CO4910156A1 - Metodos y composiciones para inhibir la liberacion de pepti- do beta-amiloide y/o su sintesis - Google Patents
Metodos y composiciones para inhibir la liberacion de pepti- do beta-amiloide y/o su sintesisInfo
- Publication number
- CO4910156A1 CO4910156A1 CO97068215A CO97068215A CO4910156A1 CO 4910156 A1 CO4910156 A1 CO 4910156A1 CO 97068215 A CO97068215 A CO 97068215A CO 97068215 A CO97068215 A CO 97068215A CO 4910156 A1 CO4910156 A1 CO 4910156A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- alkyl
- group
- aryl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75544296A | 1996-11-22 | 1996-11-22 | |
US80852897A | 1997-02-28 | 1997-02-28 | |
US80752897A | 1997-02-28 | 1997-02-28 | |
US80742797A | 1997-02-28 | 1997-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4910156A1 true CO4910156A1 (es) | 2000-04-24 |
Family
ID=27505670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97068215A CO4910156A1 (es) | 1996-11-22 | 1997-11-21 | Metodos y composiciones para inhibir la liberacion de pepti- do beta-amiloide y/o su sintesis |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0942924A2 (fr) |
JP (1) | JP2001503782A (fr) |
KR (1) | KR20000069064A (fr) |
CN (1) | CN1238779A (fr) |
AR (1) | AR016751A1 (fr) |
AU (1) | AU5356198A (fr) |
BR (1) | BR9713400A (fr) |
CA (1) | CA2267634A1 (fr) |
CO (1) | CO4910156A1 (fr) |
CZ (1) | CZ122899A3 (fr) |
EA (1) | EA199900490A1 (fr) |
HR (1) | HRP970627A2 (fr) |
HU (1) | HUP0100270A3 (fr) |
ID (1) | ID22044A (fr) |
IL (1) | IL129083A0 (fr) |
NO (1) | NO992368L (fr) |
NZ (1) | NZ334690A (fr) |
PE (1) | PE16999A1 (fr) |
TR (3) | TR199902937T2 (fr) |
WO (1) | WO1998022494A2 (fr) |
YU (1) | YU46097A (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
JP2002518483A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ,インコーポレイテッド | β−アミロイドペプチド放出を阻害するための化合物および/またはその合成 |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
WO1999066934A1 (fr) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | COMPOSES D'ACIDES AMINES CYCLIQUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET METHODES D'INHIBITION DE LA LIBERATION DU PEPTIDE β-AMYLOIDE ET/OU DE SA SYNTHESE A L'AIDE DE CES COMPOSES |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
EP1089977A1 (fr) * | 1998-06-22 | 2001-04-11 | Elan Pharmaceuticals, Inc. | Composes destines a inhiber la liberation et/ou la synthese du peptide beta-amyloide |
DE19828113A1 (de) * | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
US6486350B1 (en) | 1998-09-30 | 2002-11-26 | Elan Pharmaceuticals Inc. | Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
JP2002531576A (ja) | 1998-12-10 | 2002-09-24 | エフ.ホフマン−ラ ロシュ アーゲー | プロコラーゲンc−プロテイナーゼ阻害剤 |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
RO121640B1 (ro) * | 1999-05-07 | 2008-01-30 | Texas Biotechnology Corporation | Derivaţi de acid propionic ce inhibă legarea integrinelor de receptorii acestora, compoziţie farmaceutică ce îi conţine şi utilizare a acesteia |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
WO2001034639A2 (fr) * | 1999-11-09 | 2001-05-17 | Eli Lilly And Company | COMPOSES CONTENANT DES β-ACIDES AMINES UTILES POUR INHIBER LA LIBERATION ET/OU LA SYNTHESE DU PEPTIDE β-AMYLOIDE |
EP2055302B1 (fr) | 2000-03-31 | 2014-09-10 | Royalty Pharma Collection Trust | Procédé d'amélioration de signalisation d'îlots dans le diabète sucré et pour sa prévention |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
FR2832152A1 (fr) * | 2001-11-09 | 2003-05-16 | Aventis Pharma Sa | Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible |
GB0016681D0 (en) | 2000-07-06 | 2000-08-23 | Merck Sharp & Dohme | Therapeutic compounds |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
FR2840899B1 (fr) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
DE10143840A1 (de) * | 2001-09-06 | 2003-03-27 | Probiodrug Ag | Neue Inhibitoren der Dipeptidylpeptidase I |
BR0206354A (pt) | 2001-11-09 | 2003-12-23 | Aventis Pharma Sa | Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvel |
SK3622004A3 (sk) | 2002-02-28 | 2005-02-04 | Prosidion Limited | Inhibítory DPIV na báze glutaminylu |
CN1777577B (zh) | 2003-01-08 | 2011-07-06 | 诺华疫苗和诊断公司 | 抗菌剂 |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
CN101837127A (zh) | 2003-05-05 | 2010-09-22 | 前体生物药物股份公司 | 谷氨酰胺酰基和谷氨酸环化酶效应物的应用 |
WO2005027969A1 (fr) * | 2003-09-24 | 2005-03-31 | Santen Pharmaceutical Co., Ltd. | Remede pour maladies des yeux accompagnees de blessures du nerf optique |
WO2005039548A2 (fr) | 2003-10-15 | 2005-05-06 | Probiodrug Ag | Utilisation d'effecteurs de cyclases du glutaminyle et du glutamate |
CN101765585B (zh) | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
EP2062909A1 (fr) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Production de peptides et procédé de purification |
BG110141A (en) | 2008-05-23 | 2009-12-31 | "Софарма" Ад | GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE |
WO2013170165A1 (fr) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Agents antibactériens |
WO2017004560A1 (fr) * | 2015-07-02 | 2017-01-05 | The Regents Of The University Of California | Procédés et compositions pour des agrégats amyloïdes |
US20240010642A1 (en) * | 2021-01-05 | 2024-01-11 | Southern Research Institute | Modulators of programmed death-ligand-1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0518955A4 (en) * | 1990-03-05 | 1993-09-22 | Cephalon, Inc. | Chymotrypsin-like proteases and their inhibitors |
WO1995013084A1 (fr) * | 1992-05-11 | 1995-05-18 | Miles Inc. | Identification de la cathepsine d comme protease amyloïdogene de la maladie d'alzheimer |
IL110525A0 (en) * | 1993-08-09 | 1994-11-11 | Lilly Co Eli | Identification and use of protease inhibitors |
AU687449B2 (en) * | 1993-10-01 | 1998-02-26 | Aventis Inc. | Inhibitors of beta-amyloid protein production |
US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
CA2221684A1 (fr) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine |
-
1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/es not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/hr not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/es not_active Application Discontinuation
- 1997-11-21 CN CN97199803A patent/CN1238779A/zh active Pending
- 1997-11-21 CA CA002267634A patent/CA2267634A1/fr not_active Abandoned
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/cs unknown
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 EP EP97950601A patent/EP0942924A2/fr not_active Withdrawn
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/xx unknown
- 1997-11-21 ID IDW990394A patent/ID22044A/id unknown
- 1997-11-21 EA EA199900490A patent/EA199900490A1/ru unknown
- 1997-11-21 YU YU46097A patent/YU46097A/sh unknown
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/fr not_active Application Discontinuation
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/ko not_active Application Discontinuation
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/xx unknown
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 IL IL12908397A patent/IL129083A0/xx unknown
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/pt not_active IP Right Cessation
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/hu unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/ja active Pending
- 1997-11-21 CO CO97068215A patent/CO4910156A1/es unknown
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/xx unknown
-
1999
- 1999-05-14 NO NO992368A patent/NO992368L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TR199902938T2 (xx) | 2002-06-21 |
TR199901133T2 (xx) | 1999-07-21 |
WO1998022494A3 (fr) | 1998-11-26 |
IL129083A0 (en) | 2000-02-17 |
EA199900490A1 (ru) | 2000-02-28 |
KR20000069064A (ko) | 2000-11-25 |
NO992368L (no) | 1999-06-21 |
AR016751A1 (es) | 2001-08-01 |
JP2001503782A (ja) | 2001-03-21 |
NO992368D0 (no) | 1999-05-14 |
AU5356198A (en) | 1998-06-10 |
NZ334690A (en) | 2001-09-28 |
CA2267634A1 (fr) | 1998-05-28 |
HRP970627A2 (en) | 1998-08-31 |
PE16999A1 (es) | 1999-02-19 |
BR9713400A (pt) | 2000-01-25 |
WO1998022494A2 (fr) | 1998-05-28 |
TR199902937T2 (xx) | 2001-01-22 |
CZ122899A3 (cs) | 1999-10-13 |
ID22044A (id) | 1999-08-26 |
HUP0100270A3 (en) | 2001-09-28 |
YU46097A (sh) | 2000-10-30 |
HUP0100270A2 (hu) | 2001-08-28 |
CN1238779A (zh) | 1999-12-15 |
EP0942924A2 (fr) | 1999-09-22 |
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