PE20081776A1 - Moduladores 2-aminopirimidina del receptor histamina h4 - Google Patents

Moduladores 2-aminopirimidina del receptor histamina h4

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Publication number
PE20081776A1
PE20081776A1 PE2008000324A PE2008000324A PE20081776A1 PE 20081776 A1 PE20081776 A1 PE 20081776A1 PE 2008000324 A PE2008000324 A PE 2008000324A PE 2008000324 A PE2008000324 A PE 2008000324A PE 20081776 A1 PE20081776 A1 PE 20081776A1
Authority
PE
Peru
Prior art keywords
cyclopentil
pyrimidin
aminopyrimidine
histamine
modulators
Prior art date
Application number
PE2008000324A
Other languages
English (en)
Inventor
Hui Cai
Frank Chavez
Anne E Fitzgerald
Danielle K Neff
Brad M Savall
Deborah M Smith
Jennifer D Venable
Jianmei Wei
Ronald L Wolin
Jing Liu
Neelakandha S Mani
Michele C Rizzolio
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20081776A1 publication Critical patent/PE20081776A1/es

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 2-AMINOPIRIMIDINA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON OH, CF3, ENTRE OTROS SUSTITUYENTES, BENCIL, CICLOALQUILO MONOCICLICO, ADAMANTIL, ENTRE OTROS; R2 ES H, F, METIL O METOXI; -N(R3)R4 ES UNO DE LOS SIGUIENTES SISTEMAS DE ANILLOS ACICLICOS, MONOCICLICOS, ESPIROCICLICOS DE FORMULA (i), (ii), (iii), ENTRE OTROS, DONDE Rb ES H O ALQUILO(C1-C3). SON COMPUESTOS PREFERIDOS: 4-CICLOPENTIL-6-(4-METIL-PIPERAZIN-1-IL)-PIRIMIDIN-2-ILAMINA, (R)-4-(3-AMINO-PIPERIDIN-1-IL)-6-CICLOPENTIL-PIRIMIDIN-2-ILAMINA, 4-CICLOPENTIL-6-(CIS-OCTAHIDRO-PIRROLO[3,4-b]PIRIDIN-6-IL)-PIRIMIDIN-2-ILAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA H4 SIENDO UTILES EN EL TRATAMIENTO DE ALERGIA, ARTRITIS REUMATOIDEA, ASMA, ENFERMEDADES AUTOINMUNES
PE2008000324A 2007-02-14 2008-02-14 Moduladores 2-aminopirimidina del receptor histamina h4 PE20081776A1 (es)

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US88979807P 2007-02-14 2007-02-14

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PE20081776A1 true PE20081776A1 (es) 2008-12-18

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PE2008000324A PE20081776A1 (es) 2007-02-14 2008-02-14 Moduladores 2-aminopirimidina del receptor histamina h4

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US (6) US7923451B2 (es)
EP (2) EP2599386A1 (es)
JP (1) JP5281586B2 (es)
KR (1) KR20090110877A (es)
CN (1) CN101668423B (es)
AR (1) AR065354A1 (es)
AU (1) AU2008216727B2 (es)
BR (1) BRPI0807815A2 (es)
CA (1) CA2678077A1 (es)
CL (1) CL2008000467A1 (es)
CO (1) CO6210771A2 (es)
CR (1) CR11027A (es)
EA (1) EA016133B1 (es)
EC (1) ECSP099582A (es)
GT (1) GT200900231A (es)
IL (1) IL200335A0 (es)
MX (1) MX2009008787A (es)
NI (1) NI200900159A (es)
NZ (1) NZ578977A (es)
PE (1) PE20081776A1 (es)
TW (1) TW200904437A (es)
UY (1) UY30917A1 (es)
WO (1) WO2008100565A1 (es)

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