PE20191494A1 - Inmunoconjugados de un anticuerpo anti-pd-1 con un il-2 mutante o con il-15 - Google Patents
Inmunoconjugados de un anticuerpo anti-pd-1 con un il-2 mutante o con il-15Info
- Publication number
- PE20191494A1 PE20191494A1 PE2019001547A PE2019001547A PE20191494A1 PE 20191494 A1 PE20191494 A1 PE 20191494A1 PE 2019001547 A PE2019001547 A PE 2019001547A PE 2019001547 A PE2019001547 A PE 2019001547A PE 20191494 A1 PE20191494 A1 PE 20191494A1
- Authority
- PE
- Peru
- Prior art keywords
- immunoconjugates
- mutant
- antibody
- polynucleotide molecules
- relates
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 4
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Abstract
La presente invencion se refiere de manera general a inmunoconjugados, en particular inmunoconjugados que comprenden un polipeptido interleuquina-2 mutante y un anticuerpo que se une a PD-1. Ademas, la invencion se refiere a moleculas de polinucleotido codificantes de los inmunoconjugados y a vectores y celulas huesped que comprenden dichas moleculas de polinucleotido. La invencion se refiere ademas a metodos para producir los polipeptidos mutantes, a composiciones farmaceuticas que los comprenden y a usos de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17164533 | 2017-04-03 | ||
PCT/EP2018/058034 WO2018184964A1 (en) | 2017-04-03 | 2018-03-29 | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20191494A1 true PE20191494A1 (es) | 2019-10-21 |
Family
ID=58488892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019001547A PE20191494A1 (es) | 2017-04-03 | 2018-03-29 | Inmunoconjugados de un anticuerpo anti-pd-1 con un il-2 mutante o con il-15 |
Country Status (31)
Country | Link |
---|---|
US (2) | US11413331B2 (es) |
EP (2) | EP4201953A1 (es) |
JP (3) | JP7426825B2 (es) |
KR (2) | KR20190121816A (es) |
CN (2) | CN110392692B (es) |
AR (2) | AR111400A1 (es) |
AU (1) | AU2018247765B2 (es) |
BR (1) | BR112019017329A2 (es) |
CA (1) | CA3053357A1 (es) |
CL (1) | CL2019002346A1 (es) |
CO (1) | CO2019009354A2 (es) |
CR (1) | CR20190426A (es) |
DK (1) | DK3606946T3 (es) |
ES (1) | ES2928718T3 (es) |
HR (1) | HRP20221254T1 (es) |
HU (1) | HUE059885T2 (es) |
IL (1) | IL269395A (es) |
LT (1) | LT3606946T (es) |
MA (1) | MA49033B1 (es) |
MX (2) | MX2019011770A (es) |
PE (1) | PE20191494A1 (es) |
PH (1) | PH12019502273A1 (es) |
PL (1) | PL3606946T3 (es) |
PT (1) | PT3606946T (es) |
RS (1) | RS63663B1 (es) |
RU (1) | RU2761377C2 (es) |
SG (1) | SG11201909205YA (es) |
TW (1) | TWI800506B (es) |
UA (1) | UA125700C2 (es) |
WO (1) | WO2018184964A1 (es) |
ZA (1) | ZA201905517B (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108137699B (zh) | 2015-10-02 | 2022-05-27 | 豪夫迈·罗氏有限公司 | 对pd1和tim3特异性的双特异性抗体 |
JP2019530704A (ja) * | 2016-10-06 | 2019-10-24 | ファイザー・インコーポレイテッド | がんの処置のためのアベルマブの投与レジメン |
AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
CN107082812B (zh) * | 2017-03-29 | 2018-11-13 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
DK3606946T3 (da) | 2017-04-03 | 2022-10-24 | Hoffmann La Roche | Immunkonjugater af et anti-PD-1-antistof med et muteret IL-2 eller med IL-15 |
TWI747215B (zh) | 2017-04-05 | 2021-11-21 | 瑞士商赫孚孟拉羅股份公司 | 特異性結合至pd1至lag3的雙特異性抗體 |
AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
PT3661954T (pt) | 2017-08-03 | 2022-04-14 | Amgen Inc | Muteínas de interleuquina-21 e métodos de tratamento |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
SG11202005605SA (en) | 2018-01-12 | 2020-07-29 | Amgen Inc | Anti-pd-1 antibodies and methods of treatment |
CA3086486A1 (en) | 2018-09-17 | 2020-03-26 | Gi Innovation, Inc. | Fusion protein comprising il-2 protein and cd80 protein, and use thereof |
CA3117853A1 (en) * | 2018-10-29 | 2020-05-07 | 1Globe Biomedical Co., Ltd. | Novel rationally designed protein compositions |
WO2020127369A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional molecule directed against human pd-1 |
WO2020127377A1 (en) * | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
EP3972992A4 (en) | 2019-05-20 | 2023-07-19 | Pandion Operations, Inc. | ANTI-MADCAM IMMUNE TOLERANCE |
AU2020287373A1 (en) * | 2019-06-05 | 2022-01-06 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function |
EP3988576A4 (en) * | 2019-06-24 | 2023-08-09 | Nanjing GenScript Biotech Co., Ltd. | MONOCLONAL ANTIBODY CYTOKINE FUSION PROTEIN DIMER AND ITS USE |
CN116574183A (zh) * | 2019-08-22 | 2023-08-11 | 盛禾(中国)生物制药有限公司 | 多功能抗体、其制备及其用途 |
CN112679615B (zh) * | 2019-10-17 | 2023-09-22 | 瑞阳(苏州)生物科技有限公司 | 一种融合蛋白 |
CN117004564A (zh) * | 2019-11-20 | 2023-11-07 | 吉爱希公司 | 调节性t细胞培养组合物及其用途 |
US11692020B2 (en) | 2019-11-20 | 2023-07-04 | Anwita Biosciences, Inc. | Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications |
BR112022010063A2 (pt) * | 2019-11-27 | 2022-09-06 | Gi Cell Inc | Composição para tratamento anticâncer, compreendendo células nk e proteína de fusão que compreende proteína il-2 e proteína cd80 |
CA3164353A1 (en) * | 2019-12-13 | 2021-06-17 | Cugene Inc. | Cytokine-based bioactivatable drugs and methods of uses thereof |
BR112022012112A2 (pt) | 2019-12-20 | 2022-09-06 | Regeneron Pharma | Agonistas de il2 e métodos de uso dos mesmos |
CA3162406A1 (en) | 2020-01-10 | 2021-07-15 | Vijaya Raghavan PATTABIRAMAN | Modified il-2 polypeptides and uses thereof |
KR102559355B1 (ko) * | 2020-01-31 | 2023-07-25 | 주식회사 제넥신 | 항-taa 항체, 항-pd-l1 항체 및 il-2를 포함하는 융합단백질 및 이의 용도 |
AU2021219957A1 (en) | 2020-02-13 | 2022-08-04 | F. Hoffmann-La Roche Ag | Method for determining the loading state of an AAV particle by nuclear magnetic resonance relaxometry |
EP4143329A2 (en) | 2020-04-28 | 2023-03-08 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
CN115551540A (zh) | 2020-05-11 | 2022-12-30 | 豪夫迈·罗氏有限公司 | 使用经修饰的pbmc和免疫缀合物的组合疗法 |
GB2621482A (en) | 2020-05-13 | 2024-02-14 | Bonum Therapeutics Inc | Compositions of protein complexes and methods of use thereof |
US20230257438A1 (en) * | 2020-06-30 | 2023-08-17 | Gi Innovation, Inc. | Fusion protein comprising anti-lag-3 antibody and il-2, and use thereof |
US11865082B2 (en) | 2020-09-09 | 2024-01-09 | Hoffmann-La Roche Inc. | Combination therapy of PD-1-targeted IL-2 variant immunocytokines and antibodies against human PD-L1 |
WO2022098954A1 (en) | 2020-11-06 | 2022-05-12 | Nektar Therapeutics | Tlr agonist compounds and related cancer immunotherapy methods |
EP4255923A2 (en) | 2020-12-04 | 2023-10-11 | F. Hoffmann-La Roche AG | Ph-dependent mutant interleukin-2 polypeptides |
WO2022125694A1 (en) * | 2020-12-09 | 2022-06-16 | Asher Biotherapeutics, Inc. | Fusions of interleukin polypeptides with bispecific antigen binding molecules for modulating immune cell function |
WO2022140774A1 (en) | 2020-12-22 | 2022-06-30 | Neogene Therapeutics B.V. | Peptide markers to track genetically engineered cells |
