DE60131967D1 - Nr1h4-kern-rezeptor-bindende verbindungen - Google Patents
Nr1h4-kern-rezeptor-bindende verbindungenInfo
- Publication number
- DE60131967D1 DE60131967D1 DE60131967T DE60131967T DE60131967D1 DE 60131967 D1 DE60131967 D1 DE 60131967D1 DE 60131967 T DE60131967 T DE 60131967T DE 60131967 T DE60131967 T DE 60131967T DE 60131967 D1 DE60131967 D1 DE 60131967D1
- Authority
- DE
- Germany
- Prior art keywords
- nuclear receptor
- receptor binding
- binding compounds
- nr1h4
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01119473A EP1285914B1 (de) | 2001-08-13 | 2001-08-13 | Nr1h4-kern-rezeptor-bindende verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60131967D1 true DE60131967D1 (de) | 2008-01-31 |
Family
ID=8178316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60131967T Expired - Lifetime DE60131967D1 (de) | 2001-08-13 | 2001-08-13 | Nr1h4-kern-rezeptor-bindende verbindungen |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6974830B2 (de) |
| EP (3) | EP1285914B1 (de) |
| AT (1) | ATE381542T1 (de) |
| DE (1) | DE60131967D1 (de) |
| WO (2) | WO2003015771A1 (de) |
Families Citing this family (95)
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| EP1677803A2 (de) * | 2003-09-26 | 2006-07-12 | Forbes Medi-Tech Inc. | Verfahren zur hemmung der expression von genen mit multi-arzneimittel-resistenz und hemmung der produktion von proteinen, die sich aus der expression dieser gene ergeben, und so verstärkung der wirksamkeit von chemotherapeutika zur behandlung von krebs |
| WO2005042692A2 (en) * | 2003-10-31 | 2005-05-12 | Forbes Medi-Tech Inc. | A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors |
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| CA2551611C (en) * | 2003-12-26 | 2013-06-25 | Kyowa Hakko Kogyo Co., Ltd. | Thiazole derivatives for treating or preventing parkinson's disease |
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| US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
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| ES2452031T3 (es) | 2006-02-03 | 2014-03-31 | Eli Lilly & Company | Compuestos y procedimientos para modular receptores FX |
| EP2029558B1 (de) * | 2006-05-24 | 2010-03-10 | Eli Lilly And Company | Verbindungen und verfahren zur modulierung von fx-rezeptoren |
| CA2651378C (en) | 2006-05-24 | 2012-08-28 | Eli Lilly And Company | Fxr agonists |
| EP1886685A1 (de) * | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methoden, Verwendungen und Zusammensetzungen zur Modulation der Replikation von HCV durch Aktivierung oder Hemmung des Farnesoid X Rezeptors |
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| EP1894928A1 (de) * | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Fxr bindende heterocyclische verbindungen |
| CL2007003035A1 (es) | 2006-10-24 | 2008-05-16 | Smithkline Beechman Corp | Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos, |
| JP5292310B2 (ja) | 2007-01-19 | 2013-09-18 | インターセプト ファーマシューティカルズ， インコーポレイテッド | Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法 |
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| EP2128158A1 (de) | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclische Cyclopropyl-substituierte FXR-bindende Verbindungen |
| WO2010014836A2 (en) | 2008-07-30 | 2010-02-04 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
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| JPH11263775A (ja) * | 1997-09-08 | 1999-09-28 | Sankyo Co Ltd | ヒドロキシアニリン誘導体 |
| ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
| DE69940958D1 (de) * | 1998-12-23 | 2009-07-16 | Glaxo Group Ltd | Bestimmungsmethode fur liganden der nuklearen rezeptoren |
| US6201020B1 (en) * | 1998-12-31 | 2001-03-13 | Guilford Pharmaceuticals, Inc. | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp |
| NZ515087A (en) * | 1999-04-28 | 2003-11-28 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as PPAR receptor ligands |
| DE19943636A1 (de) * | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| EP1274705A1 (de) * | 2000-03-29 | 2003-01-15 | Cyclacel Limited | 2-substituierte 4-heteroaryl-pyrimidine und ihre verwendung zur behandlung von proliferativen erkrankungen |
| GB0030710D0 (en) * | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
-
2001
- 2001-08-13 AT AT01119473T patent/ATE381542T1/de not_active IP Right Cessation
- 2001-08-13 DE DE60131967T patent/DE60131967D1/de not_active Expired - Lifetime
- 2001-08-13 EP EP01119473A patent/EP1285914B1/de not_active Expired - Lifetime
-
2002
- 2002-07-01 US US10/185,731 patent/US6974830B2/en not_active Expired - Lifetime
- 2002-07-01 US US10/185,721 patent/US7034046B2/en not_active Expired - Lifetime
- 2002-08-13 WO PCT/US2002/025437 patent/WO2003015771A1/en not_active Application Discontinuation
- 2002-08-13 EP EP02750472A patent/EP1423370A4/de not_active Withdrawn
- 2002-08-13 EP EP02750473A patent/EP1423111A4/de not_active Withdrawn
- 2002-08-13 WO PCT/US2002/025436 patent/WO2003016288A1/en not_active Application Discontinuation
- 2002-08-13 US US10/217,141 patent/US7098336B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030130296A1 (en) | 2003-07-10 |
| US20030187042A1 (en) | 2003-10-02 |
| EP1423111A1 (de) | 2004-06-02 |
| ATE381542T1 (de) | 2008-01-15 |
| WO2003016288A1 (en) | 2003-02-27 |
| US20030149087A1 (en) | 2003-08-07 |
| EP1285914B1 (de) | 2007-12-19 |
| EP1423370A1 (de) | 2004-06-02 |
| EP1423111A4 (de) | 2007-04-18 |
| EP1423370A4 (de) | 2007-04-18 |
| WO2003015771A1 (en) | 2003-02-27 |
| EP1285914A1 (de) | 2003-02-26 |
| US7034046B2 (en) | 2006-04-25 |
| US7098336B2 (en) | 2006-08-29 |
| US6974830B2 (en) | 2005-12-13 |
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