PE20010044A1 - Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona - Google Patents
Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-dionaInfo
- Publication number
- PE20010044A1 PE20010044A1 PE2000000365A PE0003652000A PE20010044A1 PE 20010044 A1 PE20010044 A1 PE 20010044A1 PE 2000000365 A PE2000000365 A PE 2000000365A PE 0003652000 A PE0003652000 A PE 0003652000A PE 20010044 A1 PE20010044 A1 PE 20010044A1
- Authority
- PE
- Peru
- Prior art keywords
- polymorph
- diona
- pyridyl
- ethoxy
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
SE REFIERE A UNA FORMA POLIMORFICA DE LA SAL DEL ACIDO MALEICO DE 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA AISLADO EN FORMA PURA, CRISTALINA CARACTERIZADO POR SUS PROPIEDADES FISICAS: ESPECTRO INFRARROJO, ESPECTRO RAMAN, ESPECTRO DE RESONANCIA MAGNETICA NUCLEAR, PATRON DE DIFRACCION DE RAYOS X. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE: a) EL COMPUESTO SE SUSPENDE EN ACETONA Y SE AGITA A UNA TEMPERATURA ELEVADA DURANTE UN PERIODO DE TIEMPO PROLONGADO; b) SE SIEMBRA EL COMPUESTO EN ETANOL DESNATURALIZADO A UNA TEMPERATURA ELEVADA CON CRISTALES DEL POLIMORFO, ENTONCES SE ENFRIA LA MEZCLA DE REACCION PARA PROPORCIONAR EL POLIMORFO, DESPUES DE LO CUAL SE RECUPERA EL POLIMORFO DEL ETANOL DESNATURALIZADO. EL POLIMORFO DE LA SAL DEL ACIDO MALEICO DE 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA ES UTIL PARA EL TRATAMIENTO DE DIABETES MELLITUS Y SUS COMPLICACIONES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9909473.2A GB9909473D0 (en) | 1999-04-23 | 1999-04-23 | Novel compounds |
GBGB9912196.4A GB9912196D0 (en) | 1999-05-25 | 1999-05-25 | Novel pharmaceutical |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010044A1 true PE20010044A1 (es) | 2001-03-10 |
Family
ID=26315461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000365A PE20010044A1 (es) | 1999-04-23 | 2000-04-19 | Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona |
Country Status (40)
Country | Link |
---|---|
US (2) | US6806280B1 (es) |
EP (2) | EP1304330A3 (es) |
JP (1) | JP2002543077A (es) |
KR (1) | KR100744360B1 (es) |
CN (1) | CN1167702C (es) |
AP (1) | AP1598A (es) |
AR (2) | AR023561A1 (es) |
AT (1) | ATE246191T1 (es) |
AU (1) | AU765005B2 (es) |
BG (1) | BG65485B1 (es) |
BR (1) | BR0009932A (es) |
CA (1) | CA2370280A1 (es) |
CO (1) | CO5170421A1 (es) |
CZ (1) | CZ20013800A3 (es) |
DE (1) | DE60004196T2 (es) |
DK (1) | DK1173435T3 (es) |
DZ (1) | DZ3156A1 (es) |
EA (1) | EA004541B1 (es) |
ES (1) | ES2203453T3 (es) |
HK (1) | HK1045153B (es) |
HR (1) | HRP20010772B1 (es) |
HU (1) | HUP0200931A3 (es) |
IL (1) | IL146111A0 (es) |
MA (1) | MA25356A1 (es) |
MX (1) | MXPA01010821A (es) |
MY (1) | MY131973A (es) |
NO (1) | NO320574B1 (es) |
NZ (1) | NZ515168A (es) |
OA (1) | OA11872A (es) |
PE (1) | PE20010044A1 (es) |
PL (1) | PL351684A1 (es) |
PT (1) | PT1173435E (es) |
SK (1) | SK286427B6 (es) |
TR (1) | TR200103062T2 (es) |
TW (1) | TWI283677B (es) |
UA (1) | UA67844C2 (es) |
UY (1) | UY26121A1 (es) |
WO (1) | WO2000064896A1 (es) |
YU (1) | YU75301A (es) |
ZA (1) | ZA200108719B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
PL351684A1 (en) * | 1999-04-23 | 2003-06-02 | Smithkline Beecham Plc | Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt |
WO2000064892A2 (en) | 1999-04-23 | 2000-11-02 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
GB0006133D0 (en) | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
US7241895B2 (en) | 2000-09-26 | 2007-07-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
BR0114196A (pt) * | 2000-09-26 | 2003-07-22 | Reddy S Res Foundation | Formas polimórficas de maleato de 5-[4-[2-[n-metil-n-(2-piridil) amino]etóxi]benzil]tiazolidina-2,4-diona e processo para a preparação das mesmas. |
KR100673140B1 (ko) * | 2002-04-19 | 2007-01-22 | 파에스 파마, 에스.에이. | 4-[2-[4-[1-(2-에톡시에틸)-1H-벤즈이미다졸-2-일] -1-피페리디닐]에틸]- α,α-디메틸- 벤젠아세틱 애시드의 동질이상체 |
GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
EP1468997A3 (en) * | 2003-04-18 | 2004-11-03 | CHEMI S.p.A. | Polymorphous forms of rosiglitazone maleate |
GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
EP1709038A2 (en) * | 2004-01-28 | 2006-10-11 | Usv Limited | A process for the preparation of 5- 4- 2- n-methyl -n-(2-pyridyl) amino ethoxy phenyl methyl thiaz olidine-2, 4-dione maleate |
ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
US20090076093A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched rosiglitazone |
EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | 4−[2−[1−(2−エトキシエチル)−1H−ベンズイミダゾール−2−イル]−1−ピペリジニル]エチル]−α,α−ジメチルベンゼノ酢酸の多形体 |
JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Jak激酶家族之小分子抑制劑 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3856378T2 (de) | 1987-09-04 | 2000-05-11 | Beecham Group Plc | Substituierte Thiazolidindionderivate |