CN114712495A (zh) * | 2021-01-06 | 2022-07-08 | 盛禾(中国)生物制药有限公司 | 一种多功能抗体的组合物 |
WO2022148853A1 (en) * | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
JP2024508949A (ja) | 2021-03-09 | 2024-02-28 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Pd-1標的化il-2変異体イムノコンジュゲートとfap/4-1bb結合分子との併用療法 |
JP2024512382A (ja) | 2021-03-09 | 2024-03-19 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Pd-1標的化il-2バリアント免疫コンジュゲートと抗tyrp1/抗cd3二重特異性抗体の併用療法 |
CN117157312A (zh) | 2021-03-30 | 2023-12-01 | 豪夫迈·罗氏有限公司 | 蛋白酶活化的多肽 |
CA3213917A1 (en) | 2021-04-09 | 2022-10-13 | Nicolas Poirier | New scaffold for bifunctional molecules with improved properties |
AU2022296794A1 (en) | 2021-06-23 | 2023-12-14 | Cytune Pharma | Interleukin-15 based immunocytokines |
CA3220418A1 (en) | 2021-06-23 | 2022-12-29 | Guy Luc Michel De Martynoff | Interleukin 15 variants |
CN115521379B (zh) * | 2021-07-16 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-1抗体及其用途 |
TW202320862A (zh) * | 2021-09-22 | 2023-06-01 | 大陸商信達生物製藥(蘇州)有限公司 | 介白素2突變體以及其融合蛋白 |
WO2023046156A1 (en) * | 2021-09-26 | 2023-03-30 | Wuxi Biologics (Shanghai) Co. Ltd. | Il-2 variants and fusion proteins thereof |
TW202330628A (zh) * | 2021-11-17 | 2023-08-01 | 瑞士商赫孚孟拉羅股份公司 | 蛋白複合體之組成物及其使用方法 |
TW202342535A (zh) * | 2022-02-11 | 2023-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 免疫綴合物及其用途 |
US20240076343A1 (en) | 2022-06-16 | 2024-03-07 | Cephalon Llc | Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof |
WO2024043643A1 (ko) * | 2022-08-23 | 2024-02-29 | 머스트바이오 주식회사 | Il2 변이체 및 이를 포함하는 단백질 복합체 |
WO2024068705A1 (en) | 2022-09-29 | 2024-04-04 | F. Hoffmann-La Roche Ag | Protease-activated polypeptides |
CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
Family Cites Families (181)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1156905B (it) | 1977-04-18 | 1987-02-04 | Hitachi Metals Ltd | Articolo di ornamento atto ad essere fissato mediante un magnete permanente |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
EP0229108B1 (en) | 1985-06-26 | 1990-12-27 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
EP1997894B1 (en) | 1992-02-06 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
JP3920928B2 (ja) | 1996-11-29 | 2007-05-30 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | 移植片拒絶反応の防止法および普遍的遺伝子治療宿主細胞の生産法 |
ES2246069T3 (es) | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
MXPA02003456A (es) | 1999-10-04 | 2002-10-23 | Medicago Inc | Metodo para regular la transcripcion de genes foraneos. |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
WO2001044463A1 (en) | 1999-12-15 | 2001-06-21 | Genentech, Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
KR100919593B1 (ko) | 2000-06-29 | 2009-09-29 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물 |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
CN101940189A (zh) | 2000-11-30 | 2011-01-12 | 米德列斯公司 | 用于生产人类抗体的转基因转染色体啮齿动物 |
US7371371B2 (en) | 2001-08-13 | 2008-05-13 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
EP1456652A4 (en) | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
WO2003063792A2 (en) | 2002-01-30 | 2003-08-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods related to tim-3, a th1-specific cell surface molecule |
AU2003239966B9 (en) | 2002-06-03 | 2010-08-26 | Genentech, Inc. | Synthetic antibody phage libraries |
ATE481985T1 (de) | 2002-07-03 | 2010-10-15 | Ono Pharmaceutical Co | Immunpotenzierende zusammensetzungen |
BR0315123A (pt) | 2002-10-10 | 2005-08-16 | Merck Patent Gmbh | Composições farmacêuticas direcionadas a receptores erb-b1 |
US7488802B2 (en) | 2002-12-23 | 2009-02-10 | Wyeth | Antibodies against PD-1 |
EP1585767A2 (en) | 2003-01-16 | 2005-10-19 | Genentech, Inc. | Synthetic antibody phage libraries |
EP1591527B1 (en) | 2003-01-23 | 2015-08-26 | Ono Pharmaceutical Co., Ltd. | Substance specific to human pd-1 |
US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CA2515100A1 (en) | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring t cell response |
PL1897548T3 (pl) | 2003-02-28 | 2014-03-31 | Univ Johns Hopkins | Regulacja komórek T |
AU2003272065A1 (en) | 2003-04-03 | 2004-10-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof |
US7759472B2 (en) | 2003-08-27 | 2010-07-20 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
JP5128935B2 (ja) | 2004-03-31 | 2013-01-23 | ジェネンテック, インコーポレイテッド | ヒト化抗TGF−β抗体 |
US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
EP2360186B1 (en) | 2004-04-13 | 2017-08-30 | F. Hoffmann-La Roche AG | Anti-P-selectin antibodies |
TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
NZ580115A (en) | 2004-09-23 | 2010-10-29 | Genentech Inc | Cysteine engineered antibody light chains and conjugates |
DK1871805T3 (da) | 2005-02-07 | 2019-12-02 | Roche Glycart Ag | Antigenbindende molekyler der binder egfr, vektorer der koder derfor, og anvendelser deraf |
EP3623473A1 (en) | 2005-03-31 | 2020-03-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
MX349137B (es) | 2005-06-08 | 2017-07-13 | Dana-Farber Cancer Inst | Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1). |
JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
EP1907424B1 (en) | 2005-07-01 | 2015-07-29 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
EP1962961B1 (en) | 2005-11-29 | 2013-01-09 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
EP1973951A2 (en) | 2005-12-02 | 2008-10-01 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
CA2646965C (en) | 2006-03-24 | 2016-06-21 | Jonathan H. Davis | Engineered heterodimeric protein domains |
TW200812616A (en) | 2006-05-09 | 2008-03-16 | Genentech Inc | Binding polypeptides with optimized scaffolds |
NZ612319A (en) | 2006-06-12 | 2015-04-24 | Emergent Product Dev Seattle | Single-chain multivalent binding proteins with effector function |
CN101490085A (zh) | 2006-06-12 | 2009-07-22 | 特鲁比昂药品公司 | 具有效应功能的单链多价结合蛋白 |
WO2007147901A1 (en) | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
ATE514785T1 (de) | 2006-09-20 | 2011-07-15 | Mt Biomethan Gmbh | Verfahren und vorrichtung zur trennung von methan und kohlendioxid aus biogas |
EP2102241A2 (en) | 2006-12-15 | 2009-09-23 | Ablynx N.V. | Amino acid sequences that modulate the interaction between cells of the immune system |
CN105056226A (zh) | 2006-12-27 | 2015-11-18 | 埃默里大学 | 用于治疗传染病和肿瘤的组合物和方法 |
US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
WO2009015917A2 (en) | 2007-05-14 | 2009-02-05 | F. Hoffmann-La Roche Ag | Dihydroquinone and dihydronaphthridine inhibitors of jnk |
PL2170959T3 (pl) | 2007-06-18 | 2014-03-31 | Merck Sharp & Dohme | Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1 |
JP5545814B2 (ja) | 2007-06-18 | 2014-07-09 | 中外製薬株式会社 | 抗体依存性細胞障害活性を模擬する抗体の結合活性測定法 |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
US9243052B2 (en) | 2007-08-17 | 2016-01-26 | Daniel Olive | Method for treating and diagnosing hematologic malignancies |
US9416165B2 (en) | 2007-10-26 | 2016-08-16 | The Regents Of The University Of California | Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors |
US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
US8592562B2 (en) | 2008-01-07 | 2013-11-26 | Amgen Inc. | Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects |
RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
CA3092223C (en) | 2008-07-21 | 2023-01-03 | Apogenix Ag | Tnfsf single chain molecules |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
US20110223188A1 (en) | 2008-08-25 | 2011-09-15 | Solomon Langermann | Targeted costimulatory polypeptides and methods of use to treat cancer |
AU2009288730B2 (en) | 2008-08-25 | 2013-06-20 | Amplimmune, Inc. | Compositions of PD-1 antagonists and methods of use |
EP2342228B1 (en) | 2008-09-12 | 2017-09-06 | Oxford University Innovation Limited | Pd-1 specific antibodies and uses thereof |
US8927697B2 (en) | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도 |
CN102282265B (zh) | 2008-11-28 | 2020-07-24 | 埃默里大学 | 用于治疗传染病和肿瘤的方法 |
WO2010084999A1 (en) | 2009-01-26 | 2010-07-29 | Protegene, Inc. | Immunosuppressive agents and prophylactic and therapeutic agents for autoimmune diseases |
ES2629337T3 (es) | 2009-02-09 | 2017-08-08 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos |
US20110313129A1 (en) | 2009-02-11 | 2011-12-22 | Life Technologies Corporation | Large stokes shift dyes |
BRPI1014089A2 (pt) | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
KR101588598B1 (ko) | 2009-08-17 | 2016-01-29 | 로슈 글리카트 아게 | 표적화된 면역접합체 |
JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Pd−l1/pd−l2の同時阻害 |
EP2519544A1 (en) | 2009-12-29 | 2012-11-07 | Emergent Product Development Seattle, LLC | Polypeptide heterodimers and uses thereof |
EP2542590B2 (en) * | 2010-03-05 | 2020-04-01 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
US8993731B2 (en) | 2010-03-11 | 2015-03-31 | Ucb Biopharma Sprl | PD-1 antibody |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
WO2011143545A1 (en) | 2010-05-14 | 2011-11-17 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
KR101846590B1 (ko) | 2010-06-11 | 2018-04-09 | 교와 핫꼬 기린 가부시키가이샤 | 항 tim-3 항체 |
JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
UA113712C2 (xx) | 2010-08-13 | 2017-02-27 | Антитіло до fap і способи його застосування | |
CN103429620B (zh) | 2010-11-05 | 2018-03-06 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
JP5878182B2 (ja) * | 2011-02-10 | 2016-03-08 | ロシュ グリクアート アーゲー | ミュータントインターロイキン−2ポリペプチド |
DK2691417T3 (en) | 2011-03-29 | 2018-11-19 | Roche Glycart Ag | ANTIBODY FC VARIANTS |
JP6047142B2 (ja) | 2011-04-01 | 2016-12-21 | ウニヴェルズィテート シュトゥットガルト | 抗体結合ドメインを有する組換えtnfリガンドファミリーメンバーポリペプチドおよびそれらの使用 |
KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들 |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
FR2977674B1 (fr) | 2011-07-06 | 2015-08-14 | Cisbio Bioassays | Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule |
EP2543680A1 (en) | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
CA2840018C (en) | 2011-07-24 | 2019-07-16 | Curetech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
SG2014012298A (en) | 2011-08-11 | 2014-06-27 | Medarex Llc | Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof |
FR2980271B1 (fr) | 2011-09-16 | 2013-10-11 | Cisbio Bioassays | Procede de determination de la glycosylation d'un anticorps |
