PE20161388A1 - Inhibidores de la jak1 para el tratamiento de sindromes mielodisplasicos - Google Patents
Inhibidores de la jak1 para el tratamiento de sindromes mielodisplasicosInfo
- Publication number
- PE20161388A1 PE20161388A1 PE2016001538A PE2016001538A PE20161388A1 PE 20161388 A1 PE20161388 A1 PE 20161388A1 PE 2016001538 A PE2016001538 A PE 2016001538A PE 2016001538 A PE2016001538 A PE 2016001538A PE 20161388 A1 PE20161388 A1 PE 20161388A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrrolo
- treatment
- pyrazol
- pyrimidin
- jak1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
Se refiere a un metodo para tratar un sindrome mielodisplasico que comprende administrar a un paciente un compuesto derivado de pirrolo[2,3-d]pirimidina o pirrolo[2,3-b]piridina que inhiben selectivamente la quinasa Janus 1 (JAK1), donde el compuesto es seleccionado de 3-[1-(6-cloropiridin-2-il)pirrolidin-3-il]-3-[4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il]propanonitrilo, 3-[1-(1,3]oxazolo[5,4-b]piridin-2ilpirrolidin-3-il)-3-[4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il]propanonitrilo o sales farmaceuticamente aceptables de los mismos. Los sindromes mielodisplasicos son citopenia refractaria con displasia unilinaje (RCUD), anemia refractaria con sideroblastos en anillo (RARS), entre otros
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461946124P | 2014-02-28 | 2014-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20161388A1 true PE20161388A1 (es) | 2016-12-28 |
Family
ID=52693052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001538A PE20161388A1 (es) | 2014-02-28 | 2015-02-27 | Inhibidores de la jak1 para el tratamiento de sindromes mielodisplasicos |
Country Status (28)
Country | Link |
---|---|
US (4) | US20150246046A1 (es) |
EP (1) | EP3110409B1 (es) |
JP (1) | JP6576941B2 (es) |
KR (1) | KR20160136323A (es) |
CN (2) | CN106456773A (es) |
AU (1) | AU2015222913B2 (es) |
CA (1) | CA2940659C (es) |
CL (1) | CL2016002144A1 (es) |
CR (1) | CR20160449A (es) |
CY (1) | CY1120857T1 (es) |
DK (1) | DK3110409T3 (es) |
EA (1) | EA201691745A1 (es) |
ES (1) | ES2688553T3 (es) |
HR (1) | HRP20181661T1 (es) |
HU (1) | HUE041456T2 (es) |
IL (1) | IL247475B (es) |
LT (1) | LT3110409T (es) |
MX (1) | MX2016011103A (es) |
MY (1) | MY185392A (es) |
PE (1) | PE20161388A1 (es) |
PL (1) | PL3110409T3 (es) |
PT (1) | PT3110409T (es) |
RS (1) | RS57723B1 (es) |
SG (2) | SG10201807952PA (es) |
SI (1) | SI3110409T1 (es) |
UA (1) | UA121857C2 (es) |
WO (1) | WO2015131031A1 (es) |
ZA (1) | ZA201606610B (es) |
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MY162590A (en) | 2005-12-13 | 2017-06-30 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors |
EP3495369B1 (en) | 2007-06-13 | 2021-10-27 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
MX2011012262A (es) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
SG10201910912TA (en) | 2010-05-21 | 2020-01-30 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
BR112013012502A2 (pt) | 2010-11-19 | 2019-03-06 | Incyte Corporation | pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak |
MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
SG10201703533VA (en) | 2012-11-01 | 2017-06-29 | Incyte Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
SG11201503695XA (en) | 2012-11-15 | 2015-06-29 | Incyte Corp | Sustained-release dosage forms of ruxolitinib |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
EA030705B1 (ru) | 2013-03-06 | 2018-09-28 | Инсайт Холдингс Корпорейшн | Способы и промежуточные соединения при получении ингибитора jak |
PE20160126A1 (es) | 2013-05-17 | 2016-02-24 | Incyte Corp | Derivados del bipirazol como inhibidores jak |
ES2792549T3 (es) | 2013-08-07 | 2020-11-11 | Incyte Corp | Formas de dosificación de liberación sostenida para un inhibidor de JAK1 |
WO2015027124A1 (en) | 2013-08-23 | 2015-02-26 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
KR20220066179A (ko) | 2014-04-08 | 2022-05-23 | 인사이트 코포레이션 | Jak 및 pi3k 억제제 조합에 의한 b-세포 악성종양의 치료 |
AU2015253192B2 (en) | 2014-04-30 | 2019-05-16 | Incyte Holdings Corporation | Processes of preparing a JAK1 inhibitor and new forms thereto |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
US20190183900A1 (en) * | 2016-03-09 | 2019-06-20 | University Of Ulsan Foundation For Industry Cooperation | Composition for proliferation, differentiation promotion, or senescence inhibition of stem cells, containing jak1 inhibitor as active ingredient |
KR101934107B1 (ko) * | 2016-12-15 | 2018-12-31 | 가톨릭대학교산학협력단 | 골수형성이상 증후군 환자의 저메틸화 제제 치료 반응성 및 생존 예후 예측용 조성물 |
US11524961B2 (en) | 2017-01-23 | 2022-12-13 | Shanghai Longwood Biopharmaceuticals Co., Ltd. | JAK kinase inhibitor and preparation method and use thereof |
CN109867676B (zh) * | 2017-12-01 | 2020-10-30 | 北京普祺医药科技有限公司 | 一种吡咯并嘧啶衍生的化合物、药物组合物以及其用途 |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
PL3746429T3 (pl) | 2018-01-30 | 2022-06-20 | Incyte Corporation | Procesy do otrzymywania (1-(3-fluoro-2-(trifluorometylo)izonikotynoilo)piperydyn-4-onu) |
EP4085965A1 (en) | 2018-02-01 | 2022-11-09 | Shifamed Holdings, LLC | Intravascular blood pumps and methods of use and manufacture |
SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
US11584961B2 (en) | 2018-03-30 | 2023-02-21 | Incyte Corporation | Biomarkers for inflammatory skin disease |
WO2019191684A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
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KR20210137087A (ko) * | 2019-03-05 | 2021-11-17 | 인사이트 코포레이션 | 만성 폐 동종이식 기능장애의 치료를 위한 jak1 경로 억제제 |
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KR20230118118A (ko) | 2020-12-08 | 2023-08-10 | 인사이트 코포레이션 | 백반증의 치료를 위한 jak1 경로 저해제 |
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SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
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2015
- 2015-02-27 CN CN201580017178.XA patent/CN106456773A/zh active Pending
- 2015-02-27 EP EP15710994.3A patent/EP3110409B1/en active Active
- 2015-02-27 AU AU2015222913A patent/AU2015222913B2/en active Active
- 2015-02-27 RS RS20181194A patent/RS57723B1/sr unknown
- 2015-02-27 WO PCT/US2015/017963 patent/WO2015131031A1/en active Application Filing
- 2015-02-27 CR CR20160449A patent/CR20160449A/es unknown
- 2015-02-27 DK DK15710994.3T patent/DK3110409T3/en active
- 2015-02-27 HU HUE15710994A patent/HUE041456T2/hu unknown
- 2015-02-27 CA CA2940659A patent/CA2940659C/en active Active
- 2015-02-27 LT LTEP15710994.3T patent/LT3110409T/lt unknown
- 2015-02-27 MY MYPI2016001574A patent/MY185392A/en unknown
- 2015-02-27 SG SG10201807952PA patent/SG10201807952PA/en unknown
- 2015-02-27 PL PL15710994T patent/PL3110409T3/pl unknown
- 2015-02-27 MX MX2016011103A patent/MX2016011103A/es active IP Right Grant
- 2015-02-27 PE PE2016001538A patent/PE20161388A1/es unknown
- 2015-02-27 SG SG11201607083VA patent/SG11201607083VA/en unknown
- 2015-02-27 PT PT15710994T patent/PT3110409T/pt unknown
- 2015-02-27 CN CN202010986614.7A patent/CN112494652A/zh active Pending
- 2015-02-27 UA UAA201609815A patent/UA121857C2/uk unknown
- 2015-02-27 KR KR1020167026668A patent/KR20160136323A/ko not_active IP Right Cessation
- 2015-02-27 US US14/633,605 patent/US20150246046A1/en not_active Abandoned
- 2015-02-27 ES ES15710994.3T patent/ES2688553T3/es active Active
- 2015-02-27 SI SI201530368T patent/SI3110409T1/sl unknown
- 2015-02-27 JP JP2016554471A patent/JP6576941B2/ja active Active
- 2015-02-27 EA EA201691745A patent/EA201691745A1/ru unknown
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2016
- 2016-08-24 CL CL2016002144A patent/CL2016002144A1/es unknown
- 2016-08-25 IL IL247475A patent/IL247475B/en active IP Right Grant
- 2016-09-23 ZA ZA2016/06610A patent/ZA201606610B/en unknown
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2018
- 2018-05-15 US US15/980,052 patent/US20190111058A1/en not_active Abandoned
- 2018-10-12 HR HRP20181661TT patent/HRP20181661T1/hr unknown
- 2018-11-13 CY CY181101196T patent/CY1120857T1/el unknown
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2020
- 2020-04-03 US US16/839,972 patent/US20210069193A1/en not_active Abandoned
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2021
- 2021-12-20 US US17/556,374 patent/US20220378791A1/en active Pending
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