PE20221628A1 - Compuestos inhibidores de rip1 y metodos para hacer y utilizar los mismos - Google Patents

Compuestos inhibidores de rip1 y metodos para hacer y utilizar los mismos

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Publication number
PE20221628A1
PE20221628A1 PE2022000369A PE2022000369A PE20221628A1 PE 20221628 A1 PE20221628 A1 PE 20221628A1 PE 2022000369 A PE2022000369 A PE 2022000369A PE 2022000369 A PE2022000369 A PE 2022000369A PE 20221628 A1 PE20221628 A1 PE 20221628A1
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PE
Peru
Prior art keywords
oxo
making
methods
oxazepin
methyl
Prior art date
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PE2022000369A
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English (en)
Inventor
Yan Chen
Jiaxin Yu
Simon Shaw
Ihab Darwish
Vanessa Taylor
Somasekhar Bhamidipati
Zhushou Luo
Rao Kolluri
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Rigel Pharmaceuticals Inc
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Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of PE20221628A1 publication Critical patent/PE20221628A1/es

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 4-OXO-2,3,4,5-TETRAHIDROBENZO[B][1,4]OXAZEPINA DE FORMULA (I) DONDE R1, R2, R3, R4, L, Z, m, n Y EL ANILLO B SON TAL COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO. SON COMPUESTOS PREFERIDOS: (S)-N-(7-((1-HIDROXICICLOPENTIL)ETINIL)-5-METIL-4-OXO-2,3,4,5-TETRAHIDROBENZO[B][1,4]OXAZEPIN-3-IL)-4-FENOXIPICOLINAMIDA; (S)-N-(5-METIL-7-(3-METILBUT-3-EN-1-IN-1-IL)-4-OXO-2,3,4,5-TETRAHIDROBENZO[B][1,4]OXAZEPIN-3-IL)-4-FENOXIPICOLINAMIDA; (S)-4-(4-FLUOROFENOXI)-N-(7-(3-HIDROXI-3-METILBUT-1-IN-1-IL)-5-METIL-4-OXO-2,3,4,5-TETRAHIDROBENZO[B][1,4]OXAZEPIN-3-IL)PICOLINAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA 1 QUE INTERACTUA CON EL RECEPTOR (RIP1) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS AUTOINMUNES Y PROLIFERATIVOS.
PE2022000369A 2019-09-06 2020-09-04 Compuestos inhibidores de rip1 y metodos para hacer y utilizar los mismos PE20221628A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962897223P 2019-09-06 2019-09-06
US201962932404P 2019-11-07 2019-11-07
US202063001016P 2020-03-27 2020-03-27
US202063004301P 2020-04-02 2020-04-02
US202063004290P 2020-04-02 2020-04-02
US202063004319P 2020-04-02 2020-04-02
PCT/US2020/049487 WO2021046407A1 (en) 2019-09-06 2020-09-04 Rip1 inhibitory compounds and methods for making and using the same

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