PE20230160A1 - Anticuerpos especificos para cd47, pd-l1 y sus usos - Google Patents

Anticuerpos especificos para cd47, pd-l1 y sus usos

Info

Publication number
PE20230160A1
PE20230160A1 PE2022001109A PE2022001109A PE20230160A1 PE 20230160 A1 PE20230160 A1 PE 20230160A1 PE 2022001109 A PE2022001109 A PE 2022001109A PE 2022001109 A PE2022001109 A PE 2022001109A PE 20230160 A1 PE20230160 A1 PE 20230160A1
Authority
PE
Peru
Prior art keywords
antibodies
seq
sequence
region
heavy chain
Prior art date
Application number
PE2022001109A
Other languages
English (en)
Inventor
Riggers Javier Fernando Chaparro
Shih-Hsun Chen
Sheng Ding
Pawel Kamil Dominik
Shahram Salek-Ardakani
Jessica Lynn Stanfield
Blarcom Thomas John Van
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20230160A1 publication Critical patent/PE20230160A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente invencion se refiere a anticuerpos que se unen especificamente a CD47 que comprenden una region variable de cadena pesada (VH) con una secuencia de aminoacidos de SEQ ID NO: 1, 3, 7, 8 o 9, y una region variable de cadena ligera (VL) con una secuencia de SEQ ID NO: 2 o 6; anticuerpos que se unen a especificamente PD-L1, que comprenden una region VH que comprende la secuencia de SEQ ID NO: 4, 5, 10, 11 o 12 y una region VL que comprende la secuencia de SEQ ID NO: 2 o 6; y anticuerpos biespecificos que se unen a CD47 y PD-L1. Tambien proporciona acidos nucleicos que codifican dichos anticuerpos y una composicion farmaceutica que los comprende. Asimismo, refiere metodos para producir y purificar dichos anticuerpos
PE2022001109A 2019-12-17 2020-12-14 Anticuerpos especificos para cd47, pd-l1 y sus usos PE20230160A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962949120P 2019-12-17 2019-12-17
US202063110693P 2020-11-06 2020-11-06
PCT/IB2020/061896 WO2021124073A1 (en) 2019-12-17 2020-12-14 Antibodies specific for cd47, pd-l1, and uses thereof

Publications (1)

Publication Number Publication Date
PE20230160A1 true PE20230160A1 (es) 2023-02-01

Family

ID=74046010

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022001109A PE20230160A1 (es) 2019-12-17 2020-12-14 Anticuerpos especificos para cd47, pd-l1 y sus usos

Country Status (14)

Country Link
US (2) US11702474B2 (es)
EP (1) EP4077387A1 (es)
JP (1) JP7369297B2 (es)
KR (1) KR20220114049A (es)
CN (1) CN115397853A (es)
AU (1) AU2020410410A1 (es)
BR (1) BR112022009723A2 (es)
CA (1) CA3164623A1 (es)
CO (1) CO2022008407A2 (es)
IL (1) IL293926A (es)
MX (1) MX2022006578A (es)
PE (1) PE20230160A1 (es)
TW (2) TWI784373B (es)
WO (1) WO2021124073A1 (es)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CN115317603A (zh) 2016-07-07 2022-11-11 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
CA3227875A1 (en) 2021-08-02 2023-02-09 Pfizer Inc. Improved expression vectors and uses thereof
CN115702931A (zh) * 2021-08-06 2023-02-17 百奥泰生物制药股份有限公司 抗pd-l1/cd47双特异抗体在治疗疾病中的应用
AR127270A1 (es) * 2021-10-09 2024-01-03 Hutchmed Ltd Formulación de anticuerpos anti-cd47
WO2023140950A1 (en) * 2022-01-18 2023-07-27 Fbd Biologics Limited Cd47/pd-l1-targeting protein complex and methods of use thereof
WO2024006538A1 (en) * 2022-06-30 2024-01-04 The Johns Hopkins University Use of a conjugate of anti-cd47 antibody and toll-like receptor agonist
WO2024052830A1 (en) * 2022-09-09 2024-03-14 Pfizer Inc. Treatment regimens with anti-cd47 / anti-pd-l1 bispecific antibodies

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