PE20171307A1 - Compuestos de triazolopirimidina y usos de los mismos - Google Patents

Compuestos de triazolopirimidina y usos de los mismos

Info

Publication number
PE20171307A1
PE20171307A1 PE2017001154A PE2017001154A PE20171307A1 PE 20171307 A1 PE20171307 A1 PE 20171307A1 PE 2017001154 A PE2017001154 A PE 2017001154A PE 2017001154 A PE2017001154 A PE 2017001154A PE 20171307 A1 PE20171307 A1 PE 20171307A1
Authority
PE
Peru
Prior art keywords
halogen
compounds
dihydrobenzofuran
triazolo
pyrimidin
Prior art date
Application number
PE2017001154A
Other languages
English (en)
Inventor
Ho Man Chan
Xiang-Ju Justin Gu
Ying Huang
Ling Li
Yuan Mi
Wei Qi
Martin Sendzik
Yongfeng Sun
Long Wang
Zhengtian Yu
Hailong Zhang
Ji Yue Zhang (Jeff)
Man Zhang
Qiong Zhang
Kehao Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20171307A1 publication Critical patent/PE20171307A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRIMIDINA DE FORMULA (I) DONDE ----- ES UN ENLACE SIMPLE O UN ENLACE DOBLE; R1 Y R2 SON H O HALOGENO; R3 ES HALOGENO, FENILO, ENTRE OTROS; R4 ES H, HALOGENO O ALQUILO C1-C4; R5 ES OH O ALQUILO C1-C4; n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 8-(1,3-DIMETIL-1H-PIRAZOL-5-IL)-N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA; N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-8-(2-METILPIRIDIN-3-IL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL COMPLEJO REPRESIVO DEL POLINOMIO 2 (PRC2) SIENDO UTILES EN EL TRATAMIENTO DE LINFOMAS, TUMORES Y CANCER
PE2017001154A 2014-12-23 2015-12-21 Compuestos de triazolopirimidina y usos de los mismos PE20171307A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014094644 2014-12-23
CN2015095320 2015-11-23

Publications (1)

Publication Number Publication Date
PE20171307A1 true PE20171307A1 (es) 2017-09-05

Family

ID=55071101

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017001154A PE20171307A1 (es) 2014-12-23 2015-12-21 Compuestos de triazolopirimidina y usos de los mismos

Country Status (40)

Country Link
US (5) US10220036B2 (es)
EP (1) EP3237418B1 (es)
JP (1) JP6736559B2 (es)
KR (1) KR102534028B1 (es)
CN (1) CN107108637B (es)
AU (1) AU2015370524B2 (es)
BR (1) BR112017010354B8 (es)
CA (1) CA2969090C (es)
CL (1) CL2017001572A1 (es)
CO (1) CO2017005992A2 (es)
CR (1) CR20170285A (es)
CY (1) CY1121901T1 (es)
DK (1) DK3237418T3 (es)
DO (1) DOP2017000149A (es)
EA (1) EA032416B1 (es)
EC (1) ECSP17047153A (es)
ES (1) ES2722048T3 (es)
GT (1) GT201700146A (es)
HR (1) HRP20190805T1 (es)
HU (1) HUE043060T2 (es)
IL (1) IL252135B (es)
JO (1) JO3489B1 (es)
LT (1) LT3237418T (es)
ME (1) ME03385B (es)
MX (1) MX2017008529A (es)
MY (1) MY186837A (es)
NZ (1) NZ731664A (es)
PE (1) PE20171307A1 (es)
PH (1) PH12017501016A1 (es)
PL (1) PL3237418T3 (es)
PT (1) PT3237418T (es)
RS (1) RS58679B1 (es)
SG (1) SG11201703880VA (es)
SI (1) SI3237418T1 (es)
SV (1) SV2017005472A (es)
TN (1) TN2017000204A1 (es)
TW (1) TWI694076B (es)
UA (1) UA120945C2 (es)
UY (1) UY36462A (es)
WO (1) WO2016103155A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6736559B2 (ja) * 2014-12-23 2020-08-05 ノバルティス アーゲー トリアゾロピリミジン化合物およびその使用
US11786533B2 (en) 2016-06-01 2023-10-17 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
CN109906224B (zh) * 2016-06-20 2022-02-25 诺华股份有限公司 ***吡啶化合物及其应用
WO2017221100A1 (en) * 2016-06-20 2017-12-28 Novartis Ag Imidazopyrimidine compounds useful for the treatment of cancer
IL263429B (en) 2016-06-20 2022-08-01 Novartis Ag Crystalline forms of a triazolopyrimidine compound
CA3030167A1 (en) 2016-07-12 2018-01-18 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
CN106831601A (zh) * 2017-01-13 2017-06-13 河北博伦特药业有限公司 一种2‑氨基甲基嘧啶盐酸盐及其衍生物的合成方法
WO2018136264A1 (en) 2017-01-23 2018-07-26 Revolution Medicines, Inc. Pyridine compounds as allosteric shp2 inhibitors
KR20190111079A (ko) 2017-01-23 2019-10-01 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 이환 화합물
WO2018170290A1 (en) * 2017-03-15 2018-09-20 Fulcrum Therapeutics, Inc. Compositions and methods for increasing fmr1 expression
US10266542B2 (en) 2017-03-15 2019-04-23 Mirati Therapeutics, Inc. EZH2 inhibitors
MX2019010354A (es) * 2017-03-16 2019-10-22 Jiangsu Hengrui Medicine Co Derivado de heteroaril[4,3-c]pirimidina-5-amina, metodo de preparacion del mismo y usos medicos del mismo.
EP3630080A4 (en) 2017-06-02 2021-03-10 Epizyme, Inc. USE OF EZH2 INHIBITORS FOR THE TREATMENT OF CANCER
CN109575013A (zh) * 2017-09-28 2019-04-05 中国科学院上海药物研究所 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗prc2介导的疾病
WO2019062435A1 (zh) * 2017-09-28 2019-04-04 中国科学院上海药物研究所 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗prc2介导的疾病
BR112020007058A2 (pt) 2017-10-12 2020-10-06 Revolution Medicines, Inc. compostos de piridina, pirazina, e triazina como inibidores de shp2 alostéricos
