PE20080259A1 - Compuestos y metodos para modular fxr - Google Patents
Compuestos y metodos para modular fxrInfo
- Publication number
- PE20080259A1 PE20080259A1 PE2007000629A PE2007000629A PE20080259A1 PE 20080259 A1 PE20080259 A1 PE 20080259A1 PE 2007000629 A PE2007000629 A PE 2007000629A PE 2007000629 A PE2007000629 A PE 2007000629A PE 20080259 A1 PE20080259 A1 PE 20080259A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- haloalkyl
- compounds
- ilmetoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE p 0-1; X1 y X2 SON C, N CON LA CONDICION DE QUE AMBOS X1 y X2 NO SON N; R1 y R2 SON H, ALQUILO C1-C3, HALOALQUILO C1-C3, ENTRE OTROS; R4b ES H, ALQUILO C1-C3, HALOALQUILO C1-C3, ENTRE OTROS; R5 y R5a SON CADA UNO H, ALQUILO C1-C3; R6 ES H, ALQUILO C1-C3, HALOALQUILO C1-C3, ENTRE OTROS; L1 ES ENLACE, ETINILO, ALQUILO C1-C3, ENTRE OTROS; Ar1 ES INDOLILO, BENZOTIENILO, NAFTILO, ENTRE OTROS; R7 ES -COOH, -ALQUILO C1-C3COOH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 4-[({4-[3-(2,6-DICLOROFENIL)-5-TRIFLUOROMETIL-3H-[1,2,3]TRIAZOL-4-ILMETOXI]-2-METILOFENIL}-METILAMINO)-METILO]-2-METIL-BENZOICO; ACIDO 3-[({4-[3-(2,6-DICLORO-FENIL)-5-ISOPROPIL-3H-[1,2,3]TRIAZOL-4-ILMETOXI]-2-METIL-FENIL}-METIL-AMINO)-METILO]-BENZOICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON AGONISTAS SELECTIVOS PARA EL FXR (RECEPTOR FARMESOIDE X) UTILES EN EL TRATAMIENTO DE DISLIPIDEMIA, ATEROESCLEROSIS, DIABETES Y ENFERMEDADES RELACIONADAS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80810406P | 2006-05-24 | 2006-05-24 | |
US87000106P | 2006-12-14 | 2006-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080259A1 true PE20080259A1 (es) | 2008-04-10 |
Family
ID=38626336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000629A PE20080259A1 (es) | 2006-05-24 | 2007-05-22 | Compuestos y metodos para modular fxr |
Country Status (16)
Country | Link |
---|---|
US (1) | US8106077B2 (es) |
EP (1) | EP2029558B1 (es) |
JP (1) | JP5225984B2 (es) |
AR (1) | AR061101A1 (es) |
AT (1) | ATE460403T1 (es) |
AU (1) | AU2007267692B2 (es) |
BR (1) | BRPI0711875A2 (es) |
CA (1) | CA2651373A1 (es) |
CL (1) | CL2007001451A1 (es) |
DE (1) | DE602007005256D1 (es) |
EA (1) | EA014720B1 (es) |
ES (1) | ES2340221T3 (es) |
MX (1) | MX2008014959A (es) |
PE (1) | PE20080259A1 (es) |
TW (1) | TW200812982A (es) |
WO (1) | WO2007140174A2 (es) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1894928A1 (en) * | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
EP1894924A1 (en) * | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
TW200906823A (en) * | 2007-07-16 | 2009-02-16 | Lilly Co Eli | Compounds and methods for modulating FXR |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101945848A (zh) | 2007-12-20 | 2011-01-12 | 英维沃医药有限公司 | 四取代的苯 |
WO2009102761A1 (en) | 2008-02-12 | 2009-08-20 | Bristol-Myers Squibb Company | 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors |
EP2128158A1 (en) * | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclic cyclopropyl-substituted FXR binding compounds |
CA2735886A1 (en) | 2008-09-25 | 2010-04-01 | F. Hoffmann-La Roche Ag | Indazole or 4,5,6,7-tetrahydro-indazole derivatives |
EP2289883A1 (en) * | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8252826B2 (en) | 2010-03-24 | 2012-08-28 | Hoffmann-La Roche Inc. | Cyclopentyl- and cycloheptylpyrazoles |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
EA201390476A1 (ru) | 2010-09-28 | 2013-08-30 | Бристол-Майерс Сквибб Компани | Новые пиперазиновые аналоги с замещенными гетероарильными группами в качестве противовирусных средств широкого применения против гриппа |
US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
WO2012062623A1 (en) * | 2010-11-09 | 2012-05-18 | F. Hoffmann-La Roche Ag | Triazole derivatives as ligands for gaba receptors |
CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
IL253437A0 (en) * | 2011-07-13 | 2017-09-28 | Gilead Sciences Inc | New compounds modulate fxr (nr1h4) activity and bind |
EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
WO2013037482A1 (en) | 2011-09-15 | 2013-03-21 | Phenex Pharmaceuticals Ag | Farnesoid x receptor agonists for cancer treatment and prevention |
JP6223443B2 (ja) * | 2012-06-26 | 2017-11-01 | サニオナ・エイピイエス | フェニルトリアゾール誘導体及びgabaa受容体複合体を調節するための該フェニルトリアゾール誘導体の使用 |
JP6366721B2 (ja) | 2013-09-11 | 2018-08-01 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | B型肝炎ウイルス感染症を処置するための方法及び医薬組成物 |
CN106660967A (zh) | 2014-01-24 | 2017-05-10 | 西纳福克斯股份有限公司 | (杂)芳基1,3‑偶极化合物与(杂)环炔的环加成方法 |
EP3006939A1 (en) | 2014-10-06 | 2016-04-13 | Gilead Sciences, Inc. | Histidine-rich Glycoprotein as a marker for hepatic Farnesoid X receptor activation |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
MA41094A (fr) * | 2014-12-02 | 2017-10-10 | Lilly Co Eli | Procédés de traitement de troubles rénaux |
EP3034501A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
EP3034499A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
US11311557B2 (en) | 2015-02-06 | 2022-04-26 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions for combination therapy |
TWI698430B (zh) | 2015-02-13 | 2020-07-11 | 南北兄弟藥業投資有限公司 | 三環化合物及其在藥物中的應用 |
PE20180034A1 (es) | 2015-04-07 | 2018-01-09 | Intercept Pharmaceuticals Inc | Composiciones farmaceuticas para terapias combinadas |
SG11201810600WA (en) | 2016-06-13 | 2018-12-28 | Gilead Sciences Inc | Fxr (nr1h4) modulating compounds |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
TW201808283A (zh) | 2016-08-05 | 2018-03-16 | 廣東東陽光藥業有限公司 | 含氮三環化合物及其在藥物中的應用 |
WO2018153933A1 (en) | 2017-02-21 | 2018-08-30 | Genfit | Combination of a ppar agonist with a fxr agonist |
JP6906626B2 (ja) | 2017-03-28 | 2021-07-21 | ギリアード サイエンシーズ, インコーポレイテッド | 肝疾患を処置するための治療的組み合わせ |
JP2020515564A (ja) | 2017-03-30 | 2020-05-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エピソーマルウイルスの持続性及び発現を低下させるための方法及び医薬組成物 |
PE20191792A1 (es) * | 2017-04-12 | 2019-12-24 | Il Dong Pharma | Derivados de isoxazol como agonistas del receptor nuclear y usos de los mismos |
US11370785B2 (en) | 2017-11-01 | 2022-06-28 | Bristol-Myers Squibb Company | Multicyclic compounds as farnesoid X receptor modulators |
AU2018360575A1 (en) | 2017-11-01 | 2020-06-18 | Bristol-Myers Squibb Company | Alkene spirocyclic compounds as farnesoid X receptor modulators |
EP3704106B1 (en) | 2017-11-01 | 2023-04-12 | Bristol-Myers Squibb Company | Alkene compounds as farnesoid x receptor modulators |
CN110128432B (zh) | 2018-02-02 | 2021-03-02 | 广东东阳光药业有限公司 | 含氮三环化合物及其在药物中的应用 |
BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
CN113302190A (zh) | 2019-01-15 | 2021-08-24 | 吉利德科学公司 | Fxr(nr1h4)调节化合物 |
JP2022519906A (ja) | 2019-02-19 | 2022-03-25 | ギリアード サイエンシーズ, インコーポレイテッド | Fxrアゴニストの固体形態 |
BR112021024109A2 (pt) | 2019-05-30 | 2022-03-22 | Intercept Pharmaceuticals Inc | Composições farmacêuticas compreendendo um agonista fxr e um fibrato para uso no tratamento de doença hepática colestática |
MX2022000742A (es) | 2019-07-18 | 2022-02-14 | Enyo Pharma | Metodo para disminuir los efectos adversos del interferon. |
CN110878052B (zh) * | 2019-12-11 | 2021-05-07 | 山东大学 | 一种含有fxr激动剂的化合物及其制备方法和应用 |
CN114945361A (zh) | 2020-01-15 | 2022-08-26 | 法国国家卫生及研究医学协会 | Fxr激动剂在治疗丁型肝炎病毒感染中的用途 |
EP4126858A1 (en) | 2020-03-26 | 2023-02-08 | Richter Gedeon Nyrt. | Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
CN117202905A (zh) | 2021-01-14 | 2023-12-08 | 埃尼奥制药公司 | Fxr激动剂和ifn用于治疗hbv感染的协同效果 |
CN117320722A (zh) | 2021-04-28 | 2023-12-29 | 埃尼奥制药公司 | 使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
DE60131967D1 (de) * | 2001-08-13 | 2008-01-31 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
WO2004048349A1 (en) * | 2002-11-22 | 2004-06-10 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
AU2004311909A1 (en) * | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Triazole, oxadiazole and thiadiazole derivative as PPAR modulators for the treatment of diabetes |
-
2007
- 2007-05-22 JP JP2009512254A patent/JP5225984B2/ja active Active
- 2007-05-22 DE DE602007005256T patent/DE602007005256D1/de active Active
- 2007-05-22 WO PCT/US2007/069416 patent/WO2007140174A2/en active Application Filing
- 2007-05-22 PE PE2007000629A patent/PE20080259A1/es not_active Application Discontinuation
- 2007-05-22 AT AT07811915T patent/ATE460403T1/de not_active IP Right Cessation
- 2007-05-22 CL CL2007001451A patent/CL2007001451A1/es unknown
- 2007-05-22 BR BRPI0711875-9A patent/BRPI0711875A2/pt not_active IP Right Cessation
- 2007-05-22 EA EA200870569A patent/EA014720B1/ru not_active IP Right Cessation
- 2007-05-22 AU AU2007267692A patent/AU2007267692B2/en not_active Ceased
- 2007-05-22 MX MX2008014959A patent/MX2008014959A/es active IP Right Grant
- 2007-05-22 AR ARP070102216A patent/AR061101A1/es not_active Application Discontinuation
- 2007-05-22 CA CA002651373A patent/CA2651373A1/en not_active Abandoned
- 2007-05-22 TW TW096118230A patent/TW200812982A/zh unknown
- 2007-05-22 ES ES07811915T patent/ES2340221T3/es active Active
- 2007-05-22 US US12/298,769 patent/US8106077B2/en active Active
- 2007-05-22 EP EP07811915A patent/EP2029558B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2007140174A3 (en) | 2008-03-20 |
EP2029558A2 (en) | 2009-03-04 |
JP2009538333A (ja) | 2009-11-05 |
ATE460403T1 (de) | 2010-03-15 |
CL2007001451A1 (es) | 2008-01-11 |
EP2029558B1 (en) | 2010-03-10 |
EA200870569A1 (ru) | 2009-06-30 |
BRPI0711875A2 (pt) | 2012-01-10 |
DE602007005256D1 (de) | 2010-04-22 |
US20090093524A1 (en) | 2009-04-09 |
EA014720B1 (ru) | 2011-02-28 |
ES2340221T3 (es) | 2010-05-31 |
TW200812982A (en) | 2008-03-16 |
WO2007140174A2 (en) | 2007-12-06 |
JP5225984B2 (ja) | 2013-07-03 |
AU2007267692A1 (en) | 2007-12-06 |
US8106077B2 (en) | 2012-01-31 |
MX2008014959A (es) | 2008-12-09 |
CA2651373A1 (en) | 2007-12-06 |
AR061101A1 (es) | 2008-08-06 |
AU2007267692B2 (en) | 2012-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20080259A1 (es) | Compuestos y metodos para modular fxr | |
PE20050018A1 (es) | Compuesto pentaciclico heteroaromatico como inhibidor de la proteina tirosina fosfatasa 1b (ptb1b) | |
PE20110905A1 (es) | Arilpirrolidinas pesticidas | |
PE20051173A1 (es) | Compuestos azabiciclico (3.1.0) hexanos como moduladores de receptores de dopamina d3 | |
PE20080362A1 (es) | Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 | |
PE20110672A1 (es) | 4-fenil-1-h-pirazoles insecticidas | |
PE20110341A1 (es) | COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA | |
PE20050444A1 (es) | Compuestos de piridina como inhibidores de la peptidasa | |
PE20090641A1 (es) | Amidas heterociclicas | |
PE20090992A1 (es) | Derivados de fenil-amino-pirimidina como agentes inhibidores de cinasa | |
PE20010987A1 (es) | Inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias | |
PE20051054A1 (es) | Compuestos heterociclicos utiles como secretagogos de la hormona de crecimiento | |
PE20081545A1 (es) | Derivados de sulfonamida como inhibidores de acido graso sintasas | |
PE20051147A1 (es) | Compuestos de heteroaril y fenilsulfamoilo sustituidos | |
PE20060427A1 (es) | Derivados de pirazol como inhibidores de la union del glucagon y composiciones | |
PE20091425A1 (es) | Derivados de aminotiazol | |
AR094588A2 (es) | Proceso de obtención de un compuesto derivado de benzimidazol y composición farmacéutica | |
PE20081404A1 (es) | Derivados de sulfonil-fenil-2h-[1,2,4]oxadiazol-5-ona y procesos para su preparacion | |
CO5550431A2 (es) | Cristales que incluyen una sal de acido malico de n-[2 (dietilamino)etil]-5-[(5-fluoro-2oxo-3h-indol-3-ilideno) metil]-2,4-dimetil-1h-pirrol-3-carboxamida, proceso para su preparacion y composiciones de esta | |
PE20010749A1 (es) | Inhibidores de tirosin-cinasas | |
PE20030547A1 (es) | Derivados de imidazol para el tratamiento de la obesidad | |
PE20060240A1 (es) | Derivados de pirimidina para tratar el crecimiento celular anomalo | |
PE20080858A1 (es) | Compuestos de n-aril pirazol y composiciones que los contienen | |
PE20060554A1 (es) | Saliciltiazoles sustituidos con difenilamina o derivados de difenilamina como inhibidores de la fosfotirosina fosfatasa 1b y procedimientos para su preparacion | |
PE20071034A1 (es) | Compuestos heterociclicos como inhibidores de cetp |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |