PE10999A1 - Compuestos triciclicos sustituidos - Google Patents
Compuestos triciclicos sustituidosInfo
- Publication number
- PE10999A1 PE10999A1 PE1997000950A PE00095097A PE10999A1 PE 10999 A1 PE10999 A1 PE 10999A1 PE 1997000950 A PE1997000950 A PE 1997000950A PE 00095097 A PE00095097 A PE 00095097A PE 10999 A1 PE10999 A1 PE 10999A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- compounds
- formula
- piridyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 2
- -1 CYCLOHEXENYL Chemical class 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (III), EN DONDE: "A" ES FENILO O PIRIDILO; "B" Y "D" ES UNO N Y EL OTRO C; "Z" ES CICLOHEXENILO, FENILO, PIRIDILO, ENTRE OTROS; R20 ES a) ALQUILO, ALQUENILO, ALQUINILO C5-C20, CARBOCICLO O HETEROCICLO, b) ES (a) CON SUSTITUTOS NO INTERFERENTES o c) L-R80; "L" ES UN GRUPO ENLAZANTE DIVALENTE; R80 ES (a) o (b); R1` ES NHNH2, NH2; R2' ES OH o O(CH2)tR5; t ES 1-5; R5 ES CN, FENILO o La-GRUPO ACIDO; La ES UN LIGADOR ACIDO; R3' ES CARBOCICLO O HETEROCICLO; CON LA CONDICION DE QUE SI: R3' ES H; R20 ES BENCILO Y m ES 1-2, ENTONCES: R2' NO ES O(CH2)mH. TAMBIEN SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES NHNH2, NH2; R2 ES OH, O(CH2)mR5; R3 ES H, O-ALQUILO C1-C4 o (CH2)nR8; R4 ES H, ALQUILO C5-C14, CICLOALQUILO C3-C14, FENILO OPCIONALMENTE SUSTITUIDO; R5 ES H, CO2H, CO2-ALQUILO C1-C4, POR6R7, FENILO OPCIONALMENTE SUSTITUIDO CON CO2H o CO2-ALQUILO C1-C4; R6 Y R7 SON OH o O-ALQUILO C1-C4; R8 ES H, NR9R10, CONH2, CN o FENILO; R9 Y R10 ES ALQUILO C1-C4 o FENIL-ALQUILO C1-C4; m ES 1-3; n ES 1-8; "Z" ES CICLOHEXENILO o FENILO. LOS COMPUESTOS DE FORMULA (III) Y (I) ACTUAN INHIBIENDO LA LIBERACION DE ACIDOS GRASOS PRODUCIDA POR LA ENZIMA FOSFOLIPASA SECRETORA NO PANCREATICA HUMANA sPLA2, SIENDO UTILES EN EL TRATAMIENTO DEL SHOCK SEPTICO, SINDROME DE DIFICULTAD RESPIRATORIA EN ADULTOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2984996P | 1996-10-30 | 1996-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE10999A1 true PE10999A1 (es) | 1999-02-10 |
Family
ID=21851210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000950A PE10999A1 (es) | 1996-10-30 | 1997-10-24 | Compuestos triciclicos sustituidos |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0839806B1 (es) |
| JP (1) | JP2001503055A (es) |
| KR (1) | KR20000049210A (es) |
| CN (1) | CN1233176A (es) |
| AR (1) | AR010050A1 (es) |
| AT (1) | ATE244703T1 (es) |
| AU (1) | AU734096B2 (es) |
| BR (1) | BR9713261A (es) |
| CA (1) | CA2269203A1 (es) |
| CO (1) | CO4920250A1 (es) |
| CZ (1) | CZ136899A3 (es) |
| DE (1) | DE69723393T2 (es) |
| DK (1) | DK0839806T3 (es) |
| EA (1) | EA003992B1 (es) |
| ES (1) | ES2202560T3 (es) |
| ID (1) | ID18685A (es) |
| IL (1) | IL129481A0 (es) |
| NO (1) | NO314899B1 (es) |
| NZ (1) | NZ335246A (es) |
| PE (1) | PE10999A1 (es) |
| PL (1) | PL332896A1 (es) |
| PT (1) | PT839806E (es) |
| TR (1) | TR199900956T2 (es) |
| TW (1) | TW513428B (es) |
| WO (1) | WO1998018464A1 (es) |
| YU (1) | YU19299A (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1011670A4 (en) * | 1997-08-28 | 2004-10-27 | Lilly Co Eli | PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS |
| CN1303384A (zh) | 1998-03-31 | 2001-07-11 | 盐野义制药株式会社 | 吡咯并[1,2－a]吡嗪sPLA2抑制剂 |
| ID23219A (id) * | 1998-04-17 | 2000-03-30 | Lilly Co Eli | Trisiklik tersubstitusi |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| BR9910095A (pt) | 1998-05-01 | 2000-12-26 | Lilly Co Eli | Compostos inibidores de spla2 para tratamento de doença |
| CN1302300A (zh) | 1998-05-21 | 2001-07-04 | 盐野义制药株式会社 | 吡咯并[1,2－b]哒嗪sPLA2抑制剂 |
| DE69931963D1 (de) * | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| US6448284B1 (en) * | 1998-12-22 | 2002-09-10 | Eli Lilly And Company | Substituted tricyclics |
| WO2001005789A1 (fr) | 1999-07-19 | 2001-01-25 | Shionogi & Co., Ltd. | Composes tricycliques a action inhibitrice a l'encontre de spla¿2? |
| AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
| MY125942A (en) | 1999-09-07 | 2006-09-29 | Upjohn Co | Aminoalkoxy carbazoles for the treatment of cns diseases |
| US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
| AU2728301A (en) * | 2000-01-06 | 2001-07-16 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
| WO2002000256A1 (en) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
| WO2002000621A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Composes inhibiteurs de la spla2 de type x |
| US6872743B2 (en) | 2000-12-18 | 2005-03-29 | Eli Lilly And Company | sPLA2 inhibitors |
| TWI314457B (es) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| DK1852433T3 (da) | 2004-10-29 | 2012-01-30 | Zeria Pharm Co Ltd | Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf |
| US10632102B2 (en) | 2015-06-15 | 2020-04-28 | Raziel Therapeutics Ltd | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
| CN112409493B (zh) * | 2020-08-12 | 2022-09-30 | 浙江工业大学 | 一种重组融合酶及其在乙醛酸甲酯合成中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3479391A (en) * | 1966-10-03 | 1969-11-18 | Squibb & Sons Inc | Delta**3,14-17alpha-hydroxy-norprogesterone and esters |
| US3939177A (en) * | 1972-11-22 | 1976-02-17 | Sterling Drug Inc. | 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles |
| US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
-
1997
- 1997-10-23 NZ NZ335246A patent/NZ335246A/en unknown
- 1997-10-23 WO PCT/US1997/019183 patent/WO1998018464A1/en not_active Application Discontinuation
- 1997-10-23 EA EA199900305A patent/EA003992B1/ru not_active IP Right Cessation
- 1997-10-23 YU YU19299A patent/YU19299A/sh unknown
- 1997-10-23 AU AU51494/98A patent/AU734096B2/en not_active Ceased
- 1997-10-23 IL IL12948197A patent/IL129481A0/xx unknown
- 1997-10-23 CA CA002269203A patent/CA2269203A1/en not_active Abandoned
- 1997-10-23 BR BR9713261-6A patent/BR9713261A/pt unknown
- 1997-10-23 PL PL97332896A patent/PL332896A1/xx unknown
- 1997-10-23 JP JP10520585A patent/JP2001503055A/ja active Pending
- 1997-10-23 TR TR1999/00956T patent/TR199900956T2/xx unknown
- 1997-10-23 CN CN97198834A patent/CN1233176A/zh active Pending
- 1997-10-23 CZ CZ991368A patent/CZ136899A3/cs unknown
- 1997-10-23 KR KR1019990703309A patent/KR20000049210A/ko not_active Application Discontinuation
- 1997-10-24 PE PE1997000950A patent/PE10999A1/es not_active Application Discontinuation
- 1997-10-27 ID IDP973534A patent/ID18685A/id unknown
- 1997-10-28 CO CO97063171A patent/CO4920250A1/es unknown
- 1997-10-28 AR ARP970104997A patent/AR010050A1/es active IP Right Grant
- 1997-10-29 ES ES97308645T patent/ES2202560T3/es not_active Expired - Lifetime
- 1997-10-29 DE DE69723393T patent/DE69723393T2/de not_active Expired - Lifetime
- 1997-10-29 AT AT97308645T patent/ATE244703T1/de active
- 1997-10-29 PT PT97308645T patent/PT839806E/pt unknown
- 1997-10-29 EP EP97308645A patent/EP0839806B1/en not_active Expired - Lifetime
- 1997-10-29 DK DK97308645T patent/DK0839806T3/da active
- 1997-10-30 TW TW086116217A patent/TW513428B/zh not_active IP Right Cessation
-
1999
- 1999-04-16 NO NO19991831A patent/NO314899B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO991831D0 (no) | 1999-04-16 |
| CA2269203A1 (en) | 1998-05-07 |
| EA003992B1 (ru) | 2003-12-25 |
| NO991831L (no) | 1999-06-21 |
| TW513428B (en) | 2002-12-11 |
| AR010050A1 (es) | 2000-05-17 |
| NZ335246A (en) | 2001-09-28 |
| ID18685A (id) | 1998-04-30 |
| TR199900956T2 (xx) | 1999-07-21 |
| AU5149498A (en) | 1998-05-22 |
| BR9713261A (pt) | 2000-03-28 |
| IL129481A0 (en) | 2000-02-29 |
| ATE244703T1 (de) | 2003-07-15 |
| CO4920250A1 (es) | 2000-05-29 |
| CN1233176A (zh) | 1999-10-27 |
| YU19299A (sh) | 2000-03-21 |
| AU734096B2 (en) | 2001-06-07 |
| EP0839806A1 (en) | 1998-05-06 |
| CZ136899A3 (cs) | 1999-09-15 |
| EP0839806B1 (en) | 2003-07-09 |
| PT839806E (pt) | 2003-11-28 |
| PL332896A1 (en) | 1999-10-25 |
| KR20000049210A (ko) | 2000-07-25 |
| NO314899B1 (no) | 2003-06-10 |
| EA199900305A1 (ru) | 1999-12-29 |
| JP2001503055A (ja) | 2001-03-06 |
| WO1998018464A1 (en) | 1998-05-07 |
| ES2202560T3 (es) | 2004-04-01 |
| DE69723393T2 (de) | 2004-06-09 |
| DE69723393D1 (de) | 2003-08-14 |
| DK0839806T3 (da) | 2003-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |