AR124692A2 - Anticuerpos anti-cd40 y sus usos - Google Patents
Anticuerpos anti-cd40 y sus usosInfo
- Publication number
- AR124692A2 AR124692A2 ARP220100135A ARP220100135A AR124692A2 AR 124692 A2 AR124692 A2 AR 124692A2 AR P220100135 A ARP220100135 A AR P220100135A AR P220100135 A ARP220100135 A AR P220100135A AR 124692 A2 AR124692 A2 AR 124692A2
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- cdr
- cdrs
- chain
- antibodies
- Prior art date
Links
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Nuevos anticuerpos anti-CD40, composiciones que los incluyen, ácidos nucleicos que los codifican, y métodos para su elaboración y su uso. Reivindicación 1: Un anticuerpo o fragmento de unión anti-CD40 caracterizado porque comprende (i) una cadena VH que comprende tres CDR; y (ii) una cadena VL que comprende tres CDR, en donde: VH CDR#1 se selecciona entre: GYTFTSYWMH (SEQ ID Nº 6), GYTFTDYYIN (SEQ ID Nº 7), GYSITSNYYWN (SEQ ID Nº 8), GYSISSNYYWN (SEQ ID Nº 9), GYDITSNYYWN (SEQ ID Nº 10); VH CDR#2 se selecciona entre: WIFPGSGSVYCNEQFKG (SEQ ID Nº 17), YIRYDGSNNYNPSLKN (SEQ ID Nº 18), NIDPSNGETHYAQKFQG (SEQ ID Nº 19), WIFPGSGSVYSNEQFKG (SEQ ID Nº 20), YIRYDGSNNYNPSLKS (SEQ ID Nº 21), y YIRYDGSNNYNPSLKG (SEQ ID Nº 22); VH CDR#3 se selecciona entre: LDY (SEQ ID Nº 35), ERIYYSGSTYDGYFDV (SEQ ID Nº 36), y SLGKFAY (SEQ ID Nº 37); VL CDR#1 se selecciona entre: SASSSLSYMH (SEQ ID Nº 56), KASQSVVTAVA (SEQ ID Nº 57), y RSSQSLENTNGNTFLN (SEQ ID Nº 58); VL CDR#2 se selecciona entre: DTSKLAS (SEQ ID Nº 66), SASNRYT (SEQ ID Nº 67), y RVSNRFS (SEQ ID Nº 68); VL CDR#3 se selecciona entre: QQWSSNPWT (SEQ ID Nº 86), QQYSSYPYT (SEQ ID Nº 87), y LQVTHVPFT (SEQ ID Nº 88).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342417P | 2016-05-27 | 2016-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124692A2 true AR124692A2 (es) | 2023-04-26 |
Family
ID=59014833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101447A AR108611A1 (es) | 2016-05-27 | 2017-05-26 | Anticuerpos anti-cd40 y sus usos |
| ARP220100135A AR124692A2 (es) | 2016-05-27 | 2022-01-24 | Anticuerpos anti-cd40 y sus usos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101447A AR108611A1 (es) | 2016-05-27 | 2017-05-26 | Anticuerpos anti-cd40 y sus usos |
Country Status (34)
| Country | Link |
|---|---|
| US (8) | US10519243B2 (es) |
| EP (2) | EP3464361B1 (es) |
| JP (2) | JP2019523221A (es) |
| KR (2) | KR102366355B1 (es) |
| CN (1) | CN109476750B (es) |
| AR (2) | AR108611A1 (es) |
| AU (1) | AU2017271602A1 (es) |
| BR (1) | BR112018074468A2 (es) |
| CA (1) | CA3025347A1 (es) |
| CL (1) | CL2018003366A1 (es) |
| CO (1) | CO2018012699A2 (es) |
| CR (1) | CR20180605A (es) |
| CY (1) | CY1124806T1 (es) |
| DO (1) | DOP2018000258A (es) |
| EC (1) | ECSP18094829A (es) |
| ES (1) | ES2901722T3 (es) |
| HR (1) | HRP20211882T1 (es) |
| HU (1) | HUE056670T2 (es) |
| IL (1) | IL263223B2 (es) |
| LT (1) | LT3464361T (es) |
| MX (1) | MX2018014630A (es) |
| MY (1) | MY195442A (es) |
| NZ (1) | NZ748644A (es) |
| PE (1) | PE20190970A1 (es) |
| PH (1) | PH12018502456A1 (es) |
| PL (1) | PL3464361T3 (es) |
| PT (1) | PT3464361T (es) |
| RS (1) | RS62726B1 (es) |
| RU (1) | RU2752049C2 (es) |
| SG (2) | SG10201914132RA (es) |
| SI (1) | SI3464361T1 (es) |
| TW (2) | TWI814279B (es) |
| UA (1) | UA123111C2 (es) |
| WO (1) | WO2017205742A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE047164T2 (hu) * | 2007-11-01 | 2020-04-28 | Univ Arkansas | Kompozíciók és eljárások eimeria elleni immunválasz fokozására |
| MX2018014630A (es) * | 2016-05-27 | 2019-06-10 | Abbvie Biotherapeutics Inc | Anticuerpos anti-cd40 y sus usos. |
| WO2019204756A1 (en) | 2018-04-20 | 2019-10-24 | Lyvgen Biopharma Co., Ltd. | Anti-cd40 antibodies and uses thereof |
| CN113226357A (zh) | 2018-11-23 | 2021-08-06 | 斯特赖克药物公司 | 双特异性缀合物 |
| CA3120793A1 (en) * | 2018-11-30 | 2020-06-04 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-cd40 antibody, antigen binding fragment and pharmaceutical use thereof |
| CN109912717B (zh) * | 2019-03-04 | 2020-05-26 | 北京天广实生物技术股份有限公司 | 结合cd40的抗体及其用途 |
| CN113811547A (zh) | 2019-03-27 | 2021-12-17 | 国家医疗保健研究所 | 具有cd40激活特性的重组蛋白 |
| SG11202111188VA (en) * | 2019-04-10 | 2021-11-29 | Univ Nankai | Anti-cd40 antibody and use thereof |
| EP4027998A1 (en) | 2019-09-09 | 2022-07-20 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| US20220332836A1 (en) * | 2019-09-11 | 2022-10-20 | Novartis Ag | A method for preventing human virus associated disorders in patients |
| US20230002492A1 (en) * | 2019-11-08 | 2023-01-05 | Simcere (Shanghai) Pharmaceutical Co., Ltd. | Anti-human programmed cell death ligand-1 (pd-l1) antibody and use thereof |
| CA3163358A1 (en) * | 2019-12-03 | 2021-06-10 | Evotec International Gmbh | Interferon-associated antigen binding proteins and uses thereof |
| GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
| EP4185320A1 (en) * | 2020-07-23 | 2023-05-31 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof in treating muscle atrophy |
| CN115403670A (zh) * | 2021-05-26 | 2022-11-29 | 安徽瀚海博兴生物技术有限公司 | 抗cd40抗体及其用途 |
| WO2024059899A1 (en) * | 2022-09-20 | 2024-03-28 | Currus Biologics Pty Ltd | Bispecific polypeptides and uses thereof |
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-
2017
- 2017-05-26 MX MX2018014630A patent/MX2018014630A/es unknown
- 2017-05-26 WO PCT/US2017/034681 patent/WO2017205742A1/en active Application Filing
- 2017-05-26 PL PL17728411T patent/PL3464361T3/pl unknown
- 2017-05-26 SG SG10201914132RA patent/SG10201914132RA/en unknown
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