PE20151728A1 - 6-((s)-1-{1-[5-(2-hidroxi-etoxi)-piridin-2-il]1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-ona como un antagonista del receptor ampa dependiente de tarp-gamma 8 - Google Patents

6-((s)-1-{1-[5-(2-hidroxi-etoxi)-piridin-2-il]1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-ona como un antagonista del receptor ampa dependiente de tarp-gamma 8

Info

Publication number
PE20151728A1
PE20151728A1 PE2015000694A PE2015000694A PE20151728A1 PE 20151728 A1 PE20151728 A1 PE 20151728A1 PE 2015000694 A PE2015000694 A PE 2015000694A PE 2015000694 A PE2015000694 A PE 2015000694A PE 20151728 A1 PE20151728 A1 PE 20151728A1
Authority
PE
Peru
Prior art keywords
tarp
benzothiazol
pyrazol
pyridin
hydroxy
Prior art date
Application number
PE2015000694A
Other languages
English (en)
Inventor
Jon Kevin Reel
Warren Jaye Porter
Jeffrey Michael Witkin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20151728A1 publication Critical patent/PE20151728A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invencion se refiere al compuesto 6-((S)-1-{1-[5-(2-hidroxi-etoxi)-piridin-2-il]1H-pirazol-3-il}-etil)3H-1, 3-benzotiazol-2-ona que actua como antagonista del receptor AMPA dependiente de TARP gamma8, usos, y metodos para su preparacion; util como antiepileptico
PE2015000694A 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-hidroxi-etoxi)-piridin-2-il]1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-ona como un antagonista del receptor ampa dependiente de tarp-gamma 8 PE20151728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261730273P 2012-11-27 2012-11-27

Publications (1)

Publication Number Publication Date
PE20151728A1 true PE20151728A1 (es) 2015-12-02

Family

ID=49753484

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015000694A PE20151728A1 (es) 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-hidroxi-etoxi)-piridin-2-il]1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-ona como un antagonista del receptor ampa dependiente de tarp-gamma 8

Country Status (36)

Country Link
US (1) US8765960B2 (es)
EP (1) EP2925754B1 (es)
JP (1) JP6246227B2 (es)
KR (1) KR101693133B1 (es)
CN (1) CN104797578B (es)
AP (1) AP2015008489A0 (es)
AR (1) AR093527A1 (es)
AU (1) AU2013352594B2 (es)
BR (1) BR112015011200A2 (es)
CA (1) CA2889243C (es)
CL (1) CL2015001419A1 (es)
CR (1) CR20150267A (es)
CY (1) CY1118657T1 (es)
DK (1) DK2925754T3 (es)
DO (1) DOP2015000113A (es)
EA (1) EA026686B1 (es)
ES (1) ES2618260T3 (es)
HK (1) HK1209116A1 (es)
HR (1) HRP20170274T1 (es)
HU (1) HUE033447T2 (es)
IL (1) IL238831B (es)
JO (1) JO3225B1 (es)
MA (1) MA38126B1 (es)
MX (1) MX356478B (es)
MY (1) MY177721A (es)
PE (1) PE20151728A1 (es)
PH (1) PH12015501154B1 (es)
PL (1) PL2925754T3 (es)
PT (1) PT2925754T (es)
SG (1) SG11201504164VA (es)
SI (1) SI2925754T1 (es)
TN (1) TN2015000200A1 (es)
TW (2) TW201825484A (es)
UA (1) UA114345C2 (es)
WO (1) WO2014085153A1 (es)
ZA (1) ZA201503733B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609719A (zh) * 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
EP3288945B1 (en) 2015-04-29 2019-09-18 Janssen Pharmaceutica NV Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
BR112017023147B1 (pt) * 2015-04-29 2024-04-30 Rapport Therapeutics, Inc Derivados de azabenzimidazóis, seus usos como moduladores do receptor de ampa e composições farmacêuticas
AU2016256413B2 (en) 2015-04-29 2020-10-08 Janssen Pharmaceutica Nv Indolone compounds and their use as AMPA receptor modulators
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
SG11201902884YA (en) * 2016-10-26 2019-05-30 Janssen Pharmaceutica Nv Fused bicylic pyridine compounds and their use as ampa receptor modulators
RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
RU2703286C1 (ru) * 2019-06-18 2019-10-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY132385A (en) * 1995-08-31 2007-10-31 Novartis Ag 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
JP2000281676A (ja) * 1999-01-25 2000-10-10 Yamanouchi Pharmaceut Co Ltd Ａｍｐａ拮抗化合物の新規製造法
ATE420862T1 (de) * 2000-06-12 2009-01-15 Eisai R&D Man Co Ltd 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung
US8995993B2 (en) * 2000-10-11 2015-03-31 Gogo Llc System for managing mobile internet protocol addresses in an airborne wireless cellular network
MX2007007226A (es) * 2004-12-17 2007-08-21 Lilly Co Eli Antagonistas receptores novedosos de hormona concentradora de melanina (mch).
WO2007076161A2 (en) 2005-12-27 2007-07-05 Myriad Genetics, Inc Compounds with therapeutic activity
TW200817385A (en) * 2006-07-04 2008-04-16 Organon Nv Heterocyclic derivatives
US20110178165A1 (en) * 2008-10-08 2011-07-21 Pfizer Inc. Tetrahydrofuranyl sulfonamides and pharmaceutical compositions thereof
BRPI1006128A2 (pt) * 2009-01-12 2016-11-01 Cagen Inc derivados de sulfonamida
US8513291B2 (en) * 2010-06-01 2013-08-20 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
US9527807B2 (en) * 2011-04-05 2016-12-27 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
TW201609719A (zh) 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物

Also Published As

Publication number Publication date
EP2925754B1 (en) 2016-12-28
HK1209116A1 (en) 2016-03-24
AU2013352594A1 (en) 2015-06-04
EA026686B1 (ru) 2017-05-31
CN104797578A (zh) 2015-07-22
WO2014085153A8 (en) 2014-07-31
CN104797578B (zh) 2016-11-23
MA38126A1 (fr) 2017-03-31
CL2015001419A1 (es) 2015-10-02
US20140148441A1 (en) 2014-05-29
MX2015006697A (es) 2015-08-05
IL238831B (en) 2018-08-30
PT2925754T (pt) 2017-02-27
JP6246227B2 (ja) 2017-12-13
SG11201504164VA (en) 2015-07-30
TW201434834A (zh) 2014-09-16
US8765960B2 (en) 2014-07-01
CA2889243A1 (en) 2014-06-05
CY1118657T1 (el) 2017-07-12
CA2889243C (en) 2017-06-13
BR112015011200A2 (pt) 2017-07-11
ES2618260T3 (es) 2017-06-21
UA114345C2 (uk) 2017-05-25
TW201825484A (zh) 2018-07-16
AP2015008489A0 (en) 2015-05-31
TWI618705B (zh) 2018-03-21
ZA201503733B (en) 2017-09-27
IL238831A0 (en) 2015-06-30
MX356478B (es) 2018-05-30
PH12015501154A1 (en) 2015-08-10
JO3225B1 (ar) 2018-03-08
CR20150267A (es) 2015-09-16
MY177721A (en) 2020-09-23
KR20150070401A (ko) 2015-06-24
EP2925754A1 (en) 2015-10-07
DK2925754T3 (en) 2017-02-20
SI2925754T1 (sl) 2017-02-28
AR093527A1 (es) 2015-06-10
TN2015000200A1 (en) 2016-10-03
EA201590823A1 (ru) 2015-08-31
KR101693133B1 (ko) 2017-01-04
HUE033447T2 (en) 2017-11-28
MA38126B1 (fr) 2017-11-30
PH12015501154B1 (en) 2015-08-10
WO2014085153A1 (en) 2014-06-05
AU2013352594B2 (en) 2016-02-18
JP2016501219A (ja) 2016-01-18
PL2925754T3 (pl) 2017-07-31
HRP20170274T1 (hr) 2017-04-07
DOP2015000113A (es) 2015-06-15

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