GB9124513D0 (en) | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
US5741803A (en) | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
GB9218830D0 (en) | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
US5478852C1 (en) * | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
DE4404198A1 (de) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | 2-Fluor-6-nitroaniline |
UY24886A1 (es) * | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
GB9711683D0 (en) * | 1997-06-05 | 1997-08-06 | Smithkline Beecham Plc | Composition |
US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
GB9726566D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
GB9726563D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
US6613785B2 (en) * | 1998-07-21 | 2003-09-02 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing post-ischemic injury of the heart |
PL351684A1 (en) * | 1999-04-23 | 2003-06-02 | Smithkline Beecham Plc | Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt |
EP1175418A2 (en) | 1999-04-23 | 2002-01-30 | Smithkline Beecham Plc | Thiazolidinedione derivative and its use as antidiabetic |
WO2000064892A2 (en) | 1999-04-23 | 2000-11-02 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
CN1277965A (zh) | 2000-06-14 | 2000-12-27 | 中国医药研究开发中心 | 盐酸罗格列酮及其应用 |
BR0114196A (pt) | 2000-09-26 | 2003-07-22 | Reddy S Res Foundation | Formas polimórficas de maleato de 5-[4-[2-[n-metil-n-(2-piridil) amino]etóxi]benzil]tiazolidina-2,4-diona e processo para a preparação das mesmas. |
-
2000
- 2000-04-19 PL PL00351684A patent/PL351684A1/xx not_active Application Discontinuation
- 2000-04-19 PT PT00920892T patent/PT1173435E/pt unknown
- 2000-04-19 ES ES00920892T patent/ES2203453T3/es not_active Expired - Lifetime
- 2000-04-19 EP EP02080321A patent/EP1304330A3/en not_active Withdrawn
- 2000-04-19 CA CA002370280A patent/CA2370280A1/en not_active Abandoned
- 2000-04-19 MX MXPA01010821A patent/MXPA01010821A/es active IP Right Grant
- 2000-04-19 PE PE2000000365A patent/PE20010044A1/es not_active Application Discontinuation
- 2000-04-19 NZ NZ515168A patent/NZ515168A/xx unknown
- 2000-04-19 IL IL14611100A patent/IL146111A0/xx unknown
- 2000-04-19 CO CO00028929A patent/CO5170421A1/es not_active Application Discontinuation
- 2000-04-19 KR KR1020017013540A patent/KR100744360B1/ko not_active IP Right Cessation
- 2000-04-19 HU HU0200931A patent/HUP0200931A3/hu unknown
- 2000-04-19 TR TR2001/03062T patent/TR200103062T2/xx unknown
- 2000-04-19 OA OA1200100276A patent/OA11872A/en unknown
- 2000-04-19 EP EP00920892A patent/EP1173435B1/en not_active Expired - Lifetime
- 2000-04-19 CZ CZ20013800A patent/CZ20013800A3/cs unknown
- 2000-04-19 US US10/048,123 patent/US6806280B1/en not_active Expired - Fee Related
- 2000-04-19 EA EA200101121A patent/EA004541B1/ru not_active IP Right Cessation
- 2000-04-19 JP JP2000614248A patent/JP2002543077A/ja active Pending
- 2000-04-19 AR ARP000101862A patent/AR023561A1/es unknown
- 2000-04-19 UA UA2001117939A patent/UA67844C2/uk unknown
- 2000-04-19 AU AU41308/00A patent/AU765005B2/en not_active Ceased
- 2000-04-19 SK SK1492-2001A patent/SK286427B6/sk not_active IP Right Cessation
- 2000-04-19 AR ARP000101867A patent/AR023565A1/es unknown
- 2000-04-19 WO PCT/GB2000/001520 patent/WO2000064896A1/en not_active Application Discontinuation
- 2000-04-19 AP APAP/P/2001/002330A patent/AP1598A/en active
- 2000-04-19 YU YU75301A patent/YU75301A/sh unknown
- 2000-04-19 DE DE60004196T patent/DE60004196T2/de not_active Expired - Fee Related
- 2000-04-19 BR BR0009932-5A patent/BR0009932A/pt not_active Application Discontinuation
- 2000-04-19 AT AT00920892T patent/ATE246191T1/de not_active IP Right Cessation
- 2000-04-19 CN CNB008091463A patent/CN1167702C/zh not_active Expired - Fee Related
- 2000-04-19 DZ DZ003156A patent/DZ3156A1/xx active
- 2000-04-19 DK DK00920892T patent/DK1173435T3/da active
- 2000-04-21 MY MYPI20001708A patent/MY131973A/en unknown
- 2000-04-24 UY UY26121A patent/UY26121A1/es not_active Application Discontinuation
- 2000-05-11 TW TW089108962A patent/TWI283677B/zh not_active IP Right Cessation
-
2001
- 2001-10-22 NO NO20015147A patent/NO320574B1/no unknown
- 2001-10-22 HR HR20010772A patent/HRP20010772B1/xx not_active IP Right Cessation
- 2001-10-22 MA MA26378A patent/MA25356A1/fr unknown
- 2001-10-23 ZA ZA200108719A patent/ZA200108719B/en unknown
- 2001-11-20 BG BG106121A patent/BG65485B1/bg unknown
-
2002
- 2002-06-28 HK HK02104879.6A patent/HK1045153B/zh not_active IP Right Cessation
-
2004
- 2004-09-08 US US10/935,939 patent/US20050080114A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |