PE20151251A1 - Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2 - Google Patents
Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2Info
- Publication number
- PE20151251A1 PE20151251A1 PE2015001537A PE2015001537A PE20151251A1 PE 20151251 A1 PE20151251 A1 PE 20151251A1 PE 2015001537 A PE2015001537 A PE 2015001537A PE 2015001537 A PE2015001537 A PE 2015001537A PE 20151251 A1 PE20151251 A1 PE 20151251A1
- Authority
- PE
- Peru
- Prior art keywords
- activity
- oxy
- bicyclic
- derivatives
- pyrimidone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE [5,6] BICICLICOS DE IMIDAZO PIRIMIDONA DE FORMULA (I) DONDE R1, R2, R3, R4, R5 Y A SON TAL COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: (R)-7-((3,5-DIFLUORO-4-((2-(TRIFLUOROMETIL)PIRIDIN-4-IL)OXI)BENCIL)OXI)-2-METIL-2,3-DIHIDROIMIDAZO[1,2-c]PIRIMIDIN-5(1H)-ONA; 7-((3,5-DIFLUORO-4-((2-(TRIFLUOROMETIL)PIRIDIN-4-IL)OXI)BENCIL)OXI)-2,2-DIMETIL-2,3-DIHIDROIMIDAZO[1,2-c]PIRIMIDIN-5(1H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LA FOSFOLIPASA A2 ASOCIADA A LAS LIPOPROTEINAS (LP-PLA2) SIENDO UTILES EN EL TRATAMIENTO DE ATEROSCLEROSIS, ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013070976 | 2013-01-25 | ||
CN2013001556 | 2013-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151251A1 true PE20151251A1 (es) | 2015-09-10 |
Family
ID=50002724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001537A PE20151251A1 (es) | 2013-01-25 | 2014-01-23 | Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2 |
Country Status (23)
Country | Link |
---|---|
US (1) | US9708330B2 (es) |
EP (1) | EP2948452B1 (es) |
JP (1) | JP6306053B2 (es) |
KR (1) | KR20150108897A (es) |
CN (1) | CN105008368B (es) |
AU (1) | AU2014209949B2 (es) |
BR (1) | BR112015017759B1 (es) |
CA (1) | CA2899091A1 (es) |
CL (1) | CL2015002060A1 (es) |
CR (1) | CR20150390A (es) |
EA (1) | EA025885B1 (es) |
ES (1) | ES2642762T3 (es) |
HK (1) | HK1216425A1 (es) |
IL (1) | IL240046A0 (es) |
MA (1) | MA38284B1 (es) |
MX (1) | MX2015009633A (es) |
PE (1) | PE20151251A1 (es) |
PH (1) | PH12015501586A1 (es) |
SG (1) | SG11201505520WA (es) |
TW (1) | TW201443054A (es) |
UY (1) | UY35276A (es) |
WO (1) | WO2014114694A1 (es) |
ZA (1) | ZA201505025B (es) |
Families Citing this family (13)
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---|---|---|---|---|
WO2014114694A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
WO2016012916A1 (en) * | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
RU2690190C2 (ru) | 2014-07-22 | 2019-05-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения |
WO2016012917A1 (en) * | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
CN104892459A (zh) * | 2015-06-16 | 2015-09-09 | 苏州明锐医药科技有限公司 | 利奥西呱中间体及其制备方法 |
CN112574221B (zh) * | 2019-09-30 | 2022-03-04 | 上海纽思克生物科技有限公司 | 四环嘧啶酮类化合物、其制备方法、其组合物和用途 |
MX2022005615A (es) * | 2019-11-09 | 2022-07-27 | Shanghai Simr Biotechnology Co Ltd | Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo. |
CN111533699B (zh) * | 2020-05-27 | 2023-12-01 | 龙曦宁(上海)医药科技有限公司 | 一种2-(三氟甲基)嘧啶-5-醇的合成方法 |
CN113861220B (zh) * | 2020-06-30 | 2023-06-16 | 上海纽思克生物科技有限公司 | 三环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN113912622B (zh) * | 2020-07-10 | 2023-12-01 | 上海纽思克生物科技有限公司 | 三环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
CN114057740B (zh) * | 2021-12-15 | 2024-04-02 | 上海赛默罗生物科技有限公司 | 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途 |
WO2024027116A1 (en) * | 2022-08-04 | 2024-02-08 | 4B Technologies (Beijing) Co., Limited | Dihydroimidazo-pyrimidinone compounds as lp-pla2 inhibitors and use thereof |
Family Cites Families (48)
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WO1993018035A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
GB9421816D0 (en) | 1994-10-29 | 1994-12-14 | Smithkline Beecham Plc | Novel compounds |
MX9704736A (es) | 1994-12-22 | 1997-10-31 | Smithkline Beecham Plc | Acetidin 2-onas sustituidas, procedimiento para prepararlas, uso de las mismas y composiciones que las contienen. |
CH690264A5 (fr) | 1995-06-30 | 2000-06-30 | Symphar Sa | Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques. |
CN1197452A (zh) | 1995-07-01 | 1998-10-28 | 史密丝克莱恩比彻姆有限公司 | 用于治疗动脉粥样硬化的氮杂环丁烷酮衍生物 |
JP2002515728A (ja) | 1995-09-29 | 2002-05-28 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 新規用途 |
EP0869943A1 (en) | 1995-12-08 | 1998-10-14 | Smithkline Beecham Plc | Monocyclic beta-lactame derivatives for treatment of atherosclerosis |
WO1997021676A1 (en) | 1995-12-08 | 1997-06-19 | Smithkline Beecham Plc | Azetidinone compounds for the treatment of atherosclerosis |
GB9608649D0 (en) | 1996-04-26 | 1996-07-03 | Smithkline Beecham Plc | Novel compounds |
TR199802160T2 (xx) | 1996-04-26 | 1999-04-21 | Smithkline Beecham Plc | Ateroskleroz tedavisi i�in azetidinon t�revleri. |
GB9626615D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
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GB9626616D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
ES2203988T3 (es) | 1997-11-06 | 2004-04-16 | Smithkline Beecham Plc | Compuestos de pirimidinona y composiciones farmaceuticas que los contienen. |
DE69911980T2 (de) | 1998-08-21 | 2004-09-09 | Smithkline Beecham P.L.C., Brentford | Pyrimidinonderivate zur behandlung von atheroscleros |
GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
ATE432265T1 (de) | 1999-05-01 | 2009-06-15 | Smithkline Beecham Plc | Pyrimidinon verbindungen |
GB9910378D0 (en) | 1999-05-05 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
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GB0024807D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
GB0119793D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel compounds |
GB0127143D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0127140D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0127141D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham Plc | Novel compounds |
GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
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US20080090852A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
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ES2847883T3 (es) | 2010-12-17 | 2021-08-04 | Glaxo Group Ltd | Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares |
CN103827116B (zh) | 2011-07-27 | 2016-08-31 | 葛兰素集团有限公司 | 用作LP-PLA2抑制剂的2,3-二氢咪唑并[1,2-c]嘧啶-5(1H)-酮化合物 |
EP2739627A4 (en) * | 2011-07-27 | 2015-01-21 | Glaxo Group Ltd | 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2 |
WO2014114694A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
-
2014
- 2014-01-23 WO PCT/EP2014/051286 patent/WO2014114694A1/en active Application Filing
- 2014-01-23 MX MX2015009633A patent/MX2015009633A/es unknown
- 2014-01-23 PE PE2015001537A patent/PE20151251A1/es not_active Application Discontinuation
- 2014-01-23 JP JP2015554138A patent/JP6306053B2/ja not_active Expired - Fee Related
- 2014-01-23 EP EP14701355.1A patent/EP2948452B1/en active Active
- 2014-01-23 AU AU2014209949A patent/AU2014209949B2/en not_active Ceased
- 2014-01-23 US US14/761,636 patent/US9708330B2/en active Active
- 2014-01-23 ES ES14701355.1T patent/ES2642762T3/es active Active
- 2014-01-23 UY UY0001035276A patent/UY35276A/es not_active Application Discontinuation
- 2014-01-23 EA EA201591379A patent/EA025885B1/ru not_active IP Right Cessation
- 2014-01-23 TW TW103102388A patent/TW201443054A/zh unknown
- 2014-01-23 MA MA38284A patent/MA38284B1/fr unknown
- 2014-01-23 CA CA2899091A patent/CA2899091A1/en not_active Abandoned
- 2014-01-23 BR BR112015017759-0A patent/BR112015017759B1/pt not_active IP Right Cessation
- 2014-01-23 CN CN201480013675.8A patent/CN105008368B/zh not_active Expired - Fee Related
- 2014-01-23 SG SG11201505520WA patent/SG11201505520WA/en unknown
- 2014-01-23 KR KR1020157022396A patent/KR20150108897A/ko not_active Application Discontinuation
-
2015
- 2015-07-13 ZA ZA2015/05025A patent/ZA201505025B/en unknown
- 2015-07-20 PH PH12015501586A patent/PH12015501586A1/en unknown
- 2015-07-20 IL IL240046A patent/IL240046A0/en unknown
- 2015-07-23 CL CL2015002060A patent/CL2015002060A1/es unknown
- 2015-07-24 CR CR20150390A patent/CR20150390A/es unknown
-
2016
- 2016-04-18 HK HK16104389.3A patent/HK1216425A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US9708330B2 (en) | 2017-07-18 |
EP2948452B1 (en) | 2017-08-09 |
CA2899091A1 (en) | 2014-07-31 |
MA38284A1 (fr) | 2017-12-29 |
PH12015501586A1 (en) | 2015-10-05 |
KR20150108897A (ko) | 2015-09-30 |
EP2948452A1 (en) | 2015-12-02 |
CN105008368B (zh) | 2017-02-01 |
HK1216425A1 (zh) | 2016-11-11 |
EA025885B1 (ru) | 2017-02-28 |
US20150361082A1 (en) | 2015-12-17 |
WO2014114694A1 (en) | 2014-07-31 |
CN105008368A (zh) | 2015-10-28 |
BR112015017759B1 (pt) | 2022-05-24 |
EA201591379A1 (ru) | 2016-01-29 |
UY35276A (es) | 2014-08-29 |
AU2014209949A1 (en) | 2015-07-30 |
JP6306053B2 (ja) | 2018-04-04 |
AU2014209949B2 (en) | 2016-09-08 |
IL240046A0 (en) | 2015-08-31 |
CR20150390A (es) | 2015-10-19 |
MA38284B1 (fr) | 2018-05-31 |
ZA201505025B (en) | 2017-08-30 |
SG11201505520WA (en) | 2015-08-28 |
TW201443054A (zh) | 2014-11-16 |
ES2642762T3 (es) | 2017-11-20 |
MX2015009633A (es) | 2015-11-30 |
BR112015017759A2 (pt) | 2017-07-11 |
CL2015002060A1 (es) | 2015-11-27 |
JP2016505058A (ja) | 2016-02-18 |
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