PT2794905T (pt) | 2011-12-20 | 2020-06-30 | Medimmune Llc | Polipéptidos modificados para estrutura de anticorpos bispecíficos |
CN106443016B (zh) | 2012-02-01 | 2019-08-13 | 弗·哈夫曼-拉罗切有限公司 | 用于检测多特异性结合物的结合搭档的方法 |
JP6152120B2 (ja) | 2012-02-15 | 2017-06-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Fc受容体に基づくアフィニティークロマトグラフィー |
JP5585973B2 (ja) | 2012-03-22 | 2014-09-10 | 三井造船株式会社 | Fret計測装置及びfret計測方法 |
AU2013249985B2 (en) | 2012-04-20 | 2017-11-23 | Merus N.V. | Methods and means for the production of Ig-like molecules |
CN108503711A (zh) | 2012-04-30 | 2018-09-07 | 比奥孔有限公司 | 靶向/免疫调节性融合蛋白及其制造方法 |
UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
PL3495387T3 (pl) | 2012-07-13 | 2022-01-10 | Roche Glycart Ag | Dwuswoiste przeciwciała anty-VEGF/anty-ANG-2 i ich zastosowanie w leczeniu chorób naczyniowych oka |
SG11201407580YA (en) * | 2012-08-07 | 2014-12-30 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
CN105121630B (zh) | 2012-10-03 | 2018-09-25 | 酵活有限公司 | 定量重链和轻链多肽对的方法 |
SI2970464T1 (sl) | 2013-03-15 | 2020-08-31 | Glaxosmithkline Intellectual Propety Development Limited | Anti-LAG-3 vezavni proteini |
WO2014179664A2 (en) | 2013-05-02 | 2014-11-06 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
SI3444271T1 (sl) | 2013-08-08 | 2022-03-31 | Cytune Pharma | Modulokini na osnovi IL-15 in IL-15Ralfa sushi domene |
ES2728578T3 (es) | 2013-09-20 | 2019-10-25 | Bristol Myers Squibb Co | Combinación de anticuerpos anti-LAG-3 y anticuerpos anti-PD-1 para tratar tumores |
EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
SI3081576T1 (sl) | 2013-12-12 | 2019-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd., | Protitelo PD-1, njegov antigen-vezavni fragment in njegova medicinska uporaba |
US20150190506A1 (en) | 2013-12-17 | 2015-07-09 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
CA2931986A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
US10794898B2 (en) | 2014-01-17 | 2020-10-06 | Regents Of The University Of Minnesota | High-throughput, high-precision methods for detecting protein structural changes in living cells |
TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) * | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JP2017505773A (ja) | 2014-01-28 | 2017-02-23 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 血液悪性腫瘍を処置するための抗lag−3抗体 |
CN113583129A (zh) | 2014-03-14 | 2021-11-02 | 诺华股份有限公司 | 针对lag-3的抗体分子及其用途 |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
MX2016014007A (es) | 2014-04-25 | 2017-01-11 | Genentech Inc | Metodos para el tratamiento de cancer de mama temprano con trastuzumab-emtansina(mcc-dm1) y pertuzumab. |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
SG11201701157UA (en) | 2014-08-29 | 2017-03-30 | Hoffmann La Roche | Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 |
MY193661A (en) | 2014-11-06 | 2022-10-24 | Hoffmann La Roche | Anti-tim3 antibodies and methods of use |
RS61870B1 (sr) | 2014-11-14 | 2021-06-30 | Hoffmann La Roche | Antigen vezujući molekuli koji sadrže trimer liganda iz tnf familije |
ES2835823T3 (es) | 2014-11-20 | 2021-06-23 | Hoffmann La Roche | Politerapia de moléculas de unión a antígeno biespecíficas activadoras de linfocitos T para CD3 y para el receptor de folato 1 (FolR1) y antagonistas de la unión al eje de PD-1 |
TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
EP3237446B1 (en) | 2014-12-22 | 2021-05-05 | PD-1 Acquisition Group, LLC | Anti-pd-1 antibodies |
MA41463A (fr) | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
EP3064507A1 (en) * | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
CN114133448A (zh) | 2015-06-23 | 2022-03-04 | 纪念斯隆-凯特琳癌症中心 | 新型pd-1免疫调节剂 |
WO2017015560A2 (en) | 2015-07-22 | 2017-01-26 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind lag3 |
JP7074341B2 (ja) | 2015-09-02 | 2022-05-24 | イムテップ エス.アー.エス. | 抗lag-3抗体 |
MA43018B1 (fr) | 2015-10-02 | 2021-11-30 | Hoffmann La Roche | Anticorps anti-pd1 et procédés d'utilisation |
CN108137699B (zh) | 2015-10-02 | 2022-05-27 | 豪夫迈·罗氏有限公司 | 对pd1和tim3特异性的双特异性抗体 |
WO2017055399A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Cellular based fret assay for the determination of simultaneous binding |
CR20180171A (es) | 2015-10-07 | 2018-05-03 | Hoffmann La Roche | Anticuerpos biespecíficos con tetravalencia para un receptor de fnt coestimulador |
MX2018005230A (es) | 2015-11-03 | 2018-08-15 | Hoffmann La Roche | Terapia de combinacion de un inhibidor del ensamble de la capside del hbv y un interferon. |
KR20180085793A (ko) | 2015-12-02 | 2018-07-27 | 주식회사 에스티큐브 | 글리코실화된 pd-1에 대해 특이적인 항체 및 이의 사용 방법 |
WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
WO2017172517A1 (en) | 2016-03-29 | 2017-10-05 | Stcube & Co., Inc. | Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins |
CN109071652B (zh) | 2016-05-11 | 2022-09-23 | 豪夫迈·罗氏有限公司 | 包含tnf家族配体三聚体和生腱蛋白结合模块的抗原结合分子 |
EP3243836A1 (en) | 2016-05-11 | 2017-11-15 | F. Hoffmann-La Roche AG | C-terminally fused tnf family ligand trimer-containing antigen binding molecules |
EP3243832A1 (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
CN106519034B (zh) * | 2016-12-22 | 2020-09-18 | 鲁南制药集团股份有限公司 | 抗pd-1抗体及其用途 |
DK3606946T3 (da) | 2017-04-03 | 2022-10-24 | Hoffmann La Roche | Immunkonjugater af et anti-PD-1-antistof med et muteret IL-2 eller med IL-15 |
EP3606947B1 (en) | 2017-04-03 | 2022-12-21 | F. Hoffmann-La Roche AG | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
EP4116328A1 (en) | 2017-04-05 | 2023-01-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combination therapies targeting pd-1, tim-3, and lag-3 |
TWI747215B (zh) | 2017-04-05 | 2021-11-21 | 瑞士商赫孚孟拉羅股份公司 | 特異性結合至pd1至lag3的雙特異性抗體 |
SI3606954T1 (sl) | 2017-04-05 | 2022-10-28 | F. Hoffmann - La Roche Ag | Protitelesa proti LAG3 |
EP3606556A1 (en) | 2017-04-05 | 2020-02-12 | Boehringer Ingelheim International GmbH | Anticancer combination therapy |
-
2018
- 2018-03-29 DK DK18715008.1T patent/DK3606946T3/da active
- 2018-03-29 EP EP22191366.8A patent/EP4201953A1/en active Pending
- 2018-03-29 CR CR20190426A patent/CR20190426A/es unknown
- 2018-03-29 KR KR1020197027871A patent/KR20190121816A/ko not_active IP Right Cessation
- 2018-03-29 LT LTEPPCT/EP2018/058034T patent/LT3606946T/lt unknown
- 2018-03-29 JP JP2019554375A patent/JP7426825B2/ja active Active
- 2018-03-29 PL PL18715008.1T patent/PL3606946T3/pl unknown
- 2018-03-29 MX MX2019011770A patent/MX2019011770A/es unknown
- 2018-03-29 RU RU2019134338A patent/RU2761377C2/ru active
- 2018-03-29 HR HRP20221254TT patent/HRP20221254T1/hr unknown
- 2018-03-29 HU HUE18715008A patent/HUE059885T2/hu unknown
- 2018-03-29 RS RS20220957A patent/RS63663B1/sr unknown
- 2018-03-29 EP EP18715008.1A patent/EP3606946B1/en active Active
- 2018-03-29 BR BR112019017329A patent/BR112019017329A2/pt unknown
- 2018-03-29 ES ES18715008T patent/ES2928718T3/es active Active
- 2018-03-29 PE PE2019001547A patent/PE20191494A1/es unknown
- 2018-03-29 UA UAA201910599A patent/UA125700C2/uk unknown
- 2018-03-29 KR KR1020217031434A patent/KR102461885B1/ko active IP Right Grant
- 2018-03-29 SG SG11201909205Y patent/SG11201909205YA/en unknown
- 2018-03-29 CN CN201880017251.7A patent/CN110392692B/zh active Active
- 2018-03-29 AU AU2018247765A patent/AU2018247765B2/en active Active
- 2018-03-29 CA CA3053357A patent/CA3053357A1/en active Pending
- 2018-03-29 CN CN202310831443.4A patent/CN117003887A/zh active Pending
- 2018-03-29 MA MA49033A patent/MA49033B1/fr unknown
- 2018-03-29 WO PCT/EP2018/058034 patent/WO2018184964A1/en unknown
- 2018-03-29 PT PT187150081T patent/PT3606946T/pt unknown
- 2018-04-02 TW TW107111572A patent/TWI800506B/zh active
- 2018-04-02 US US15/943,237 patent/US11413331B2/en active Active
- 2018-04-03 AR ARP180100833A patent/AR111400A1/es unknown
-
2019
- 2019-08-20 CL CL2019002346A patent/CL2019002346A1/es unknown
- 2019-08-21 ZA ZA2019/05517A patent/ZA201905517B/en unknown
- 2019-08-28 CO CONC2019/0009354A patent/CO2019009354A2/es unknown
- 2019-09-16 IL IL26939519A patent/IL269395A/en unknown
- 2019-09-30 MX MX2023003397A patent/MX2023003397A/es unknown
- 2019-10-02 PH PH12019502273A patent/PH12019502273A1/en unknown
-
2022
- 2022-01-05 JP JP2022000421A patent/JP2022062001A/ja not_active Withdrawn
- 2022-06-30 US US17/810,041 patent/US20230134606A1/en active Pending
- 2022-09-06 AR ARP220102406A patent/AR126987A2/es unknown
-
2023
- 2023-12-27 JP JP2023221984A patent/JP2024045143A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2019009354A2 (es) | Immunoconjugados de un anticuerpo anti-pd-1 con un mutante il-2 o con il-15 | |
ECSP19026178A (es) | Anticuerpos anti-pd-1 y sus usos | |
CR20190330A (es) | Anticuerpos anti-ox40 y sus usos | |
CL2021000717A1 (es) | Constructos de anticuerpo para cd70 y cd3. divisional de solicitud 270-2018 | |
CO2018002450A2 (es) | Proteínas de fusión de gitrl y usos de las mismas | |
MX2018016364A (es) | Anticuerpos anti-pd-l1. | |
AR111288A1 (es) | Anticuerpos anti-phf-tau y sus usos | |
BR112018015670A2 (pt) | construtos de anticorpo biespecíficos envolvendo células t | |
CL2018000829A1 (es) | Anticuerpos anti-cd19 humano con alta afinidad | |
PH12020550690A1 (en) | Radiolabeling of polypeptides | |
PE20181013A1 (es) | Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3 | |
ECSP18094829A (es) | Anticuerpos anti-cd40 y sus usos | |
BR112018012262A2 (pt) | composições de interleucina-15 e seus usos | |
UY37456A (es) | Inmunoglobulinas y sus usos | |
AR085335A1 (es) | Polipeptidos interleuquina-2 mutantes | |
AR119338A1 (es) | Inmunoconjugados que comprenden un polipéptido interleuquina-2 (il-2) mutante y un anticuerpo que se une a cd8 | |
AR115389A1 (es) | Anticuerpo antagonista de cd73 | |
AR115695A1 (es) | Moléculas proteicas multifuncionales que comprenden decorina y uso de estas | |
CO2022014884A2 (es) | Inmunoconjugados | |
BR112016021066A2 (pt) | anticorpos humanizados com estabilidade aumentada | |
AR112069A1 (es) | Inmunoglobulinas que fijan aggrecan | |
AR120886A1 (es) | Anticuerpos anti-fgfr2b | |
AR120883A1 (es) | Anticuerpos anti-fgfr2b | |
AR120884A1 (es) | Anticuerpos anti-fgfr2b | |
AR115987A1 (es) | Anticuerpos anti-gdf15, composiciones y métodos de uso |