EA201791369A1 - Твердые формы конденсированных гетероароматических пирролидинонов - Google Patents

Твердые формы конденсированных гетероароматических пирролидинонов

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Publication number
EA201791369A1
EA201791369A1 EA201791369A EA201791369A EA201791369A1 EA 201791369 A1 EA201791369 A1 EA 201791369A1 EA 201791369 A EA201791369 A EA 201791369A EA 201791369 A EA201791369 A EA 201791369A EA 201791369 A1 EA201791369 A1 EA 201791369A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid forms
condensed heteroaromatic
chemical compounds
pyrrolidinones
heteroaromatic pyrrolidinones
Prior art date
Application number
EA201791369A
Other languages
English (en)
Other versions
EA032291B1 (ru
Inventor
Жунлян Чэнь
Томонори Итибакасе
Чуньжун Ма
Кристофер Мэттьюс
Хадзиме Мотойоси
Колин О'Брайан
Кентаро Ядзи
Наоки Йосикава
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55299676&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791369(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201791369A1 publication Critical patent/EA201791369A1/ru
Publication of EA032291B1 publication Critical patent/EA032291B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Описаны химические соединения, которые представляют собой ингибиторы селезеночной тирозинкиназы, а именно химические соединения, содержащие 6-((1R,2S)-2-аминоциклогексиламино)-7-фтор-4-(1-метил-1Н-пиразол-4-ил)-1Н-пирроло[3,4-с]пиридин-3(2H)-он, а также их некоторые твердые формы. Описаны также способы применения указанных химических соединений для лечения расстройств, таких как рак.
EA201791369A 2014-12-18 2015-12-17 Твердые формы конденсированных гетероароматических пирролидинонов EA032291B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462093564P 2014-12-18 2014-12-18
US201562115223P 2015-02-12 2015-02-12
US201562180222P 2015-06-16 2015-06-16
PCT/IB2015/002489 WO2016097862A2 (en) 2014-12-18 2015-12-17 Solid state forms of fused heteroaromatic pyrrolidinones

Publications (2)

Publication Number Publication Date
EA201791369A1 true EA201791369A1 (ru) 2017-10-31
EA032291B1 EA032291B1 (ru) 2019-05-31

Family

ID=55299676

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791369A EA032291B1 (ru) 2014-12-18 2015-12-17 Твердые формы конденсированных гетероароматических пирролидинонов

Country Status (29)

Country Link
US (3) US10676473B2 (ru)
EP (2) EP3233857B1 (ru)
JP (3) JP6778195B2 (ru)
KR (1) KR102037502B1 (ru)
CN (1) CN107108609B (ru)
AU (1) AU2015365580B2 (ru)
BR (1) BR112017013149B1 (ru)
CA (1) CA2970864C (ru)
CL (1) CL2017001561A1 (ru)
CO (1) CO2017005910A2 (ru)
CR (1) CR20170249A (ru)
DK (1) DK3233857T3 (ru)
DO (1) DOP2017000130A (ru)
EA (1) EA032291B1 (ru)
EC (1) ECSP17038100A (ru)
ES (1) ES2788454T3 (ru)
GE (1) GEP20197050B (ru)
HK (1) HK1243406A1 (ru)
IL (1) IL252941B (ru)
MX (1) MX2017007162A (ru)
NZ (1) NZ732371A (ru)
PE (1) PE20171179A1 (ru)
PH (1) PH12017501123A1 (ru)
PL (1) PL3233857T3 (ru)
SG (1) SG11201701911QA (ru)
TN (1) TN2017000080A1 (ru)
UA (1) UA120632C2 (ru)
WO (1) WO2016097862A2 (ru)
ZA (1) ZA201701800B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2818103C2 (ru) * 2018-12-14 2024-04-24 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Соль ингибитора syk и ее кристаллическая форма

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BR112017013149B1 (pt) * 2014-12-18 2022-10-11 Takeda Pharmaceutical Company Limited Composto, composição farmacêutica e uso dos mesmos
WO2018013239A1 (en) * 2016-07-13 2018-01-18 Takeda Pharmaceutical Company Limited Combination of spleen tyrosine kinase inhibitors and other therapeutic agents
BR112020007679A2 (pt) 2017-10-19 2020-10-20 Bayer Animal Health Gmbh uso de pirrolidonas heteroaromáticas fundidas para tratamento e prevenção de doenças em animais.
WO2019088039A1 (en) 2017-10-30 2019-05-09 Takeda Pharmaceutical Company Limited Treatment of acute myeloid leukemia
SG11202106210QA (en) 2018-12-14 2021-07-29 Chia Tai Tianqing Pharmaceutical Group Co Ltd Salt of syk inhibitor and crystalline form thereof
AU2020218154A1 (en) 2019-02-07 2021-08-05 Janssen Biotech, Inc. Dihydroorotate dehydrogenase inhibitors
TW202104207A (zh) 2019-04-17 2021-02-01 美商健生生物科技公司 二氫乳清酸脫氫酶抑制劑
JP2022552496A (ja) 2019-10-10 2022-12-16 ヤンセン バイオテツク，インコーポレーテツド ビアリールジヒドロオロト酸デヒドロゲナーゼ阻害剤
WO2022074534A1 (en) 2020-10-05 2022-04-14 Janssen Biotech, Inc. Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents
CN115698005B (zh) * 2020-12-18 2024-02-06 山东轩竹医药科技有限公司 稠环类AhR抑制剂
PE20240588A1 (es) 2021-05-11 2024-03-21 Janssen Pharmaceutica Nv Terapias de combinacion
JP2024518497A (ja) 2021-05-11 2024-05-01 ヤンセン ファーマシューティカ エヌ．ベー． 併用療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007070872A1 (en) * 2005-12-15 2007-06-21 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
ES2545616T3 (es) 2009-12-23 2015-09-14 Takeda Pharmaceutical Company Limited Pirrolidinonas heteroaromáticas condensadas como inhibidores de SYK
EP2723739B1 (en) * 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
WO2016048982A2 (en) * 2014-09-24 2016-03-31 Millennium Pharmaceuticals, Inc. COMBINATION TREATMENT WITH PI3Kα INHIBITORS AND TAXANES
BR112017013149B1 (pt) * 2014-12-18 2022-10-11 Takeda Pharmaceutical Company Limited Composto, composição farmacêutica e uso dos mesmos

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2818103C2 (ru) * 2018-12-14 2024-04-24 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Соль ингибитора syk и ее кристаллическая форма

Also Published As

Publication number Publication date
EA032291B1 (ru) 2019-05-31
CA2970864C (en) 2020-04-14
BR112017013149A2 (pt) 2018-04-10
BR112017013149B1 (pt) 2022-10-11
EP3233857B1 (en) 2020-03-11
CO2017005910A2 (es) 2017-10-20
CL2017001561A1 (es) 2018-01-12
US20230348461A1 (en) 2023-11-02
EP3677582A1 (en) 2020-07-08
EP3233857A2 (en) 2017-10-25
ES2788454T3 (es) 2020-10-21
DOP2017000130A (es) 2017-07-15
ECSP17038100A (es) 2017-12-01
CA2970864A1 (en) 2016-06-23
KR20170095374A (ko) 2017-08-22
MX2017007162A (es) 2017-08-28
AU2015365580B2 (en) 2020-04-02
AU2015365580A1 (en) 2017-07-06
JP2022017477A (ja) 2022-01-25
DK3233857T3 (da) 2020-04-27
UA120632C2 (uk) 2020-01-10
CN107108609A (zh) 2017-08-29
US10676473B2 (en) 2020-06-09
JP2020143081A (ja) 2020-09-10
CR20170249A (es) 2017-09-25
WO2016097862A2 (en) 2016-06-23
IL252941A0 (en) 2017-08-31
GEP20197050B (en) 2019-12-10
US11352355B2 (en) 2022-06-07
JP6974534B2 (ja) 2021-12-01
KR102037502B1 (ko) 2019-10-28
PE20171179A1 (es) 2017-08-22
SG11201701911QA (en) 2017-04-27
HK1243406A1 (zh) 2018-07-13
WO2016097862A3 (en) 2016-08-11
NZ732371A (en) 2023-04-28
PH12017501123A1 (en) 2017-11-27
ZA201701800B (en) 2020-05-27
JP6778195B2 (ja) 2020-10-28
US20160176869A1 (en) 2016-06-23
EP3677582B1 (en) 2023-01-25
TN2017000080A1 (en) 2018-07-04
JP2017537969A (ja) 2017-12-21
US20200339573A1 (en) 2020-10-29
IL252941B (en) 2020-11-30
PL3233857T3 (pl) 2020-07-27
CN107108609B (zh) 2020-02-18

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