AR112069A1 - Inmunoglobulinas que fijan aggrecan - Google Patents

Inmunoglobulinas que fijan aggrecan

Info

Publication number
AR112069A1
AR112069A1 ARP180101495A ARP180101495A AR112069A1 AR 112069 A1 AR112069 A1 AR 112069A1 AR P180101495 A ARP180101495 A AR P180101495A AR P180101495 A ARP180101495 A AR P180101495A AR 112069 A1 AR112069 A1 AR 112069A1
Authority
AR
Argentina
Prior art keywords
immunoglobulins
polypeptides
aggrecan
bind
bind aggrecan
Prior art date
Application number
ARP180101495A
Other languages
English (en)
Original Assignee
Ablynx Nv
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv, Merck Patent Gmbh filed Critical Ablynx Nv
Publication of AR112069A1 publication Critical patent/AR112069A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Inmunoglobulinas que fijan específicamente a Aggrecan y más particularmente a polipéptidos, ácidos nucleicos que codifican a tales polipéptidos; a métodos para preparar tales polipéptidos; a composiciones y en particular a composiciones farmacéuticas que contienen tales polipéptidos, para propósitos profilácticos, terapéuticos o de diagnóstico. En particular, las inmunoglobulinas inhiben la actividad de Aggrecan.
ARP180101495A 2017-06-02 2018-06-04 Inmunoglobulinas que fijan aggrecan AR112069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762514180P 2017-06-02 2017-06-02

Publications (1)

Publication Number Publication Date
AR112069A1 true AR112069A1 (es) 2019-09-18

Family

ID=62620830

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101495A AR112069A1 (es) 2017-06-02 2018-06-04 Inmunoglobulinas que fijan aggrecan

Country Status (14)

Country Link
US (2) US11603401B2 (es)
EP (1) EP3630818A1 (es)
JP (2) JP7320457B2 (es)
KR (1) KR20200013247A (es)
CN (2) CN118085076A (es)
AR (1) AR112069A1 (es)
BR (1) BR112019025392A2 (es)
CA (1) CA3065630A1 (es)
IL (1) IL270969A (es)
MX (1) MX2019014504A (es)
NZ (1) NZ759601A (es)
SG (1) SG10202113337YA (es)
TW (1) TWI811220B (es)
WO (1) WO2018220225A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108659121A (zh) 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
CN110177875B (zh) 2016-11-28 2023-11-28 中外制药株式会社 包含抗原结合结构域和运送部分的多肽
JP7438180B2 (ja) * 2018-03-20 2024-02-26 ウーシー バイオロジクス アイルランド リミテッド 新規抗ｌａｇ－３抗体ポリペプチド
JP7414736B2 (ja) * 2018-05-30 2024-01-16 中外製薬株式会社 アグリカン結合ドメインおよび運搬部分を含むポリペプチド
WO2023086441A1 (en) * 2021-11-12 2023-05-19 Regents Of The University Of Minnesota Compositions and methods for transcriptional activation

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Also Published As

Publication number Publication date
CA3065630A1 (en) 2018-12-06
AU2018277310A1 (en) 2019-12-12
JP7320457B2 (ja) 2023-08-03
NZ759601A (en) 2023-06-30
JP2020522515A (ja) 2020-07-30
WO2018220225A1 (en) 2018-12-06
BR112019025392A2 (pt) 2020-07-07
US11603401B2 (en) 2023-03-14
US20220089703A9 (en) 2022-03-24
TW201902930A (zh) 2019-01-16
US20230312694A1 (en) 2023-10-05
IL270969A (en) 2020-01-30
EP3630818A1 (en) 2020-04-08
RU2019143589A3 (es) 2021-08-16
SG10202113337YA (en) 2021-12-30
JP2023153140A (ja) 2023-10-17
RU2019143589A (ru) 2021-07-09
CN110997716A (zh) 2020-04-10
US20200140532A1 (en) 2020-05-07
TWI811220B (zh) 2023-08-11
CN118085076A (zh) 2024-05-28
US20210115117A9 (en) 2021-04-22
CN110997716B (zh) 2024-03-15
KR20200013247A (ko) 2020-02-06
MX2019014504A (es) 2020-07-20

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