DE69810800T2 - Azetidinonderivate zur behandlung von hcmv entzündungen - Google Patents

Azetidinonderivate zur behandlung von hcmv entzündungen

Info

Publication number: DE69810800T2
Authority: DE; Germany
Prior art keywords: lower alkyl; phenyl; het; optionally substituted; alkyl
Prior art date: 1997-10-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69810800T

Other languages

English (en)

Other versions

DE69810800D1 (de

Inventor

Christiane Yoakim

Catherine Chabot

Robert Deziel

Stephen Kawai

W Ogilvie

Jeffrey O'meara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Canada Ltd

Original Assignee

Boehringer Ingelheim Canada Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-07

Filing date

1998-10-06

Publication date

2003-09-18

1998-10-06 Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd

2003-02-20 Application granted granted Critical

2003-02-20 Publication of DE69810800D1 publication Critical patent/DE69810800D1/de

2003-09-18 Publication of DE69810800T2 publication Critical patent/DE69810800T2/de

2018-10-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

241000701024 Human betaherpesvirus 5 Species 0.000 title 1
206010061218 Inflammation Diseases 0.000 title 1
HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical class C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 title 1
230000004054 inflammatory process Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
206010011831 Cytomegalovirus infection Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
-1 methoxy, ethoxy Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DE69810800T 1997-10-07 1998-10-06 Azetidinonderivate zur behandlung von hcmv entzündungen Expired - Lifetime DE69810800T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6154897P	1997-10-07	1997-10-07
PCT/CA1998/000954 WO1999018073A1 (en)	1997-10-07	1998-10-06	Azetidinone derivatives for the treatment of hcmv infections

Publications (2)

Publication Number	Publication Date
DE69810800D1 DE69810800D1 (de)	2003-02-20
DE69810800T2 true DE69810800T2 (de)	2003-09-18

Family

ID=22036473

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69810800T Expired - Lifetime DE69810800T2 (de)	1997-10-07	1998-10-06	Azetidinonderivate zur behandlung von hcmv entzündungen

Country Status (10)

Country	Link
US (1)	US6211170B1 (de)
EP (1)	EP1023265B1 (de)
JP (1)	JP2001519330A (de)
AT (1)	ATE231124T1 (de)
AU (1)	AU9426198A (de)
CA (1)	CA2301967C (de)
DE (1)	DE69810800T2 (de)
DK (1)	DK1023265T3 (de)
ES (1)	ES2187064T3 (de)
WO (1)	WO1999018073A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7541357B2 (en)	2004-07-15	2009-06-02	Amr Technology, Inc.	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0608899D0 (en) *	2006-05-05	2006-06-14	Leuven K U Res & Dev	Novel viral replication inhibitors
WO2009045382A1 (en) *	2007-10-04	2009-04-09	Merck & Co., Inc.	Substituted aryl sulfone derivatives as calcium channel blockers
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
CN102458123A (zh) *	2009-05-12	2012-05-16	阿尔巴尼分子研究公司	芳基、杂芳基和杂环取代的四氢异喹啉及其用途
PE20120373A1 (es) *	2009-05-12	2012-05-17	Albany Molecular Res Inc	7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
WO2014055644A2 (en) *	2012-10-02	2014-04-10	New York University	Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated rna decay
AU2019339777B2 (en)	2018-09-12	2022-09-01	Novartis Ag	Antiviral pyridopyrazinedione compounds
CA3155287A1 (en)	2019-09-26	2021-04-01	Novartis Ag	Antiviral pyrazolopyridinone compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en)	1983-12-01	1993-07-20	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
NZ228600A (en) *	1988-04-11	1992-02-25	Merck & Co Inc	1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives
EP0377549B1 (de)	1989-01-03	1998-12-09	Marcos Y. Kleinerman	Fernmessung physikalischer Variablen mit faseroptischen Systemen
US5104862A (en)	1991-03-20	1992-04-14	Merck & Co., Inc.	Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en)	1991-03-20	1992-03-31	Merck & Co., Inc.	Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
GB2266527A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted azetidinones useful in the treatment of leukemia
GB9314350D0 (en) *	1993-07-12	1993-08-25	Zeneca Ltd	Armide derivatives
BR9507165A (pt) *	1994-03-23	1997-09-09	Tokyo Tanase Company Limited	Inibidor da triptase clara agente terapêutico ou profilático para doenças virais processo terapêutico para doenças virais e uso da antileucoprotease

