EA199900305A1 - Замещенные трициклические соединения - Google Patents
Замещенные трициклические соединенияInfo
- Publication number
- EA199900305A1 EA199900305A1 EA199900305A EA199900305A EA199900305A1 EA 199900305 A1 EA199900305 A1 EA 199900305A1 EA 199900305 A EA199900305 A EA 199900305A EA 199900305 A EA199900305 A EA 199900305A EA 199900305 A1 EA199900305 A1 EA 199900305A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tricyclic compounds
- substituted tricyclic
- compounds
- spla
- mediated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Pyridine Compounds (AREA)
Abstract
Описывается класс новых трициклических соединений и применение таких соединений для ингибирования опосредуемого сФЛАвысвобождения жирных кислот с целью лечения таких состояний, как септический шок.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2984996P | 1996-10-30 | 1996-10-30 | |
PCT/US1997/019183 WO1998018464A1 (en) | 1996-10-30 | 1997-10-23 | Substituted tricyclics |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900305A1 true EA199900305A1 (ru) | 1999-12-29 |
EA003992B1 EA003992B1 (ru) | 2003-12-25 |
Family
ID=21851210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900305A EA003992B1 (ru) | 1996-10-30 | 1997-10-23 | Замещенные трициклические соединения |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0839806B1 (ru) |
JP (1) | JP2001503055A (ru) |
KR (1) | KR20000049210A (ru) |
CN (1) | CN1233176A (ru) |
AR (1) | AR010050A1 (ru) |
AT (1) | ATE244703T1 (ru) |
AU (1) | AU734096B2 (ru) |
BR (1) | BR9713261A (ru) |
CA (1) | CA2269203A1 (ru) |
CO (1) | CO4920250A1 (ru) |
CZ (1) | CZ136899A3 (ru) |
DE (1) | DE69723393T2 (ru) |
DK (1) | DK0839806T3 (ru) |
EA (1) | EA003992B1 (ru) |
ES (1) | ES2202560T3 (ru) |
ID (1) | ID18685A (ru) |
IL (1) | IL129481A0 (ru) |
NO (1) | NO314899B1 (ru) |
NZ (1) | NZ335246A (ru) |
PE (1) | PE10999A1 (ru) |
PL (1) | PL332896A1 (ru) |
PT (1) | PT839806E (ru) |
TR (1) | TR199900956T2 (ru) |
TW (1) | TW513428B (ru) |
WO (1) | WO1998018464A1 (ru) |
YU (1) | YU19299A (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2301586A1 (en) * | 1997-08-28 | 1999-03-04 | William Louis Macias | Method for treatment of non-rheumatoid arthritis |
HUP0102981A3 (en) | 1998-03-31 | 2002-10-28 | Shionogi & Co | Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof |
ID23219A (id) * | 1998-04-17 | 2000-03-30 | Lilly Co Eli | Trisiklik tersubstitusi |
DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
SK16342000A3 (sk) | 1998-05-01 | 2002-04-04 | Eli Lilly And Company | Liečivo na liečbu zápalového ochorenia čreva obsahujúce 1H-indol-3-glyoxylamidy |
EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
EP1157704B1 (en) | 1998-10-14 | 2006-06-14 | Shionogi & Co., Ltd. | Spla2 inhibitors for the treatment of ischaemic reperfusion injury |
EP1140943B1 (en) * | 1998-12-22 | 2003-08-13 | Eli Lilly And Company | Substituted pyrroloindoles |
AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
JP4636522B2 (ja) | 1999-08-02 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環式化合物 |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
MY125942A (en) | 1999-09-07 | 2006-09-29 | Upjohn Co | Aminoalkoxy carbazoles for the treatment of cns diseases |
US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
AU2728301A (en) * | 2000-01-06 | 2001-07-16 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
US7026318B2 (en) | 2000-06-29 | 2006-04-11 | Shionogi & Co., Ltd. | Compounds exhibiting X-type sPLA2 inhibiting effect |
WO2002000256A1 (en) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
US6872743B2 (en) | 2000-12-18 | 2005-03-29 | Eli Lilly And Company | sPLA2 inhibitors |
TWI314457B (ru) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
ATE534646T1 (de) | 2004-10-29 | 2011-12-15 | Zeria Pharm Co Ltd | Carbazolderivat, solvat davon und pharmazeutisch unbedenkliches salz davon |
WO2016203468A1 (en) * | 2015-06-15 | 2016-12-22 | Raziel Therapeutics Ltd. | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
CN112409493B (zh) * | 2020-08-12 | 2022-09-30 | 浙江工业大学 | 一种重组融合酶及其在乙醛酸甲酯合成中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3479391A (en) * | 1966-10-03 | 1969-11-18 | Squibb & Sons Inc | Delta**3,14-17alpha-hydroxy-norprogesterone and esters |
US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
US3939177A (en) * | 1972-11-22 | 1976-02-17 | Sterling Drug Inc. | 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles |
US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
-
1997
- 1997-10-23 WO PCT/US1997/019183 patent/WO1998018464A1/en not_active Application Discontinuation
- 1997-10-23 BR BR9713261-6A patent/BR9713261A/pt unknown
- 1997-10-23 YU YU19299A patent/YU19299A/sh unknown
- 1997-10-23 CZ CZ991368A patent/CZ136899A3/cs unknown
- 1997-10-23 CA CA002269203A patent/CA2269203A1/en not_active Abandoned
- 1997-10-23 PL PL97332896A patent/PL332896A1/xx unknown
- 1997-10-23 EA EA199900305A patent/EA003992B1/ru not_active IP Right Cessation
- 1997-10-23 TR TR1999/00956T patent/TR199900956T2/xx unknown
- 1997-10-23 NZ NZ335246A patent/NZ335246A/en unknown
- 1997-10-23 AU AU51494/98A patent/AU734096B2/en not_active Ceased
- 1997-10-23 IL IL12948197A patent/IL129481A0/xx unknown
- 1997-10-23 JP JP10520585A patent/JP2001503055A/ja active Pending
- 1997-10-23 CN CN97198834A patent/CN1233176A/zh active Pending
- 1997-10-23 KR KR1019990703309A patent/KR20000049210A/ko not_active Application Discontinuation
- 1997-10-24 PE PE1997000950A patent/PE10999A1/es not_active Application Discontinuation
- 1997-10-27 ID IDP973534A patent/ID18685A/id unknown
- 1997-10-28 CO CO97063171A patent/CO4920250A1/es unknown
- 1997-10-28 AR ARP970104997A patent/AR010050A1/es active IP Right Grant
- 1997-10-29 DK DK97308645T patent/DK0839806T3/da active
- 1997-10-29 EP EP97308645A patent/EP0839806B1/en not_active Expired - Lifetime
- 1997-10-29 PT PT97308645T patent/PT839806E/pt unknown
- 1997-10-29 DE DE69723393T patent/DE69723393T2/de not_active Expired - Lifetime
- 1997-10-29 ES ES97308645T patent/ES2202560T3/es not_active Expired - Lifetime
- 1997-10-29 AT AT97308645T patent/ATE244703T1/de active
- 1997-10-30 TW TW086116217A patent/TW513428B/zh not_active IP Right Cessation
-
1999
- 1999-04-16 NO NO19991831A patent/NO314899B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TR199900956T2 (xx) | 1999-07-21 |
ID18685A (id) | 1998-04-30 |
DE69723393D1 (de) | 2003-08-14 |
CZ136899A3 (cs) | 1999-09-15 |
PE10999A1 (es) | 1999-02-10 |
KR20000049210A (ko) | 2000-07-25 |
WO1998018464A1 (en) | 1998-05-07 |
IL129481A0 (en) | 2000-02-29 |
AR010050A1 (es) | 2000-05-17 |
EP0839806A1 (en) | 1998-05-06 |
YU19299A (sh) | 2000-03-21 |
CN1233176A (zh) | 1999-10-27 |
NO314899B1 (no) | 2003-06-10 |
AU734096B2 (en) | 2001-06-07 |
NO991831D0 (no) | 1999-04-16 |
CO4920250A1 (es) | 2000-05-29 |
ATE244703T1 (de) | 2003-07-15 |
TW513428B (en) | 2002-12-11 |
NZ335246A (en) | 2001-09-28 |
JP2001503055A (ja) | 2001-03-06 |
ES2202560T3 (es) | 2004-04-01 |
PL332896A1 (en) | 1999-10-25 |
PT839806E (pt) | 2003-11-28 |
DE69723393T2 (de) | 2004-06-09 |
EP0839806B1 (en) | 2003-07-09 |
AU5149498A (en) | 1998-05-22 |
NO991831L (no) | 1999-06-21 |
CA2269203A1 (en) | 1998-05-07 |
EA003992B1 (ru) | 2003-12-25 |
BR9713261A (pt) | 2000-03-28 |
DK0839806T3 (da) | 2003-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |