PE20050080A1 - Antagonistas del receptor opioide - Google Patents

Antagonistas del receptor opioide

Info

Publication number
PE20050080A1
PE20050080A1 PE2003000959A PE2003000959A PE20050080A1 PE 20050080 A1 PE20050080 A1 PE 20050080A1 PE 2003000959 A PE2003000959 A PE 2003000959A PE 2003000959 A PE2003000959 A PE 2003000959A PE 20050080 A1 PE20050080 A1 PE 20050080A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
butylamine
phenoxy
receptor antagonists
Prior art date
Application number
PE2003000959A
Other languages
English (en)
Inventor
Steven James Quimby
Maria Jesus Blanco-Pillado
Mark Donald Chappell
Buezo Nuria Diaz
William Glen Holloway
Charles Howard Mitch
Miles Goodman Siegel
Russell Dean Stucky
Elizabeth Marie Thomas
Chad Nolan Wolfe
Kumiko Takeuchi
Dana Rae Smith
Concepcion Pedregal-Tercero
James Edward Matt Jr
James Erwin Fritz
De La Torre Marta Garcia
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20050080A1 publication Critical patent/PE20050080A1/es

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • C07D213/6432-Phenoxypyridines; Derivatives thereof
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C235/46Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE LOS ANILLOS A Y B SON CADA UNO ES FENILO, PIRIDINA, PIRAZINA, ENTRE OTROS; X1, X2, X3, X4, X5, X6, X7, X8, X9 Y X10 SON CADA UNO C, CH, N, CON TAL QUE CADA ANILLO A O B NO TENGA MAS DE 2 ATOMOS DE NITROGENO; E ES O O NH; v ES 1-3; R1 Y R2 SON CADA UNO H, ALQUILO C1-C8, HETEROCICLILO, ENTRE OTROS; R3 Y R3' SON CADA UNO H, ALQUILO C1-C8, ALQUILC1-C8CICLOALQUILO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, -ALQUINIL C2-C8, -ALCOXI C1-C8 ALQUILO, ENTRE OTROS; R6 Y R7 SON CADA UNO H, ALQUINILO C2-C8, ALQUENILO C2-C8, ENTRE OTROS; Y ES 0-3; Z 0-3. TAMBIEN REFERIDA A LA PREPARACION DE ESTOS COMPUESTOS CUYOS PREFERIDOS SON: 6-{4-[(3-METIL-BUTILAMINO)-METIL]-FENOXI}-NICOTINAMIDA; 5-{2-FLUORO-4-[(3-METIL-BUTILAMINO)-METIL]-FENOXI}-PIRAZINA-2-CARBOXAMIDA Y 3,5-DIFLUORO-4-{4-[(3-METIL-BUTILAMINO)-METIL]-FENOXI}-BENZAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO, PREVENCION O MEJORA DE LA OBESIDAD Y ENFERMEDADES RELACIONADAS
PE2003000959A 2002-09-19 2003-09-18 Antagonistas del receptor opioide PE20050080A1 (es)

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US20080255152A1 (en) 2008-10-16
NO330740B1 (no) 2011-06-27
ES2305491T3 (es) 2008-11-01
US7560463B2 (en) 2009-07-14
US20080269296A1 (en) 2008-10-30
HRP20050253A2 (en) 2005-12-31
EP2208727A1 (en) 2010-07-21
NO20051871D0 (no) 2005-04-18
US7381719B2 (en) 2008-06-03
DE60321207D1 (en) 2008-07-03
EA200500508A1 (ru) 2005-08-25

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