PE20120370A1 - Derivados de 2,4-diaminopirimidinas como inhibidores de ptk2 - Google Patents
Derivados de 2,4-diaminopirimidinas como inhibidores de ptk2Info
- Publication number
- PE20120370A1 PE20120370A1 PE2011002012A PE2011002012A PE20120370A1 PE 20120370 A1 PE20120370 A1 PE 20120370A1 PE 2011002012 A PE2011002012 A PE 2011002012A PE 2011002012 A PE2011002012 A PE 2011002012A PE 20120370 A1 PE20120370 A1 PE 20120370A1
- Authority
- PE
- Peru
- Prior art keywords
- ilamine
- methyl
- orc
- indan
- benzamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UN DERIVADO DE 2,4-DIAMINOPIRIMIDINA DE FORMULA (1), DONDE A ES ARILO C6-C15 O HETEROARILO DE 5 A 12 MIEMBROS; B ES ARILO C6-C10 O HETEROARILO DE 5 A 10 MIEMBROS; R1, R2, R4 Y Rx SON H, Ra, Rb, ENTRE OTROS; R3 ES NRcRc, N(ORc)Rc, N[C(O)Rc]2, ENTRE OTROS; R5 ES HALOGENO, CN, CO2, ORc, ENTRE OTROS; Ra ES ALQUILO C1-C6, CICLOALQUILO C3-C10, ARILO C6-C10, ENTRE OTROS; Rb ES =O, ORc, OCF3, ENTRE OTROS; Rc ES H, Rd, Re, ENTRE OTROS; Rd ES O, ORe, OCF3, ENTRE OTROS; Re ES H, Rf, Rg, ENTRE OTROS; m ES 1, 2 O 3; n ES 0, 1, 2, 3 O 4; p ES 0, 1, 2 O 3. SON COMPUESTOS PREFERIDOS: N-(2-DIMETILAMINO-ETIL)-4-[4-((1R,2R)-1-METANSULFONILAMINO-INDAN-2-ILAMINO)-5-TRIFLUOROMETIL-PIRIMIDIN-2-ILAMINO]-3-METOXI-BENZAMIDA, 4-{4-[(1R,2R)-1-(METANSULFONIL-METIL-AMINO)-INDAN-2-ILAMINO]-5-TRIFLUOROMETIL-PIRIMIDIN-2-ILAMINO}-3-METOXI-N-(1-METIL-PIPERIDIN-4-IL)-BENZAMIDA, 2-FLUORO-4-{4-(1R,2R)-1-METANSULFONIL-METIL-AMINO)-INDAN-2-ILAMINO]-5-TRIFLUOROMETIL-PIRIMIDIN-2-ILAMINO}-5-METOXI-N-(1-METIL-PIPERIDIN-4-IL)-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORAS DE LA ENZIMA PTK2 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON LA PROLIFERACION EXCESIVA O ANOMALA DE CELULAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09161496 | 2009-05-29 | ||
| EP10161628 | 2010-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120370A1 true PE20120370A1 (es) | 2012-05-09 |
Family
ID=42289495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011002012A PE20120370A1 (es) | 2009-05-29 | 2010-05-28 | Derivados de 2,4-diaminopirimidinas como inhibidores de ptk2 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8410126B2 (es) |
| EP (1) | EP2435411B1 (es) |
| JP (1) | JP5756799B2 (es) |
| KR (1) | KR20120135010A (es) |
| CN (1) | CN102448943A (es) |
| AP (1) | AP2011005978A0 (es) |
| AR (1) | AR076620A1 (es) |
| AU (1) | AU2010251943A1 (es) |
| BR (1) | BRPI1014994A2 (es) |
| CA (1) | CA2763700A1 (es) |
| CL (1) | CL2011003022A1 (es) |
| CO (1) | CO6470899A2 (es) |
| EA (1) | EA201101674A1 (es) |
| EC (1) | ECSP11011558A (es) |
| IL (1) | IL216084A0 (es) |
| MA (1) | MA33302B1 (es) |
| MX (1) | MX2011012643A (es) |
| PE (1) | PE20120370A1 (es) |
| SG (1) | SG176599A1 (es) |
| TW (1) | TW201107308A (es) |
| UY (1) | UY32673A (es) |
| WO (1) | WO2010136559A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009540013A (ja) * | 2006-06-15 | 2009-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アニリノ−４−（複素環）アミノ−ピリミジン |
| ES2645689T3 (es) | 2008-05-21 | 2017-12-07 | Ariad Pharmaceuticals, Inc. | Derivados de fósforo como inhibidores de quinasas |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| ES2691673T3 (es) | 2011-02-17 | 2018-11-28 | Cancer Therapeutics Crc Pty Limited | Inhibidores de Fak |
| DK2675794T3 (da) | 2011-02-17 | 2019-05-06 | Cancer Therapeutics Crc Pty Ltd | Selektive fak-inhibitorer |
| EA201391626A1 (ru) | 2011-05-04 | 2014-03-31 | Ариад Фармасьютикалз, Инк. | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| WO2018005356A1 (en) | 2016-06-27 | 2018-01-04 | Rigel Pharmaceuticals, Inc. | 2,4-diamino-pyrimidine compounds and method for making and using the compounds |
| KR20190114910A (ko) * | 2018-03-30 | 2019-10-10 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 설폰아마이드 유도체 |
| CN117203199A (zh) * | 2021-04-02 | 2023-12-08 | 毕利吉生物科技股份有限公司 | N2-苯基嘧啶-2,4-二胺化合物及其制备方法和使用方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003534327A (ja) * | 2000-05-22 | 2003-11-18 | レオ・ファーマ・アクティーゼルスカブ | ＩＬ−１βおよびＴＮＦ−αの抑制剤としてのベンゾフェノン |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| ATE407678T1 (de) * | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| WO2004002964A1 (ja) * | 2002-06-28 | 2004-01-08 | Yamanouchi Pharmaceutical Co., Ltd. | ジアミノピリミジンカルボキサミド誘導体 |
| AP2385A (en) * | 2002-12-20 | 2012-03-23 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth. |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2005111023A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| US8623887B2 (en) | 2006-05-15 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Compounds |
| US8193197B2 (en) * | 2006-10-19 | 2012-06-05 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US8138339B2 (en) * | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| KR20100132550A (ko) * | 2008-04-16 | 2010-12-17 | 포톨라 파마슈티컬스, 인코포레이티드 | ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드 |
-
2010
- 2010-05-21 US US12/784,813 patent/US8410126B2/en active Active
- 2010-05-28 MX MX2011012643A patent/MX2011012643A/es not_active Application Discontinuation
- 2010-05-28 TW TW099117275A patent/TW201107308A/zh unknown
- 2010-05-28 AP AP2011005978A patent/AP2011005978A0/xx unknown
- 2010-05-28 SG SG2011086790A patent/SG176599A1/en unknown
- 2010-05-28 CN CN2010800234907A patent/CN102448943A/zh active Pending
- 2010-05-28 AU AU2010251943A patent/AU2010251943A1/en not_active Abandoned
- 2010-05-28 EA EA201101674A patent/EA201101674A1/ru unknown
- 2010-05-28 JP JP2012512388A patent/JP5756799B2/ja active Active
- 2010-05-28 UY UY0001032673A patent/UY32673A/es not_active Application Discontinuation
- 2010-05-28 BR BRPI1014994A patent/BRPI1014994A2/pt not_active Application Discontinuation
- 2010-05-28 CA CA2763700A patent/CA2763700A1/en not_active Abandoned
- 2010-05-28 KR KR1020117031173A patent/KR20120135010A/ko not_active Application Discontinuation
- 2010-05-28 PE PE2011002012A patent/PE20120370A1/es not_active Application Discontinuation
- 2010-05-28 AR ARP100101883A patent/AR076620A1/es unknown
- 2010-05-28 WO PCT/EP2010/057408 patent/WO2010136559A1/en active Application Filing
- 2010-05-28 MA MA34394A patent/MA33302B1/fr unknown
- 2010-05-28 EP EP10724385.9A patent/EP2435411B1/en active Active
-
2011
- 2011-11-01 IL IL216084A patent/IL216084A0/en unknown
- 2011-11-29 CL CL2011003022A patent/CL2011003022A1/es unknown
- 2011-12-15 CO CO11173252A patent/CO6470899A2/es not_active Application Discontinuation
- 2011-12-27 EC EC2011011558A patent/ECSP11011558A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110130401A1 (en) | 2011-06-02 |
| WO2010136559A1 (en) | 2010-12-02 |
| CO6470899A2 (es) | 2012-06-29 |
| IL216084A0 (en) | 2012-01-31 |
| UY32673A (es) | 2010-12-31 |
| KR20120135010A (ko) | 2012-12-12 |
| EP2435411B1 (en) | 2014-10-29 |
| CN102448943A (zh) | 2012-05-09 |
| SG176599A1 (en) | 2012-01-30 |
| AP2011005978A0 (en) | 2011-12-31 |
| JP5756799B2 (ja) | 2015-07-29 |
| MX2011012643A (es) | 2011-12-14 |
| ECSP11011558A (es) | 2012-01-31 |
| US8410126B2 (en) | 2013-04-02 |
| TW201107308A (en) | 2011-03-01 |
| EP2435411A1 (en) | 2012-04-04 |
| MA33302B1 (fr) | 2012-05-02 |
| CL2011003022A1 (es) | 2012-07-13 |
| AR076620A1 (es) | 2011-06-22 |
| EA201101674A1 (ru) | 2012-06-29 |
| AU2010251943A1 (en) | 2011-12-01 |
| BRPI1014994A2 (pt) | 2016-05-03 |
| CA2763700A1 (en) | 2010-12-02 |
| JP2012528121A (ja) | 2012-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20120370A1 (es) | Derivados de 2,4-diaminopirimidinas como inhibidores de ptk2 | |
| PE20061366A1 (es) | Compuestos y composiciones como inhibidores de quinasa de proteina | |
| PE20210128A1 (es) | Inhibidores de la ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos | |
| PE20120861A1 (es) | Compuestos y composiciones como inhibidores de cinasa de proteina | |
| PE20091656A1 (es) | Compuestos heterociclicos como inhibidores de la cinasa raf | |
| PE20161427A1 (es) | Inhibidores heteroarilo de syk | |
| PE20090237A1 (es) | Derivados de sulfonamidas como inhibidores de los canales de sodio | |
| EA201000562A1 (ru) | Производные n-(пиразол-3-ил)бензамида в качестве активаторов глюкокиназы | |
| PE20141120A1 (es) | Compuestos heterociclicos | |
| NO20074634L (no) | Substituerte heterocykler og deres anvendelse som CHK1-, PDK1- og PAK-inhibitorer | |
| NO20081893L (no) | 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft | |
| DK1776349T3 (da) | 2-amino-puinazolin derivater anvendelige som inhibitorer af beta-sekretase (BACE) | |
| NO20084923L (no) | N-(2-thiazolyl)-amid derivater som GSK-3 inhibitorer | |
| EA201391670A1 (ru) | 1,3-оксазины в качестве ингибиторов bace1 и/или bace2 | |
| EA200700142A1 (ru) | Замещенные гетероциклом циклические производные мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназы | |
| PE20090773A1 (es) | Derivados de morfolina pirimidina | |
| PE20081344A1 (es) | Inhibidores del virus de la hepatitis c | |
| NO20082388L (no) | Heteroaryl substituerte piperidinderivater som L-CPT1 inhibitorer | |
| NO20083514L (no) | Heterobicykliske sulfonamidderivater for behandling av diabetes | |
| DK1789398T3 (da) | 2-amino-quinazolin derivater anvendelige som inhibitorer af B-sekretase (BACE) | |
| EA201190158A1 (ru) | Производные бензофуранила для применения в качестве ингибиторов глюкокиназы | |
| EA200701257A1 (ru) | Пирролопиразолы в качестве сильнодействующих ингибиторов киназы | |
| PE20142185A1 (es) | Pirrolidina-2-carboxamidas sustituidas | |
| NO20091596L (no) | Benzoylamino-heterocykliske forbindelser som Glucokinase-(GLK)-activatorer | |
| NO20083598L (no) | Karbosykliske og heterosykliske arylsulfoner som inhibitorer av gamma-sekretase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |