PE20090689A1 - Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes - Google Patents

Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes

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Publication number
PE20090689A1
PE20090689A1 PE2008000393A PE2008000393A PE20090689A1 PE 20090689 A1 PE20090689 A1 PE 20090689A1 PE 2008000393 A PE2008000393 A PE 2008000393A PE 2008000393 A PE2008000393 A PE 2008000393A PE 20090689 A1 PE20090689 A1 PE 20090689A1
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Peru
Prior art keywords
amino acid
acid sequence
seq
antibody
inflammatory
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PE2008000393A
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English (en)
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Zhengbin Yao
Sanjaya Singh
Salah-Eddine Lamhamedi-Cherradi
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Genentech Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620235&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090689(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20090689A1 publication Critical patent/PE20090689A1/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A UN ANTICUERPO QUIMERICO, HUMANIZADO, MONOCLONAL O RECOMBINANTE QUE SE ENLAZA A UN EPITOPE OX40 HUMANO, QUE COMPRENDE: A) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE i) UN VH CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 17, ii) UN VH CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 18, Y iii) UN VH CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 19; B) UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE: i) UN VL CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 12, 15 O 61, ii) UN VL CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 13, Y iii) UN VL CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 14 O 16; Y C) UNA REGION CONSTANTE DE DOMINIO CH1, CH2 O CH3 QUE ES DE UN ANTICUERPO DE IgG1, IgG2, IgG3 O IgG4. SE REFIERE TAMBIEN A UNA MOLECULA DE ACIDO NUCLEICO QUE CODIFICA EL ANTICUERPO, UN VECTOR, UNA CELULA HUESPED, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y A UN METODO DE PRODUCCION. DICHO ANTICUERPO ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES TALES COMO ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN
PE2008000393A 2007-02-27 2008-02-27 Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes PE20090689A1 (es)

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US90369307P 2007-02-27 2007-02-27

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PE20090689A1 true PE20090689A1 (es) 2009-06-20

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PE2008000393A PE20090689A1 (es) 2007-02-27 2008-02-27 Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes

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US (1) US20100136030A1 (es)
EP (1) EP2125891A2 (es)
JP (1) JP2010518873A (es)
KR (1) KR20100014588A (es)
CN (1) CN101668776A (es)
AR (1) AR065506A1 (es)
AU (1) AU2008219666A1 (es)
BR (1) BRPI0807269A2 (es)
CA (1) CA2679399A1 (es)
CL (1) CL2008000578A1 (es)
CO (1) CO6231009A2 (es)
CR (1) CR11042A (es)
EC (1) ECSP099656A (es)
IL (1) IL200572A0 (es)
MA (1) MA31246B1 (es)
MX (1) MX2009009194A (es)
PE (1) PE20090689A1 (es)
RU (1) RU2009135824A (es)
TW (1) TW200846367A (es)
WO (1) WO2008106116A2 (es)

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