CN109867645B (zh) * 2017-12-05 2021-09-14 中国医学科学院药物研究所 一种2,2-二氟-2,3-二氢取代苯并呋喃类化合物的合成方法
MX2020006273A (es) * 2017-12-15 2020-09-14 Revolution Medicines Inc Compuestos policiclicos como inhibidores alostericos de shp2.
CN109942556A (zh) * 2017-12-21 2019-06-28 上海青煜医药科技有限公司 嘧啶酮化合物及其应用
WO2019145176A1 (en) * 2018-01-23 2019-08-01 Basf Se Halogenation of pyridine derivatives
CN112004816B (zh) 2018-01-31 2024-01-05 米拉蒂医疗股份有限公司 Prc2抑制剂
CN110156787B (zh) * 2018-02-13 2021-11-02 中国科学院上海药物研究所 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途
CN110563722A (zh) * 2018-06-06 2019-12-13 上海青煜医药科技有限公司 吡啶或哒嗪并环化合物及其应用
CN110734436A (zh) * 2018-07-19 2020-01-31 上海青煜医药科技有限公司 嘧啶或吡嗪并环化合物及其应用
EP3889153A4 (en) * 2018-11-30 2022-09-07 Tuojie Biotech (Shanghai) Co., Ltd. PYRIMIDINE AND PENTAGONAL HETEROCYCLE DERIVATIVE OF NITROGEN, METHOD FOR THE PREPARATION AND MEDICAL APPLICATIONS
CN111518100A (zh) * 2019-02-02 2020-08-11 上海青煜医药科技有限公司 环丙烯并苯并呋喃取代的氮杂芳基化合物及其应用
AU2020241254A1 (en) * 2019-03-15 2021-10-07 Fulcrum Therapeutics, Inc. Macrocyclic azolopyridine derivatives as EED and PRC2 modulators
EP3950064A4 (en) * 2019-04-03 2023-01-04 Tera Stone Co., Ltd THYMINE NUCLEOBASE BASED TRIAZOLOPYRIMIDINES AND PROCESS FOR THEIR PRODUCTION
US20220213097A1 (en) * 2019-04-22 2022-07-07 Mirati Therapeutics, Inc. Naphthyridine derivatives as prc2 inhibitors
US11814734B2 (en) 2019-05-13 2023-11-14 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor
KR20220027933A (ko) * 2019-06-05 2022-03-08 미라티 테라퓨틱스, 인크. 암을 치료하기 위한 prc2 억제제로서의 이미다조[1,2-c]피리미딘 유도체
EP3980021A4 (en) * 2019-06-05 2023-06-14 Atnx Spv, Llc METHODS OF TREATMENT AND/OR PREVENTION OF PSORIASIS
JP7357146B2 (ja) * 2019-08-22 2023-10-05 ブルーレイ セラピューティクス （シャンハイ） カンパニー，リミティド アザヘテロアリール化合物及びその使用
CN114746414A (zh) * 2019-09-26 2022-07-12 诺华公司 氮杂-喹啉化合物及其用途
EP4056570A4 (en) * 2019-11-01 2023-12-20 ShanghaiTech University EED INHIBITOR AND PRODUCTION METHOD AND USE THEREOF
CN113004233B (zh) * 2019-12-18 2022-12-20 南京优氟医药科技有限公司 一种用于制备prc2抑制剂的化合物、其制备方法和用途
CN111333655B (zh) * 2020-04-13 2021-07-13 武汉工程大学 一种***并嘧啶类化合物及其制备方法和应用
WO2021228034A1 (en) * 2020-05-11 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Preparation method of (5-fluoro-2, 3-dihydrobenzofuran-4-yl) methanamine or its salt, and intermediates thereof
WO2021240373A1 (en) 2020-05-28 2021-12-02 Novartis Ag Dosing regimens for n-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, or a pharmaceutically acceptable salt thereof, for use in treating prc2-mediated diseases or disorders
CN114907385A (zh) 2021-02-10 2022-08-16 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用
WO2023016511A1 (zh) * 2021-08-11 2023-02-16 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用
CN117384153A (zh) * 2022-07-12 2024-01-12 上海赛岚生物科技有限公司 一类甲基转移酶抑制剂及其用途

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
CA2346448A1 (en) 1998-12-16 2000-06-22 Warner-Lambert Company Treatment of arthritis with mek inhibitors
NL1014106C2 (nl) 2000-01-18 2001-07-20 Univ Amsterdam Werkwijze voor het detecteren van een pathologische afwijking bij een cel, een antistof en een assay kit.
DZ3401A1 (fr) 2000-07-19 2002-01-24 Warner Lambert Co Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques
SE519662C2 (sv) * 2001-07-04 2003-03-25 Asept Int Ab Ventilanordning vid utportioneringsanordningar
US6894055B2 (en) * 2001-10-24 2005-05-17 Iconix Pharmaceuticals Inc. Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase
US6921762B2 (en) * 2001-11-16 2005-07-26 Amgen Inc. Substituted indolizine-like compounds and methods of use
JP4575667B2 (ja) 2002-03-08 2010-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬として有用な大環状化合物
SI1482932T1 (sl) 2002-03-13 2010-02-26 Array Biopharma Inc N3-alkilirani derivati benzimidazola kot inhibitorji mek
GB0228900D0 (en) 2002-12-11 2003-01-15 Ml Lab Plc Cancer Immunotherapy
JP2004238296A (ja) * 2003-02-04 2004-08-26 Kissei Pharmaceut Co Ltd 新規なトリアゾロピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20060246505A1 (en) 2003-09-02 2006-11-02 Reinhard Walther Modulation of the synthesis of insulin
ATE449168T1 (de) 2004-06-01 2009-12-15 Univ North Carolina Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7452892B2 (en) 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
ES2481402T3 (es) 2005-07-21 2014-07-30 Ardea Biosciences, Inc. Inhibidores de N-(arilamino)sulfonamida de MEK
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US7890267B2 (en) 2006-03-31 2011-02-15 Ordway Research Institute Prognostic and diagnostic method for cancer therapy
CA2673784A1 (en) 2006-12-27 2008-07-10 Usc Stevens-University Of Southern California Dna methylation markers based on epigenetic stem cell signatures in cancer
WO2009017670A2 (en) 2007-07-26 2009-02-05 University Of Massachusetts Ras-mediated epigenetic silencing effectors and uses thereof
US8907091B2 (en) 2007-08-29 2014-12-09 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
EP2205242B1 (en) 2007-09-12 2015-04-15 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
WO2009055730A1 (en) 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
GB0822248D0 (en) 2008-12-05 2009-01-14 Medical Res Council Crystal meths
WO2010111712A2 (en) 2009-03-27 2010-09-30 Cold Spring Harbor Laboratory Identification of rnai targets and use of rnai for rational therapy of chemotherapy-resistant leukemia and other cancers
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
TW201200518A (en) 2010-03-10 2012-01-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
JP5864545B2 (ja) * 2010-05-07 2016-02-17 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ インドール
KR102061353B1 (ko) 2010-09-10 2020-01-02 에피자임, 인코포레이티드 인간 ｅｚｈ2의 억제제 및 이의 사용 방법
WO2012151277A1 (en) 2011-05-02 2012-11-08 Applied Informatic Solutions, Inc. Kits and methods for selecting a treatment for ovarian cancer
WO2013010181A2 (en) 2011-07-14 2013-01-17 University Of Massachusetts Methods of diagnosing cancer using epigenetic biomarkers
RU2014117632A (ru) 2011-09-30 2015-11-10 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Способы лечения злокачественной опухоли
TR201904660T4 (tr) 2012-03-12 2019-05-21 Epizyme Inc İnsan EZH2 inhibitörleri ve bunun kullanım yöntemleri.
WO2014078813A1 (en) 2012-11-19 2014-05-22 Irm Llc Compounds and compositions for the treatment of parasitic diseases
EP2934531A4 (en) 2012-12-19 2016-06-15 Glaxosmithkline Llc COMBINATION
WO2014124326A1 (en) 2013-02-08 2014-08-14 Stem Centrx, Inc. Novel multispecific constructs
PL2953941T3 (pl) 2013-02-11 2017-11-30 Constellation Pharmaceuticals, Inc. Modulatory enzymów modyfikujących metyl, ich kompozycje i zastosowania
EP2968565A2 (en) 2013-03-14 2016-01-20 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
EP2970305B1 (en) 2013-03-15 2017-02-22 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US9776996B2 (en) * 2013-03-15 2017-10-03 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US10167286B2 (en) 2014-02-11 2019-01-01 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
KR102486616B1 (ko) 2014-11-14 2023-01-09 바스프 에스이 질화작용 억제제로서의 벤질프로파르길에테르
NO3033944T3 (es) 2014-12-16 2018-07-14
JP6736559B2 (ja) * 2014-12-23 2020-08-05 ノバルティス アーゲー トリアゾロピリミジン化合物およびその使用
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
MA41272A (fr) 2014-12-23 2017-10-31 Adama Makhteshim Ltd 5-fluoro-4-imino-3-(alkyle/alkyle substitué)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one en tant que traitement des semences

Also Published As

Publication number Publication date
PT3237418T (pt) 2019-05-23
RS58679B1 (sr) 2019-06-28
SV2017005472A (es) 2018-06-12
CR20170285A (es) 2017-08-21
PL3237418T3 (pl) 2019-07-31
AU2015370524B2 (en) 2018-11-01
HRP20190805T1 (hr) 2019-06-28
CA2969090C (en) 2023-05-02
CY1121901T1 (el) 2020-10-14
GT201700146A (es) 2019-06-12
KR20170095882A (ko) 2017-08-23
TWI694076B (zh) 2020-05-21
US20190142837A1 (en) 2019-05-16
US20160176882A1 (en) 2016-06-23
AU2015370524A1 (en) 2017-06-01
CO2017005992A2 (es) 2017-10-20
US11931363B2 (en) 2024-03-19
UY36462A (es) 2016-07-29
KR102534028B1 (ko) 2023-05-19
ECSP17047153A (es) 2019-02-28
EA032416B1 (ru) 2019-05-31
NZ731664A (en) 2024-02-23
SG11201703880VA (en) 2017-07-28
BR112017010354B8 (pt) 2022-10-18
DOP2017000149A (es) 2017-07-15
MX2017008529A (es) 2017-10-25
CN107108637A (zh) 2017-08-29
US20170348312A1 (en) 2017-12-07
CA2969090A1 (en) 2016-06-30
MY186837A (en) 2021-08-25
DK3237418T3 (da) 2019-05-13
US20230033320A1 (en) 2023-02-02
PH12017501016B1 (en) 2017-12-11
LT3237418T (lt) 2019-05-10
US9580437B2 (en) 2017-02-28
BR112017010354B1 (pt) 2022-09-20
EA201791420A1 (ru) 2017-10-31
US20200323859A1 (en) 2020-10-15
WO2016103155A1 (en) 2016-06-30
US10220036B2 (en) 2019-03-05
ME03385B (me) 2020-01-20
HUE043060T2 (hu) 2019-07-29
SI3237418T1 (sl) 2019-06-28
TW201629065A (zh) 2016-08-16
IL252135A0 (en) 2017-07-31
TN2017000204A1 (en) 2018-10-19
CN107108637B (zh) 2019-10-29
UA120945C2 (uk) 2020-03-10
IL252135B (en) 2020-06-30
BR112017010354A2 (pt) 2017-12-26
EP3237418B1 (en) 2019-01-30
JO3489B1 (ar) 2020-07-05
ES2722048T3 (es) 2019-08-07
CL2017001572A1 (es) 2018-01-12
US11207325B2 (en) 2021-12-28
PH12017501016A1 (en) 2017-12-11
EP3237418A1 (en) 2017-11-01
JP2018500342A (ja) 2018-01-11
JP6736559B2 (ja) 2020-08-05

Similar Documents

Publication Publication Date Title
PE20171307A1 (es) Compuestos de triazolopirimidina y usos de los mismos
PE20181298A1 (es) Inhibidores de bromodominio bivalentes y usos de los mismos
PH12018500987A1 (en) Dihydroimidazopyrazinone derivatives useful in the treatment of cancer
NI201600152A (es) Compuestos de heteroarilo o arilo bicíclicos fusionados y su uso como inhibidores de irak4
MD20170016A2 (ro) Compuşi aminopirimidinici ca inhibitori JAK
PE20152033A1 (es) Heterociclos bicicliclos como inhibidores de fgfr
EA201791256A1 (ru) Производные хиназолина, применяемые для лечения вич
EA201791563A1 (ru) Замещенные нуклеозидные производные, полезные в качестве агентов против рака
PE20211782A1 (es) Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos
PE20170666A1 (es) 2-(morfolin-4-il)-1,7-naftiridinas
PE20191245A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
PE20190656A1 (es) Compuestos de tiazolo-piridina sustituida como inhibidores de malt1
EA201591255A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-РОДСТВЕННЫХ КИНАЗ (JAK)
EA201791094A1 (ru) Аналоги простых эфиров фосфолипидов в качестве носителей лекарственных средств, нацеленных на раковые клетки
EA202090291A2 (ru) Производные бипиразола в качестве ингибиторов jak
EA201691484A1 (ru) Соли и твердая форма ингибитора btk
MX2015010858A (es) Formas solidas de un inhbidor de cdk4/6 selectivo.
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
EA201891526A2 (ru) Ингибиторы лизин-специфической деметилазы-1
EA201791304A1 (ru) Производные изохинолина для лечения вич
EA201591781A1 (ru) Химические соединения
PE20160689A1 (es) Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas
EA201790603A1 (ru) Ингибиторы гистондеметилазы
TW201613864A (en) Novel compounds
MX2018004664A (es) Antagonistas de ep4.