PE20100093A1 - Derivados de acetileno - Google Patents
Derivados de acetilenoInfo
- Publication number
- PE20100093A1 PE20100093A1 PE2009001286A PE2009001286A PE20100093A1 PE 20100093 A1 PE20100093 A1 PE 20100093A1 PE 2009001286 A PE2009001286 A PE 2009001286A PE 2009001286 A PE2009001286 A PE 2009001286A PE 20100093 A1 PE20100093 A1 PE 20100093A1
- Authority
- PE
- Peru
- Prior art keywords
- chloro
- hydroxy
- phenyl
- compounds
- ethynyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ACETILENO DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C12); R2 ES HETEROCICLO O ARILO OPCIONALMENTE SUSTITUIDOS; R3 ES ALQUILO(C1-C12) O HALOGENO; X ES UN ENLACE SIMPLE O ALCANDIILO. SON COMPUESTOS PREFERIDOS: [(1S,3S)-3-(3-CLORO-FENIL-ETINIL)-3-HIDROXI-CICLOHEXIL]-AMIDA DEL ACIDO FURAN-3-CARBOXILICO, [(1S,3S)-3-(3-CLORO-FENIL-ETINIL)-3-HIDROXI-CICLOHEXIL]-AMIDA DEL ACIDO BENZOFURAN-3-CARBOXILICO, N-[(1S,3S)-3-(3-CLORO-FENIL-ETINIL)-3-HIDROXI-CICLOHEXIL]-2-(2-METOXI-FENOXI)-ACETAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO METABOTROPICOS HUMANOS (mGluRs) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, DEMENCIA SENIL, ESCLEROSIS MULTIPLE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0508319.1A GB0508319D0 (en) | 2005-04-25 | 2005-04-25 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20100093A1 true PE20100093A1 (es) | 2010-02-16 |
Family
ID=34640067
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000424A PE20061295A1 (es) | 2005-04-25 | 2006-04-24 | Derivados de acetileno |
PE2009001286A PE20100093A1 (es) | 2005-04-25 | 2006-04-24 | Derivados de acetileno |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000424A PE20061295A1 (es) | 2005-04-25 | 2006-04-24 | Derivados de acetileno |
Country Status (26)
Country | Link |
---|---|
US (2) | US7696379B2 (es) |
EP (1) | EP1877365B1 (es) |
JP (1) | JP2008538777A (es) |
KR (2) | KR20090028841A (es) |
CN (1) | CN101160282A (es) |
AR (1) | AR056987A1 (es) |
AT (1) | ATE487691T1 (es) |
AU (1) | AU2006239547B2 (es) |
BR (1) | BRPI0610833A2 (es) |
CA (1) | CA2605265A1 (es) |
DE (1) | DE602006018127D1 (es) |
GB (1) | GB0508319D0 (es) |
GT (1) | GT200600142A (es) |
IL (1) | IL186669A0 (es) |
MA (1) | MA29412B1 (es) |
MX (1) | MX2007013073A (es) |
NO (1) | NO20076006L (es) |
PE (2) | PE20061295A1 (es) |
PT (1) | PT1877365E (es) |
RU (1) | RU2007143505A (es) |
SA (1) | SA06270088B1 (es) |
SG (1) | SG152287A1 (es) |
TN (1) | TNSN07397A1 (es) |
TW (1) | TW200716518A (es) |
WO (1) | WO2006114262A1 (es) |
ZA (1) | ZA200708778B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
GB0508318D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0508314D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
MX2009002684A (es) * | 2006-09-11 | 2009-06-05 | Novartis Ag | Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropico. |
JP5322477B2 (ja) * | 2007-09-28 | 2013-10-23 | 富士フイルム株式会社 | 新規アセチレン化合物、その塩、その製造方法、それを構成単位として含むポリマー、該ポリマーの製造方法、該ポリマーの組成物、該ポリマー組成物を硬化させてなる硬化物 |
WO2009047303A2 (en) * | 2007-10-12 | 2009-04-16 | Novartis Ag | Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder |
AU2012254934B2 (en) * | 2007-10-12 | 2013-10-17 | Novartis Ag | Metabotropic glutamate receptor modulators for the treatment of Parkinson's disease |
CN101854935A (zh) * | 2007-10-12 | 2010-10-06 | 诺瓦提斯公司 | 用于治疗帕金森氏病的代谢型谷氨酸受体调节剂 |
AU2009265760B2 (en) * | 2008-06-30 | 2013-07-18 | Novartis Ag | Combinations comprising mGluR modulators for the treatment of parkinson's disease |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
WO2011048150A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Use of 1h-quinazoline-2,4-diones |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
AR080055A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1 |
JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
JP2013529622A (ja) | 2010-06-24 | 2013-07-22 | ノバルティス アーゲー | 1h−キナゾリン−2,4−ジオンの使用 |
JP2014503568A (ja) | 2011-01-27 | 2014-02-13 | ノバルティス アーゲー | ニコチン酸アセチルコリン受容体α7活性化因子の使用 |
WO2013036224A1 (en) | 2011-09-07 | 2013-03-14 | Novartis Ag | Use of 1h-quinazoline- 2, 4 -diones for use in the prevention or treatment photosensitive epilepsy |
MX362819B (es) | 2013-01-15 | 2019-02-18 | Novartis Ag | Uso de agonistas del receptor nicotinico de acetilcolina alfa 7 para el tratamiento de la narcolepsia. |
CN105246485B (zh) | 2013-01-15 | 2019-03-15 | 诺华有限公司 | α7烟碱型乙酰胆碱受体激动剂的应用 |
CN106187838B (zh) * | 2016-07-13 | 2018-05-01 | 广东东阳光药业有限公司 | 芳基炔烃类化合物及其制备方法和用途 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991064A (en) | 1975-01-17 | 1976-11-09 | Warner-Lambert Company | Benzonaphthyridines |
WO1994020459A2 (en) | 1993-03-01 | 1994-09-15 | Merck Sharp & Dohme Limited | Pyrrolo-pyridine derivatives as dopamine receptor ligands |
AU6215594A (en) | 1993-03-18 | 1994-10-11 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
EP0689535B1 (en) | 1993-03-18 | 1998-09-23 | MERCK SHARP & DOHME LTD. | Benzimidazole derivatives |
US5521297A (en) * | 1993-06-04 | 1996-05-28 | Salk Institute Biotechnology/Industrial Associates | Nucleic acids encoding human metabotropic glutamate receptors |
JPH09512542A (ja) | 1994-04-28 | 1997-12-16 | メルク シヤープ エンド ドーム リミテツド | D▲下4▼リセプタ拮抗剤としてのベンゾフラン誘導体 |
AU699196B2 (en) | 1994-08-10 | 1998-11-26 | Merck Sharp & Dohme Limited | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine |
US5688798A (en) | 1995-10-10 | 1997-11-18 | Hoffmann-La Roche Inc. | Pyrimidine compounds |
FR2744449B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
FR2761069A1 (fr) | 1997-03-20 | 1998-09-25 | Pf Medicament | Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments |
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
EP1126833A4 (en) | 1998-10-29 | 2004-09-08 | Trega Biosciences Inc | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES CONTAINING THESE DERIVATIVES |
US6265434B1 (en) | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
JP2003512422A (ja) | 1999-10-29 | 2003-04-02 | メルク シャープ エンド ドーム リミテッド | ベンズイミダゾールnmda/nr2bアンタゴニストを使用する疼痛の治療方法 |
WO2001054503A1 (en) | 2000-01-28 | 2001-08-02 | Akkadix Corporation | Methods for killing nematodes and nematode eggs using 4-phenoxy-6-aminopyrimidine derivatives |
KR20020073586A (ko) | 2000-02-11 | 2002-09-27 | 버텍스 파마슈티칼스 인코포레이티드 | 피페라진 및 피페리딘 유도체 |
CN1257894C (zh) | 2000-12-04 | 2006-05-31 | 弗·哈夫曼-拉罗切有限公司 | 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 |
AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
GB0103045D0 (en) | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
WO2003037338A2 (en) | 2001-11-01 | 2003-05-08 | Vertex Pharmaceuticals Incorporated | Modulators of the cholesterol biosynthetic pathway |
GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
US6806279B2 (en) | 2001-12-17 | 2004-10-19 | Sunesis Pharmaceuticals, Inc. | Small-molecule inhibitors of interleukin-2 |
US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
AU2003248122A1 (en) | 2002-07-25 | 2004-02-16 | Kotobuki Pharmaceutical Co., Ltd. | Sodium channel inhibitor |
MXPA05003471A (es) | 2002-10-03 | 2005-07-01 | Vertex Pharma | Derivados de piperazina y piperadina para el tratamiento de enfermedades neurologicas. |
CA2503245A1 (en) | 2002-10-24 | 2004-05-06 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
JP2007530654A (ja) * | 2004-03-30 | 2007-11-01 | ファイザー・プロダクツ・インク | シグナル伝達阻害剤の組合せ |
JP2008501628A (ja) | 2004-06-02 | 2008-01-24 | 武田薬品工業株式会社 | インドール誘導体およびがんの治療用途 |
GB0503646D0 (en) | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
GB0508314D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0508318D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
GB0514296D0 (en) | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
-
2005
- 2005-04-25 GB GBGB0508319.1A patent/GB0508319D0/en not_active Ceased
-
2006
- 2006-04-07 GT GT200600142A patent/GT200600142A/es unknown
- 2006-04-08 SA SA06270088A patent/SA06270088B1/ar unknown
- 2006-04-24 MX MX2007013073A patent/MX2007013073A/es not_active Application Discontinuation
- 2006-04-24 KR KR1020097003946A patent/KR20090028841A/ko not_active Application Discontinuation
- 2006-04-24 PT PT06724539T patent/PT1877365E/pt unknown
- 2006-04-24 EP EP06724539A patent/EP1877365B1/en not_active Not-in-force
- 2006-04-24 AU AU2006239547A patent/AU2006239547B2/en not_active Expired - Fee Related
- 2006-04-24 DE DE602006018127T patent/DE602006018127D1/de not_active Expired - Fee Related
- 2006-04-24 WO PCT/EP2006/003766 patent/WO2006114262A1/en active Application Filing
- 2006-04-24 RU RU2007143505/04A patent/RU2007143505A/ru not_active Application Discontinuation
- 2006-04-24 AT AT06724539T patent/ATE487691T1/de active
- 2006-04-24 JP JP2008508133A patent/JP2008538777A/ja active Pending
- 2006-04-24 PE PE2006000424A patent/PE20061295A1/es not_active Application Discontinuation
- 2006-04-24 TW TW095114571A patent/TW200716518A/zh unknown
- 2006-04-24 CN CNA2006800128742A patent/CN101160282A/zh active Pending
- 2006-04-24 CA CA002605265A patent/CA2605265A1/en not_active Abandoned
- 2006-04-24 US US11/912,626 patent/US7696379B2/en not_active Expired - Fee Related
- 2006-04-24 BR BRPI0610833-4A patent/BRPI0610833A2/pt not_active IP Right Cessation
- 2006-04-24 SG SG200902980-2A patent/SG152287A1/en unknown
- 2006-04-24 PE PE2009001286A patent/PE20100093A1/es not_active Application Discontinuation
- 2006-04-25 AR ARP060101637A patent/AR056987A1/es not_active Application Discontinuation
-
2007
- 2007-10-15 IL IL186669A patent/IL186669A0/en unknown
- 2007-10-15 ZA ZA200708778A patent/ZA200708778B/xx unknown
- 2007-10-24 KR KR1020077024448A patent/KR100917068B1/ko not_active IP Right Cessation
- 2007-10-24 TN TNP2007000397A patent/TNSN07397A1/en unknown
- 2007-10-29 MA MA30336A patent/MA29412B1/fr unknown
- 2007-11-21 NO NO20076006A patent/NO20076006L/no not_active Application Discontinuation
-
2009
- 2009-09-17 US US12/561,390 patent/US20100099682A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008538777A (ja) | 2008-11-06 |
US20100099682A1 (en) | 2010-04-22 |
EP1877365A1 (en) | 2008-01-16 |
AU2006239547B2 (en) | 2010-11-04 |
KR100917068B1 (ko) | 2009-09-15 |
TNSN07397A1 (en) | 2009-03-17 |
AR056987A1 (es) | 2007-11-07 |
ZA200708778B (en) | 2009-08-26 |
PE20061295A1 (es) | 2006-12-24 |
US7696379B2 (en) | 2010-04-13 |
WO2006114262A1 (en) | 2006-11-02 |
SA06270088B1 (ar) | 2010-06-23 |
IL186669A0 (en) | 2008-01-20 |
ATE487691T1 (de) | 2010-11-15 |
KR20070116147A (ko) | 2007-12-06 |
NO20076006L (no) | 2007-11-21 |
PT1877365E (pt) | 2010-12-13 |
AU2006239547A1 (en) | 2006-11-02 |
SG152287A1 (en) | 2009-05-29 |
CA2605265A1 (en) | 2006-11-02 |
US20080214673A1 (en) | 2008-09-04 |
GT200600142A (es) | 2006-11-22 |
BRPI0610833A2 (pt) | 2010-07-27 |
CN101160282A (zh) | 2008-04-09 |
EP1877365B1 (en) | 2010-11-10 |
TW200716518A (en) | 2007-05-01 |
KR20090028841A (ko) | 2009-03-19 |
DE602006018127D1 (de) | 2010-12-23 |
GB0508319D0 (en) | 2005-06-01 |
MX2007013073A (es) | 2008-01-14 |
RU2007143505A (ru) | 2009-06-10 |
MA29412B1 (fr) | 2008-04-01 |
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