HK1206335A1 - 具有抗腫瘤活性的色烯酮衍生物 - Google Patents

具有抗腫瘤活性的色烯酮衍生物

Info

Publication number: HK1206335A1
Authority: HK; Hong Kong
Prior art keywords: tumour activity; chromenone derivatives; chromenone; derivatives; tumour
Prior art date: 2009-10-27

Application number

HK15106851.8A

Other languages

English (en)

Inventor

Bernard Christophe Barlaam

Sebastien Louis Degorce

Christine Marie Paul Lambert-Van Der Brempt

Remy Robert Morgentin

Patrick Ple

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-27

Filing date

2015-07-20

Publication date

2016-01-08

2015-07-20 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2016-01-08 Publication of HK1206335A1 publication Critical patent/HK1206335A1/zh

Links

230000000259 anti-tumor effect Effects 0.000 title 1
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title 1
230000000694 effects Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK15106851.8A 2009-10-27 2015-07-20 具有抗腫瘤活性的色烯酮衍生物 HK1206335A1 (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP09306017		2009-10-27

Publications (1)

Publication Number	Publication Date
HK1206335A1 true HK1206335A1 (zh)	2016-01-08

Family

ID=43085922

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK13100967.4A HK1174027A1 (zh)	2009-10-27	2013-01-22	具有抗腫瘤活性的色烯酮衍生物
HK15106851.8A HK1206335A1 (zh)	2009-10-27	2015-07-20	具有抗腫瘤活性的色烯酮衍生物

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HK13100967.4A HK1174027A1 (zh)	2009-10-27	2013-01-22	具有抗腫瘤活性的色烯酮衍生物

Country Status (41)

Country	Link
US (5)	US8399460B2 (zh)
EP (1)	EP2493870B1 (zh)
JP (2)	JP5657010B2 (zh)
KR (1)	KR101738195B1 (zh)
CN (2)	CN104447657B (zh)
AR (1)	AR078786A1 (zh)
AU (1)	AU2010311107B9 (zh)
BR (1)	BR112012010124B8 (zh)
CA (1)	CA2776994C (zh)
CL (1)	CL2012001056A1 (zh)
CO (1)	CO6541528A2 (zh)
CR (1)	CR20120217A (zh)
CU (1)	CU20120069A7 (zh)
CY (1)	CY1116143T1 (zh)
DK (1)	DK2493870T3 (zh)
DO (1)	DOP2012000124A (zh)
EA (1)	EA020523B9 (zh)
EC (1)	ECSP12011838A (zh)
ES (1)	ES2530943T3 (zh)
GT (1)	GT201200126A (zh)
HK (2)	HK1174027A1 (zh)
HN (1)	HN2012000889A (zh)
HR (1)	HRP20150146T1 (zh)
IL (1)	IL219191A0 (zh)
IN (1)	IN2012DN03328A (zh)
ME (1)	ME02050B (zh)
MX (1)	MX2012005027A (zh)
MY (1)	MY179833A (zh)
NI (1)	NI201200081A (zh)
NZ (1)	NZ599457A (zh)
PE (1)	PE20130149A1 (zh)
PL (1)	PL2493870T3 (zh)
PT (1)	PT2493870E (zh)
RS (1)	RS53813B1 (zh)
SA (1)	SA110310808B1 (zh)
SI (1)	SI2493870T1 (zh)
SM (1)	SMT201500036B (zh)
TW (1)	TWI483939B (zh)
UA (1)	UA107474C2 (zh)
UY (1)	UY32978A (zh)
WO (1)	WO2011051704A1 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5599783B2 (ja)	2008-05-30	2014-10-01	アムジエン・インコーポレーテツド	Ｐｉ３キナーゼの阻害薬
US8399460B2 (en) *	2009-10-27	2013-03-19	Astrazeneca Ab	Chromenone derivatives
UY34013A (es)	2011-04-13	2012-11-30	Astrazeneca Ab	?compuestos de cromenona con actividad anti-tumoral?.
JP6307096B2 (ja)	2013-01-23	2018-04-04	アストラゼネカアクチボラグ	化合物
CN105142629B (zh) *	2013-03-04	2018-11-23	阿斯利康(瑞典)有限公司	组合治疗
CA2952012A1 (en)	2014-06-13	2015-12-17	Gilead Sciences, Inc.	Phosphatidylinositol 3-kinase inhibitors
EA201692266A1 (ru)	2014-06-13	2017-06-30	Джилид Сайэнс, Инк.	Ингибиторы фосфатидилинозитол-3-киназы
CA2952037A1 (en)	2014-06-13	2015-12-17	Gilead Sciences, Inc.	Phosphatidylinositol 3-kinase inhibitors
EP3154962B1 (en)	2014-06-13	2019-08-07	Gilead Sciences, Inc.	Phosphatidylinositol 3-kinase inhibitors
EA201692267A1 (ru)	2014-06-13	2017-06-30	Джилид Сайэнс, Инк.	Ингибиторы фосфатидилинозитол-3-киназы
CN104744376A (zh) *	2015-03-14	2015-07-01	长沙深橙生物科技有限公司	一种2-异丙基嘧啶衍生物的制备方法
CN104803921A (zh) *	2015-03-14	2015-07-29	长沙深橙生物科技有限公司	一种苯取代嘧啶衍生物的制备方法
KR101766731B1 (ko)	2015-06-23	2017-08-10	충남대학교산학협력단	강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물
US10526316B2 (en) *	2015-10-09	2020-01-07	Janssen Pharmaceutica Nv	Quinoxaline and pyridopyrazine derivatives as PI3Kβ inhibitors
TW201825465A (zh)	2016-09-23	2018-07-16	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh)	2016-09-23	2018-05-01	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh)	2016-09-23	2018-04-16	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
WO2018057808A1 (en)	2016-09-23	2018-03-29	Gilead Sciences, Inc.	Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
AR121719A1 (es)	2020-04-03	2022-06-29	Petra Pharma Corp	Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) *	2020-05-15	2021-11-23	제이투에이치바이오텍 (주)	3원환 화합물 및 이의 의약 용도
AU2022214080A1 (en) *	2021-02-01	2023-09-14	Geode Therapeutics Inc.	Phosphoinositide 3 kinase beta inhibitors and compositions and methods thereof
AU2022269566A1 (en) *	2021-05-03	2023-11-02	Petra Pharma Corporation	Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
IL307950A (en) *	2021-05-03	2023-12-01	Petra Pharma Corp	Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases
BR112023022890A2 (pt) *	2021-05-27	2024-01-23	Petra Pharma Corp	Inibidores de cromenona alostéricos de fosfoinositídio 3-cinase (pi3k), composições farmacêuticas que os compreendem e usos dos mesmos
CA3237760A1 (en) *	2021-12-08	2023-06-15	Xiaolin Hao	Fused heterocyclic compounds as pi3kalpha inhibitors
WO2024003241A1 (en)	2022-06-30	2024-01-04	Astrazeneca Ab	Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4
WO2024081904A1 (en) *	2022-10-14	2024-04-18	Genesis Therapeutics, Inc.	Methods for treating cancer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6027A (en) *		1849-01-09		Rotary blacksmith s twyer
AU634994B2 (en)	1988-12-21	1993-03-11	Pharmacia & Upjohn Company	Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH05509302A (ja)	1990-06-20	1993-12-22	ジ・アップジョン・カンパニー	抗アテローム性動脈硬化性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類
DE4318756A1 (de)	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
HUP9901155A3 (en)	1996-02-13	2003-04-28	Astrazeneca Ab	Quinazoline derivatives as vegf inhibitors
KR100489174B1 (ko)	1996-03-05	2005-09-30	제네카-파마 소시에떼아노님	4-아닐리노퀴나졸린유도체
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
GB9900752D0 (en)	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
CZ306810B6 (cs)	1999-02-10	2017-07-19	Astrazeneca Ab	Použití chinazolinového derivátu jako inhibitoru angiogeneze
CA2398163C (en)	2000-01-24	2011-02-22	Kinacia Pty Ltd.	Therapeutic morpholino-substituted compounds
KR20030013433A (ko)	2000-05-31	2003-02-14	아스트라제네카 아베	혈관 손상 활성을 가진 인돌 유도체
UA73993C2 (uk)	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
HUP0301742A3 (en)	2000-07-07	2005-08-29	Angiogene Pharm Ltd	Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use
EP1301497A1 (en)	2000-07-07	2003-04-16	Angiogene Pharmaceuticals Limited	Colchinol derivatives as vascular damaging agents
NZ538420A (en) *	2002-08-16	2007-06-29	Kinacia Pty Ltd	Inhibition of phosphoinositide 3-kinase beta
AR054438A1 (es) *	2005-04-15	2007-06-27	Kudos Pharm Ltd	Inhibidores de adn -pk
EP1957475A1 (en)	2005-10-21	2008-08-20	Merz Pharma GmbH & Co.KGaA	Chromenones and their use as modulators of metabotropic glutamate receptors
CN101448505A (zh) *	2006-04-04	2009-06-03	加利福尼亚大学董事会	Pi3激酶拮抗剂
WO2008064244A2 (en)	2006-11-20	2008-05-29	The Trustees Of Columbia University In The City Of New York	Phosphoinositide modulation for the treatment of neurodegenerative diseases
EP2112145A1 (en)	2008-04-24	2009-10-28	AxoGlia Therapeutics S.A.	Chromenone derivatives useful for the treatment of neurodegenerative diseases
WO2010134082A1 (en)	2009-05-21	2010-11-25	Proteologics Ltd	Chromenone derivatives for treatment of cancer
US8399460B2 (en) *	2009-10-27	2013-03-19	Astrazeneca Ab	Chromenone derivatives

