi minerali
TW372955B (en) Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
PE25195A1 (es) Sintesis de l-aspartil-d-aminoalcanoil-(s)-o-alquilbencil amida utilizada como endulzante artificial
ES2167777T3 (es) Procedimiento para la preparacion de paclitaxel.

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed