PE20090958A1 - Compuestos heterociclicos moduladores de miosina - Google Patents
Compuestos heterociclicos moduladores de miosinaInfo
- Publication number
- PE20090958A1 PE20090958A1 PE2008001391A PE2008001391A PE20090958A1 PE 20090958 A1 PE20090958 A1 PE 20090958A1 PE 2008001391 A PE2008001391 A PE 2008001391A PE 2008001391 A PE2008001391 A PE 2008001391A PE 20090958 A1 PE20090958 A1 PE 20090958A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- members
- myosin
- carbamoyloxy
- carboxamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pregnancy & Childbirth (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE W1 Y W2 SON CR11R12, NR13, O; W3 ES CR1R2, NR14, O; R1, R2, R11 Y R12 SON H, OH, CARBOXI, SULFANILO, SULFONILO, ENTRE OTROS; R13 Y R14 SON H, ALQUILO C1-C20, ALQUENILO C2-C20, ENTRE OTROS; Z1 ES HETEROARILO DE 5 A 7 MIEMBROS CON 1 A 3 HETEROATOMOS DE N, O Y S O HETEROCICLOALQUILO DE 3 A 7 MIEMBROS CON 1 A 3 HETEROATOMOS DE O, S Y N; Z2 ES ARILO, HETEROARILO DE 5 A 7 MIEMBROS CON 1 A 3 HETEROATOMOS DE N, O Y S O HETEROCICLOALQUILO DE 3 A 7 MIEMBROS CON 1 A 3 HETEROATOMOS DE O, S Y N; R3, R4, R5 Y R6 SON H, OH, CARBOXI, SULFONILO, ENTRE OTROS; R7 Y R10 SON H, OH, CN, HALO, ENTRE OTROS; R8 ES H, ALQUILO C1-C20, CICLOALQUILO, ENTRE OTROS; m Y p SON UN ENTERO DE 0 A 3; n ES UN ENTERO DE 0 A 4; q ES UN ENTERO DE 1 A 4. SON COMPUESTOS PREFERIDOS: N-[(2-CLOROFENIL)METIL](4-{[N-(1-ETIL(4-PIPERIDIL))CARBAMOILOXI]METIL}(2H-3,4,5,6-TETRAHIDROPIRAN-4-IL))CARBOXAMIDA, N-[(2-CLOROFENIL)METIL](4-{[N-(4-METIL-2-FENIL(1,3-TIAZOL-5-IL))CARBAMOILOXI]METIL}(2H-3,4,5,6-TETRAHIDROPIRAN-4-IL))CARBOXAMIDA, {1-(2-AMINOACETIL)-4-[(N-(2-TIENIL)CARBAMOILOXI)METIL](4-PIPERIDIL)}-N-[(2-CLOROFENIL)METIL]CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MODULAN LA MIOSINA DEL MUSCULO LISO Y/O LA MIOSINA NO MUSCULAR Y SON UTILES EN EL TRATAMIENTO DE HIPERTENSION, ASMA, GLAUCOMA, APOPLEJIAS, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96502007P | 2007-08-15 | 2007-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090958A1 true PE20090958A1 (es) | 2009-08-07 |
Family
ID=40350992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001391A PE20090958A1 (es) | 2007-08-15 | 2008-08-14 | Compuestos heterociclicos moduladores de miosina |
Country Status (14)
Country | Link |
---|---|
US (3) | US8088793B2 (es) |
EP (1) | EP2195328A4 (es) |
JP (1) | JP5670731B2 (es) |
KR (1) | KR20100044251A (es) |
CN (1) | CN101821279A (es) |
AR (1) | AR069364A1 (es) |
AU (1) | AU2008287435B2 (es) |
CA (1) | CA2696321A1 (es) |
CL (1) | CL2008002411A1 (es) |
MX (1) | MX2010001692A (es) |
NZ (1) | NZ583351A (es) |
PE (1) | PE20090958A1 (es) |
TW (1) | TWI426908B (es) |
WO (1) | WO2009023193A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US8063082B2 (en) * | 2006-08-02 | 2011-11-22 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
US8071625B2 (en) * | 2006-08-02 | 2011-12-06 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
NZ583351A (en) | 2007-08-15 | 2012-05-25 | Cytokinetics Inc | Modulate smooth muscle myosin and/or non-muscle myosin |
WO2012080284A2 (en) * | 2010-12-17 | 2012-06-21 | F. Hoffmann-La Roche Ag | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof |
WO2013138753A1 (en) | 2012-03-16 | 2013-09-19 | Fox Chase Chemical Diversity Center, Inc. | Prodrugs of riluzole and their method of use |
KR20160046693A (ko) * | 2012-04-02 | 2016-04-29 | 싸이토키네틱스, 인코포레이티드 | 횡격막 기능을 향상시키는 방법들 |
CN106748951B (zh) | 2012-07-19 | 2020-07-24 | 开曼化学股份有限公司 | 作为在治疗ep4介导的疾病和病状中使用的ep4受体选择性激动剂的二氟内酰胺化合物 |
CA2903314C (en) * | 2013-03-15 | 2023-02-14 | Cayman Chemical Company, Inc. | Methods of synthesizing a difluorolactam analog |
AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
KR20190135029A (ko) | 2017-03-30 | 2019-12-05 | 에프. 호프만-라 로슈 아게 | Hpk1의 억제제인 이소퀴놀린 |
US10407424B2 (en) | 2017-03-30 | 2019-09-10 | Genentech, Inc. | Naphthyridines as inhibitors of HPK1 |
US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
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WO2008016676A2 (en) * | 2006-08-02 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
NZ583351A (en) | 2007-08-15 | 2012-05-25 | Cytokinetics Inc | Modulate smooth muscle myosin and/or non-muscle myosin |
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2008
- 2008-08-11 NZ NZ583351A patent/NZ583351A/xx not_active IP Right Cessation
- 2008-08-11 MX MX2010001692A patent/MX2010001692A/es active IP Right Grant
- 2008-08-11 US US12/228,421 patent/US8088793B2/en not_active Expired - Fee Related
- 2008-08-11 WO PCT/US2008/009636 patent/WO2009023193A1/en active Application Filing
- 2008-08-11 AU AU2008287435A patent/AU2008287435B2/en not_active Ceased
- 2008-08-11 EP EP08795242A patent/EP2195328A4/en not_active Withdrawn
- 2008-08-11 CA CA2696321A patent/CA2696321A1/en not_active Abandoned
- 2008-08-11 JP JP2010521009A patent/JP5670731B2/ja active Active
- 2008-08-11 KR KR1020107005370A patent/KR20100044251A/ko not_active Application Discontinuation
- 2008-08-11 CN CN200880111558A patent/CN101821279A/zh active Pending
- 2008-08-14 CL CL2008002411A patent/CL2008002411A1/es unknown
- 2008-08-14 TW TW097130926A patent/TWI426908B/zh active
- 2008-08-14 PE PE2008001391A patent/PE20090958A1/es not_active Application Discontinuation
- 2008-08-14 AR ARP080103556A patent/AR069364A1/es unknown
-
2011
- 2011-11-30 US US13/308,287 patent/US8759374B2/en active Active
-
2012
- 2012-09-12 US US13/612,713 patent/US8895582B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2008287435A1 (en) | 2009-02-19 |
TW200922583A (en) | 2009-06-01 |
JP5670731B2 (ja) | 2015-02-18 |
AU2008287435B2 (en) | 2013-05-16 |
EP2195328A4 (en) | 2011-06-15 |
MX2010001692A (es) | 2010-04-22 |
CL2008002411A1 (es) | 2009-07-17 |
EP2195328A1 (en) | 2010-06-16 |
AR069364A1 (es) | 2010-01-20 |
CN101821279A (zh) | 2010-09-01 |
TWI426908B (zh) | 2014-02-21 |
US20130053348A1 (en) | 2013-02-28 |
NZ583351A (en) | 2012-05-25 |
US8895582B2 (en) | 2014-11-25 |
WO2009023193A1 (en) | 2009-02-19 |
US20120135964A1 (en) | 2012-05-31 |
US8759374B2 (en) | 2014-06-24 |
KR20100044251A (ko) | 2010-04-29 |
US20090275537A1 (en) | 2009-11-05 |
JP2010536752A (ja) | 2010-12-02 |
US8088793B2 (en) | 2012-01-03 |
CA2696321A1 (en) | 2009-02-19 |
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