1998
- 1998-10-06 US US09/167,141 patent/US6211170B1/en not_active Expired - Lifetime
- 1998-10-06 JP JP2000514885A patent/JP2001519330A/ja not_active Ceased
- 1998-10-06 ES ES98947257T patent/ES2187064T3/es not_active Expired - Lifetime
- 1998-10-06 AU AU94261/98A patent/AU9426198A/en not_active Abandoned
- 1998-10-06 DE DE69810800T patent/DE69810800T2/de not_active Expired - Lifetime
- 1998-10-06 EP EP98947257A patent/EP1023265B1/de not_active Expired - Lifetime
- 1998-10-06 WO PCT/CA1998/000954 patent/WO1999018073A1/en active IP Right Grant
- 1998-10-06 AT AT98947257T patent/ATE231124T1/de active
- 1998-10-06 DK DK98947257T patent/DK1023265T3/da active
- 1998-10-06 CA CA002301967A patent/CA2301967C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2301967A1 (en)	1999-04-15
ATE231124T1 (de)	2003-02-15
CA2301967C (en)	2005-05-17
DE69810800D1 (de)	2003-02-20
DK1023265T3 (da)	2003-02-24
ES2187064T3 (es)	2003-05-16
WO1999018073A1 (en)	1999-04-15
EP1023265B1 (de)	2003-01-15
EP1023265A1 (de)	2000-08-02
AU9426198A (en)	1999-04-27
JP2001519330A (ja)	2001-10-23
US6211170B1 (en)	2001-04-03

Legal Events

Date	Code	Title	Description
2004-02-12	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE69902634T2 (de)	2003-04-24	Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien
NO931529L (no)	1993-10-29	Cykliske fruktopyranosesulfitter og -sulfater med antikonvulsiv effekt
MX9701765A (es)	1997-06-28	Derivado heterociclico y medicina.
MY104652A (en)	1994-05-31	A spiro compound
PT849269E (pt)	2002-11-29	Vinil-pirrolidina cefalosporinas com substituintes basicos
DE69810800T2 (de)	2003-09-18	Azetidinonderivate zur behandlung von hcmv entzündungen
FI925871A0 (fi)	1992-12-23	Menetelmä terapeuttisesti aktiivisten fenyyliguanidiinijohdannaisten valmistamiseksi
DE3888340D1 (de)	1994-04-14	Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
ATE324113T1 (de)	2006-05-15	Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom
DE69127072D1 (de)	1997-09-04	Substituierte harnstoffe, herstellung und verwendung
DE69502587T2 (de)	1998-11-26	2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e] [1,4]diazepine und ihre verwendung zur vorbeugung und behandlung von hiv-infektion
ATE83234T1 (de)	1992-12-15	Oxadiazol-pyrimidinone, ihre herstellung und ihre kosmetische und dermopharmazeutische verwendung.
DE69808326D1 (de)	2002-10-31	Azetidinonderivate zur behandlung von hcmv entzündungen
DE69810651D1 (de)	2003-02-13	Azetidinonderivate zur behandlung von hcmv entzündungen
ATE250594T1 (de)	2003-10-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
MX9606531A (es)	1997-06-28	Compuestos farmaceuticos.
ATE215075T1 (de)	2002-04-15	Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend
NZ336876A (en)	2000-12-22	Process for preparation of 4-H-4-oxo-quinolizine-3-carboxylic acid derivatives
DE3770481D1 (de)	1991-07-11	Verwendung von imidazochinazolinen zur behandlung und verhinderung von nephritis.
SE8702697D0 (sv)	1987-06-30	Method of treating ischaemic vascular diseases
ATE227718T1 (de)	2002-11-15	N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen