CO6640254A2 - Método para preparar anticuerpos con propiedades mejoradas - Google Patents

Método para preparar anticuerpos con propiedades mejoradas

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Publication number
CO6640254A2
CO6640254A2 CO12215100A CO12215100A CO6640254A2 CO 6640254 A2 CO6640254 A2 CO 6640254A2 CO 12215100 A CO12215100 A CO 12215100A CO 12215100 A CO12215100 A CO 12215100A CO 6640254 A2 CO6640254 A2 CO 6640254A2
Authority
CO
Colombia
Prior art keywords
improved properties
preparing antibodies
antibodies
glycoproteins
cytotoxicity
Prior art date
Application number
CO12215100A
Other languages
English (en)
Inventor
Terrance A Stadheim
Dongxing Zha
Liming Liu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CO6640254A2 publication Critical patent/CO6640254A2/es

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Abstract

La presente invención proporciona métodos de preparación de polipéptidos o proteínas glicosiladas (glicoproteínas) y, específicamente, anticuerpos que son útiles como agentes terapéuticos para seres humanos o animales, que se caracterizan por presentar una región constante del anticuerpo (Fc), con mutaciones en las posiciones 243 y 264, que le confieren propiedades mejoradas relacionadas con la afinidad molecular y la citotoxicidad de los mismos.
CO12215100A 2010-05-27 2012-11-27 Método para preparar anticuerpos con propiedades mejoradas CO6640254A2 (es)

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Application Number Priority Date Filing Date Title
US34896810P 2010-05-27 2010-05-27

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CO6640254A2 true CO6640254A2 (es) 2013-03-22

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KR20130109983A (ko) 2013-10-08
US20210047670A1 (en) 2021-02-18
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CA2799595A1 (en) 2011-12-01
MX2012013771A (es) 2013-01-24
RU2012157270A (ru) 2014-07-10
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US11959118B2 (en) 2024-04-16
US9187552B2 (en) 2015-11-17
EP2576616A4 (en) 2014-05-21
US20130071390A1 (en) 2013-03-21
AU2011258425B2 (en) 2015-12-10
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AU2011258425A1 (en) 2012-12-20
BR112012030179A8 (pt) 2023-03-14

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