PE109298A1 - Compuestos heterociclicos inhibidores de metaloproteasas - Google Patents
Compuestos heterociclicos inhibidores de metaloproteasasInfo
- Publication number
- PE109298A1 PE109298A1 PE1997000772A PE00077297A PE109298A1 PE 109298 A1 PE109298 A1 PE 109298A1 PE 1997000772 A PE1997000772 A PE 1997000772A PE 00077297 A PE00077297 A PE 00077297A PE 109298 A1 PE109298 A1 PE 109298A1
- Authority
- PE
- Peru
- Prior art keywords
- hetero
- aryl
- compounds
- alkyl
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: Ar ES ALQUILO, ARILO, CARBOCICLO, HETEROCICLO O HETEROARILO; "W" ES O o S; "Y" ES H, OH, OXO, ENTRE OTROS; "Z" ES (CH2)m(CR1R2)oSR3, -(SH)CHCH2COOCH3 o -(SH)CHCH2SR3; R1 ES H, ALQUILO, CH2SR3, CH2C(W)R4; R2 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, ARILO, ENTRE OTROS, DE PREFERENCIA ES HETEROARILO; R4 ES ALCOXI, OH, NR5, ALQUILTIO o TIO; R5 ES HETEROCICLILALQUILO, ALQUILO, ARILO, ENTRE OTROS; n ES 1; 2 o 3, DE PREFERENCIA n ES 2; m Y o SON 0; 1 o 2. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES DE LAS ENZIMAS METALOPROTEASAS DE LA MATRIZ, SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOARTRITIS, METASTASIS DE LAS CELULAS DEL TUMOR, DESORDENES CARDIOVASCULARES, DESORDENES OCULARES Y LESIONES ULCERATIVAS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2474696P | 1996-08-28 | 1996-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE109298A1 true PE109298A1 (es) | 1999-01-31 |
Family
ID=21822181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000772A PE109298A1 (es) | 1996-08-28 | 1997-08-28 | Compuestos heterociclicos inhibidores de metaloproteasas |
Country Status (20)
Country | Link |
---|---|
US (1) | US6121272A (es) |
EP (1) | EP0923547A1 (es) |
JP (1) | JP2000516954A (es) |
KR (1) | KR20000035921A (es) |
CN (1) | CN1228767A (es) |
AU (1) | AU4074097A (es) |
BR (1) | BR9712792A (es) |
CA (1) | CA2263914A1 (es) |
CO (1) | CO5420196A1 (es) |
CZ (1) | CZ62499A3 (es) |
HU (1) | HUP0000616A2 (es) |
ID (1) | ID18417A (es) |
IL (1) | IL128665A0 (es) |
NO (1) | NO990896L (es) |
PE (1) | PE109298A1 (es) |
PL (1) | PL331803A1 (es) |
SK (1) | SK24899A3 (es) |
TR (1) | TR199900401T2 (es) |
WO (1) | WO1998008814A1 (es) |
ZA (1) | ZA977697B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001513484A (ja) | 1997-07-31 | 2001-09-04 | ザ プロクター アンド ギャンブル カンパニー | 非環式メタロプロテアーゼ阻害剤 |
US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
HUP0101176A3 (en) | 1998-02-04 | 2002-06-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them |
US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
CN1295561A (zh) | 1998-06-03 | 2001-05-16 | Gpinil控股公司 | N-杂环羧酸或羧酸等排物的n-结合氨磺酰 |
CA2344412A1 (en) | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Thiol compound, their production and use |
BR0009244A (pt) | 1999-03-03 | 2002-04-16 | Procter & Gamble | Inibidores de metaloprotease di-hétero substituìdos |
HUP0202199A2 (en) | 1999-03-03 | 2002-10-28 | Procter & Gamble | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
AU6499000A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent compounds |
AU6388500A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent sulfonamides |
PE20020102A1 (es) | 2000-06-30 | 2002-03-06 | Procter & Gamble | Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
AU7847901A (en) * | 2000-07-19 | 2002-02-05 | Hoffmann La Roche | Pyrrolidine derivatives as metalloprotease inhibitors |
BR0112580A (pt) * | 2000-07-19 | 2003-06-17 | Hoffmann La Roche | Compostos, composições farmacêuticas que contêm os mesmos, utilização desses compostos, processo para tratamento terapêutico e/ou profilático e processo para a preparação desses compostos |
BR0112656A (pt) * | 2000-07-19 | 2003-06-24 | Hoffmann La Roche | Compostos, composições farmacêuticas que contêm os mesmos, utilização desses compostos,: processo para tratamento terapêutico e/ou profilático e processo para a preparação desses compostos |
FR2819252A1 (fr) * | 2001-01-11 | 2002-07-12 | Servier Lab | Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
WO2004056766A1 (en) * | 2002-12-19 | 2004-07-08 | Vertex Pharmaceuticals Incorporated | Inhibitors of tace |
WO2008130718A1 (en) | 2007-04-23 | 2008-10-30 | Atherogenics, Inc. | Sulfonamide containing compounds for treatment of inflammatory disorders |
CN106905183B (zh) * | 2017-02-24 | 2018-07-31 | 三峡大学 | 一类含氨基的ɑ-酰氧基羰基酰胺类衍生物,制备方法及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3501489A (en) * | 1966-01-21 | 1970-03-17 | American Home Prod | 1-phenylsulfonyl-2-(2-thiazolin-2-yl-oxy and thiol) pyrrolidines |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
IT1215590B (it) * | 1987-06-29 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzene solfonil 2-oco 5-alchiltio pirrolidina, un loro procedimentodi preparazione e il loro impiegocome stostanze medicinali. |
GB8814813D0 (en) * | 1988-06-22 | 1988-07-27 | Beecham Group Plc | Novel compounds |
DE4011172A1 (de) * | 1990-04-06 | 1991-10-10 | Degussa | Verbindungen zur bekaempfung von pflanzenkrankheiten |
DK0471236T3 (da) * | 1990-07-30 | 1995-07-24 | Takeda Chemical Industries Ltd | Imidazopyridinderivater og deres anvendelse |
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
US6090785A (en) * | 1992-10-15 | 2000-07-18 | Merck & Co., Inc. | Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5470834A (en) * | 1993-10-06 | 1995-11-28 | Florida State University | Sulfoximine and suldodiimine matrix metalloproteinase inhibitors |
US5455262A (en) * | 1993-10-06 | 1995-10-03 | Florida State University | Mercaptosulfide metalloproteinase inhibitors |
GB2303850B (en) * | 1994-06-22 | 1998-06-10 | British Biotech Pharm | Metalloproteinase inhibitors |
PT848004E (pt) * | 1995-07-31 | 2003-07-31 | Shionogi & Co | Derivados pirrolidina tendo actividade inibidora da fosfolipase a2 |
US6153757A (en) * | 1995-12-08 | 2000-11-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors and intermediates useful for their preparation |
-
1997
- 1997-07-09 BR BR9712792-2A patent/BR9712792A/pt unknown
- 1997-08-22 PL PL97331803A patent/PL331803A1/xx unknown
- 1997-08-22 JP JP10511714A patent/JP2000516954A/ja active Pending
- 1997-08-22 SK SK248-99A patent/SK24899A3/sk unknown
- 1997-08-22 TR TR1999/00401T patent/TR199900401T2/xx unknown
- 1997-08-22 CN CN97197547A patent/CN1228767A/zh active Pending
- 1997-08-22 IL IL12866597A patent/IL128665A0/xx unknown
- 1997-08-22 CZ CZ99624A patent/CZ62499A3/cs unknown
- 1997-08-22 EP EP97938411A patent/EP0923547A1/en not_active Withdrawn
- 1997-08-22 WO PCT/US1997/014554 patent/WO1998008814A1/en not_active Application Discontinuation
- 1997-08-22 AU AU40740/97A patent/AU4074097A/en not_active Withdrawn
- 1997-08-22 KR KR1019997001657A patent/KR20000035921A/ko not_active Application Discontinuation
- 1997-08-22 HU HU0000616A patent/HUP0000616A2/hu unknown
- 1997-08-22 CA CA002263914A patent/CA2263914A1/en not_active Abandoned
- 1997-08-26 US US08/918,318 patent/US6121272A/en not_active Expired - Fee Related
- 1997-08-27 ZA ZA9407697A patent/ZA977697B/xx unknown
- 1997-08-27 CO CO97049500A patent/CO5420196A1/es not_active Application Discontinuation
- 1997-08-28 PE PE1997000772A patent/PE109298A1/es not_active Application Discontinuation
- 1997-08-28 ID IDP972998A patent/ID18417A/id unknown
-
1999
- 1999-02-25 NO NO990896A patent/NO990896L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL331803A1 (en) | 1999-08-02 |
CN1228767A (zh) | 1999-09-15 |
JP2000516954A (ja) | 2000-12-19 |
HUP0000616A2 (en) | 2000-07-28 |
ZA977697B (en) | 1998-02-23 |
US6121272A (en) | 2000-09-19 |
BR9712792A (pt) | 1999-12-14 |
SK24899A3 (en) | 2000-04-10 |
CZ62499A3 (cs) | 1999-07-14 |
CA2263914A1 (en) | 1998-03-05 |
CO5420196A1 (es) | 2004-07-30 |
ID18417A (id) | 1998-04-09 |
IL128665A0 (en) | 2000-01-31 |
EP0923547A1 (en) | 1999-06-23 |
AU4074097A (en) | 1998-03-19 |
NO990896D0 (no) | 1999-02-25 |
TR199900401T2 (xx) | 1999-05-21 |
KR20000035921A (ko) | 2000-06-26 |
WO1998008814A1 (en) | 1998-03-05 |
NO990896L (no) | 1999-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FX | Voluntary withdrawal |