PE20110675A1 - DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASA - Google Patents
DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASAInfo
- Publication number
- PE20110675A1 PE20110675A1 PE2011000203A PE2011000203A PE20110675A1 PE 20110675 A1 PE20110675 A1 PE 20110675A1 PE 2011000203 A PE2011000203 A PE 2011000203A PE 2011000203 A PE2011000203 A PE 2011000203A PE 20110675 A1 PE20110675 A1 PE 20110675A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- methyl
- indol
- amide
- ilmetil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, Ar ES DE PREFERENCIA 5-TERCBUTIL-3-METANSULFONILAMINO-2-METOXI-FENIL; R1 ES CICLOALQUILO C4-C6 CON 1-2 N, EVENTUALMENTE MONO O DI SUSTITUIDO CON R7; R7 ES ALQUILO C1-C3, HIDROXI, ALCOXI C1-C3, AMINO, ENTRE OTROS; R2 H, HALOGENO, ALQUILO C1-C4; M ES CH, N; T ES ENLACE, ALQUILENO C1-C4 SUSTITUIDO O NO; m ES 0-3; n ES 1-3; p ES 0-3. SON COMPUESTOS PREFERIDOS: (5-TERC-BUTIL-3-METANSULFONILAMINO-2-METOXI-FENIL)-AMIDA DEL ACIDO 1-METIL-7-[4-(1-METIL-PIPERIDIN-4-CARBONIL)-PIPERAZIN-1-ILMETIL]-1H-INDOL-2-CARBOXILICO; [5-TERC-BUTIL-2-METOXI-3-(4-METIL-PIPERAZIN-1-ILMETIL)-FENIL]-AMIDA DEL ACIDO (S)-1-METIL-7-[4-(1-METIL-PIRROLIDIN-2-CARBONIL)-PIPERAZIN-1-ILMETIL]-1H-INDOL-2-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE MAP-QUINASA P38 UTILES EN EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08163526 | 2008-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110675A1 true PE20110675A1 (es) | 2011-09-30 |
Family
ID=40210516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000203A PE20110675A1 (es) | 2008-09-02 | 2009-08-26 | DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASA |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8686022B2 (es) |
| EP (1) | EP2323980B1 (es) |
| JP (1) | JP5592886B2 (es) |
| KR (1) | KR20110065498A (es) |
| CN (1) | CN102186818B (es) |
| AR (1) | AR073481A1 (es) |
| AT (1) | ATE547402T1 (es) |
| AU (1) | AU2009289379B2 (es) |
| BR (1) | BRPI0918628A2 (es) |
| CA (1) | CA2735770A1 (es) |
| CL (1) | CL2011000424A1 (es) |
| CO (1) | CO6361920A2 (es) |
| DK (1) | DK2323980T3 (es) |
| EA (1) | EA021053B1 (es) |
| EC (1) | ECSP11010844A (es) |
| ES (1) | ES2383340T3 (es) |
| IL (1) | IL211012A0 (es) |
| MA (1) | MA32597B1 (es) |
| MX (1) | MX2011002053A (es) |
| NZ (1) | NZ591227A (es) |
| PE (1) | PE20110675A1 (es) |
| PL (1) | PL2323980T3 (es) |
| TW (1) | TW201014847A (es) |
| UY (1) | UY32081A (es) |
| WO (1) | WO2010026096A1 (es) |
| ZA (1) | ZA201100831B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2323980B1 (de) | 2008-09-02 | 2012-02-29 | Boehringer Ingelheim International GmbH | 7-(piperazin-1-ylmethyl)-1h-indol-2-carbonsäure (phenyl) -amidderivate und verwandte verbindungen als p38 map-kinase-inhibitoren zur behandlung von atemwegserkrankungen |
| KR20110049851A (ko) | 2008-09-02 | 2011-05-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 벤즈아미드, 이의 제조방법, 및 약제로서의 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2735201A (en) | 1999-12-28 | 2001-07-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| DE102004009238A1 (de) | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
| WO2006026235A1 (en) | 2004-08-25 | 2006-03-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| EP2083816A2 (en) * | 2006-10-27 | 2009-08-05 | Brystol-Myers Squibb Company | Heterocyclic amide compounds useful as kinase inhibitors |
| EP2323980B1 (de) | 2008-09-02 | 2012-02-29 | Boehringer Ingelheim International GmbH | 7-(piperazin-1-ylmethyl)-1h-indol-2-carbonsäure (phenyl) -amidderivate und verwandte verbindungen als p38 map-kinase-inhibitoren zur behandlung von atemwegserkrankungen |
| KR20110049851A (ko) | 2008-09-02 | 2011-05-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 벤즈아미드, 이의 제조방법, 및 약제로서의 이의 용도 |
-
2009
- 2009-08-26 EP EP09782239A patent/EP2323980B1/de active Active
- 2009-08-26 JP JP2011524373A patent/JP5592886B2/ja active Active
- 2009-08-26 BR BRPI0918628A patent/BRPI0918628A2/pt not_active IP Right Cessation
- 2009-08-26 NZ NZ591227A patent/NZ591227A/xx not_active IP Right Cessation
- 2009-08-26 WO PCT/EP2009/061025 patent/WO2010026096A1/de active Application Filing
- 2009-08-26 CA CA2735770A patent/CA2735770A1/en not_active Abandoned
- 2009-08-26 AU AU2009289379A patent/AU2009289379B2/en not_active Ceased
- 2009-08-26 DK DK09782239.9T patent/DK2323980T3/da active
- 2009-08-26 PE PE2011000203A patent/PE20110675A1/es not_active Application Discontinuation
- 2009-08-26 CN CN2009801407239A patent/CN102186818B/zh not_active Expired - Fee Related
- 2009-08-26 ES ES09782239T patent/ES2383340T3/es active Active
- 2009-08-26 PL PL09782239T patent/PL2323980T3/pl unknown
- 2009-08-26 EA EA201100422A patent/EA021053B1/ru not_active IP Right Cessation
- 2009-08-26 US US13/060,504 patent/US8686022B2/en active Active
- 2009-08-26 KR KR1020117007713A patent/KR20110065498A/ko not_active Application Discontinuation
- 2009-08-26 AT AT09782239T patent/ATE547402T1/de active
- 2009-08-26 MX MX2011002053A patent/MX2011002053A/es active IP Right Grant
- 2009-08-31 UY UY0001032081A patent/UY32081A/es not_active Application Discontinuation
- 2009-09-01 TW TW098129416A patent/TW201014847A/zh unknown
- 2009-09-01 AR ARP090103363A patent/AR073481A1/es unknown
-
2011
- 2011-02-01 ZA ZA2011/00831A patent/ZA201100831B/en unknown
- 2011-02-02 IL IL211012A patent/IL211012A0/en unknown
- 2011-02-25 EC EC2011010844A patent/ECSP11010844A/es unknown
- 2011-02-25 CL CL2011000424A patent/CL2011000424A1/es unknown
- 2011-02-28 MA MA33652A patent/MA32597B1/fr unknown
- 2011-03-16 CO CO11032840A patent/CO6361920A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR073481A1 (es) | 2010-11-10 |
| EA021053B1 (ru) | 2015-03-31 |
| IL211012A0 (en) | 2011-04-28 |
| CN102186818A (zh) | 2011-09-14 |
| EP2323980A1 (de) | 2011-05-25 |
| CL2011000424A1 (es) | 2011-07-15 |
| UY32081A (es) | 2010-03-26 |
| BRPI0918628A2 (pt) | 2015-12-01 |
| PL2323980T3 (pl) | 2012-10-31 |
| ATE547402T1 (de) | 2012-03-15 |
| TW201014847A (en) | 2010-04-16 |
| CN102186818B (zh) | 2013-10-02 |
| JP5592886B2 (ja) | 2014-09-17 |
| CA2735770A1 (en) | 2010-03-11 |
| ZA201100831B (en) | 2011-10-26 |
| JP2012501310A (ja) | 2012-01-19 |
| CO6361920A2 (es) | 2012-01-20 |
| NZ591227A (en) | 2013-02-22 |
| AU2009289379A1 (en) | 2010-03-11 |
| ECSP11010844A (es) | 2011-03-31 |
| US8686022B2 (en) | 2014-04-01 |
| ES2383340T3 (es) | 2012-06-20 |
| US20110269737A1 (en) | 2011-11-03 |
| MA32597B1 (fr) | 2011-09-01 |
| EA201100422A1 (ru) | 2011-10-31 |
| WO2010026096A1 (de) | 2010-03-11 |
| KR20110065498A (ko) | 2011-06-15 |
| EP2323980B1 (de) | 2012-02-29 |
| DK2323980T3 (da) | 2012-06-11 |
| AU2009289379B2 (en) | 2014-03-27 |
| MX2011002053A (es) | 2011-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |