PE20001303A1 - Derivados de la 4-aroilpiperidina como antagonistas del receptor ccr-3 - Google Patents
Derivados de la 4-aroilpiperidina como antagonistas del receptor ccr-3Info
- Publication number
- PE20001303A1 PE20001303A1 PE1999001151A PE00115199A PE20001303A1 PE 20001303 A1 PE20001303 A1 PE 20001303A1 PE 1999001151 A PE1999001151 A PE 1999001151A PE 00115199 A PE00115199 A PE 00115199A PE 20001303 A1 PE20001303 A1 PE 20001303A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aroylpiperidine
- ccr
- aralkyl
- heteroaryl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000004499 CCR3 Receptors Human genes 0.000 title 1
- 108010017316 CCR3 Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 abstract 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 4-AROILPIPERIDINA DE FORMULA I, DONDE: Ar1 Y Ar2 SON ARILO o HETEROARILO; R Y R1 SON H, ALQUILO; R2 ES ALQUILO C3-C6, HETEROALQUILO, ARILO, ARALQUILO, HETEROARILO, HETEROARILALQUILO, HETEROCICLILALQUILO, ALQUILENO-CO-Z; Z ES ALQUILO, HALOALQUILO, ALCOXILO, HALOALQUILOXILO, HIDROXILO, AMINO, ARILO, ARALQUILO, ARILOXILO, ARALQUILOXILO, HETEROARILO, HETEROARILOXILO, HETEROARALQUILOXILO; X ES CONR3, NR4CONR3, NR4CSNR3, SO2NR3, NR4SO2NR3; R2 Y R4 SON H, ALQUILO, ARALQUILO, HETEROARALQUILO, HETEROCICLOALQUILO, ENTRE OTROS; Y ES UN ENLACE, ALQUILENO C1-C3. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR DE LA QUIMIOCINA CCR-3 POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DEL ASMA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10879698P | 1998-11-17 | 1998-11-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001303A1 true PE20001303A1 (es) | 2000-11-30 |
Family
ID=22324087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999001151A PE20001303A1 (es) | 1998-11-17 | 1999-11-12 | Derivados de la 4-aroilpiperidina como antagonistas del receptor ccr-3 |
Country Status (22)
Country | Link |
---|---|
US (1) | US6140344A (es) |
EP (1) | EP1131291B1 (es) |
JP (1) | JP3475177B2 (es) |
KR (1) | KR20010087395A (es) |
CN (1) | CN1163484C (es) |
AR (1) | AR029150A1 (es) |
AT (1) | ATE280157T1 (es) |
AU (1) | AU757747B2 (es) |
BR (1) | BR9915403A (es) |
CA (1) | CA2350722A1 (es) |
CO (1) | CO5150176A1 (es) |
DE (2) | DE69921351T2 (es) |
ES (2) | ES2230899T3 (es) |
FR (1) | FR2785902B1 (es) |
GB (1) | GB2343891B (es) |
IT (1) | IT1307062B1 (es) |
PE (1) | PE20001303A1 (es) |
PT (1) | PT1131291E (es) |
TR (1) | TR200101155T2 (es) |
UY (1) | UY25804A1 (es) |
WO (1) | WO2000029377A1 (es) |
ZA (1) | ZA200103249B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1140086A4 (en) * | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
EP1158980B1 (en) * | 1998-12-18 | 2005-08-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
CA2346933A1 (en) * | 1998-12-18 | 2000-06-22 | Dupont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
BR0009338A (pt) | 1999-03-26 | 2001-12-26 | Astrazeneca Ab | Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
TWI227231B (en) * | 2000-07-12 | 2005-02-01 | Novartis Ag | 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3 |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
CN1678594A (zh) | 2000-09-29 | 2005-10-05 | 葛兰素集团有限公司 | 用于治疗炎性疾病的吗啉-乙酰胺衍生物 |
FR2821356A1 (fr) | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
GB0114699D0 (en) | 2001-06-15 | 2001-08-08 | Novartis Ag | Organic compounds |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
SE0102809D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | Novel compounds |
TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
PL378753A1 (pl) * | 2003-02-27 | 2006-05-15 | F.Hoffmann-La Roche Ag | Antagoniści receptora CCR-3 |
BRPI0408332A (pt) | 2003-03-14 | 2006-03-21 | Ono Pharmaceutical Co | derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo |
US7498323B2 (en) | 2003-04-18 | 2009-03-03 | Ono Pharmaceuticals Co., Ltd. | Spiro-piperidine compounds and medicinal use thereof |
KR20060061393A (ko) * | 2003-10-24 | 2006-06-07 | 에프. 호프만-라 로슈 아게 | Ccr3 수용체 길항제 |
SE0400208D0 (sv) | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
CN101775013A (zh) | 2004-09-13 | 2010-07-14 | 小野药品工业株式会社 | 含氮杂环衍生物及含有其作为活性成分的药物 |
WO2006129679A1 (ja) | 2005-05-31 | 2006-12-07 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
PL1942108T3 (pl) | 2005-10-28 | 2014-03-31 | Ono Pharmaceutical Co | Związek zawierający grupę zasadową i jego zastosowanie |
ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
WO2007105637A1 (ja) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
JP5257068B2 (ja) | 2006-05-16 | 2013-08-07 | 小野薬品工業株式会社 | 保護されていてもよい酸性基を含有する化合物およびその用途 |
EP2055705A4 (en) | 2006-07-31 | 2014-08-20 | Ono Pharmaceutical Co | COMPOUND WITH A CYCLIC GROUP BOUND BY A SPIRO BINDING THEREOF AND APPLY THEREOF |
WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
EP2787346B1 (en) | 2011-11-28 | 2017-06-21 | National University Corporation Nagoya University | Biomarker for lymphocytic infundibuloneurohypophysitis, and use applications thereof |
JP7330949B2 (ja) * | 2017-09-13 | 2023-08-22 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性キノリン(チオ)カルボキサミド誘導体 |
CN111093372B (zh) * | 2017-09-13 | 2022-05-27 | 先正达参股股份有限公司 | 杀微生物的喹啉(硫代)羧酰胺衍生物 |
JP7150009B2 (ja) * | 2017-09-13 | 2022-10-07 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性キノリン(チオ)カルボキサミド誘導体 |
Family Cites Families (15)
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DK159420C (da) * | 1983-03-09 | 1991-03-11 | Ciba Geigy Ag | N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater |
IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
JPH041128A (ja) * | 1990-03-07 | 1992-01-06 | Ajinomoto Co Inc | 抗不整脈薬 |
US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
DK60893D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Piperidinderivater, deres fremstilling og anvendelse |
WO1995000481A1 (en) * | 1993-06-23 | 1995-01-05 | Merrell Dow Pharmaceuticals Inc. | Piperidin-1-yl-2,2-dialkylpropanonearylsulfonamide derivatives |
US5728835A (en) * | 1993-12-27 | 1998-03-17 | Toa Eiyo, Ltd. | Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same |
EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
JPH09249566A (ja) * | 1996-03-19 | 1997-09-22 | Takeda Chem Ind Ltd | ピペリジン化合物含有ケモカイン受容体拮抗剤 |
DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
US6133319A (en) * | 1996-06-27 | 2000-10-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6323206B1 (en) * | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO1999004794A1 (en) * | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
CA2318088A1 (en) * | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
-
1999
- 1999-11-08 CA CA002350722A patent/CA2350722A1/en not_active Abandoned
- 1999-11-08 CN CNB998131784A patent/CN1163484C/zh not_active Expired - Fee Related
- 1999-11-08 AT AT99953974T patent/ATE280157T1/de not_active IP Right Cessation
- 1999-11-08 JP JP2000582364A patent/JP3475177B2/ja not_active Expired - Fee Related
- 1999-11-08 TR TR2001/01155T patent/TR200101155T2/xx unknown
- 1999-11-08 AU AU10459/00A patent/AU757747B2/en not_active Ceased
- 1999-11-08 DE DE69921351T patent/DE69921351T2/de not_active Expired - Fee Related
- 1999-11-08 EP EP99953974A patent/EP1131291B1/en not_active Expired - Lifetime
- 1999-11-08 BR BR9915403-0A patent/BR9915403A/pt not_active IP Right Cessation
- 1999-11-08 PT PT99953974T patent/PT1131291E/pt unknown
- 1999-11-08 KR KR1020017006070A patent/KR20010087395A/ko not_active Application Discontinuation
- 1999-11-08 ES ES99953974T patent/ES2230899T3/es not_active Expired - Lifetime
- 1999-11-08 WO PCT/EP1999/008548 patent/WO2000029377A1/en not_active Application Discontinuation
- 1999-11-12 PE PE1999001151A patent/PE20001303A1/es not_active Application Discontinuation
- 1999-11-15 GB GB9926969A patent/GB2343891B/en not_active Expired - Fee Related
- 1999-11-15 FR FR9914276A patent/FR2785902B1/fr not_active Expired - Fee Related
- 1999-11-15 AR ARP990105788A patent/AR029150A1/es unknown
- 1999-11-16 UY UY25804A patent/UY25804A1/es unknown
- 1999-11-16 ES ES009902495A patent/ES2160525B1/es not_active Expired - Fee Related
- 1999-11-16 IT IT1999TO000990A patent/IT1307062B1/it active
- 1999-11-16 CO CO99071853A patent/CO5150176A1/es unknown
- 1999-11-17 DE DE19955340A patent/DE19955340A1/de not_active Withdrawn
- 1999-11-17 US US09/441,919 patent/US6140344A/en not_active Expired - Fee Related
-
2001
- 2001-04-20 ZA ZA200103249A patent/ZA200103249B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR200101155T2 (tr) | 2001-09-21 |
AU757747B2 (en) | 2003-03-06 |
KR20010087395A (ko) | 2001-09-15 |
ES2160525B1 (es) | 2002-06-16 |
ZA200103249B (en) | 2002-07-22 |
CN1326441A (zh) | 2001-12-12 |
AU1045900A (en) | 2000-06-05 |
JP3475177B2 (ja) | 2003-12-08 |
ITTO990990A1 (it) | 2001-05-16 |
WO2000029377A1 (en) | 2000-05-25 |
IT1307062B1 (it) | 2001-10-23 |
ATE280157T1 (de) | 2004-11-15 |
DE69921351T2 (de) | 2006-03-09 |
AR029150A1 (es) | 2003-06-18 |
GB9926969D0 (en) | 2000-01-12 |
FR2785902A1 (fr) | 2000-05-19 |
GB2343891B (en) | 2001-05-30 |
BR9915403A (pt) | 2001-08-14 |
EP1131291B1 (en) | 2004-10-20 |
CN1163484C (zh) | 2004-08-25 |
PT1131291E (pt) | 2005-01-31 |
US6140344A (en) | 2000-10-31 |
ES2230899T3 (es) | 2005-05-01 |
JP2002529531A (ja) | 2002-09-10 |
DE69921351D1 (de) | 2004-11-25 |
ES2160525A1 (es) | 2001-11-01 |
UY25804A1 (es) | 2001-07-31 |
DE19955340A1 (de) | 2000-05-31 |
CA2350722A1 (en) | 2000-05-25 |
CO5150176A1 (es) | 2002-04-29 |
EP1131291A1 (en) | 2001-09-12 |
ITTO990990A0 (it) | 1999-11-16 |
FR2785902B1 (fr) | 2003-09-26 |
GB2343891A (en) | 2000-05-24 |
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