PE20151763A1 - Muteinas de interleucina-2 para la expansion de celulas t reguladoras - Google Patents
Muteinas de interleucina-2 para la expansion de celulas t reguladorasInfo
- Publication number
- PE20151763A1 PE20151763A1 PE2015002007A PE2015002007A PE20151763A1 PE 20151763 A1 PE20151763 A1 PE 20151763A1 PE 2015002007 A PE2015002007 A PE 2015002007A PE 2015002007 A PE2015002007 A PE 2015002007A PE 20151763 A1 PE20151763 A1 PE 20151763A1
- Authority
- PE
- Peru
- Prior art keywords
- muteins
- cells
- regulatory
- interleukin
- expansion
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 3
- 210000003289 regulatory T cell Anatomy 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091006020 Fc-tagged proteins Proteins 0.000 abstract 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 102000055277 human IL2 Human genes 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A MUTEINAS DE INTERLEUCINA-2 (IL-2) HUMANA Y MOLECULAS DE FUSION Fc DE MUTEINA DE LA IL-2 QUE COMPRENDE UNA SUSTITUCION V91K Y UNA SECUENCIA DE AMINOACIDOS 90% IDENTICA A LA SEQ ID N°: 1; DONDE DICHAS MUTEINAS ESTIMULAN LAS CELULAS T REGULADORAS SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNITARIAS. TAMBIEN SE REFIERE A PROTEINAS DE FUSION Fc DE IgG1 HUMANA QUE COMPRENDE MUTACIONES QUE ALTERAN LA FUNCION EFECTORA DE DICHA Fc Y QUE TIENEN ALTA ESTABILIDAD A PESAR DE LA FALTA DE GLICOSILACION EN N297
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784669P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151763A1 true PE20151763A1 (es) | 2015-12-10 |
Family
ID=50680166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002007A PE20151763A1 (es) | 2013-03-14 | 2014-03-14 | Muteinas de interleucina-2 para la expansion de celulas t reguladoras |
Country Status (40)
Country | Link |
---|---|
US (7) | US9580486B2 (es) |
EP (2) | EP2970423B1 (es) |
JP (5) | JP6450365B2 (es) |
KR (4) | KR102219124B1 (es) |
CN (2) | CN105143253B (es) |
AP (1) | AP2015008737A0 (es) |
AR (1) | AR095541A1 (es) |
AU (2) | AU2014236316B2 (es) |
BR (1) | BR112015022440B1 (es) |
CA (3) | CA2906708C (es) |
CL (2) | CL2015002686A1 (es) |
CR (2) | CR20200004A (es) |
CY (2) | CY1121767T1 (es) |
DK (2) | DK2970423T3 (es) |
EA (2) | EA032863B1 (es) |
ES (2) | ES2737598T3 (es) |
HK (1) | HK1220695A1 (es) |
HR (2) | HRP20190970T1 (es) |
HU (2) | HUE044321T2 (es) |
IL (2) | IL241349B (es) |
JO (1) | JO3796B1 (es) |
LT (2) | LT2970441T (es) |
MA (2) | MA38477B1 (es) |
ME (2) | ME03482B (es) |
MX (2) | MX366854B (es) |
MY (2) | MY202248A (es) |
NZ (1) | NZ751148A (es) |
PE (1) | PE20151763A1 (es) |
PH (1) | PH12015502051B1 (es) |
PL (2) | PL2970423T3 (es) |
PT (2) | PT2970441T (es) |
RS (2) | RS58854B1 (es) |
SG (2) | SG11201507574VA (es) |
SI (2) | SI2970423T1 (es) |
TN (1) | TN2015000416A1 (es) |
TR (2) | TR201910802T4 (es) |
TW (3) | TWI687435B (es) |
UA (1) | UA119140C2 (es) |
UY (1) | UY35454A (es) |
WO (2) | WO2014153063A1 (es) |
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