2010
- 2010-10-22 US US12/909,968 patent/US8399460B2/en active Active
- 2010-10-25 BR BR112012010124A patent/BR112012010124B8/pt active IP Right Grant
- 2010-10-25 RS RS20150090A patent/RS53813B1/en unknown
- 2010-10-25 SI SI201030875T patent/SI2493870T1/sl unknown
- 2010-10-25 ME MEP-2015-21A patent/ME02050B/me unknown
- 2010-10-25 PE PE2012000578A patent/PE20130149A1/es active IP Right Grant
- 2010-10-25 KR KR1020127012933A patent/KR101738195B1/ko active IP Right Grant
- 2010-10-25 UA UAA201206000A patent/UA107474C2/uk unknown
- 2010-10-25 IN IN3328DEN2012 patent/IN2012DN03328A/en unknown
- 2010-10-25 JP JP2012535931A patent/JP5657010B2/ja active Active
- 2010-10-25 EP EP10769052.1A patent/EP2493870B1/en active Active
- 2010-10-25 PT PT10769052T patent/PT2493870E/pt unknown
- 2010-10-25 CN CN201410654983.0A patent/CN104447657B/zh active Active
- 2010-10-25 CN CN201080060262.7A patent/CN102712615B/zh active Active
- 2010-10-25 ES ES10769052T patent/ES2530943T3/es active Active
- 2010-10-25 MX MX2012005027A patent/MX2012005027A/es active IP Right Grant
- 2010-10-25 AU AU2010311107A patent/AU2010311107B9/en not_active Ceased
- 2010-10-25 MY MYPI2012001831A patent/MY179833A/en unknown
- 2010-10-25 NZ NZ599457A patent/NZ599457A/en not_active IP Right Cessation
- 2010-10-25 WO PCT/GB2010/051788 patent/WO2011051704A1/en active Application Filing
- 2010-10-25 EA EA201200618A patent/EA020523B9/ru not_active IP Right Cessation
- 2010-10-25 CA CA2776994A patent/CA2776994C/en active Active
- 2010-10-25 DK DK10769052.1T patent/DK2493870T3/en active
- 2010-10-25 PL PL10769052T patent/PL2493870T3/pl unknown
- 2010-10-26 AR ARP100103937 patent/AR078786A1/es active IP Right Grant
- 2010-10-27 UY UY32978A patent/UY32978A/es not_active Application Discontinuation
- 2010-10-27 TW TW099136762A patent/TWI483939B/zh active
- 2010-10-27 SA SA110310808A patent/SA110310808B1/ar unknown
2012
- 2012-04-15 IL IL219191A patent/IL219191A0/en not_active IP Right Cessation
- 2012-04-25 CL CL2012001056A patent/CL2012001056A1/es unknown
- 2012-04-26 CO CO12068977A patent/CO6541528A2/es active IP Right Grant
- 2012-04-27 CU CU2012000069A patent/CU20120069A7/es unknown
- 2012-04-27 EC ECSP12011838 patent/ECSP12011838A/es unknown
- 2012-04-27 HN HN2012000889A patent/HN2012000889A/es unknown
- 2012-04-27 DO DO2012000124A patent/DOP2012000124A/es unknown
- 2012-04-27 CR CR20120217A patent/CR20120217A/es unknown
- 2012-04-27 NI NI201200081A patent/NI201200081A/es unknown
- 2012-04-27 GT GT201200126A patent/GT201200126A/es unknown
2013
- 2013-01-22 HK HK13100967.4A patent/HK1174027A1/zh not_active IP Right Cessation
- 2013-02-13 US US13/765,850 patent/US8673906B2/en active Active
2014
- 2014-01-24 US US14/163,105 patent/US9029374B2/en active Active
- 2014-11-20 JP JP2014235289A patent/JP5872016B2/ja active Active
2015
- 2015-02-05 HR HRP20150146TT patent/HRP20150146T1/hr unknown
- 2015-02-12 SM SM201500036T patent/SMT201500036B/xx unknown
- 2015-02-13 CY CY20151100157T patent/CY1116143T1/el unknown
- 2015-04-08 US US14/681,244 patent/US20160060240A1/en not_active Abandoned
- 2015-07-20 HK HK15106851.8A patent/HK1206335A1/zh unknown
2016
- 2016-03-24 US US15/079,633 patent/US9718800B2/en active Active

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Publication number	Publication date
ES2530943T3 (es)	2015-03-09
IL219191A0 (en)	2012-06-28
UA107474C2 (uk)	2015-01-12
ECSP12011838A (es)	2012-06-29
US20110098271A1 (en)	2011-04-28
US8399460B2 (en)	2013-03-19
CN104447657A (zh)	2015-03-25
AR078786A1 (es)	2011-11-30
EA020523B9 (ru)	2015-01-30
RS53813B1 (en)	2015-06-30
US9029374B2 (en)	2015-05-12
PE20130149A1 (es)	2013-03-10
DOP2012000124A (es)	2012-07-15
EA201200618A1 (ru)	2012-12-28
EP2493870B1 (en)	2014-12-17
MY179833A (en)	2020-11-17
HRP20150146T1 (hr)	2015-05-22
KR20120098724A (ko)	2012-09-05
NZ599457A (en)	2014-04-30
HK1174027A1 (zh)	2013-05-31
EP2493870A1 (en)	2012-09-05
CU20120069A7 (es)	2012-10-15
BR112012010124B8 (pt)	2021-05-25
SA110310808B1 (ar)	2013-11-24
TW201121960A (en)	2011-07-01
JP5657010B2 (ja)	2015-01-21
SI2493870T1 (sl)	2015-03-31
KR101738195B1 (ko)	2017-05-19
MX2012005027A (es)	2012-09-07
CA2776994A1 (en)	2011-05-05
CL2012001056A1 (es)	2012-10-05
IN2012DN03328A (zh)	2015-10-23
US20130158026A1 (en)	2013-06-20
WO2011051704A1 (en)	2011-05-05
CY1116143T1 (el)	2017-02-08
ME02050B (me)	2015-05-20
EA020523B1 (ru)	2014-11-28
CR20120217A (es)	2012-06-28
PL2493870T3 (pl)	2015-04-30
CA2776994C (en)	2017-10-31
US20140194419A1 (en)	2014-07-10
SMT201500036B (it)	2015-05-05
CN102712615A (zh)	2012-10-03
CO6541528A2 (es)	2012-10-16
AU2010311107B9 (en)	2014-06-19
NI201200081A (es)	2012-11-07
CN102712615B (zh)	2014-12-17
GT201200126A (es)	2014-03-03
BR112012010124B1 (pt)	2021-02-17
US20160060240A1 (en)	2016-03-03
CN104447657B (zh)	2016-08-17
AU2010311107B2 (en)	2014-03-27
US20160272607A1 (en)	2016-09-22
JP2015078202A (ja)	2015-04-23
UY32978A (es)	2011-05-31
PT2493870E (pt)	2015-02-18
HN2012000889A (es)	2015-08-03
US8673906B2 (en)	2014-03-18
DK2493870T3 (en)	2015-02-23
BR112012010124A2 (pt)	2016-06-07
JP5872016B2 (ja)	2016-03-01
JP2013508449A (ja)	2013-03-07
US9718800B2 (en)	2017-08-01
AU2010311107A1 (en)	2012-05-03
TWI483939B (zh)	2015-05-11

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HK1206335A1 (zh)	2016-01-08	具有抗腫瘤活性的色烯酮衍生物
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IL216007A0 (en)	2012-01-31	Isoxazole-pyridine derivatives
ZA201106855B (en)	2012-11-28	Oxasiazole derivatives
IL215109A0 (en)	2011-12-29	Isoxazole-pyridazine derivatives
IL214941A0 (en)	2011-11-30	Isoxazole-pyrazole derivatives
ZA201104991B (en)	2013-10-31	Deoxyactagardine derivatives
HK1172894A1 (zh)	2013-05-03	-酰基- -氟嘧啶酮衍生物
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EP2512482A4 (en)	2013-05-22	DERIVATIVES OF 2-ALDOXIMINO-5-FLUOROPYRIMIDINE
ZA201104279B (en)	2012-02-29	Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en)	2009-08-26	Indopyl-pyridone derivatives