PE16999A1 - Compuestos para inhibir la liberacion de peptido �-amiloide y/o su sintesis - Google Patents

Compuestos para inhibir la liberacion de peptido �-amiloide y/o su sintesis

Info

Publication number: PE16999A1
Authority: PE; Peru
Prior art keywords: cycloalkyl; aryl; alkyl; heterocycle; heteroaryl
Prior art date: 1996-11-22

Application number

PE1997001056A

Other languages

English (en)

Spanish (es)

Inventor

James E Audia

Thomas C Britton

Beverly K Folmer

Varghese John

Thomas E Mabry

Warren J Porter

Eugene D Thorsett

Jing Wu

William Leonard Scott

Clark Norman Eid

Jay S Tung

Jon K Reel

Jeffrey S Nissen

Lee H Latimer

George W Huffman

James J Droste

Original Assignee

Athena Neurosciences Inc

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-22

Filing date

1997-11-20

Publication date

1999-02-19

1997-11-20 Application filed by Athena Neurosciences Inc, Lilly Co Eli filed Critical Athena Neurosciences Inc

1999-02-19 Publication of PE16999A1 publication Critical patent/PE16999A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PE1997001056A 1996-11-22 1997-11-20 Compuestos para inhibir la liberacion de peptido �-amiloide y/o su sintesis PE16999A1 (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US75544296A	1996-11-22	1996-11-22
US80742797A	1997-02-28	1997-02-28
US80852897A	1997-02-28	1997-02-28
US80752897A	1997-02-28	1997-02-28

Publications (1)

Publication Number	Publication Date
PE16999A1 true PE16999A1 (es)	1999-02-19

Family

ID=27505670

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1997001056A PE16999A1 (es)	1996-11-22	1997-11-20	Compuestos para inhibir la liberacion de peptido �-amiloide y/o su sintesis

Country Status (21)

Country	Link
EP (1)	EP0942924A2 (fr)
JP (1)	JP2001503782A (fr)
KR (1)	KR20000069064A (fr)
CN (1)	CN1238779A (fr)
AR (1)	AR016751A1 (fr)
AU (1)	AU5356198A (fr)
BR (1)	BR9713400A (fr)
CA (1)	CA2267634A1 (fr)
CO (1)	CO4910156A1 (fr)
CZ (1)	CZ122899A3 (fr)
EA (1)	EA199900490A1 (fr)
HR (1)	HRP970627A2 (fr)
HU (1)	HUP0100270A3 (fr)
ID (1)	ID22044A (fr)
IL (1)	IL129083A0 (fr)
NO (1)	NO992368L (fr)
NZ (1)	NZ334690A (fr)
PE (1)	PE16999A1 (fr)
TR (3)	TR199902938T2 (fr)
WO (1)	WO1998022494A2 (fr)
YU (1)	YU46097A (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122010000020I1 (de)	1996-04-25	2010-07-08	Prosidion Ltd	Verfahren zur Senkung des Blutglukosespiegels in Säugern
US6191166B1 (en) *	1997-11-21	2001-02-20	Elan Pharmaceuticals, Inc.	Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
DE19823831A1 (de)	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
AU4707999A (en) *	1998-06-22	2000-01-10	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
WO1999066934A1 (fr) *	1998-06-22	1999-12-29	Elan Pharmaceuticals, Inc.	COMPOSES D'ACIDES AMINES CYCLIQUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET METHODES D'INHIBITION DE LA LIBERATION DU PEPTIDE β-AMYLOIDE ET/OU DE SA SYNTHESE A L'AIDE DE CES COMPOSES
US6958330B1 (en)	1998-06-22	2005-10-25	Elan Pharmaceuticals, Inc.	Polycyclic α-amino-ε-caprolactams and related compounds
JP2002518483A (ja) *	1998-06-22	2002-06-25	エランファーマシューティカルズ，インコーポレイテッド	β−アミロイドペプチド放出を阻害するための化合物および／またはその合成
DE19828114A1 (de)	1998-06-24	2000-01-27	Probiodrug Ges Fuer Arzneim	Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de) *	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de)	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
EP1131634A2 (fr) *	1998-09-30	2001-09-12	Elan Pharmaceuticals, Inc.	Reactifs biologiques et procedes servant a determiner le mecanisme implique dans la generation du peptide beta-amyloide
US6737038B1 (en)	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CA2352740A1 (fr)	1998-12-10	2000-06-15	F. Hoffmann-La Roche Ag	Inhibiteurs de la c-proteinase de procollagene
KR100767199B1 (ko) *	1999-05-07	2007-10-17	엔싸이시브 파마슈티칼즈 인코퍼레이티드	인테그린이 이의 수용체에 결합하는 것을 억제하는프로판산 유도체
US6972296B2 (en)	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en)	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
DE19926233C1 (de)	1999-06-10	2000-10-19	Probiodrug Ges Fuer Arzneim	Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de)	1999-08-24	2001-03-01	Probiodrug Ges Fuer Arzneim	Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
EP1235789A2 (fr) *	1999-11-09	2002-09-04	Eli Lilly And Company	COMPOSES CONTENANT DES $g(b)-ACIDES AMINES UTILES POUR INHIBER LA LIBERATION ET/OU LA SYNTHESE DU PEPTIDE $g(b)-AMYLOIDE
ES2525041T3 (es)	2000-03-31	2014-12-16	Royalty Pharma Collection Trust	Método para la mejora de la señalización de islotes en diabetes mellitus y para su prevención
US6878363B2 (en)	2000-05-17	2005-04-12	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
BR0106717A (pt)	2000-06-01	2002-04-16	Bristol Myers Squibb Pharma Co	Compostos, composição farmacêutica e usos dos compostos de lactama inovadora
FR2832152A1 (fr) *	2001-11-09	2003-05-16	Aventis Pharma Sa	Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible
GB0016681D0 (en)	2000-07-06	2000-08-23	Merck Sharp & Dohme	Therapeutic compounds
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
US7132104B1 (en)	2000-10-27	2006-11-07	Probiodrug Ag	Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US6890905B2 (en)	2001-04-02	2005-05-10	Prosidion Limited	Methods for improving islet signaling in diabetes mellitus and for its prevention
DE10150203A1 (de)	2001-10-12	2003-04-17	Probiodrug Ag	Peptidylketone als Inhibitoren der DPIV
US20030130199A1 (en)	2001-06-27	2003-07-10	Von Hoersten Stephan	Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7368421B2 (en)	2001-06-27	2008-05-06	Probiodrug Ag	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
FR2840899B1 (fr) *	2002-06-12	2005-02-25	Sanofi Synthelabo	Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
AR039059A1 (es) *	2001-08-06	2005-02-09	Sanofi Aventis	Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios
DE10143840A1 (de) *	2001-09-06	2003-03-27	Probiodrug Ag	Neue Inhibitoren der Dipeptidylpeptidase I
US6844316B2 (en)	2001-09-06	2005-01-18	Probiodrug Ag	Inhibitors of dipeptidyl peptidase I
JP2005526005A (ja)	2001-11-09	2005-09-02	アベンティス・ファーマ・ソシエテ・アノニム	誘導型ｎｏシンターゼの阻害剤としての２−アミノ−チアゾリン誘導体及びその使用
IL163629A0 (en)	2002-02-28	2005-12-18	Prosidion Ltd	Glutaminyl derivatives and pharmaceutical compositions containing the same
WO2004062601A2 (fr) *	2003-01-08	2004-07-29	Chiron Corporation	Agents antibacteriens
EP1620091B1 (fr)	2003-05-05	2010-03-31	Probiodrug AG	Inhibiteurs de glutaminyl-cyclase
KR20100038477A (ko)	2003-05-05	2010-04-14	프로비오드룩 아게	글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
EP1666068A4 (fr) *	2003-09-24	2010-08-04	Santen Pharmaceutical Co Ltd	Remede pour maladies des yeux accompagnees de blessures du nerf optique
WO2005039548A2 (fr)	2003-10-15	2005-05-06	Probiodrug Ag	Utilisation d'effecteurs de cyclases du glutaminyle et du glutamate
EP2170814B1 (fr)	2007-06-12	2016-08-17	Achaogen, Inc.	Agents antibacteriens
EP2062909A1 (fr) *	2007-11-21	2009-05-27	SOLVAY (Société Anonyme)	Production de peptides et procédé de purification
BG110141A (en)	2008-05-23	2009-12-31	"Софарма" Ад	GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
EP2847168A1 (fr)	2012-05-10	2015-03-18	Achaogen, Inc.	Agents antibactériens
WO2017004560A1 (fr) *	2015-07-02	2017-01-05	The Regents Of The University Of California	Procédés et compositions pour des agrégats amyloïdes
US20240010642A1 (en) *	2021-01-05	2024-01-11	Southern Research Institute	Modulators of programmed death-ligand-1

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CA2077665A1 (fr) *	1990-03-05	1991-09-06	Robert Siman	Proteases analogues a la chymotrypsine et leurs inhibiteurs
WO1995013084A1 (fr) *	1992-05-11	1995-05-18	Miles Inc.	Identification de la cathepsine d comme protease amyloïdogene de la maladie d'alzheimer
CZ184194A3 (en) *	1993-08-09	1995-03-15	Lilly Co Eli	Aspartylprotease inhibitor and method of identifying thereof
EP0721449B1 (fr) *	1993-10-01	2001-12-19	Merrell Pharmaceuticals Inc.	Inhibiteurs de la production de proteines de beta-amyloide
US5872101A (en) *	1995-01-06	1999-02-16	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
CA2221684A1 (fr) *	1995-06-06	1996-12-12	Athena Neurosciences, Inc.	Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/es not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/hr not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/es not_active Application Discontinuation
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/pt not_active IP Right Cessation
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/xx unknown
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/cs unknown
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/ko not_active Application Discontinuation
- 1997-11-21 EP EP97950601A patent/EP0942924A2/fr not_active Withdrawn
- 1997-11-21 CO CO97068215A patent/CO4910156A1/es unknown
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/xx unknown
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/hu unknown
- 1997-11-21 CN CN97199803A patent/CN1238779A/zh active Pending
- 1997-11-21 IL IL12908397A patent/IL129083A0/xx unknown
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/fr not_active Application Discontinuation
- 1997-11-21 ID IDW990394A patent/ID22044A/id unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/ja active Pending
- 1997-11-21 CA CA002267634A patent/CA2267634A1/fr not_active Abandoned
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 YU YU46097A patent/YU46097A/sh unknown
- 1997-11-21 EA EA199900490A patent/EA199900490A1/ru unknown
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/xx unknown
1999
- 1999-05-14 NO NO992368A patent/NO992368L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1238779A (zh)	1999-12-15
CO4910156A1 (es)	2000-04-24
WO1998022494A3 (fr)	1998-11-26
TR199902937T2 (xx)	2001-01-22
NO992368L (no)	1999-06-21
EA199900490A1 (ru)	2000-02-28
CA2267634A1 (fr)	1998-05-28
BR9713400A (pt)	2000-01-25
NO992368D0 (no)	1999-05-14
HRP970627A2 (en)	1998-08-31
CZ122899A3 (cs)	1999-10-13
HUP0100270A3 (en)	2001-09-28
TR199901133T2 (xx)	1999-07-21
NZ334690A (en)	2001-09-28
AU5356198A (en)	1998-06-10
ID22044A (id)	1999-08-26
IL129083A0 (en)	2000-02-17
KR20000069064A (ko)	2000-11-25
EP0942924A2 (fr)	1999-09-22
TR199902938T2 (xx)	2002-06-21
AR016751A1 (es)	2001-08-01
HUP0100270A2 (hu)	2001-08-28
JP2001503782A (ja)	2001-03-21
YU46097A (sh)	2000-10-30
WO1998022494A2 (fr)	1998-05-28

Legal Events

Date	Code	Title	Description
2003-01-14	FC	Refusal

Publication	Publication Date	Title
PE16999A1 (es)	1999-02-19	Compuestos para inhibir la liberacion de peptido �-amiloide y/o su sintesis
PE106499A1 (es)	1999-10-30	Antagonistas del receptor ccr-3
MX165512B (es)	1992-11-17	Aditivo de carbamato para composicion lubricante
PE20011047A1 (es)	2001-11-06	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas
TR200002671T2 (tr)	2000-12-21	Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler
ES2106783T3 (es)	1997-11-16	1-benzopiran-4-onas y 2-amino-1,3-benzoxacin-4-onas antiarterosclerosis y antitromboticas.
AR006720A1 (es)	1999-09-08	Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende
PE20001303A1 (es)	2000-11-30	Derivados de la 4-aroilpiperidina como antagonistas del receptor ccr-3
ES2058089T3 (es)	1994-11-01	Un procedimiento para la preparacion de un nuevo derivado de prolinal.
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